Details for: CD8A

Gene ID: 925

Symbol: CD8A

Ensembl ID: ENSG00000153563

Description: CD8 subunit alpha

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 3.4
    Marker Score: 9545
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 2.93
    Marker Score: 29063
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 2.67
    Marker Score: 3931
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 2.6
    Marker Score: 1885
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 2.52
    Marker Score: 3482
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 2.51
    Marker Score: 1543
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 2.45
    Marker Score: 4810
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 2.44
    Marker Score: 1403
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 2.4
    Marker Score: 3392
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 2.37
    Marker Score: 1993
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: 2.36
    Marker Score: 1304
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.99
    Marker Score: 1982
  • Cell Name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell (CL0000802)
    Fold Change: 1.99
    Marker Score: 646
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 1.92
    Marker Score: 825
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 1.76
    Marker Score: 3149
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 1.75
    Marker Score: 1559
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: 1.72
    Marker Score: 884
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.6
    Marker Score: 1161
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 1.5
    Marker Score: 465
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 1.41
    Marker Score: 2289
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 1.26
    Marker Score: 1068
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.25
    Marker Score: 846
  • Cell Name: activated CD8-positive, alpha-beta T cell, human (CL0001049)
    Fold Change: 1.22
    Marker Score: 278
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 1.18
    Marker Score: 508
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.14
    Marker Score: 4798
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.09
    Marker Score: 692
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 1.09
    Marker Score: 731
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 1.01
    Marker Score: 310
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71807
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48031
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30406
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.97
    Marker Score: 502
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.96
    Marker Score: 455
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.95
    Marker Score: 395.5
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2411
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5284
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.92
    Marker Score: 369
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2738
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.9
    Marker Score: 513
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.89
    Marker Score: 321
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.89
    Marker Score: 408
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 0.89
    Marker Score: 2159
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5279
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.83
    Marker Score: 633
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.81
    Marker Score: 12690
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 0.81
    Marker Score: 2354
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.78
    Marker Score: 9064
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1256
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.76
    Marker Score: 695
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 391.5
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: 0.71
    Marker Score: 628
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.71
    Marker Score: 455
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 0.7
    Marker Score: 674
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 0.69
    Marker Score: 240
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 176
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.68
    Marker Score: 495
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.66
    Marker Score: 692
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 0.62
    Marker Score: 466
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.61
    Marker Score: 306
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.6
    Marker Score: 1129
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 0.58
    Marker Score: 511
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.57
    Marker Score: 745
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.55
    Marker Score: 146
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 0.52
    Marker Score: 565
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 0.52
    Marker Score: 1641
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.47
    Marker Score: 4831
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.47
    Marker Score: 1902
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.47
    Marker Score: 152
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.46
    Marker Score: 706
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 0.46
    Marker Score: 428
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.45
    Marker Score: 271
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 0.45
    Marker Score: 264
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.45
    Marker Score: 560
  • Cell Name: naive T cell (CL0000898)
    Fold Change: 0.45
    Marker Score: 288
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.44
    Marker Score: 140
  • Cell Name: ILC1, human (CL0001077)
    Fold Change: 0.44
    Marker Score: 111
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 0.44
    Marker Score: 342
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 0.43
    Marker Score: 970
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.43
    Marker Score: 873
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.42
    Marker Score: 196
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 0.4
    Marker Score: 1110
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.39
    Marker Score: 3668.5
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.37
    Marker Score: 22773
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    Fold Change: 0.36
    Marker Score: 402
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.36
    Marker Score: 3067
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.35
    Marker Score: 597
  • Cell Name: NKp44-negative group 3 innate lymphoid cell, human (CL0001080)
    Fold Change: 0.35
    Marker Score: 76
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 0.34
    Marker Score: 265
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.34
    Marker Score: 140.5
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.33
    Marker Score: 105
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 0.33
    Marker Score: 360
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.31
    Marker Score: 637
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 0.31
    Marker Score: 526
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.31
    Marker Score: 2905
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 0.3
    Marker Score: 244
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.29
    Marker Score: 174
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.28
    Marker Score: 1100
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.27
    Marker Score: 182
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.26
    Marker Score: 152

