Details for: GPR50

Gene ID: 9248

Symbol: GPR50

Ensembl ID: ENSG00000102195

Description: G protein-coupled receptor 50

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 15.95
    Marker Score: 161,658
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 8.17
    Marker Score: 52,641
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 6.55
    Marker Score: 8,104
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 3.66
    Marker Score: 6,670
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 3.12
    Marker Score: 3,144
  • Cell Name: T cell (CL0000084)
    Fold Change: 2.14
    Marker Score: 3,695
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 1.99
    Marker Score: 2,219
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.4
    Marker Score: 438
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 1.38
    Marker Score: 438
  • Cell Name: B cell (CL0000236)
    Fold Change: 1.28
    Marker Score: 1,218
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 1.27
    Marker Score: 444
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 1.2
    Marker Score: 437
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 1.2
    Marker Score: 387
  • Cell Name: podocyte (CL0000653)
    Fold Change: 1.19
    Marker Score: 441
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.16
    Marker Score: 7,691
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 1.14
    Marker Score: 444
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 1.09
    Marker Score: 499
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 0.99
    Marker Score: 71,406
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 0.99
    Marker Score: 47,650
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.98
    Marker Score: 436
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,398
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,413
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5,327
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2,741
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.91
    Marker Score: 1,475
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.9
    Marker Score: 428
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,293
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.87
    Marker Score: 502
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.84
    Marker Score: 441
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.82
    Marker Score: 375
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.78
    Marker Score: 406
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 714
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 0.76
    Marker Score: 444
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.75
    Marker Score: 1,201
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.73
    Marker Score: 705
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.71
    Marker Score: 441
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.69
    Marker Score: 552
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.69
    Marker Score: 414
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.65
    Marker Score: 382
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.65
    Marker Score: 440
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.6
    Marker Score: 398
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.57
    Marker Score: 438
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.51
    Marker Score: 438
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.48
    Marker Score: 286
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.44
    Marker Score: 390
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.42
    Marker Score: 441
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.41
    Marker Score: 417
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.4
    Marker Score: 444
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.35
    Marker Score: 441
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.34
    Marker Score: 362
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.33
    Marker Score: 432
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.31
    Marker Score: 367
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.31
    Marker Score: 439
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.31
    Marker Score: 444
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.27
    Marker Score: 554
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.26
    Marker Score: 443
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 0.25
    Marker Score: 474
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.25
    Marker Score: 395
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.25
    Marker Score: 429
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.23
    Marker Score: 714
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.19
    Marker Score: 310
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.19
    Marker Score: 443
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 0.17
    Marker Score: 444
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.17
    Marker Score: 306
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.17
    Marker Score: 394
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.15
    Marker Score: 319
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.15
    Marker Score: 502
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.14
    Marker Score: 365
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.13
    Marker Score: 248
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.13
    Marker Score: 259
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.13
    Marker Score: 447
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.12
    Marker Score: 493
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.11
    Marker Score: 441
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 0.08
    Marker Score: 443
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.08
    Marker Score: 1,199
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.05
    Marker Score: 303
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.04
    Marker Score: 443
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.03
    Marker Score: 444
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 0.03
    Marker Score: 422
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.01
    Marker Score: 444
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.01
    Marker Score: 439

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** GPR50 exhibits several distinct characteristics that set it apart from other melatonin receptors. Its high expression levels in immune cells, particularly in T cells and plasma cells, underscore its potential role in regulating immune responses. The receptor's ability to bind melatonin and activate G protein-coupled signaling pathways suggests its involvement in various cellular processes, including cell proliferation, differentiation, and survival. Furthermore, GPR50's expression in other cell types, such as oligodendrocyte precursor cells and blood vessel endothelial cells, highlights its broader implications in tissue homeostasis and vascular health. **Pathways and Functions** GPR50's signaling pathways are intricately linked to those of other melatonin receptors, including MT1 and MT2. Upon binding melatonin, GPR50 activates G protein-coupled receptor signaling pathways, which in turn modulate downstream effector molecules, including protein kinases and phosphatases. This signaling cascade is involved in various cellular processes, including: 1. **Immune cell regulation**: GPR50 modulates T cell proliferation, differentiation, and cytokine production, influencing the overall immune response. 2. **Neuroprotection**: The receptor's expression in oligodendrocyte precursor cells and microglial cells suggests its potential role in protecting against neurodegenerative diseases, such as Alzheimer's and Parkinson's. 3. **Vascular health**: GPR50's presence in blood vessel endothelial cells and renal beta-intercalated cells indicates its involvement in maintaining vascular homeostasis and regulating blood pressure. **Clinical Significance** The discovery of GPR50 has significant implications for our understanding of immune-related disorders, particularly those involving melatonin dysregulation. The receptor's involvement in regulating immune cell activity, neuroprotection, and vascular health makes it a potential therapeutic target for various diseases, including: 1. **Autoimmune disorders**: GPR50's role in modulating immune cell activity suggests its potential as a therapeutic target for autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis. 2. **Cancer**: The receptor's expression in plasma cells and its involvement in regulating immune cell activity make it a potential target for cancer immunotherapy. 3. **Neurodegenerative diseases**: GPR50's presence in oligodendrocyte precursor cells and microglial cells highlights its potential role in protecting against neurodegenerative diseases, such as Alzheimer's and Parkinson's. In conclusion, GPR50 is a novel melatonin receptor that has emerged as a crucial player in regulating immune cell activity, neuroprotection, and vascular health. Further research is necessary to fully elucidate the receptor's mechanisms of action and its clinical significance, but its potential as a therapeutic target for immune-related disorders is undeniable.

