CRLF1 | ENSG00000006016 | NCBI 9244

Details for: CRLF1

Gene ID: 9244

Symbol: CRLF1

Ensembl ID: ENSG00000006016

Description: cytokine receptor like factor 1

Associated with

Cytokine signaling in immune system
(R-HSA-1280215)
Il-6-type cytokine receptor ligand interactions
(R-HSA-6788467)
Immune system
(R-HSA-168256)
Interleukin-6 family signaling
(R-HSA-6783589)
Interleukin-12 family signaling
(R-HSA-447115)
Interleukin-27 signaling
(R-HSA-9020956)
Signaling by interleukins
(R-HSA-449147)
Ciliary neurotrophic factor receptor binding
(GO:0005127)
Crlf-clcf1 complex
(GO:0097058)
Cytokine-mediated signaling pathway
(GO:0019221)
Cytokine activity
(GO:0005125)
Cytokine binding
(GO:0019955)
Cytokine receptor activity
(GO:0004896)
Cytosol
(GO:0005829)
External side of plasma membrane
(GO:0009897)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Negative regulation of motor neuron apoptotic process
(GO:2000672)
Negative regulation of neuron apoptotic process
(GO:0043524)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of tyrosine phosphorylation of stat protein
(GO:0042531)
Protein binding
(GO:0005515)
Receptor complex
(GO:0043235)
Ureteric bud development
(GO:0001657)

Other Information

Proteins

Cytokine receptor-like factor 1

Genular Protein ID: 2021736150

Symbol: CRLF1_HUMAN

Name: Cytokine receptor-like factor 1

UniProtKB Accession Codes:

O75462 Q9UHH5

Database IDs:

Citations:

PubMed ID: 9686600

Title: Cytokine-like factor-1, a novel soluble protein, shares homology with members of the cytokine type I receptor family.

PubMed ID: 9686600

PubMed ID: 12975309

Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

PubMed ID: 12975309

DOI: 10.1101/gr.1293003

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15340161

Title: Signal peptide prediction based on analysis of experimentally verified cleavage sites.

PubMed ID: 15340161

DOI: 10.1110/ps.04682504

PubMed ID: 10966616

Title: CLF associates with CLC to form a functional heteromeric ligand for the CNTF receptor complex.

PubMed ID: 10966616

DOI: 10.1038/78765

PubMed ID: 26858303

Title: Cytokine-like factor 1, an essential facilitator of cardiotrophin-like cytokine:ciliary neurotrophic factor receptor alpha signaling and sorLA-mediated turnover.

PubMed ID: 26858303

DOI: 10.1128/mcb.00917-15

PubMed ID: 12509788

Title: Cold-induced sweating syndrome is caused by mutations in the CRLF1 gene.

PubMed ID: 12509788

DOI: 10.1086/346120

PubMed ID: 16952376

Title: Cold-induced sweating syndrome: a report of two cases and demonstration of genetic heterogeneity.

PubMed ID: 16952376

DOI: 10.1016/j.jns.2006.07.001

PubMed ID: 17436251

Title: Mutations in cytokine receptor-like factor 1 (CRLF1) account for both Crisponi and cold-induced sweating syndromes.

PubMed ID: 17436251

DOI: 10.1086/513608

PubMed ID: 17436252

Title: Crisponi syndrome is caused by mutations in the CRLF1 gene and is allelic to cold-induced sweating syndrome type 1.

PubMed ID: 17436252

DOI: 10.1086/516843

PubMed ID: 21326283

Title: Differential secretion of the mutated protein is a major component affecting phenotypic severity in CRLF1-associated disorders.

PubMed ID: 21326283

DOI: 10.1038/ejhg.2010.253

PubMed ID: 23026229

Title: Multiple small hyperintense lesions in the subcortical white matter on cranial MR images in two Turkish brothers with cold-induced sweating syndrome caused by a novel missense mutation in the CRLF1 gene.

PubMed ID: 23026229

DOI: 10.1016/j.braindev.2012.08.011

PubMed ID: 24488861

Title: Expanding the mutational spectrum of CRLF1 in Crisponi/CISS1 syndrome.

PubMed ID: 24488861

DOI: 10.1002/humu.22522

Sequence Information:

Length: 422
Mass: 46302
Checksum: AD9DEFCB01B84228
Sequence:

MPAGRRGPAA QSARRPPPLL PLLLLLCVLG APRAGSGAHT AVISPQDPTL LIGSSLLATC 
SVHGDPPGAT AEGLYWTLNG RRLPPELSRV LNASTLALAL ANLNGSRQRS GDNLVCHARD 
GSILAGSCLY VGLPPEKPVN ISCWSKNMKD LTCRWTPGAH GETFLHTNYS LKYKLRWYGQ 
DNTCEEYHTV GPHSCHIPKD LALFTPYEIW VEATNRLGSA RSDVLTLDIL DVVTTDPPPD 
VHVSRVGGLE DQLSVRWVSP PALKDFLFQA KYQIRYRVED SVDWKVVDDV SNQTSCRLAG 
LKPGTVYFVQ VRCNPFGIYG SKKAGIWSEW SHPTAASTPR SERPGPGGGA CEPRGGEPSS 
GPVRRELKQF LGWLKKHAYC SNLSFRLYDQ WRAWMQKSHK TRNQDEGILP SGRRGTARGP 
AR

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: CRLF1

Associated with

Other Information

Cytokine-like factor-1, a novel soluble protein, shares homology with members of the cytokine type I receptor family. PubMed ID: 9686600

The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. PubMed ID: 12975309

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Signal peptide prediction based on analysis of experimentally verified cleavage sites. PubMed ID: 15340161

CLF associates with CLC to form a functional heteromeric ligand for the CNTF receptor complex. PubMed ID: 10966616

Cytokine-like factor 1, an essential facilitator of cardiotrophin-like cytokine:ciliary neurotrophic factor receptor alpha signaling and sorLA-mediated turnover. PubMed ID: 26858303

Cold-induced sweating syndrome is caused by mutations in the CRLF1 gene. PubMed ID: 12509788

Cold-induced sweating syndrome: a report of two cases and demonstration of genetic heterogeneity. PubMed ID: 16952376

Mutations in cytokine receptor-like factor 1 (CRLF1) account for both Crisponi and cold-induced sweating syndromes. PubMed ID: 17436251

Crisponi syndrome is caused by mutations in the CRLF1 gene and is allelic to cold-induced sweating syndrome type 1. PubMed ID: 17436252

Differential secretion of the mutated protein is a major component affecting phenotypic severity in CRLF1-associated disorders. PubMed ID: 21326283

Multiple small hyperintense lesions in the subcortical white matter on cranial MR images in two Turkish brothers with cold-induced sweating syndrome caused by a novel missense mutation in the CRLF1 gene. PubMed ID: 23026229

Expanding the mutational spectrum of CRLF1 in Crisponi/CISS1 syndrome. PubMed ID: 24488861