RPS6KA5 | ENSG00000100784 | NCBI 9252

Details for: RPS6KA5

Gene ID: 9252

Symbol: RPS6KA5

Ensembl ID: ENSG00000100784

Description: ribosomal protein S6 kinase A5

Associated with

C-type lectin receptors (clrs)
(R-HSA-5621481)
Cd209 (dc-sign) signaling
(R-HSA-5621575)
Creb phosphorylation
(R-HSA-199920)
Cytokine signaling in immune system
(R-HSA-1280215)
Developmental biology
(R-HSA-1266738)
Erk/mapk targets
(R-HSA-198753)
Immune system
(R-HSA-168256)
Innate immune system
(R-HSA-168249)
Interleukin-17 signaling
(R-HSA-448424)
L1cam interactions
(R-HSA-373760)
Map kinase activation
(R-HSA-450294)
Mapk targets/ nuclear events mediated by map kinases
(R-HSA-450282)
Myd88 cascade initiated on plasma membrane
(R-HSA-975871)
Myd88 dependent cascade initiated on endosome
(R-HSA-975155)
Myd88-independent tlr4 cascade
(R-HSA-166166)
Myd88:mal(tirap) cascade initiated on plasma membrane
(R-HSA-166058)
Ncam signaling for neurite out-growth
(R-HSA-375165)
Nervous system development
(R-HSA-9675108)
Nuclear events (kinase and transcription factor activation)
(R-HSA-198725)
Recycling pathway of l1
(R-HSA-437239)
Signaling by interleukins
(R-HSA-449147)
Signaling by ntrk1 (trka)
(R-HSA-187037)
Signaling by ntrks
(R-HSA-166520)
Signaling by receptor tyrosine kinases
(R-HSA-9006934)
Signal transduction
(R-HSA-162582)
Toll-like receptor cascades
(R-HSA-168898)
Toll like receptor 2 (tlr2) cascade
(R-HSA-181438)
Toll like receptor 3 (tlr3) cascade
(R-HSA-168164)
Toll like receptor 4 (tlr4) cascade
(R-HSA-166016)
Toll like receptor 5 (tlr5) cascade
(R-HSA-168176)
Toll like receptor 7/8 (tlr7/8) cascade
(R-HSA-168181)
Toll like receptor 9 (tlr9) cascade
(R-HSA-168138)
Toll like receptor 10 (tlr10) cascade
(R-HSA-168142)
Toll like receptor tlr1:tlr2 cascade
(R-HSA-168179)
Toll like receptor tlr6:tlr2 cascade
(R-HSA-168188)
Traf6 mediated induction of nfkb and map kinases upon tlr7/8 or 9 activation
(R-HSA-975138)
Trif(ticam1)-mediated tlr4 signaling
(R-HSA-937061)
Atp binding
(GO:0005524)
Axon guidance
(GO:0007411)
Chromatin remodeling
(GO:0006338)
Cytoplasm
(GO:0005737)
Histone h2as1 kinase activity
(GO:0044024)
Histone h3s10 kinase activity
(GO:0035175)
Histone h3s28 kinase activity
(GO:0044022)
Inflammatory response
(GO:0006954)
Interleukin-1-mediated signaling pathway
(GO:0070498)
Intracellular signal transduction
(GO:0035556)
Magnesium ion binding
(GO:0000287)
Negative regulation of cytokine production
(GO:0001818)
Negative regulation of dna-templated transcription
(GO:0045892)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Peptidyl-serine phosphorylation
(GO:0018105)
Positive regulation of creb transcription factor activity
(GO:0032793)
Positive regulation of nf-kappab transcription factor activity
(GO:0051092)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Post-translational protein modification
(GO:0043687)
Protein binding
(GO:0005515)
Protein phosphorylation
(GO:0006468)
Protein serine/threonine kinase activity
(GO:0004674)
Protein serine kinase activity
(GO:0106310)
Protein tyrosine kinase activity
(GO:0004713)
Regulation of dna-templated transcription
(GO:0006355)
Regulation of postsynapse organization
(GO:0099175)

Other Information

Proteins

Ribosomal protein S6 kinase alpha-5

Genular Protein ID: 1062721157

Symbol: KS6A5_HUMAN

Name: Ribosomal protein S6 kinase alpha-5

UniProtKB Accession Codes:

O75582 B7Z2Y5 O95316 Q96AF7

Database IDs:

Citations:

PubMed ID: 9687510

Title: Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB.

