NOG | ENSG00000183691 | NCBI 9241

Details for: NOG

Gene ID: 9241

Symbol: NOG

Ensembl ID: ENSG00000183691

Description: noggin

Associated with

Developmental biology
(R-HSA-1266738)
Formation of paraxial mesoderm
(R-HSA-9793380)
Gastrulation
(R-HSA-9758941)
Signaling by bmp
(R-HSA-201451)
Signaling by tgfb family members
(R-HSA-9006936)
Signal transduction
(R-HSA-162582)
Atrial cardiac muscle tissue morphogenesis
(GO:0055009)
Axial mesoderm development
(GO:0048318)
Bmp signaling pathway
(GO:0030509)
Cartilage development
(GO:0051216)
Cell differentiation in hindbrain
(GO:0021533)
Cranial skeletal system development
(GO:1904888)
Cytokine binding
(GO:0019955)
Dorsal/ventral pattern formation
(GO:0009953)
Embryonic digit morphogenesis
(GO:0042733)
Embryonic skeletal joint morphogenesis
(GO:0060272)
Embryonic skeletal system development
(GO:0048706)
Endocardial cushion formation
(GO:0003272)
Endoderm formation
(GO:0001706)
Epithelial cell proliferation
(GO:0050673)
Epithelial to mesenchymal transition
(GO:0001837)
Exploration behavior
(GO:0035640)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Face morphogenesis
(GO:0060325)
Fibroblast growth factor receptor signaling pathway
(GO:0008543)
Heart trabecula morphogenesis
(GO:0061384)
In utero embryonic development
(GO:0001701)
Limb development
(GO:0060173)
Long-term synaptic potentiation
(GO:0060291)
Lung morphogenesis
(GO:0060425)
Membranous septum morphogenesis
(GO:0003149)
Mesoderm formation
(GO:0001707)
Middle ear morphogenesis
(GO:0042474)
Motor neuron axon guidance
(GO:0008045)
Negative regulation of apoptotic signaling pathway
(GO:2001234)
Negative regulation of astrocyte differentiation
(GO:0048712)
Negative regulation of bmp signaling pathway
(GO:0030514)
Negative regulation of canonical wnt signaling pathway
(GO:0090090)
Negative regulation of cardiac epithelial to mesenchymal transition
(GO:0062044)
Negative regulation of cardiac muscle cell proliferation
(GO:0060044)
Negative regulation of cartilage development
(GO:0061037)
Negative regulation of cell migration
(GO:0030336)
Negative regulation of cytokine activity
(GO:0060302)
Negative regulation of gene expression
(GO:0010629)
Negative regulation of osteoblast differentiation
(GO:0045668)
Negative regulation of smad protein signal transduction
(GO:0060392)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Nervous system development
(GO:0007399)
Neural plate anterior/posterior regionalization
(GO:0021999)
Neural plate morphogenesis
(GO:0001839)
Neural tube closure
(GO:0001843)
Nodal signaling pathway
(GO:0038092)
Notochord morphogenesis
(GO:0048570)
Osteoblast differentiation
(GO:0001649)
Outflow tract morphogenesis
(GO:0003151)
Pharyngeal arch artery morphogenesis
(GO:0061626)
Pituitary gland development
(GO:0021983)
Positive regulation of branching involved in ureteric bud morphogenesis
(GO:0090190)
Positive regulation of epithelial cell proliferation
(GO:0050679)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of glomerulus development
(GO:0090193)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Presynapse
(GO:0098793)
Presynaptic modulation of chemical synaptic transmission
(GO:0099171)
Prostatic bud formation
(GO:0060513)
Protein binding
(GO:0005515)
Protein homodimerization activity
(GO:0042803)
Regulation of fibroblast growth factor receptor signaling pathway
(GO:0040036)
Regulation of neuronal synaptic plasticity
(GO:0048168)
Short-term synaptic potentiation
(GO:1990926)
Skeletal system development
(GO:0001501)
Smoothened signaling pathway
(GO:0007224)
Somatic stem cell population maintenance
(GO:0035019)
Somite development
(GO:0061053)
Spinal cord development
(GO:0021510)
Stem cell differentiation
(GO:0048863)
Ureteric bud formation
(GO:0060676)
Ventricular compact myocardium morphogenesis
(GO:0003223)
Ventricular septum morphogenesis
(GO:0060412)
Visual learning
(GO:0008542)
Wound healing
(GO:0042060)

Other Information

Proteins

Noggin

Genular Protein ID: 1583438292

Symbol: NOGG_HUMAN

Name: Noggin

UniProtKB Accession Codes:

Q13253

Database IDs:

Citations:

PubMed ID: 7666191

Title: Identification of mammalian noggin and its expression in the adult nervous system.

PubMed ID: 7666191

DOI: 10.1523/jneurosci.15-09-06077.1995

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21976273

Title: New insights into the molecular mechanism of multiple synostoses syndrome (SYNS): mutation within the GDF5 knuckle epitope causes noggin-resistance.

PubMed ID: 21976273

DOI: 10.1002/jbmr.532

PubMed ID: 24098149

Title: A GDF5 point mutation strikes twice--causing BDA1 and SYNS2.

