Details for: GPR50

Gene ID: 9248

Symbol: GPR50

Ensembl ID: ENSG00000102195

Description: G protein-coupled receptor 50

Associated with

Other Information

Genular Protein ID: 2914535259

Symbol: MTR1L_HUMAN

Name: Melatonin-related receptor

UniProtKB Accession Codes:

Q13585 Q0VGG3 Q3ZAR0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 EPD 1 Ensembl 1 GO 6 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 3 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 SAM 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8647286

Title: Cloning of a melatonin-related receptor from human pituitary.

PubMed ID: 8647286

DOI: 10.1016/0014-5793(96)00437-1

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16778767

Title: The orphan GPR50 receptor specifically inhibits MT1 melatonin receptor function through heterodimerization.

PubMed ID: 16778767

DOI: 10.1038/sj.emboj.7601193

PubMed ID: 16436372

Title: Sequence variants in the melatonin-related receptor gene (GPR50) associate with circulating triglyceride and HDL levels.

PubMed ID: 16436372

DOI: 10.1194/jlr.m500338-jlr200

PubMed ID: 19699797

Title: GPR50 interacts with neuronal NOGO-A and affects neurite outgrowth.

PubMed ID: 19699797

DOI: 10.1016/j.mcn.2009.08.007

PubMed ID: 21858214

Title: GPR50 interacts with TIP60 to modulate glucocorticoid receptor signalling.

PubMed ID: 21858214

DOI: 10.1371/journal.pone.0023725

PubMed ID: 29572483

Title: The orphan GPR50 receptor promotes constitutive TGFbeta receptor signaling and protects against cancer development.

PubMed ID: 29572483

DOI: 10.1038/s41467-018-03609-x

PubMed ID: 31900622

Title: GPR50-Ctail cleavage and nuclear translocation: a new signal transduction mode for G protein-coupled receptors.

PubMed ID: 31900622

DOI: 10.1007/s00018-019-03440-7

Sequence Information:

  • Length: 617
  • Mass: 67369
  • Checksum: A0B73A7ACE1053BB
  • Sequence:
    • MGPTLAVPTP YGCIGCKLPQ PEYPPALIIF MFCAMVITIV VDLIGNSMVI LAVTKNKKLR 
NSGNIFVVSL SVADMLVAIY PYPLMLHAMS IGGWDLSQLQ CQMVGFITGL SVVGSIFNIV 
AIAINRYCYI CHSLQYERIF SVRNTCIYLV ITWIMTVLAV LPNMYIGTIE YDPRTYTCIF 
NYLNNPVFTV TIVCIHFVLP LLIVGFCYVR IWTKVLAARD PAGQNPDNQL AEVRNFLTMF 
VIFLLFAVCW CPINVLTVLV AVSPKEMAGK IPNWLYLAAY FIAYFNSCLN AVIYGLLNEN 
FRREYWTIFH AMRHPIIFFS GLISDIREMQ EARTLARARA HARDQAREQD RAHACPAVEE 
TPMNVRNVPL PGDAAAGHPD RASGHPKPHS RSSSAYRKSA STHHKSVFSH SKAASGHLKP 
VSGHSKPASG HPKSATVYPK PASVHFKADS VHFKGDSVHF KPDSVHFKPA SSNPKPITGH 
HVSAGSHSKS AFSAATSHPK PTTGHIKPAT SHAEPTTADY PKPATTSHPK PTAADNPELS 
ASHCPEIPAI AHPVSDDSDL PESASSPAAG PTKPAASQLE SDTIADLPDP TVVTTSTNDY 
HDVVVIDVED DPDEMAV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.