Details for: CD7

Gene ID: 924

Symbol: CD7

Ensembl ID: ENSG00000173762

Description: CD7 molecule

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 130.5730
    Cell Significance Index: -20.3100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 82.0838
    Cell Significance Index: -20.8200
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 63.2017
    Cell Significance Index: -32.5100
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 50.9613
    Cell Significance Index: -24.0600
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: 42.4897
    Cell Significance Index: 113.8300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 16.2536
    Cell Significance Index: -20.0400
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 6.2186
    Cell Significance Index: -19.1000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 5.6360
    Cell Significance Index: -22.2400
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 5.2018
    Cell Significance Index: 152.7700
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 3.1658
    Cell Significance Index: 48.9800
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 2.5531
    Cell Significance Index: 25.6000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 2.2096
    Cell Significance Index: 47.8700
  • Cell Name: activated type II NK T cell (CL0000931)
    Fold Change: 1.5937
    Cell Significance Index: 4.0800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.2038
    Cell Significance Index: 229.0900
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.9555
    Cell Significance Index: 5.2100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.9243
    Cell Significance Index: 91.4400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.7513
    Cell Significance Index: 678.3600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.7083
    Cell Significance Index: 140.5600
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 0.5250
    Cell Significance Index: 1.6000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4624
    Cell Significance Index: 75.2100
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 0.3290
    Cell Significance Index: 3.5000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2651
    Cell Significance Index: 28.8400
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.1084
    Cell Significance Index: 1.5900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0539
    Cell Significance Index: 37.2800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0314
    Cell Significance Index: 2.1700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0169
    Cell Significance Index: 1.0900
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0035
    Cell Significance Index: -0.0600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0042
    Cell Significance Index: -0.1200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0045
    Cell Significance Index: -0.2300
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0063
    Cell Significance Index: -0.1600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0080
    Cell Significance Index: -0.2800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0118
    Cell Significance Index: -22.1700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0138
    Cell Significance Index: -25.5400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0165
    Cell Significance Index: -25.4700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0209
    Cell Significance Index: -15.5100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0213
    Cell Significance Index: -16.0900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0351
    Cell Significance Index: -19.1800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0356
    Cell Significance Index: -15.7500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0381
    Cell Significance Index: -1.2200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0397
    Cell Significance Index: -22.3900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0441
    Cell Significance Index: -32.3600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0447
    Cell Significance Index: -5.2100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0461
    Cell Significance Index: -2.0900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0504
    Cell Significance Index: -32.0200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0605
    Cell Significance Index: -27.4400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0630
    Cell Significance Index: -22.6000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0671
    Cell Significance Index: -1.4300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0939
    Cell Significance Index: -11.0800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0939
    Cell Significance Index: -27.0300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.1104
    Cell Significance Index: -2.7600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.1140
    Cell Significance Index: -22.8700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1298
    Cell Significance Index: -22.1700
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.1315
    Cell Significance Index: -1.1500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1380
    Cell Significance Index: -8.4600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.1403
    Cell Significance Index: -8.4200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.1413
    Cell Significance Index: -25.4700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1432
    Cell Significance Index: -19.6700
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.1470
    Cell Significance Index: -6.3900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1596
    Cell Significance Index: -18.2900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.1669
    Cell Significance Index: -21.3900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.1851
    Cell Significance Index: -22.7600
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1938
    Cell Significance Index: -4.0200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1981
    Cell Significance Index: -28.8000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.2025
    Cell Significance Index: -26.1700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.2085
    Cell Significance Index: -21.3000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2139
    Cell Significance Index: -22.2700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2162
    Cell Significance Index: -10.1600
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.2273
    Cell Significance Index: -3.8600
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.2283
    Cell Significance Index: -2.2300
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.2543
    Cell Significance Index: -3.4600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2561
    Cell Significance Index: -6.8500
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.2679
    Cell Significance Index: -2.5400
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: -0.2984
    Cell Significance Index: -2.2200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.3190
    Cell Significance Index: -24.4800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.3210
    Cell Significance Index: -5.5000
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.3410
    Cell Significance Index: -2.9100
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.3474
    Cell Significance Index: -3.2500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.3529
    Cell Significance Index: -23.7300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.3593
    Cell Significance Index: -26.7800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.3605
    Cell Significance Index: -22.7200
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.3702
    Cell Significance Index: -2.8800
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.3861
    Cell Significance Index: -4.5500
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.3955
    Cell Significance Index: -4.6700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.4019
    Cell Significance Index: -18.7400
  • Cell Name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell (CL0000802)
    Fold Change: -0.4173
    Cell Significance Index: -2.4200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.4193
    Cell Significance Index: -21.7800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.4229
    Cell Significance Index: -11.8200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.4288
    Cell Significance Index: -24.0600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.4310
    Cell Significance Index: -26.4900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.4802
    Cell Significance Index: -25.2100
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.4911
    Cell Significance Index: -8.2600
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: -0.4931
    Cell Significance Index: -4.3900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.4933
    Cell Significance Index: -12.6800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.5311
    Cell Significance Index: -23.4900
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.5849
    Cell Significance Index: -6.0600
  • Cell Name: mature T cell (CL0002419)
    Fold Change: -0.5976
    Cell Significance Index: -4.3000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.6201
    Cell Significance Index: -23.4800
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.6279
    Cell Significance Index: -23.0500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.6571
    Cell Significance Index: -23.0200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.6935
    Cell Significance Index: -22.7100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Transmembrane localization**: CD7 is a transmembrane receptor, spanning the cell membrane and interacting with the extracellular environment. 2. **Protein tyrosine kinase activity**: CD7 possesses intrinsic tyrosine kinase activity, which enables it to phosphorylate and regulate downstream signaling pathways. 3. **T cell specificity**: CD7 is predominantly expressed on mature T cells, including alpha-beta and gamma-delta T cells, but not on naive T cells or other immune cells. 4. **Innate lymphoid cell expression**: CD7 is also expressed on innate lymphoid cells, such as NKp46-positive cells, suggesting a broader role in innate immunity. 5. **Regulatory function**: CD7 is involved in regulating T cell activation, differentiation, and survival, making it a crucial component of the adaptive immune response. **Pathways and Functions:** 1. **T cell activation**: CD7 plays a key role in T cell activation by interacting with other surface molecules, such as CD28 and CTLA-4, and regulating signaling pathways. 2. **Differentiation and proliferation**: CD7 is involved in the differentiation and proliferation of T cells, particularly during the effector phase of immune responses. 3. **Survival and apoptosis**: CD7 regulates T cell survival and apoptosis, influencing the overall fate of T cells during immune responses. 4. **Signaling pathways**: CD7 activates various signaling pathways, including the PI3K/AKT and MAPK/ERK pathways, which regulate T cell function and survival. 5. **Immune regulation**: CD7 interacts with other immune molecules, such as cytokines and chemokines, to regulate immune responses and prevent autoimmunity. **Clinical Significance:** 1. **Cancer immunotherapy**: CD7 has been identified as a potential target for cancer immunotherapy, as its expression is often lost in cancer cells. 2. **Autoimmune diseases**: Dysregulation of CD7 expression has been implicated in various autoimmune diseases, such as multiple sclerosis and type 1 diabetes. 3. **Vaccine development**: CD7 has been explored as a potential antigen for vaccine development, as its expression is often preserved in healthy individuals. 4. **Immunodeficiency diseases**: CD7 is also involved in the regulation of natural killer cell function, making it a potential target for the treatment of immunodeficiency diseases. In conclusion, CD7 is a multifaceted molecule that plays a critical role in the adaptive immune response. Its complex expression profile and regulatory function make it an attractive target for the development of novel immunotherapies and vaccines. Further research is needed to fully elucidate the mechanisms by which CD7 regulates immune responses and to explore its potential therapeutic applications.