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Other Information

**Key characteristics:** * CD8A is a type I transmembrane receptor. * It is expressed on the surface of CD8+ T cells and other immune cells. * It is a member of the immunoglobulin superfamily. * It is a key component of the cytotoxic machinery of CD8+ T cells. **Pathways and functions:** * CD8A is involved in the adaptive immune response, including the activation of CD8+ T cells. * It is expressed on the surface of cytotoxic T cells and is responsible for the recognition of MHC class I molecules. * When CD8A binds to MHC class I molecules, it triggers the activation of the T cell. * CD8A is also involved in the regulation of the immune response. **Clinical significance:** * Mutations in the CD8A gene have been linked to a number of human diseases, including cancer and autoimmune disorders. * Targeting CD8A has been explored as a therapeutic strategy for cancer and autoimmune disorders. * Abnormalities in CD8A gene expression or function have been linked to a number of human diseases, including cancer and autoimmune disorders.

Genular Protein ID: 872863526

Symbol: CD8A_HUMAN

Name: T-cell surface glycoprotein CD8 alpha chain

UniProtKB Accession Codes:

P01732 B4DT80 D6W5M8 Q13970 Q4ZG17

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CORUM 1 CPTC 1 CTD 1 ChiTaRS 1 ComplexPortal 2 DMDM 1 DNASU 1 DisGeNET 1 EMBL 15 Ensembl 4 EvolutionaryTrace 1 ExpressionAtlas 1 GO 18 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 11 PDBsum 8 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 RNAct 1 Reactome 1 RefSeq 3 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3871356

Title: The isolation and sequence of the gene encoding T8: a molecule defining functional classes of T lymphocytes.

PubMed ID: 3871356

DOI: 10.1016/0092-8674(85)90138-2

PubMed ID: 3936473

Title: Structure of Leu-2/T8 as deduced from the sequence of a cDNA clone.

PubMed ID: 3936473

PubMed ID: 3918796

Title: The T cell differentiation antigen Leu-2/T8 is homologous to immunoglobulin and T cell receptor variable regions.

PubMed ID: 3918796

DOI: 10.1016/0092-8674(85)90207-7

PubMed ID: 2509342

Title: Structure and expression of the gene encoding CD8 alpha chain (Leu-2/T8).

PubMed ID: 2509342

DOI: 10.1007/bf02425282

PubMed ID: 2496167

Title: Alternatively spliced mRNA encodes a secreted form of human CD8 alpha. Characterization of the human CD8 alpha gene.

PubMed ID: 2496167

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 2536941

Title: A secreted form of the human lymphocyte cell surface molecule CD8 arises from alternative splicing.

PubMed ID: 2536941

DOI: 10.1073/pnas.86.3.998

PubMed ID: 6605969

Title: The T8 antigen is a multimeric complex of two distinct subunits on human thymocytes but consists of homomultimeric forms on peripheral blood T lymphocytes.

PubMed ID: 6605969

DOI: 10.1016/s0021-9258(17)43915-9

PubMed ID: 2512251

Title: Phosphorylation and down-regulation of CD4 and CD8 in human CTLs and mouse L cells.

PubMed ID: 2512251

DOI: 10.1007/bf02421181

PubMed ID: 2784196

Title: Polymorphism in the alpha 3 domain of HLA-A molecules affects binding to CD8.

PubMed ID: 2784196

DOI: 10.1038/338345a0

PubMed ID: 1460019

Title: Post-translational processing of an O-glycosylated protein, the human CD8 glycoprotein, during the intracellular transport to the plasma membrane.

PubMed ID: 1460019

DOI: 10.1016/s0021-9258(19)74024-1

PubMed ID: 7923932

Title: A distinctive form of soluble CD8 is secreted by stimulated CD8+ cells in HIV-1-infected and high-risk individuals.

PubMed ID: 7923932

DOI: 10.1006/clin.1994.1195

PubMed ID: 12853576

Title: Human inhibitory receptors Ig-like transcript 2 (ILT2) and ILT4 compete with CD8 for MHC class I binding and bind preferentially to HLA-G.

PubMed ID: 12853576

DOI: 10.1073/pnas.1431057100

PubMed ID: 16236125

Title: Ligation of CD8alpha on human natural killer cells prevents activation-induced apoptosis and enhances cytolytic activity.

PubMed ID: 16236125

DOI: 10.1111/j.1365-2567.2005.02235.x

PubMed ID: 17678538

Title: CD8 alpha is expressed by human monocytes and enhances Fc gamma R-dependent responses.