PubMed ID: 9687510

DOI: 10.1093/emboj/17.15.4426

PubMed ID: 9873047

Title: Cloning and characterization of RLPK, a novel RSK-related protein kinase.

PubMed ID: 9873047

DOI: 10.1074/jbc.274.2.1026

PubMed ID: 10702687

Title: Assignment of a member of the ribosomal protein S6 kinase family, RPS6KA5, to human chromosome 14q31-q32.1 by radiation hybrid mapping.

PubMed ID: 10702687

DOI: 10.1159/000015441

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12508121

Title: The DNA sequence and analysis of human chromosome 14.

PubMed ID: 12508121

DOI: 10.1038/nature01348

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11909979

Title: MSK1 and MSK2 are required for the mitogen- and stress-induced phosphorylation of CREB and ATF1 in fibroblasts.

PubMed ID: 11909979

DOI: 10.1128/mcb.22.8.2871-2881.2002

PubMed ID: 12628924

Title: Transcriptional activation of the NF-kappaB p65 subunit by mitogen- and stress-activated protein kinase-1 (MSK1).

PubMed ID: 12628924

DOI: 10.1093/emboj/cdg139

PubMed ID: 12773393

Title: MSK2 and MSK1 mediate the mitogen- and stress-induced phosphorylation of histone H3 and HMG-14.

PubMed ID: 12773393

DOI: 10.1093/emboj/cdg273

PubMed ID: 12763138

Title: Erythropoietin-induced serine 727 phosphorylation of STAT3 in erythroid cells is mediated by a MEK-, ERK-, and MSK1-dependent pathway.

PubMed ID: 12763138

DOI: 10.1016/s0301-472x(03)00045-6

PubMed ID: 12569367

Title: Regulation of the ER81 transcription factor and its coactivators by mitogen- and stress-activated protein kinase 1 (MSK1).

PubMed ID: 12569367

DOI: 10.1038/sj.onc.1206185

PubMed ID: 15010469

Title: Phosphorylation of histone H2A inhibits transcription on chromatin templates.

PubMed ID: 15010469

DOI: 10.1074/jbc.m400099200

PubMed ID: 15568999

Title: MSK1 activity is controlled by multiple phosphorylation sites.

PubMed ID: 15568999

DOI: 10.1042/bj20041501

PubMed ID: 17117922

Title: Identification of novel phosphorylation sites in MSK1 by precursor ion scanning MS.

PubMed ID: 17117922

DOI: 10.1042/bj20061183

PubMed ID: 18511904

Title: Altered subcellular distribution of MSK1 induced by glucocorticoids contributes to NF-kappaB inhibition.

PubMed ID: 18511904

DOI: 10.1038/emboj.2008.95

PubMed ID: 18508628

Title: MSK activation and physiological roles.

PubMed ID: 18508628

DOI: 10.2741/3122

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19464896

Title: The versatile role of MSKs in transcriptional regulation.

PubMed ID: 19464896

DOI: 10.1016/j.tibs.2009.02.007

PubMed ID: 20596523

Title: Development and validation of a method for profiling post-translational modification activities using protein microarrays.

PubMed ID: 20596523

DOI: 10.1371/journal.pone.0011332

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 25851810

Title: The E3 ubiquitin ligase Trim7 mediates c-Jun/AP-1 activation by Ras signalling.

PubMed ID: 25851810

DOI: 10.1038/ncomms7782

PubMed ID: 15274926

Title: The structure of MSK1 reveals a novel autoinhibitory conformation for a dual kinase protein.

PubMed ID: 15274926

DOI: 10.1016/j.str.2004.02.040

PubMed ID: 20382163

Title: The crystal structure of the active form of the C-terminal kinase domain of mitogen- and stress-activated protein kinase 1.

