Details for: CD7

Gene ID: 924

Gene Type:  Protein-coding  - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: CD7

Ensembl ID: ENSG00000173762

Description: CD7 molecule

Selected Context(s):  Overall

Cell Significance Landscape

Contexts:

Associated with

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

  • CD16-positive, CD56-dim natural killer cell, human CL0000939
    CSI 117.53
    rCSI 78.33%
    PRS 97.7
  • CD16-negative, CD56-bright natural killer cell, human CL0000938
    CSI 106.55
    rCSI 79.9%
    PRS 98.5
  • central memory CD8-positive, alpha-beta T cell CL0000907
    CSI 104.84
    rCSI 70.63%
    PRS 99.1
  • activated type II NK T cell CL0000931
    CSI 67.94
    rCSI 76.46%
    PRS 98.41
  • group 3 innate lymphoid cell CL0001071
    CSI 67.06
    rCSI 50.39%
    PRS 96.7
  • naive thymus-derived CD8-positive, alpha-beta T cell CL0000900
    CSI 56.18
    rCSI 39.46%
    PRS 98.28
  • double-positive, alpha-beta thymocyte CL0000809
    CSI 53.05
    rCSI 54.06%
    PRS 97.62
  • CD4-positive, alpha-beta memory T cell CL0000897
    CSI 50.75
    rCSI 36.43%
    PRS 98.96
  • gamma-delta T cell CL0000798
    CSI 48.05
    rCSI 56.44%
    PRS 96.63
  • T-helper 17 cell CL0000899
    CSI 41.84
    rCSI 33.22%
    PRS 99.15
  • mucosal invariant T cell CL0000940
    CSI 41.16
    rCSI 33.26%
    PRS 97.65
  • CD4-positive helper T cell CL0000492
    CSI 41.08
    rCSI 31.07%
    PRS 99
  • early lymphoid progenitor CL0000936
    CSI 40.58
    rCSI 35.64%
    PRS 97
  • effector CD8-positive, alpha-beta T cell CL0001050
    CSI 38.98
    rCSI 29.65%
    PRS 99.03
  • naive T cell CL0000898
    CSI 38.2
    rCSI 26.58%
    PRS 99.15
  • CD8-positive, CD28-negative, alpha-beta regulatory T cell CL0000920
    CSI 38.15
    rCSI 76.05%
    PRS 98.13
  • CD8-positive, alpha-beta memory T cell CL0000909
    CSI 36.33
    rCSI 37.94%
    PRS 97.91
  • plasmacytoid dendritic cell, human CL0001058
    CSI 34.68
    rCSI 24.22%
    PRS 96.93
  • alpha-beta T cell CL0000789
    CSI 34.27
    rCSI 40.15%
    PRS 98.52
  • mature T cell CL0002419
    CSI 31.9
    rCSI 24.81%
    PRS 98.7
  • intraepithelial lymphocyte CL0002496
    CSI 31.59
    rCSI 85.98%
    PRS 98.59
  • activated CD4-positive, alpha-beta T cell CL0000896
    CSI 31.54
    rCSI 29.15%
    PRS 98.85
  • fraction A pre-pro B cell CL0002045
    CSI 31.16
    rCSI 35.67%
    PRS 96.82
  • activated CD8-positive, alpha-beta T cell CL0000906
    CSI 30.41
    rCSI 29.9%
    PRS 97.82
  • erythrocyte CL0000232
    CSI 29.57
    rCSI 67.08%
    PRS 93.21
  • T follicular helper cell CL0002038
    CSI 29.19
    rCSI 21.85%
    PRS 98.75
  • megakaryocyte-erythroid progenitor cell CL0000050
    CSI 27.3
    rCSI 24.65%
    PRS 94.37
  • hematopoietic stem cell CL0000037
    CSI 26.93
    rCSI 17.9%
    PRS 95.84
  • mature NK T cell CL0000814
    CSI 26.9
    rCSI 34.41%
    PRS 96.91
  • effector memory CD8-positive, alpha-beta T cell CL0000913
    CSI 25.98
    rCSI 23.66%
    PRS 98.86
  • innate lymphoid cell CL0001065
    CSI 25.6
    rCSI 52.86%
    PRS 89.36
  • activated CD8-positive, alpha-beta T cell, human CL0001049
    CSI 25.11
    rCSI 42.96%
    PRS 97.94
  • naive thymus-derived CD4-positive, alpha-beta T cell CL0000895
    CSI 25.04
    rCSI 31.47%
    PRS 98.08
  • CD4-positive, alpha-beta thymocyte CL0000810
    CSI 24.61
    rCSI 19.71%
    PRS 95.9
  • CD8-positive, alpha-beta memory T cell, CD45RO-positive CL0001203
    CSI 24.05
    rCSI 29.14%
    PRS 78.5
  • natural killer cell CL0000623
    CSI 22.82
    rCSI 44.23%
    PRS 94.66
  • common myeloid progenitor CL0000049
    CSI 22.77
    rCSI 18.41%
    PRS 95.81
  • central memory CD4-positive, alpha-beta T cell CL0000904
    CSI 21.56
    rCSI 12.73%
    PRS 99.49
  • CD4-positive, CD25-positive, alpha-beta regulatory T cell CL0000792
    CSI 21.29
    rCSI 20.91%
