Details for: CD8A
Associated with
Other Information
Genular Protein ID: 872863526
Symbol: CD8A_HUMAN
Name: T-cell surface glycoprotein CD8 alpha chain
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 3871356
Title: The isolation and sequence of the gene encoding T8: a molecule defining functional classes of T lymphocytes.
PubMed ID: 3871356
PubMed ID: 3936473
Title: Structure of Leu-2/T8 as deduced from the sequence of a cDNA clone.
PubMed ID: 3936473
PubMed ID: 3918796
Title: The T cell differentiation antigen Leu-2/T8 is homologous to immunoglobulin and T cell receptor variable regions.
PubMed ID: 3918796
PubMed ID: 2509342
Title: Structure and expression of the gene encoding CD8 alpha chain (Leu-2/T8).
PubMed ID: 2509342
DOI: 10.1007/bf02425282
PubMed ID: 2496167
Title: Alternatively spliced mRNA encodes a secreted form of human CD8 alpha. Characterization of the human CD8 alpha gene.
PubMed ID: 2496167
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 15815621
Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.
PubMed ID: 15815621
DOI: 10.1038/nature03466
PubMed ID: 2536941
Title: A secreted form of the human lymphocyte cell surface molecule CD8 arises from alternative splicing.
PubMed ID: 2536941
PubMed ID: 6605969
Title: The T8 antigen is a multimeric complex of two distinct subunits on human thymocytes but consists of homomultimeric forms on peripheral blood T lymphocytes.
PubMed ID: 6605969
PubMed ID: 2512251
Title: Phosphorylation and down-regulation of CD4 and CD8 in human CTLs and mouse L cells.
PubMed ID: 2512251
DOI: 10.1007/bf02421181
PubMed ID: 2784196
Title: Polymorphism in the alpha 3 domain of HLA-A molecules affects binding to CD8.
PubMed ID: 2784196
DOI: 10.1038/338345a0
PubMed ID: 1460019
Title: Post-translational processing of an O-glycosylated protein, the human CD8 glycoprotein, during the intracellular transport to the plasma membrane.
PubMed ID: 1460019
PubMed ID: 7923932
Title: A distinctive form of soluble CD8 is secreted by stimulated CD8+ cells in HIV-1-infected and high-risk individuals.
PubMed ID: 7923932
PubMed ID: 12853576
Title: Human inhibitory receptors Ig-like transcript 2 (ILT2) and ILT4 compete with CD8 for MHC class I binding and bind preferentially to HLA-G.
PubMed ID: 12853576
PubMed ID: 16236125
Title: Ligation of CD8alpha on human natural killer cells prevents activation-induced apoptosis and enhances cytolytic activity.
PubMed ID: 16236125
PubMed ID: 17678538
Title: CD8 alpha is expressed by human monocytes and enhances Fc gamma R-dependent responses.
PubMed ID: 17678538
PubMed ID: 17341584
Title: CD8 Raft localization is induced by its assembly into CD8alpha beta heterodimers, Not CD8alpha alpha homodimers.
PubMed ID: 17341584
PubMed ID: 23657257
Title: Immune surveillance by CD8alphaalpha+ skin-resident T cells in human herpes virus infection.
PubMed ID: 23657257
DOI: 10.1038/nature12110
PubMed ID: 26082771
Title: A subset of human plasmacytoid dendritic cells expresses CD8alpha upon exposure to herpes simplex virus type 1.
PubMed ID: 26082771
PubMed ID: 1547508
Title: Crystal structure of a soluble form of the human T cell coreceptor CD8 at 2.6-A resolution.
PubMed ID: 1547508
PubMed ID: 9177355
Title: Crystal structure of the complex between human CD8alpha(alpha) and HLA-A2.
PubMed ID: 9177355
DOI: 10.1038/42523
PubMed ID: 14500983
Title: A zinc clasp structure tethers Lck to T cell coreceptors CD4 and CD8.
PubMed ID: 14500983
PubMed ID: 11435463
Title: Familial CD8 deficiency due to a mutation in the CD8 alpha gene.
PubMed ID: 11435463
DOI: 10.1172/jci10993
Sequence Information:
- Length: 235
- Mass: 25729
- Checksum: FCCA29BAA73726BB
- Sequence:
MALPVTALLL PLALLLHAAR PSQFRVSPLD RTWNLGETVE LKCQVLLSNP TSGCSWLFQP RGAAASPTFL LYLSQNKPKA AEGLDTQRFS GKRLGDTFVL TLSDFRRENE GYYFCSALSN SIMYFSHFVP VFLPAKPTTT PAPRPPTPAP TIASQPLSLR PEACRPAAGG AVHTRGLDFA CDIYIWAPLA GTCGVLLLSL VITLYCNHRN RRRVCKCPRP VVKSGDKPSL SARYV
Genular Protein ID: 3569746370
Symbol: Q6ZVS2_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Sequence Information:
- Length: 152
- Mass: 16713
- Checksum: 6911F40F86122E02
- Sequence:
MRNQAPGRPK GATFPPRRPT GSRAPPLAPE LRAKQRPGER VMALPVTALL LPLALLLHAA RPSQFRVSPL DRTWNLGETV ELKCQVLLSN PTSGCSWLFQ PRGAAASPTF LLYLSQNKPK AAEGLDTQRF SGKRLGDTFV LTLSDFRREN EG
Genular Protein ID: 3883293718
Symbol: Q8TAW8_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
Sequence Information:
- Length: 235
- Mass: 25669
- Checksum: FCDFC9B5472D26BB
- Sequence:
MALPVTALLL PLALLLHAAR PSQFRVSPLD RTWNLGETVE LKCQVLLSNP TSGCSWLFQP RGAAASPTFL LYLSQNKPKA AEGLDTQRFS GKRLGDTFVL TLSDFRRENE GCYFCSALSN SIMYFSHFVP VFLPAKPTTT PAPRPPTPAP TIASQPLSLR PEACRPAAGG AVHTRGLDFA CDIYIWAPLA GTCGVLLLSL VITLYCNHRN RRRVCKCPRP VVKSGDKPSL SARYV
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.