Details for: CD8B

Gene ID: 926

Symbol: CD8B

Ensembl ID: ENSG00000172116

Description: CD8 subunit beta

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 49.4069
    Cell Significance Index: -7.6900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 31.8459
    Cell Significance Index: -8.0800
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 28.1841
    Cell Significance Index: -11.4500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 6.0708
    Cell Significance Index: -7.4900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 2.2567
    Cell Significance Index: 102.2900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 2.0730
    Cell Significance Index: -8.1800
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.9255
    Cell Significance Index: 29.7900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.7937
    Cell Significance Index: 341.3600
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 1.7614
    Cell Significance Index: -5.4100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.4125
    Cell Significance Index: 139.7300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.2948
    Cell Significance Index: 27.5800
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 1.1930
    Cell Significance Index: 12.3700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.9784
    Cell Significance Index: 883.4500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.7399
    Cell Significance Index: 80.4800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.7291
    Cell Significance Index: 118.5900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.5880
    Cell Significance Index: 35.3000
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 0.5753
    Cell Significance Index: 4.2800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3898
    Cell Significance Index: 26.9600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.3841
    Cell Significance Index: 76.2300
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 0.2198
    Cell Significance Index: 1.7100
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 0.1789
    Cell Significance Index: 1.5100
  • Cell Name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell (CL0000802)
    Fold Change: 0.0966
    Cell Significance Index: 0.5600
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 0.0834
    Cell Significance Index: 0.6000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.0514
    Cell Significance Index: 14.7800
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: 0.0443
    Cell Significance Index: 0.4100
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 0.0422
    Cell Significance Index: 0.4000
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.0358
    Cell Significance Index: 1.0500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0239
    Cell Significance Index: 0.6900
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 0.0168
    Cell Significance Index: 0.2900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0089
    Cell Significance Index: 1.0400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0028
    Cell Significance Index: 0.0700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0009
    Cell Significance Index: -0.0300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0037
    Cell Significance Index: -6.8900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0046
    Cell Significance Index: -0.1000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0055
    Cell Significance Index: -10.2300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0069
    Cell Significance Index: -10.5900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0070
    Cell Significance Index: -1.4000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0080
    Cell Significance Index: -10.8800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0089
    Cell Significance Index: -4.8600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0094
    Cell Significance Index: -6.9900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0096
    Cell Significance Index: -7.2600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0114
    Cell Significance Index: -4.1100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0134
    Cell Significance Index: -0.8200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0154
    Cell Significance Index: -0.5400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0156
    Cell Significance Index: -8.7900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0170
    Cell Significance Index: -12.4500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0181
    Cell Significance Index: -11.3100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0189
    Cell Significance Index: -12.0200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0246
    Cell Significance Index: -11.1800
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: -0.0252
    Cell Significance Index: -0.2100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0381
    Cell Significance Index: -4.8900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0386
    Cell Significance Index: -8.1400
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.0412
    Cell Significance Index: -0.5900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0539
    Cell Significance Index: -9.2100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0540
    Cell Significance Index: -9.7400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0555
    Cell Significance Index: -7.6300
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: -0.0613
    Cell Significance Index: -0.4900
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.0650
    Cell Significance Index: -0.6600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0658
    Cell Significance Index: -8.5000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0689
    Cell Significance Index: -8.1200
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0695
    Cell Significance Index: -3.0200
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: -0.0725
    Cell Significance Index: -0.5100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0730
    Cell Significance Index: -3.4300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0760
    Cell Significance Index: -9.3500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0768
    Cell Significance Index: -11.1700
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: -0.0768