PubMed ID: 20382163

DOI: 10.1016/j.jmb.2010.03.064

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

Length: 802
Mass: 89865
Checksum: 76C27D0F6639BFA4
Sequence:

MEEEGGSSGG AAGTSADGGD GGEQLLTVKH ELRTANLTGH AEKVGIENFE LLKVLGTGAY 
GKVFLVRKIS GHDTGKLYAM KVLKKATIVQ KAKTTEHTRT ERQVLEHIRQ SPFLVTLHYA 
FQTETKLHLI LDYINGGELF THLSQRERFT EHEVQIYVGE IVLALEHLHK LGIIYRDIKL 
ENILLDSNGH VVLTDFGLSK EFVADETERA YSFCGTIEYM APDIVRGGDS GHDKAVDWWS 
LGVLMYELLT GASPFTVDGE KNSQAEISRR ILKSEPPYPQ EMSALAKDLI QRLLMKDPKK 
RLGCGPRDAD EIKEHLFFQK INWDDLAAKK VPAPFKPVIR DELDVSNFAE EFTEMDPTYS 
PAALPQSSEK LFQGYSFVAP SILFKRNAAV IDPLQFHMGV ERPGVTNVAR SAMMKDSPFY 
QHYDLDLKDK PLGEGSFSIC RKCVHKKSNQ AFAVKIISKR MEANTQKEIT ALKLCEGHPN 
IVKLHEVFHD QLHTFLVMEL LNGGELFERI KKKKHFSETE ASYIMRKLVS AVSHMHDVGV 
VHRDLKPENL LFTDENDNLE IKIIDFGFAR LKPPDNQPLK TPCFTLHYAA PELLNQNGYD 
ESCDLWSLGV ILYTMLSGQV PFQSHDRSLT CTSAVEIMKK IKKGDFSFEG EAWKNVSQEA 
KDLIQGLLTV DPNKRLKMSG LRYNEWLQDG SQLSSNPLMT PDILGSSGAA VHTCVKATFH 
AFNKYKREGF CLQNVDKAPL AKRRKMKKTS TSTETRSSSS ESSHSSSSHS HGKTTPTKTL 
QPSNPADSNN PETLFQFSDS VA

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: RPS6KA5

Associated with

Other Information

Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB. PubMed ID: 9687510

Cloning and characterization of RLPK, a novel RSK-related protein kinase. PubMed ID: 9873047

Assignment of a member of the ribosomal protein S6 kinase family, RPS6KA5, to human chromosome 14q31-q32.1 by radiation hybrid mapping. PubMed ID: 10702687

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence and analysis of human chromosome 14. PubMed ID: 12508121

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

MSK1 and MSK2 are required for the mitogen- and stress-induced phosphorylation of CREB and ATF1 in fibroblasts. PubMed ID: 11909979

Transcriptional activation of the NF-kappaB p65 subunit by mitogen- and stress-activated protein kinase-1 (MSK1). PubMed ID: 12628924

MSK2 and MSK1 mediate the mitogen- and stress-induced phosphorylation of histone H3 and HMG-14. PubMed ID: 12773393

Erythropoietin-induced serine 727 phosphorylation of STAT3 in erythroid cells is mediated by a MEK-, ERK-, and MSK1-dependent pathway. PubMed ID: 12763138

Regulation of the ER81 transcription factor and its coactivators by mitogen- and stress-activated protein kinase 1 (MSK1). PubMed ID: 12569367

Phosphorylation of histone H2A inhibits transcription on chromatin templates. PubMed ID: 15010469

MSK1 activity is controlled by multiple phosphorylation sites. PubMed ID: 15568999

Identification of novel phosphorylation sites in MSK1 by precursor ion scanning MS. PubMed ID: 17117922

Altered subcellular distribution of MSK1 induced by glucocorticoids contributes to NF-kappaB inhibition. PubMed ID: 18511904

MSK activation and physiological roles. PubMed ID: 18508628

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. PubMed ID: 19690332

The versatile role of MSKs in transcriptional regulation. PubMed ID: 19464896

Development and validation of a method for profiling post-translational modification activities using protein microarrays. PubMed ID: 20596523

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

Initial characterization of the human central proteome. PubMed ID: 21269460

The E3 ubiquitin ligase Trim7 mediates c-Jun/AP-1 activation by Ras signalling. PubMed ID: 25851810

The structure of MSK1 reveals a novel autoinhibitory conformation for a dual kinase protein. PubMed ID: 15274926

The crystal structure of the active form of the C-terminal kinase domain of mitogen- and stress-activated protein kinase 1. PubMed ID: 20382163

Patterns of somatic mutation in human cancer genomes. PubMed ID: 17344846