Genular Protein ID: 2914535259

Symbol: MTR1L_HUMAN

Name: Melatonin-related receptor

UniProtKB Accession Codes:

Q13585 Q0VGG3 Q3ZAR0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 EPD 1 Ensembl 1 GO 6 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 3 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 SAM 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8647286

Title: Cloning of a melatonin-related receptor from human pituitary.

PubMed ID: 8647286

DOI: 10.1016/0014-5793(96)00437-1

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16778767

Title: The orphan GPR50 receptor specifically inhibits MT1 melatonin receptor function through heterodimerization.

PubMed ID: 16778767

DOI: 10.1038/sj.emboj.7601193

PubMed ID: 16436372

Title: Sequence variants in the melatonin-related receptor gene (GPR50) associate with circulating triglyceride and HDL levels.

PubMed ID: 16436372

DOI: 10.1194/jlr.m500338-jlr200

PubMed ID: 19699797

Title: GPR50 interacts with neuronal NOGO-A and affects neurite outgrowth.

PubMed ID: 19699797

DOI: 10.1016/j.mcn.2009.08.007

PubMed ID: 21858214

Title: GPR50 interacts with TIP60 to modulate glucocorticoid receptor signalling.

PubMed ID: 21858214

DOI: 10.1371/journal.pone.0023725

PubMed ID: 29572483

Title: The orphan GPR50 receptor promotes constitutive TGFbeta receptor signaling and protects against cancer development.

PubMed ID: 29572483

DOI: 10.1038/s41467-018-03609-x

PubMed ID: 31900622

Title: GPR50-Ctail cleavage and nuclear translocation: a new signal transduction mode for G protein-coupled receptors.

PubMed ID: 31900622

DOI: 10.1007/s00018-019-03440-7

Sequence Information:

  • Length: 617
  • Mass: 67369
  • Checksum: A0B73A7ACE1053BB
  • Sequence:
    • MGPTLAVPTP YGCIGCKLPQ PEYPPALIIF MFCAMVITIV VDLIGNSMVI LAVTKNKKLR 
NSGNIFVVSL SVADMLVAIY PYPLMLHAMS IGGWDLSQLQ CQMVGFITGL SVVGSIFNIV 
AIAINRYCYI CHSLQYERIF SVRNTCIYLV ITWIMTVLAV LPNMYIGTIE YDPRTYTCIF 
NYLNNPVFTV TIVCIHFVLP LLIVGFCYVR IWTKVLAARD PAGQNPDNQL AEVRNFLTMF 
VIFLLFAVCW CPINVLTVLV AVSPKEMAGK IPNWLYLAAY FIAYFNSCLN AVIYGLLNEN 
FRREYWTIFH AMRHPIIFFS GLISDIREMQ EARTLARARA HARDQAREQD RAHACPAVEE 
TPMNVRNVPL PGDAAAGHPD RASGHPKPHS RSSSAYRKSA STHHKSVFSH SKAASGHLKP 
VSGHSKPASG HPKSATVYPK PASVHFKADS VHFKGDSVHF KPDSVHFKPA SSNPKPITGH 
HVSAGSHSKS AFSAATSHPK PTTGHIKPAT SHAEPTTADY PKPATTSHPK PTAADNPELS 
ASHCPEIPAI AHPVSDDSDL PESASSPAAG PTKPAASQLE SDTIADLPDP TVVTTSTNDY 
HDVVVIDVED DPDEMAV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.