Genular Protein ID: 3625797808

Symbol: CD7_HUMAN

Name: T-cell antigen CD7

UniProtKB Accession Codes:

P09564

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 1 ExpressionAtlas 1 GO 9 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3501369

Title: Molecular cloning of two CD7 (T-cell leukemia antigen) cDNAs by a COS cell expression system.

PubMed ID: 3501369

DOI: 10.1002/j.1460-2075.1987.tb02651.x

PubMed ID: 1703303

Title: Isolation and characterization of the genomic human CD7 gene: structural similarity with the murine Thy-1 gene.

PubMed ID: 1703303

DOI: 10.1073/pnas.88.2.603

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1711009

Title: Molecular cloning of the gene coding for the human T cell differentiation antigen CD7.

PubMed ID: 1711009

DOI: 10.1007/bf00216694

PubMed ID: 2479685

Title: Characterization of the surface topography and putative tertiary structure of the human CD7 molecule.

PubMed ID: 2479685

PubMed ID: 1709867

Title: Direct involvement of CD7 (gp40) in activation of TcR gamma/delta+ T cells.

PubMed ID: 1709867

DOI: 10.1002/eji.1830210515

PubMed ID: 7506726

Title: Expression and function of CD7 molecule on human natural killer cells.

PubMed ID: 7506726

PubMed ID: 10652336

Title: Identification of CD7 as a cognate of the human K12 (SECTM1) protein.

PubMed ID: 10652336

DOI: 10.1074/jbc.275.5.3431

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 19349973

Title: Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins.

PubMed ID: 19349973

DOI: 10.1038/nbt.1532

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

Sequence Information:

  • Length: 240
  • Mass: 25409
  • Checksum: EBBCE08279552108
  • Sequence:
    • MAGPPRLLLL PLLLALARGL PGALAAQEVQ QSPHCTTVPV GASVNITCST SGGLRGIYLR 
QLGPQPQDII YYEDGVVPTT DRRFRGRIDF SGSQDNLTIT MHRLQLSDTG TYTCQAITEV 
NVYGSGTLVL VTEEQSQGWH RCSDAPPRAS ALPAPPTGSA LPDPQTASAL PDPPAASALP 
AALAVISFLL GLGLGVACVL ARTQIKKLCS WRDKNSAACV VYEDMSHSRC NTLSSPNQYQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.