PubMed ID: 24098149

DOI: 10.1371/journal.pgen.1003846

PubMed ID: 26643732

Title: A New Subtype of Multiple-Synostoses Syndrome is Caused by a Mutation in GDF6 that Decreases its Sensitivity to Noggin and Enhances its Potency as a BMP Signal.

PubMed ID: 26643732

DOI: 10.1002/jbmr.2761

PubMed ID: 31138930

Title: SMAD6 is frequently mutated in nonsyndromic radioulnar synostosis.

PubMed ID: 31138930

DOI: 10.1038/s41436-019-0552-8

PubMed ID: 12478285

Title: Structural basis of BMP signalling inhibition by the cystine knot protein Noggin.

PubMed ID: 12478285

DOI: 10.1038/nature01245

PubMed ID: 10080184

Title: Heterozygous mutations in the gene encoding noggin affect human joint morphogenesis.

PubMed ID: 10080184

DOI: 10.1038/6821

PubMed ID: 11846737

Title: Mutations of the NOG gene in individuals with proximal symphalangism and multiple synostosis syndrome.

PubMed ID: 11846737

DOI: 10.1034/j.1399-0004.2001.600607.x

PubMed ID: 11545688

Title: Identical mutations in NOG can cause either tarsal/carpal coalition syndrome or proximal symphalangism.

PubMed ID: 11545688

DOI: 10.1097/00125817-200109000-00004

PubMed ID: 12089654

Title: Autosomal dominant stapes ankylosis with broad thumbs and toes, hyperopia, and skeletal anomalies is caused by heterozygous nonsense and frameshift mutations in NOG, the gene encoding noggin.

PubMed ID: 12089654

DOI: 10.1086/342067

PubMed ID: 11857750

Title: Identification of a novel NOG gene mutation (P35S) in an Italian family with symphalangism.

PubMed ID: 11857750

DOI: 10.1002/humu.9016.abs

PubMed ID: 15770128

Title: The facio-audio-symphalangism syndrome in a four generation family with a nonsense mutation in the NOG-gene.

PubMed ID: 15770128

DOI: 10.1097/00019605-200504000-00004

PubMed ID: 17668388

Title: A new subtype of brachydactyly type B caused by point mutations in the bone morphogenetic protein antagonist NOGGIN.

PubMed ID: 17668388

DOI: 10.1086/519697

PubMed ID: 20503332

Title: Facioaudiosymphalangism syndrome and growth acceleration associated with a heterozygous NOG mutation.

PubMed ID: 20503332

DOI: 10.1002/ajmg.a.33387

Sequence Information:

Length: 232
Mass: 25774
Checksum: FCA0D8E1E2098580
Sequence:

MERCPSLGVT LYALVVVLGL RATPAGGQHY LHIRPAPSDN LPLVDLIEHP DPIFDPKEKD 
LNETLLRSLL GGHYDPGFMA TSPPEDRPGG GGGAAGGAED LAELDQLLRQ RPSGAMPSEI 
KGLEFSEGLA QGKKQRLSKK LRRKLQMWLW SQTFCPVLYA WNDLGSRFWP RYVKVGSCFS 
KRSCSVPEGM VCKPSKSVHL TVLRWRCQRR GGQRCGWIPI QYPIISECKC SC

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: NOG

Associated with

Other Information

Identification of mammalian noggin and its expression in the adult nervous system. PubMed ID: 7666191

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

New insights into the molecular mechanism of multiple synostoses syndrome (SYNS): mutation within the GDF5 knuckle epitope causes noggin-resistance. PubMed ID: 21976273

A GDF5 point mutation strikes twice--causing BDA1 and SYNS2. PubMed ID: 24098149

A New Subtype of Multiple-Synostoses Syndrome is Caused by a Mutation in GDF6 that Decreases its Sensitivity to Noggin and Enhances its Potency as a BMP Signal. PubMed ID: 26643732

SMAD6 is frequently mutated in nonsyndromic radioulnar synostosis. PubMed ID: 31138930

Structural basis of BMP signalling inhibition by the cystine knot protein Noggin. PubMed ID: 12478285

Heterozygous mutations in the gene encoding noggin affect human joint morphogenesis. PubMed ID: 10080184

Mutations of the NOG gene in individuals with proximal symphalangism and multiple synostosis syndrome. PubMed ID: 11846737

Identical mutations in NOG can cause either tarsal/carpal coalition syndrome or proximal symphalangism. PubMed ID: 11545688

Autosomal dominant stapes ankylosis with broad thumbs and toes, hyperopia, and skeletal anomalies is caused by heterozygous nonsense and frameshift mutations in NOG, the gene encoding noggin. PubMed ID: 12089654

Identification of a novel NOG gene mutation (P35S) in an Italian family with symphalangism. PubMed ID: 11857750

The facio-audio-symphalangism syndrome in a four generation family with a nonsense mutation in the NOG-gene. PubMed ID: 15770128

A new subtype of brachydactyly type B caused by point mutations in the bone morphogenetic protein antagonist NOGGIN. PubMed ID: 17668388

Facioaudiosymphalangism syndrome and growth acceleration associated with a heterozygous NOG mutation. PubMed ID: 20503332