Details for: CD8A

Gene ID: 925

Symbol: CD8A

Ensembl ID: ENSG00000153563

Description: CD8 subunit alpha

Associated with

Other Information

Genular Protein ID: 872863526

Symbol: CD8A_HUMAN

Name: T-cell surface glycoprotein CD8 alpha chain

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 3871356

Title: The isolation and sequence of the gene encoding T8: a molecule defining functional classes of T lymphocytes.

PubMed ID: 3871356

DOI: 10.1016/0092-8674(85)90138-2

PubMed ID: 3936473

Title: Structure of Leu-2/T8 as deduced from the sequence of a cDNA clone.

PubMed ID: 3936473

PubMed ID: 3918796

Title: The T cell differentiation antigen Leu-2/T8 is homologous to immunoglobulin and T cell receptor variable regions.

PubMed ID: 3918796

DOI: 10.1016/0092-8674(85)90207-7

PubMed ID: 2509342

Title: Structure and expression of the gene encoding CD8 alpha chain (Leu-2/T8).

PubMed ID: 2509342

DOI: 10.1007/bf02425282

PubMed ID: 2496167

Title: Alternatively spliced mRNA encodes a secreted form of human CD8 alpha. Characterization of the human CD8 alpha gene.

PubMed ID: 2496167

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 2536941

Title: A secreted form of the human lymphocyte cell surface molecule CD8 arises from alternative splicing.

PubMed ID: 2536941

DOI: 10.1073/pnas.86.3.998

PubMed ID: 6605969

Title: The T8 antigen is a multimeric complex of two distinct subunits on human thymocytes but consists of homomultimeric forms on peripheral blood T lymphocytes.

PubMed ID: 6605969

DOI: 10.1016/s0021-9258(17)43915-9

PubMed ID: 2512251

Title: Phosphorylation and down-regulation of CD4 and CD8 in human CTLs and mouse L cells.

PubMed ID: 2512251

DOI: 10.1007/bf02421181

PubMed ID: 2784196

Title: Polymorphism in the alpha 3 domain of HLA-A molecules affects binding to CD8.

PubMed ID: 2784196

DOI: 10.1038/338345a0

PubMed ID: 1460019

Title: Post-translational processing of an O-glycosylated protein, the human CD8 glycoprotein, during the intracellular transport to the plasma membrane.

PubMed ID: 1460019

DOI: 10.1016/s0021-9258(19)74024-1

PubMed ID: 7923932

Title: A distinctive form of soluble CD8 is secreted by stimulated CD8+ cells in HIV-1-infected and high-risk individuals.

PubMed ID: 7923932

DOI: 10.1006/clin.1994.1195

PubMed ID: 12853576

Title: Human inhibitory receptors Ig-like transcript 2 (ILT2) and ILT4 compete with CD8 for MHC class I binding and bind preferentially to HLA-G.

PubMed ID: 12853576

DOI: 10.1073/pnas.1431057100

PubMed ID: 16236125

Title: Ligation of CD8alpha on human natural killer cells prevents activation-induced apoptosis and enhances cytolytic activity.

PubMed ID: 16236125

DOI: 10.1111/j.1365-2567.2005.02235.x

PubMed ID: 17678538

Title: CD8 alpha is expressed by human monocytes and enhances Fc gamma R-dependent responses.

PubMed ID: 17678538

DOI: 10.1186/1471-2172-8-12

PubMed ID: 17341584

Title: CD8 Raft localization is induced by its assembly into CD8alpha beta heterodimers, Not CD8alpha alpha homodimers.

PubMed ID: 17341584

DOI: 10.1074/jbc.m701027200

PubMed ID: 23657257

Title: Immune surveillance by CD8alphaalpha+ skin-resident T cells in human herpes virus infection.

PubMed ID: 23657257

DOI: 10.1038/nature12110

PubMed ID: 26082771

Title: A subset of human plasmacytoid dendritic cells expresses CD8alpha upon exposure to herpes simplex virus type 1.

PubMed ID: 26082771

DOI: 10.3389/fmicb.2015.00557

PubMed ID: 1547508

Title: Crystal structure of a soluble form of the human T cell coreceptor CD8 at 2.6-A resolution.

PubMed ID: 1547508

DOI: 10.1016/0092-8674(92)90085-q

PubMed ID: 9177355

Title: Crystal structure of the complex between human CD8alpha(alpha) and HLA-A2.

PubMed ID: 9177355

DOI: 10.1038/42523

PubMed ID: 14500983

Title: A zinc clasp structure tethers Lck to T cell coreceptors CD4 and CD8.

PubMed ID: 14500983

DOI: 10.1126/science.1085643

PubMed ID: 11435463

Title: Familial CD8 deficiency due to a mutation in the CD8 alpha gene.

PubMed ID: 11435463

DOI: 10.1172/jci10993

Sequence Information:

  • Length: 235
  • Mass: 25729
  • Checksum: FCCA29BAA73726BB
  • Sequence:
  • MALPVTALLL PLALLLHAAR PSQFRVSPLD RTWNLGETVE LKCQVLLSNP TSGCSWLFQP 
    RGAAASPTFL LYLSQNKPKA AEGLDTQRFS GKRLGDTFVL TLSDFRRENE GYYFCSALSN 
    SIMYFSHFVP VFLPAKPTTT PAPRPPTPAP TIASQPLSLR PEACRPAAGG AVHTRGLDFA 
    CDIYIWAPLA GTCGVLLLSL VITLYCNHRN RRRVCKCPRP VVKSGDKPSL SARYV

Genular Protein ID: 3569746370

Symbol: Q6ZVS2_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 152
  • Mass: 16713
  • Checksum: 6911F40F86122E02
  • Sequence:
  • MRNQAPGRPK GATFPPRRPT GSRAPPLAPE LRAKQRPGER VMALPVTALL LPLALLLHAA 
    RPSQFRVSPL DRTWNLGETV ELKCQVLLSN PTSGCSWLFQ PRGAAASPTF LLYLSQNKPK 
    AAEGLDTQRF SGKRLGDTFV LTLSDFRREN EG

Genular Protein ID: 3883293718

Symbol: Q8TAW8_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 235
  • Mass: 25669
  • Checksum: FCDFC9B5472D26BB
  • Sequence:
  • MALPVTALLL PLALLLHAAR PSQFRVSPLD RTWNLGETVE LKCQVLLSNP TSGCSWLFQP 
    RGAAASPTFL LYLSQNKPKA AEGLDTQRFS GKRLGDTFVL TLSDFRRENE GCYFCSALSN 
    SIMYFSHFVP VFLPAKPTTT PAPRPPTPAP TIASQPLSLR PEACRPAAGG AVHTRGLDFA 
    CDIYIWAPLA GTCGVLLLSL VITLYCNHRN RRRVCKCPRP VVKSGDKPSL SARYV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.