CD8B | ENSG00000172116 | NCBI 926

Details for: CD8B

Gene ID: 926

Symbol: CD8B

Ensembl ID: ENSG00000172116

Description: CD8 subunit beta

Associated with

Adaptive immune system
(R-HSA-1280218)
Disease
(R-HSA-1643685)
Hiv infection
(R-HSA-162906)
Host interactions of hiv factors
(R-HSA-162909)
Immune system
(R-HSA-168256)
Immunoregulatory interactions between a lymphoid and a non-lymphoid cell
(R-HSA-198933)
Infectious disease
(R-HSA-5663205)
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters
(R-HSA-164938)
Nef mediated cd8 down-regulation
(R-HSA-182218)
The role of nef in hiv-1 replication and disease pathogenesis
(R-HSA-164952)
Viral infection pathways
(R-HSA-9824446)
Adaptive immune response
(GO:0002250)
Cell surface
(GO:0009986)
Coreceptor activity
(GO:0015026)
Early endosome membrane
(GO:0031901)
Extracellular region
(GO:0005576)
Immune response
(GO:0006955)
Mhc class i protein binding
(GO:0042288)
Plasma membrane
(GO:0005886)
Protein binding
(GO:0005515)
Receptor complex
(GO:0043235)
T cell activation
(GO:0042110)
T cell receptor complex
(GO:0042101)
T cell receptor signaling pathway
(GO:0050852)
Transmembrane receptor protein tyrosine kinase signaling pathway
(GO:0007169)

Other Information

Proteins

T-cell surface glycoprotein CD8 beta chain
Q53QL8_HUMAN

Genular Protein ID: 2767409943

Symbol: CD8B_HUMAN

Name: T-cell surface glycoprotein CD8 beta chain

UniProtKB Accession Codes:

P10966 P14860 P14861 Q15980 Q496E0 Q496E1 Q496E2 Q9UDB4 Q9UDB5 Q9UDB6 Q9UDB7 Q9UDB8 Q9UDB9 Q9UDC0 Q9UQ55

Database IDs:

Citations:

PubMed ID: 3145195

Title: A second subunit of CD8 is expressed in human T cells.

PubMed ID: 3145195

DOI: 10.1002/j.1460-2075.1988.tb03217.x

PubMed ID: 3145196

Title: The human Lyt-3 molecule requires CD8 for cell surface expression.

PubMed ID: 3145196

DOI: 10.1002/j.1460-2075.1988.tb03221.x

PubMed ID: 3264320

Title: A second chain of human CD8 is expressed on peripheral blood lymphocytes.

PubMed ID: 3264320

DOI: 10.1084/jem.168.6.1993

PubMed ID: 1541829

Title: Recent duplication of the two human CD8 beta-chain genes.

PubMed ID: 1541829

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8436166

Title: Transcriptional diversity at the duplicated human CD8 beta loci.

PubMed ID: 8436166

DOI: 10.1002/eji.1830230203

PubMed ID: 10925291

Title: Essential role of CD8 palmitoylation in CD8 coreceptor function.

PubMed ID: 10925291

DOI: 10.4049/jimmunol.165.4.2068

PubMed ID: 11714755

Title: CD8beta endows CD8 with efficient coreceptor function by coupling T cell receptor/CD3 to raft-associated CD8/p56(lck) complexes.

PubMed ID: 11714755

DOI: 10.1084/jem.194.10.1485

PubMed ID: 17145893

Title: Influence of human CD8 on antigen recognition by T-cell receptor-transduced cells.

PubMed ID: 17145893

DOI: 10.1158/0008-5472.can-06-2379

Sequence Information:

Length: 210
Mass: 23722
Checksum: 675AD919585F4B80
Sequence:

MRPRLWLLLA AQLTVLHGNS VLQQTPAYIK VQTNKMVMLS CEAKISLSNM RIYWLRQRQA 
PSSDSHHEFL ALWDSAKGTI HGEEVEQEKI AVFRDASRFI LNLTSVKPED SGIYFCMIVG 
SPELTFGKGT QLSVVDFLPT TAQPTKKSTL KKRVCRLPRP ETQKGPLCSP ITLGLLVAGV 
LVLLVSLGVA IHLCCRRRRA RLRFMKQFYK

Genular Protein ID: 933438988

Symbol: Q53QL8_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q53QL8

Database IDs:

Sequence Information:

Length: 246
Mass: 27699
Checksum: 348BD12A23CE59CD
Sequence:

MRPRLWLLLA AQLTVLHGNS VLQQTPAYIK VQTNKMVMLS CEAKISLSNM RIYWLRQRQA 
PSSDSHHEFL ALWDSAKGTI HGEEVEQEKI AVFRDASRFI LNLTSVKPED SGIYFCMIVG 
SPELTFGKGT QLSVVDFLPT TAQPTKKSTL KKRVCRLPRP ETQKGPLCSP ITLGLLVAGV 
LVLLVSLGVA IHLCCRRRRA RLRFMKQKFN IVCLKISGFT TCCCFQILQM SREYGFGVLL 
QKDIGQ

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: CD8B

Associated with

Other Information

A second subunit of CD8 is expressed in human T cells. PubMed ID: 3145195

The human Lyt-3 molecule requires CD8 for cell surface expression. PubMed ID: 3145196

A second chain of human CD8 is expressed on peripheral blood lymphocytes. PubMed ID: 3264320

Recent duplication of the two human CD8 beta-chain genes. PubMed ID: 1541829

Generation and annotation of the DNA sequences of human chromosomes 2 and 4. PubMed ID: 15815621

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Transcriptional diversity at the duplicated human CD8 beta loci. PubMed ID: 8436166

Essential role of CD8 palmitoylation in CD8 coreceptor function. PubMed ID: 10925291

CD8beta endows CD8 with efficient coreceptor function by coupling T cell receptor/CD3 to raft-associated CD8/p56(lck) complexes. PubMed ID: 11714755

Influence of human CD8 on antigen recognition by T-cell receptor-transduced cells. PubMed ID: 17145893