    PRS 98.94
  • granulocyte CL0000094
    CSI 21.27
    rCSI 32.5%
    PRS 97.33
  • mononuclear phagocyte CL0000113
    CSI 20.79
    rCSI 45.76%
    PRS 96.66
  • natural T-regulatory cell CL0000903
    CSI 20.11
    rCSI 38.09%
    PRS 99.05
  • double negative thymocyte CL0002489
    CSI 19.29
    rCSI 13.41%
    PRS 98.76
  • CD8-positive, alpha-beta cytotoxic T cell CL0000794
    CSI 19.22
    rCSI 22.95%
    PRS 98.62
  • T-helper 1 cell CL0000545
    CSI 19.17
    rCSI 34.61%
    PRS 98.61
  • platelet CL0000233
    CSI 18.5
    rCSI 76.74%
    PRS 91.22
  • T cell CL0000084
    CSI 18.28
    rCSI 35.74%
    PRS 97.13
  • promyelocyte CL0000836
    CSI 17.02
    rCSI 24.55%
    PRS 95.86
  • effector memory CD4-positive, alpha-beta T cell CL0000905
    CSI 16.28
    rCSI 22.17%
    PRS 99.04
  • regulatory T cell CL0000815
    CSI 15.52
    rCSI 17.99%
    PRS 88.83
  • ependymal cell CL0000065
    CSI 14.17
    rCSI 28.76%
    PRS 81.54
  • common dendritic progenitor CL0001029
    CSI 13.22
    rCSI 16.59%
    PRS 97.57
  • memory T cell CL0000813
    CSI 12.8
    rCSI 24.66%
    PRS 98.78
  • group 2 innate lymphoid cell CL0001069
    CSI 12.62
    rCSI 68.27%
    PRS 98.65
  • thymocyte CL0000893
    CSI 11.8
    rCSI 41.95%
    PRS 99.01
  • M cell of gut CL0000682
    CSI 10.72
    rCSI 11.39%
    PRS 95.89
  • CD4-positive, alpha-beta cytotoxic T cell CL0000934
    CSI 9.91
    rCSI 13.62%
    PRS 99
  • effector CD4-positive, alpha-beta T cell CL0001044
    CSI 8.95
    rCSI 25.68%
    PRS 99.26
  • CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell CL0000915
    CSI 8.9
    rCSI 40.46%
    PRS 98.61
  • helper T cell CL0000912
    CSI 8.44
    rCSI 11.94%
    PRS 90.21
  • effector memory CD8-positive, alpha-beta T cell, terminally differentiated CL0001062
    CSI 8.21
    rCSI 41.17%
    PRS 98.53
  • decidual natural killer cell, human CL0002343
    CSI 7.9
    rCSI 80.34%
    PRS 97.27
  • plasmablast CL0000980
    CSI 7.23
    rCSI 5.69%
    PRS 95.83
  • CD8-positive, alpha-beta thymocyte CL0000811
    CSI 6.02
    rCSI 9.38%
    PRS 97.48
  • mature alpha-beta T cell CL0000791
    CSI 5.99
    rCSI 21.7%
    PRS 99.34
  • CD34-positive, CD56-positive, CD117-positive common innate lymphoid precursor, human CL0001074
    CSI 5.95
    rCSI 69.03%
    PRS 98.34
  • common lymphoid progenitor CL0000051
    CSI 5.92
    rCSI 7.91%
    PRS 98.73
  • activated CD4-positive, alpha-beta T cell, human CL0001043
    CSI 4.87
    rCSI 11.71%
    PRS 98.75
  • lung resident memory CD8-positive, alpha-beta T cell CL4033039
    CSI 3.88
    rCSI 10.05%
    PRS 98.52
  • dendritic cell, human CL0001056
    CSI 3.6
    rCSI 5.53%
    PRS 98.08
  • granulocyte monocyte progenitor cell CL0000557
    CSI 3.32
    rCSI 2.87%
    PRS 96.08
  • basophil mast progenitor cell CL0002028
    CSI 3.29
    rCSI 17.56%
    PRS 98.66
  • megakaryocyte CL0000556
    CSI 3.02
    rCSI 13.1%
    PRS 94.89
  • hepatic pit cell CL2000054
    CSI 2.61
    rCSI 35.81%
    PRS 96.63
  • myeloid lineage restricted progenitor cell CL0000839
    CSI 2.34
    rCSI 12.07%
    PRS 98.77
  • pro-T cell CL0000827
    CSI 2.1
    rCSI 48.88%
    PRS 99.24
  • lung resident memory CD4-positive, alpha-beta T cell CL4033038
    CSI 1.97
    rCSI 19.36%
    PRS 97.66
  • cytotoxic T cell CL0000910
    CSI 1.94
    rCSI 11.1%
    PRS 92.44
  • NKp44-negative group 3 innate lymphoid cell, human CL0001080
    CSI 1.93
    rCSI 59.93%
    PRS 98.51
  • myeloid dendritic cell CL0000782
    CSI 1.47
    rCSI 2.14%
    PRS 98.88
  • immature alpha-beta T cell CL0000790
    CSI 1.33
    rCSI 19.02%
    PRS 98.56
  • group 3 innate lymphoid cell, human CL0001078
    CSI 1.17
    rCSI 24.65%
    PRS 97.28
  • eosinophil CL0000771
    CSI 0.66
    rCSI 4.32%
    PRS 98.42
  • pre-conventional dendritic cell CL0002010
    CSI 0.56
    rCSI 7.36%
    PRS 98.68

