Details for: CD8B

Gene ID: 926

Symbol: CD8B

Ensembl ID: ENSG00000172116

Description: CD8 subunit beta

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 5.15
    Marker Score: 7103
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 2.9
    Marker Score: 8122
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 2.47
    Marker Score: 24412
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 2.27
    Marker Score: 4450
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 2.12
    Marker Score: 1217
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 2.05
    Marker Score: 3662
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 2.04
    Marker Score: 1479
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 2
    Marker Score: 2944
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: 1.97
    Marker Score: 1086
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 1.96
    Marker Score: 1646
  • Cell Name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell (CL0000802)
    Fold Change: 1.89
    Marker Score: 616
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 1.89
    Marker Score: 1878
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 1.64
    Marker Score: 1007
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 1.5
    Marker Score: 2117
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: 1.48
    Marker Score: 4740
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 1.39
    Marker Score: 2278
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.38
    Marker Score: 1380
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 1.35
    Marker Score: 582
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: 1.34
    Marker Score: 689
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 1.19
    Marker Score: 1928
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 1.14
    Marker Score: 353
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 1.09
    Marker Score: 929
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 1.06
    Marker Score: 1024
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.06
    Marker Score: 670
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 1.03
    Marker Score: 1580.5
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71810
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48034
  • Cell Name: activated CD8-positive, alpha-beta T cell, human (CL0001049)
    Fold Change: 1
    Marker Score: 226
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30407
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 504
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.98
    Marker Score: 661
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 457
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2411
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5290
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.92
    Marker Score: 383
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2739
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 322
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 0.89
    Marker Score: 274
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5287
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 0.85
    Marker Score: 572
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.82
    Marker Score: 598
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: 0.81
    Marker Score: 717
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.81
    Marker Score: 618
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.79
    Marker Score: 315
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1269
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.76
    Marker Score: 695
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 392
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.74
    Marker Score: 3104.5
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 0.73
    Marker Score: 550
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.7
    Marker Score: 8177
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 176
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 0.64
    Marker Score: 573
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 0.63
    Marker Score: 237
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.56
    Marker Score: 319
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.56
    Marker Score: 356
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 0.56
    Marker Score: 192
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 0.52
    Marker Score: 491
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 0.5
    Marker Score: 539
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.5
    Marker Score: 132
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.49
    Marker Score: 160
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.49
    Marker Score: 926
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 0.48
    Marker Score: 206
  • Cell Name: naive T cell (CL0000898)
    Fold Change: 0.47
    Marker Score: 304
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.47
    Marker Score: 235
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 0.46
    Marker Score: 1129
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.46
    Marker Score: 481
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 0.44
    Marker Score: 390
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.44
    Marker Score: 892
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 0.39
    Marker Score: 226
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 0.35
    Marker Score: 105
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 0.34
    Marker Score: 584
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 0.33
    Marker Score: 733
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.32
    Marker Score: 195
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.31
    Marker Score: 99
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.31
    Marker Score: 313
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 0.3
    Marker Score: 169
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 0.3
    Marker Score: 328
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 0.29
    Marker Score: 231
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.28
    Marker Score: 369
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.28
    Marker Score: 4446
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.28
    Marker Score: 212
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.27
    Marker Score: 163
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    Fold Change: 0.27
    Marker Score: 299
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.26
    Marker Score: 448
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.26
    Marker Score: 92
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.25
    Marker Score: 115
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.23
    Marker Score: 120
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.23
    Marker Score: 286
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 64
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 74
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.21
    Marker Score: 1322
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.21
    Marker Score: 95
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.21
    Marker Score: 118
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 0.2
    Marker Score: 642.5
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 0.2
    Marker Score: 181
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 0.2
    Marker Score: 147
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.2
    Marker Score: 39
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.2
    Marker Score: 89
  • Cell Name: type II NK T cell (CL0000922)
    Fold Change: 0.19
    Marker Score: 60

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Other Information

**Key characteristics:** * CD8B is a type I transmembrane receptor. * It is expressed on the surface of double-negative thymocytes, CD8-positive, alpha-beta memory T cells, CD45RO-positive, mature T cells, double-positive, alpha-beta thymocyte, exhausted T cell, naive thymus-derived CD8-positive, alpha-beta T cell, activated CD8-positive, alpha-beta T cell, effector memory CD8-positive, alpha-beta T cell, and terminally differentiated CD8-positive, alpha-beta thymocyte. * It is a highly conserved protein, with a similar sequence found in humans, rodents, and primates. **Pathways and functions:** * CD8B is expressed on the surface of T cells and is involved in the recognition of MHC class I molecules. * When an MHC class I molecule binds to CD8B, it triggers the intracellular signaling pathway, which leads to the activation of the T cell. * CD8B is also involved in the regulation of T cell activation. It can block the activation of T cells by binding to MHC class I molecules and preventing them from interacting with CD28. **Clinical significance:** * Mutations in the CD8B gene have been linked to the development of several human cancers, including lung cancer, breast cancer, and prostate cancer. * Targeting CD8B has been explored as a therapeutic strategy for these cancers. * In clinical trials, anti-CD8B antibodies have shown some efficacy in treating cancer, but they have also shown to be associated with serious side effects.

