UBE2L6 | ENSG00000156587 | NCBI 9246

Details for: UBE2L6

Gene ID: 9246

Symbol: UBE2L6

Ensembl ID: ENSG00000156587

Description: ubiquitin conjugating enzyme E2 L6

Associated with

Adaptive immune system
(R-HSA-1280218)
Amyloid fiber formation
(R-HSA-977225)
Antigen processing: ubiquitination & proteasome degradation
(R-HSA-983168)
Antiviral mechanism by ifn-stimulated genes
(R-HSA-1169410)
Class i mhc mediated antigen processing & presentation
(R-HSA-983169)
Cytokine signaling in immune system
(R-HSA-1280215)
Ddx58/ifih1-mediated induction of interferon-alpha/beta
(R-HSA-168928)
Disease
(R-HSA-1643685)
Dna damage bypass
(R-HSA-73893)
Dna repair
(R-HSA-73894)
Immune system
(R-HSA-168256)
Infectious disease
(R-HSA-5663205)
Innate immune system
(R-HSA-168249)
Interferon signaling
(R-HSA-913531)
Isg15 antiviral mechanism
(R-HSA-1169408)
Metabolism of proteins
(R-HSA-392499)
Negative regulators of ddx58/ifih1 signaling
(R-HSA-936440)
Pkr-mediated signaling
(R-HSA-9833482)
Respiratory syncytial virus infection pathway
(R-HSA-9820952)
Rsv-host interactions
(R-HSA-9833110)
Termination of translesion dna synthesis
(R-HSA-5656169)
Translesion synthesis by y family dna polymerases bypasses lesions on dna template
(R-HSA-110313)
Viral infection pathways
(R-HSA-9824446)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Innate immune response
(GO:0045087)
Isg15 transferase activity
(GO:0042296)
Isg15-protein conjugation
(GO:0032020)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Protein binding
(GO:0005515)
Protein modification process
(GO:0036211)
Protein polyubiquitination
(GO:0000209)
Ubiquitin-dependent protein catabolic process
(GO:0006511)
Ubiquitin-protein transferase activity
(GO:0004842)
Ubiquitin binding
(GO:0043130)
Ubiquitin conjugating enzyme activity
(GO:0061631)
Ubiquitin ligase complex
(GO:0000151)
Ubiquitin protein ligase binding
(GO:0031625)

Other Information

Proteins

Ubiquitin/ISG15-conjugating enzyme E2 L6

Genular Protein ID: 157815280

Symbol: UB2L6_HUMAN

Name: Ubiquitin/ISG15-conjugating enzyme E2 L6

UniProtKB Accession Codes:

O14933 A6NDM6 A8MY53 Q8N5D8 Q9UEZ0

Database IDs:

Citations:

PubMed ID: 10894956

Title: Genomic organization of the human ubiquitin-conjugating enzyme gene, UBE2L6 on chromosome 11q12.

PubMed ID: 10894956

DOI: 10.1159/000015593

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9153201

Title: Physical interaction between specific E2 and Hect E3 enzymes determines functional cooperativity.

PubMed ID: 9153201

DOI: 10.1074/jbc.272.21.13548

PubMed ID: 15131269

Title: The UbcH8 ubiquitin E2 enzyme is also the E2 enzyme for ISG15, an IFN-alpha/beta-induced ubiquitin-like protein.

PubMed ID: 15131269

DOI: 10.1073/pnas.0402528101

PubMed ID: 11237715

Title: A novel centrosomal ring-finger protein, dorfin, mediates ubiquitin ligase activity.

PubMed ID: 11237715

DOI: 10.1006/bbrc.2001.4414

PubMed ID: 16428300

Title: Link between the ubiquitin conjugation system and the ISG15 conjugation system: ISG15 conjugation to the UbcH6 ubiquitin E2 enzyme.

PubMed ID: 16428300

DOI: 10.1093/jb/mvi172

PubMed ID: 16427630

Title: The p53-inducible E3 ubiquitin ligase p53RFP induces p53-dependent apoptosis.

PubMed ID: 16427630

DOI: 10.1016/j.febslet.2005.09.105

PubMed ID: 16709802

Title: NK lytic-associated molecule, involved in NK cytotoxic function, is an E3 ligase.

PubMed ID: 16709802

DOI: 10.4049/jimmunol.176.11.6454

PubMed ID: 20508617

Title: Ubiquitin conjugase UBCH8 targets active FMS-like tyrosine kinase 3 for proteasomal degradation.

PubMed ID: 20508617

DOI: 10.1038/leu.2010.114

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 19928833

Title: The structure of the UbcH8-ubiquitin complex shows a unique ubiquitin interaction site.

PubMed ID: 19928833

DOI: 10.1021/bi901686j

Sequence Information:

Length: 153
Mass: 17769
Checksum: D79768775344EFAE
Sequence:

MMASMRVVKE LEDLQKKPPP YLRNLSSDDA NVLVWHALLL PDQPPYHLKA FNLRISFPPE 
YPFKPPMIKF TTKIYHPNVD ENGQICLPII SSENWKPCTK TCQVLEALNV LVNRPNIREP 
LRMDLADLLT QNPELFRKNA EEFTLRFGVD RPS

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: UBE2L6

Associated with

Other Information

Genomic organization of the human ubiquitin-conjugating enzyme gene, UBE2L6 on chromosome 11q12. PubMed ID: 10894956

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

Human chromosome 11 DNA sequence and analysis including novel gene identification. PubMed ID: 16554811

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Physical interaction between specific E2 and Hect E3 enzymes determines functional cooperativity. PubMed ID: 9153201

The UbcH8 ubiquitin E2 enzyme is also the E2 enzyme for ISG15, an IFN-alpha/beta-induced ubiquitin-like protein. PubMed ID: 15131269

A novel centrosomal ring-finger protein, dorfin, mediates ubiquitin ligase activity. PubMed ID: 11237715

Link between the ubiquitin conjugation system and the ISG15 conjugation system: ISG15 conjugation to the UbcH6 ubiquitin E2 enzyme. PubMed ID: 16428300

The p53-inducible E3 ubiquitin ligase p53RFP induces p53-dependent apoptosis. PubMed ID: 16427630

NK lytic-associated molecule, involved in NK cytotoxic function, is an E3 ligase. PubMed ID: 16709802

Ubiquitin conjugase UBCH8 targets active FMS-like tyrosine kinase 3 for proteasomal degradation. PubMed ID: 20508617

Initial characterization of the human central proteome. PubMed ID: 21269460

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

The structure of the UbcH8-ubiquitin complex shows a unique ubiquitin interaction site. PubMed ID: 19928833