PubMed ID: 17678538

DOI: 10.1186/1471-2172-8-12

PubMed ID: 17341584

Title: CD8 Raft localization is induced by its assembly into CD8alpha beta heterodimers, Not CD8alpha alpha homodimers.

PubMed ID: 17341584

DOI: 10.1074/jbc.m701027200

PubMed ID: 23657257

Title: Immune surveillance by CD8alphaalpha+ skin-resident T cells in human herpes virus infection.

PubMed ID: 23657257

DOI: 10.1038/nature12110

PubMed ID: 26082771

Title: A subset of human plasmacytoid dendritic cells expresses CD8alpha upon exposure to herpes simplex virus type 1.

PubMed ID: 26082771

DOI: 10.3389/fmicb.2015.00557

PubMed ID: 1547508

Title: Crystal structure of a soluble form of the human T cell coreceptor CD8 at 2.6-A resolution.

PubMed ID: 1547508

DOI: 10.1016/0092-8674(92)90085-q

PubMed ID: 9177355

Title: Crystal structure of the complex between human CD8alpha(alpha) and HLA-A2.

PubMed ID: 9177355

DOI: 10.1038/42523

PubMed ID: 14500983

Title: A zinc clasp structure tethers Lck to T cell coreceptors CD4 and CD8.

PubMed ID: 14500983

DOI: 10.1126/science.1085643

PubMed ID: 11435463

Title: Familial CD8 deficiency due to a mutation in the CD8 alpha gene.

PubMed ID: 11435463

DOI: 10.1172/jci10993

Sequence Information:

  • Length: 235
  • Mass: 25729
  • Checksum: FCCA29BAA73726BB
  • Sequence:
    • MALPVTALLL PLALLLHAAR PSQFRVSPLD RTWNLGETVE LKCQVLLSNP TSGCSWLFQP 
RGAAASPTFL LYLSQNKPKA AEGLDTQRFS GKRLGDTFVL TLSDFRRENE GYYFCSALSN 
SIMYFSHFVP VFLPAKPTTT PAPRPPTPAP TIASQPLSLR PEACRPAAGG AVHTRGLDFA 
CDIYIWAPLA GTCGVLLLSL VITLYCNHRN RRRVCKCPRP VVKSGDKPSL SARYV

Genular Protein ID: 3569746370

Symbol: Q6ZVS2_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q6ZVS2

Database IDs:

ARBA 8 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 EMBL 2 GO 1 Gene3D 1 Genevisible 1 GenomeRNAi 1 InterPro 4 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 Pfam 2 PharmGKB 1 RefSeq 2 SAM 2 SUPFAM 1

Sequence Information:

  • Length: 152
  • Mass: 16713
  • Checksum: 6911F40F86122E02
  • Sequence:
    • MRNQAPGRPK GATFPPRRPT GSRAPPLAPE LRAKQRPGER VMALPVTALL LPLALLLHAA 
RPSQFRVSPL DRTWNLGETV ELKCQVLLSN PTSGCSWLFQ PRGAAASPTF LLYLSQNKPK 
AAEGLDTQRF SGKRLGDTFV LTLSDFRREN EG

Genular Protein ID: 3883293718

Symbol: Q8TAW8_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q8TAW8

Database IDs:

ARBA 9 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 2 GO 1 Gene3D 1 Genevisible 1 GenomeRNAi 1 InterPro 6 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PeptideAtlas 1 Pfam 1 PharmGKB 1 RefSeq 3 SAM 2 SMART 2 SMR 1 SUPFAM 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 235
  • Mass: 25669
  • Checksum: FCDFC9B5472D26BB
  • Sequence:
    • MALPVTALLL PLALLLHAAR PSQFRVSPLD RTWNLGETVE LKCQVLLSNP TSGCSWLFQP 
RGAAASPTFL LYLSQNKPKA AEGLDTQRFS GKRLGDTFVL TLSDFRRENE GCYFCSALSN 
SIMYFSHFVP VFLPAKPTTT PAPRPPTPAP TIASQPLSLR PEACRPAAGG AVHTRGLDFA 
CDIYIWAPLA GTCGVLLLSL VITLYCNHRN RRRVCKCPRP VVKSGDKPSL SARYV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.