Genular Protein ID: 2767409943

Symbol: CD8B_HUMAN

Name: T-cell surface glycoprotein CD8 beta chain

UniProtKB Accession Codes:

P10966 P14860 P14861 Q15980 Q496E0 Q496E1 Q496E2 Q9UDB4 Q9UDB5 Q9UDB6 Q9UDB7 Q9UDB8 Q9UDB9 Q9UDC0 Q9UQ55

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 5 CDD 1 CTD 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 37 Ensembl 5 ExpressionAtlas 1 GO 13 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 8 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 9 RNAct 1 Reactome 2 RefSeq 5 SMART 2 SMR 1 SUPFAM 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 3145195

Title: A second subunit of CD8 is expressed in human T cells.

PubMed ID: 3145195

DOI: 10.1002/j.1460-2075.1988.tb03217.x

PubMed ID: 3145196

Title: The human Lyt-3 molecule requires CD8 for cell surface expression.

PubMed ID: 3145196

DOI: 10.1002/j.1460-2075.1988.tb03221.x

PubMed ID: 3264320

Title: A second chain of human CD8 is expressed on peripheral blood lymphocytes.

PubMed ID: 3264320

DOI: 10.1084/jem.168.6.1993

PubMed ID: 1541829

Title: Recent duplication of the two human CD8 beta-chain genes.

PubMed ID: 1541829

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8436166

Title: Transcriptional diversity at the duplicated human CD8 beta loci.

PubMed ID: 8436166

DOI: 10.1002/eji.1830230203

PubMed ID: 10925291

Title: Essential role of CD8 palmitoylation in CD8 coreceptor function.

PubMed ID: 10925291

DOI: 10.4049/jimmunol.165.4.2068

PubMed ID: 11714755

Title: CD8beta endows CD8 with efficient coreceptor function by coupling T cell receptor/CD3 to raft-associated CD8/p56(lck) complexes.

PubMed ID: 11714755

DOI: 10.1084/jem.194.10.1485

PubMed ID: 17145893

Title: Influence of human CD8 on antigen recognition by T-cell receptor-transduced cells.

PubMed ID: 17145893

DOI: 10.1158/0008-5472.can-06-2379

Sequence Information:

  • Length: 210
  • Mass: 23722
  • Checksum: 675AD919585F4B80
  • Sequence:
    • MRPRLWLLLA AQLTVLHGNS VLQQTPAYIK VQTNKMVMLS CEAKISLSNM RIYWLRQRQA 
PSSDSHHEFL ALWDSAKGTI HGEEVEQEKI AVFRDASRFI LNLTSVKPED SGIYFCMIVG 
SPELTFGKGT QLSVVDFLPT TAQPTKKSTL KKRVCRLPRP ETQKGPLCSP ITLGLLVAGV 
LVLLVSLGVA IHLCCRRRRA RLRFMKQFYK

Genular Protein ID: 933438988

Symbol: Q53QL8_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q53QL8

Database IDs:

ARBA 7 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 EMBL 2 GO 4 Gene3D 1 GenomeRNAi 1 InterPro 6 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 Pfam 1 RefSeq 1 SAM 2 SMART 2 SMR 1 SUPFAM 1

Sequence Information:

  • Length: 246
  • Mass: 27699
  • Checksum: 348BD12A23CE59CD
  • Sequence:
    • MRPRLWLLLA AQLTVLHGNS VLQQTPAYIK VQTNKMVMLS CEAKISLSNM RIYWLRQRQA 
PSSDSHHEFL ALWDSAKGTI HGEEVEQEKI AVFRDASRFI LNLTSVKPED SGIYFCMIVG 
SPELTFGKGT QLSVVDFLPT TAQPTKKSTL KKRVCRLPRP ETQKGPLCSP ITLGLLVAGV 
LVLLVSLGVA IHLCCRRRRA RLRFMKQKFN IVCLKISGFT TCCCFQILQM SREYGFGVLL 
QKDIGQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.