    Cell Significance Index: -0.8400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0779
    Cell Significance Index: -8.9200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0782
    Cell Significance Index: -8.1400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0854
    Cell Significance Index: -8.7300
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.1110
    Cell Significance Index: -1.5100
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.1121
    Cell Significance Index: -1.6900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1141
    Cell Significance Index: -7.6700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1152
    Cell Significance Index: -3.2200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1162
    Cell Significance Index: -7.3300
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: -0.1173
    Cell Significance Index: -0.9500
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.1181
    Cell Significance Index: -1.1900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1248
    Cell Significance Index: -9.5800
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.1270
    Cell Significance Index: -1.5000
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.1331
    Cell Significance Index: -1.3800
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.1342
    Cell Significance Index: -2.2800
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.1367
    Cell Significance Index: -2.0000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1383
    Cell Significance Index: -8.5000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1486
    Cell Significance Index: -7.5100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1496
    Cell Significance Index: -11.1500
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1497
    Cell Significance Index: -6.1400
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: -0.1528
    Cell Significance Index: -1.7300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1574
    Cell Significance Index: -12.4700
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.1584
    Cell Significance Index: -1.6400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1720
    Cell Significance Index: -9.6500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1832
    Cell Significance Index: -4.7100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1862
    Cell Significance Index: -12.0100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1902
    Cell Significance Index: -8.8700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1931
    Cell Significance Index: -10.0300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1999
    Cell Significance Index: -8.8400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2071
    Cell Significance Index: -5.5400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.2097
    Cell Significance Index: -4.3900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2098
    Cell Significance Index: -7.3500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.2124
    Cell Significance Index: -3.6400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2192
    Cell Significance Index: -6.9800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2239
    Cell Significance Index: -7.3300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** CD8B is a transmembrane receptor protein tyrosine kinase that is expressed on the surface of double-negative thymocytes, CD8-positive T cells, and other mature T cell subsets. It is a part of the T cell receptor (TCR) complex, which enables T cells to recognize and respond to antigens presented by major histocompatibility complex (MHC) class I molecules. CD8B is composed of two subunits, α and β, with the β subunit being the focus of this review. **Pathways and Functions:** CD8B is involved in various signaling pathways that regulate T cell activation, proliferation, and differentiation. These pathways include: 1. **T cell receptor signaling pathway**: CD8B interacts with the TCR complex to trigger signaling cascades that activate transcription factors, such as NF-AT and NF-κB, which regulate gene expression. 2. **Coreceptor activity**: CD8B interacts with CD4 to enhance T cell receptor signaling and facilitate antigen recognition. 3. **Adaptive immune response**: CD8B plays a critical role in the adaptive immune response, enabling T cells to recognize and respond to antigens presented by MHC class I molecules. 4. **Immune regulation**: CD8B is involved in regulating immune responses, including the activation and suppression of T cells. **Clinical Significance:** CD8B is implicated in various immune-related disorders, including: 1. **HIV-1 infection**: CD8B is down-regulated by the HIV-1 protein Nef, leading to impaired T cell function and disease progression. 2. **Autoimmune diseases**: Abnormal CD8B expression and function have been linked to autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis. 3. **Cancer**: CD8B is involved in the regulation of anti-tumor immune responses, and its dysregulation has been implicated in cancer progression. 4. **Immunodeficiency**: CD8B mutations have been associated with immunodeficiency disorders, such as severe combined immunodeficiency (SCID). In conclusion, CD8B is a critical component of the T cell receptor complex, playing a vital role in the adaptive immune response. Its dysregulation has been implicated in various immune-related disorders, underscoring the importance of understanding its mechanisms of action and clinical significance. **Proteins:** The CD8B gene encodes for the T-cell surface glycoprotein CD8 beta chain, which is also known as CD8B_HUMAN (Q53QL8_HUMAN). This protein is composed of two subunits, α and β, with the β subunit being the focus of this review. **Significantly Expressed Cells:** CD8B is expressed on a variety of mature T cell subsets, including: 1. Double-negative thymocytes 2. CD8-positive, alpha-beta memory T cells 3. CD45RO-positive, mature T cells 4. Activated CD8-positive, alpha-beta T cells 5. Effector memory CD8-positive, alpha-beta T cells 6. Terminally differentiated, CD8-positive, alpha-beta thymocytes 7. Exhausted T cells 8. Naive thymus-derived CD8-positive, alpha-beta T cells These cells are involved in various immune responses, including the recognition and response to antigens presented by MHC class I molecules.