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

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Comma-separated if multiple.
Legend:
  • Query Gene
  • Node Color (Target Cell CSI, relative to current network):
    • Very High
    • High
    • Medium
    • Low
    • Very Low
    • CSI N/A
  • Node Size: Proportional to Target Cell CSI magnitude
  • STRING PPI Edge
  • Shared Pathway Edge (ONTOLOGY)

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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

## Summary [CD7](/details-gene/924) is a protein-coding gene located on chromosome 17q25.3, which encodes a transmembrane glycoprotein that is a well-established marker for T-cells and natural killer (NK) cells. As a member of the immunoglobulin superfamily, it functions as a signaling receptor on the plasma membrane. Its high expression significance in various lymphocyte subsets, including [CD16-positive, CD56-dim natural killer cell, human](/details-cell/CL0000939), [CD16-negative, CD56-bright natural killer cell, human](/details-cell/CL0000938), and [central memory CD8-positive, alpha-beta T cell](/details-cell/CL0000907), underscores its integral role in the adaptive immune response. Functionally, [CD7](/details-gene/924) is implicated in critical processes such as [T cell activation](/details-go/GO:0042110) and the positive regulation of cytokine production, and it is clinically associated with certain types of T-cell leukemias ([186820](https://omim.org/entry/186820)). ## Cellular Roles and Expression Landscape The expression profile of [CD7](/details-gene/924) firmly establishes it as a key molecule within the lymphoid lineage. **Overall**, its significance is highest in cytotoxic and helper lymphocyte populations, indicating a fundamental role in both innate and adaptive cell-mediated immunity. The gene shows exceptional significance in natural killer (NK) cells, ranking as a top marker in both [CD16-positive, CD56-dim natural killer cell, human](/details-cell/CL0000939) (CSI: 117.53), known for their potent cytotoxic activity, and [CD16-negative, CD56-bright natural killer cell, human](/details-cell/CL0000938) (CSI: 106.55), which are primary cytokine producers. This dual prominence is consistent with early research identifying the expression and function of the [CD7](/details-gene/924) molecule on human NK cells ([Link](https://pubmed.ncbi.nlm.nih.gov/7506726/)). Similarly, [CD7](/details-gene/924) is highly significant across the T-cell developmental and differentiation spectrum. It is a defining feature of memory T-cells, such as [central memory CD8-positive, alpha-beta T cell](/details-cell/CL0000907) (CSI: 104.84), as well as developing thymocytes like the [double-positive, alpha-beta thymocyte](/details-cell/CL0000809). Its expression extends to other specialized T-cell subsets including [gamma-delta T cell](/details-cell/CL0000798), where it has been shown to be directly involved in their activation ([Link](https://doi.org/10.1002/eji.1830210515)). The broad expression across naive, effector, memory, and regulatory T-cell populations highlights [CD7](/details-gene/924) as a pan-T-cell marker crucial for T-cell biology. The high significance in [early lymphoid progenitor](/details-cell/CL0000936) cells further suggests a role beginning early in lymphocyte development. ## Pathways and Molecular Function The molecular functions of [CD7](/details-gene/924) are intrinsically linked to its role as an immune cell surface receptor. Gene Ontology annotations place it centrally within the [plasma membrane](/details-go/GO:0005886), where it exhibits [transmembrane signaling receptor activity](/details-go/GO:0004888). This is consistent with its structural characterization as a 40-kDa glycoprotein ([Link](https://pubmed.ncbi.nlm.nih.gov/2479685/)). Its primary biological processes involve orchestrating immune responses. [CD7](/details-gene/924) is a key participant in the [adaptive immune response](/details-go/GO:0002250), specifically in [T cell activation](/details-go/GO:0042110) and the [positive regulation of t cell cytokine production](/details-go/GO:0002726). The molecular mechanism for its signaling activity involves [protein binding](/details-go/GO:0005515); notably, [CD7](/details-gene/924) has been identified as a receptor for SECTM1 (secreted and transmembrane protein 1), providing a ligand-receptor axis for cell-cell communication ([Link](https://doi.org/10.1074/jbc.275.5.3431)). Quantitative phosphoproteomic studies have also confirmed its involvement in T cell receptor signaling networks ([Link](https://doi.org/10.1126/scisignal.2000007)), reinforcing its role as a modulator of T-cell function. ## Research Directions The widespread and highly significant expression of [CD7](/details-gene/924) across functionally distinct lymphocyte subsets presents key questions regarding its specific roles in lineage commitment, cellular activation, and memory formation. **Proposed Hypotheses:** 1. Given its high significance in both cytotoxic [CD16-positive, CD56-dim natural killer cell, human](/details-cell/CL0000939) and cytokine-producing [CD16-negative, CD56-bright natural killer cell, human](/details-cell/CL0000938), it is hypothesized that [CD7](/details-gene/924) signaling, upon engagement with its ligand SECTM1, differentially regulates the effector functions of these two NK subsets, potentially enhancing cytotoxicity in the former and cytokine secretion in the latter. 2. The prominent CSI score in [central memory CD8-positive, alpha-beta T cell](/details-cell/CL0000907)s suggests that [CD7](/details-gene/924) provides critical survival or maintenance signals for long-lived memory T-cells. We hypothesize that chronic or intermittent engagement of [CD7](/details-gene/924) is required to sustain the memory T-cell pool and facilitate a rapid recall response upon secondary antigen exposure. **Experimental Approach:** To test the second hypothesis regarding the role of [CD7](/details-gene/924) in memory T-cell maintenance, one could isolate [central memory CD8-positive, alpha-beta T cell](/details-cell/CL0000907)s from healthy human donors. The function of [CD7](/details-gene/924) could be blocked using a specific monoclonal antibody or silenced using a CRISPR-Cas9 approach. These manipulated cells, along with appropriate controls, would then be cultured *in vitro* with homeostatic cytokines (e.g., IL-7 and IL-15) to simulate survival conditions, or re-stimulated through the T-cell receptor (TCR) to model a recall response. The impact of [CD7](/details-gene/924) disruption would be assessed by measuring cell viability and proliferation via flow cytometry and effector function (e.g., IFN-gamma production) via ELISA or intracellular staining. A significant decrease in survival or recall capacity in the [CD7](/details-gene/924)-deficient cells would support its role in memory T-cell biology. **Therapeutic Potential:** As a cell surface glycoprotein highly expressed on T-cells, [CD7](/details-gene/924) is a prime therapeutic target, particularly in oncology. Its association with T-cell malignancies, such as T-cell acute lymphoblastic leukemia (T-ALL), makes it a candidate for targeted cell depletion. The therapeutic strategy would involve **inhibition** or **elimination** of [CD7](/details-gene/924)-expressing cancer cells. This could be achieved through several modalities, including antibody-drug conjugates (ADCs) that deliver a cytotoxic payload, or immunotherapy approaches like Chimeric Antigen Receptor (CAR) T-cell therapy directed against [CD7](/details-gene/924). While promising, targeting [CD7](/details-gene/924) presents the challenge of on-target, off-tumor toxicity due to its expression on healthy T-cells, which requires advanced engineering strategies to overcome.