Genular Protein ID: 2767409943

Symbol: CD8B_HUMAN

Name: T-cell surface glycoprotein CD8 beta chain

UniProtKB Accession Codes:

P10966 P14860 P14861 Q15980 Q496E0 Q496E1 Q496E2 Q9UDB4 Q9UDB5 Q9UDB6 Q9UDB7 Q9UDB8 Q9UDB9 Q9UDC0 Q9UQ55

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 5 CDD 1 CTD 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 37 Ensembl 5 ExpressionAtlas 1 GO 13 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 8 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 9 RNAct 1 Reactome 2 RefSeq 5 SMART 2 SMR 1 SUPFAM 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 3145195

Title: A second subunit of CD8 is expressed in human T cells.

PubMed ID: 3145195

DOI: 10.1002/j.1460-2075.1988.tb03217.x

PubMed ID: 3145196

Title: The human Lyt-3 molecule requires CD8 for cell surface expression.

PubMed ID: 3145196

DOI: 10.1002/j.1460-2075.1988.tb03221.x

PubMed ID: 3264320

Title: A second chain of human CD8 is expressed on peripheral blood lymphocytes.

PubMed ID: 3264320

DOI: 10.1084/jem.168.6.1993

PubMed ID: 1541829

Title: Recent duplication of the two human CD8 beta-chain genes.

PubMed ID: 1541829

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8436166

Title: Transcriptional diversity at the duplicated human CD8 beta loci.

PubMed ID: 8436166

DOI: 10.1002/eji.1830230203

PubMed ID: 10925291

Title: Essential role of CD8 palmitoylation in CD8 coreceptor function.

PubMed ID: 10925291

DOI: 10.4049/jimmunol.165.4.2068

PubMed ID: 11714755

Title: CD8beta endows CD8 with efficient coreceptor function by coupling T cell receptor/CD3 to raft-associated CD8/p56(lck) complexes.

PubMed ID: 11714755

DOI: 10.1084/jem.194.10.1485

PubMed ID: 17145893

Title: Influence of human CD8 on antigen recognition by T-cell receptor-transduced cells.

PubMed ID: 17145893

DOI: 10.1158/0008-5472.can-06-2379

Sequence Information:

  • Length: 210
  • Mass: 23722
  • Checksum: 675AD919585F4B80
  • Sequence:
    • MRPRLWLLLA AQLTVLHGNS VLQQTPAYIK VQTNKMVMLS CEAKISLSNM RIYWLRQRQA 
PSSDSHHEFL ALWDSAKGTI HGEEVEQEKI AVFRDASRFI LNLTSVKPED SGIYFCMIVG 
SPELTFGKGT QLSVVDFLPT TAQPTKKSTL KKRVCRLPRP ETQKGPLCSP ITLGLLVAGV 
LVLLVSLGVA IHLCCRRRRA RLRFMKQFYK

Genular Protein ID: 933438988

Symbol: Q53QL8_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q53QL8

Database IDs:

ARBA 7 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 5 Gene3D 1 InterPro 6 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 Pfam 1 RefSeq 1 SAM 2 SMART 2 SMR 1 SUPFAM 1

Sequence Information:

  • Length: 246
  • Mass: 27699
  • Checksum: 348BD12A23CE59CD
  • Sequence:
    • MRPRLWLLLA AQLTVLHGNS VLQQTPAYIK VQTNKMVMLS CEAKISLSNM RIYWLRQRQA 
PSSDSHHEFL ALWDSAKGTI HGEEVEQEKI AVFRDASRFI LNLTSVKPED SGIYFCMIVG 
SPELTFGKGT QLSVVDFLPT TAQPTKKSTL KKRVCRLPRP ETQKGPLCSP ITLGLLVAGV 
LVLLVSLGVA IHLCCRRRRA RLRFMKQKFN IVCLKISGFT TCCCFQILQM SREYGFGVLL 
QKDIGQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.