Genular Protein ID: 3625797808

Symbol: CD7_HUMAN

Name: T-cell antigen CD7

UniProtKB Accession Codes:

P09564

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 1 ExpressionAtlas 1 GO 9 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3501369

Title: Molecular cloning of two CD7 (T-cell leukemia antigen) cDNAs by a COS cell expression system.

PubMed ID: 3501369

DOI: 10.1002/j.1460-2075.1987.tb02651.x

PubMed ID: 1703303

Title: Isolation and characterization of the genomic human CD7 gene: structural similarity with the murine Thy-1 gene.

PubMed ID: 1703303

DOI: 10.1073/pnas.88.2.603

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1711009

Title: Molecular cloning of the gene coding for the human T cell differentiation antigen CD7.

PubMed ID: 1711009

DOI: 10.1007/bf00216694

PubMed ID: 2479685

Title: Characterization of the surface topography and putative tertiary structure of the human CD7 molecule.

PubMed ID: 2479685

PubMed ID: 1709867

Title: Direct involvement of CD7 (gp40) in activation of TcR gamma/delta+ T cells.

PubMed ID: 1709867

DOI: 10.1002/eji.1830210515

PubMed ID: 7506726

Title: Expression and function of CD7 molecule on human natural killer cells.

PubMed ID: 7506726

PubMed ID: 10652336

Title: Identification of CD7 as a cognate of the human K12 (SECTM1) protein.

PubMed ID: 10652336

DOI: 10.1074/jbc.275.5.3431

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 19349973

Title: Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins.

PubMed ID: 19349973

DOI: 10.1038/nbt.1532

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

Sequence Information:

  • Length: 240
  • Mass: 25409
  • Checksum: EBBCE08279552108
  • Sequence:
    • MAGPPRLLLL PLLLALARGL PGALAAQEVQ QSPHCTTVPV GASVNITCST SGGLRGIYLR 
QLGPQPQDII YYEDGVVPTT DRRFRGRIDF SGSQDNLTIT MHRLQLSDTG TYTCQAITEV 
NVYGSGTLVL VTEEQSQGWH RCSDAPPRAS ALPAPPTGSA LPDPQTASAL PDPPAASALP 
AALAVISFLL GLGLGVACVL ARTQIKKLCS WRDKNSAACV VYEDMSHSRC NTLSSPNQYQ