Details for: MAPKAPK2

Gene ID: 9261

Symbol: MAPKAPK2

Ensembl ID: ENSG00000162889

Description: MAPK activated protein kinase 2

Associated with

Other Information

Genular Protein ID: 1315984950

Symbol: MAPK2_HUMAN

Name: MAP kinase-activated protein kinase 2

UniProtKB Accession Codes:

P49137 Q5SY30 Q5SY41 Q8IYD6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 BRENDA 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEBI 13 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 7 DrugCentral 1 EC 3 ELM 1 EMBL 7 EPD 1 Ensembl 2 EvolutionaryTrace 1 GO 37 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 38 PDBsum 28 PIR 2 PRO 1 PROSITE 3 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 10 RefSeq 2 Rhea 6 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8179591

Title: The primary structure of a human MAP kinase activated protein kinase 2.

PubMed ID: 8179591

DOI: 10.1006/bbrc.1994.1566

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8280084

Title: The substrate specificity and structure of mitogen-activated protein (MAP) kinase-activated protein kinase-2.

PubMed ID: 8280084

DOI: 10.1042/bj2960843

PubMed ID: 8093612

Title: Small heat shock proteins are molecular chaperones.

PubMed ID: 8093612

DOI: 10.1016/s0021-9258(18)53882-5

PubMed ID: 8846784

Title: Identification of novel phosphorylation sites required for activation of MAPKAP kinase-2.

PubMed ID: 8846784

DOI: 10.1002/j.1460-2075.1995.tb00280.x

PubMed ID: 8774846

Title: A comparison of the substrate specificity of MAPKAP kinase-2 and MAPKAP kinase-3 and their activation by cytokines and cellular stress.

PubMed ID: 8774846

DOI: 10.1016/0014-5793(96)00816-2

PubMed ID: 10383393

Title: Regulation of Hsp27 oligomerization, chaperone function, and protective activity against oxidative stress/tumor necrosis factor alpha by phosphorylation.

PubMed ID: 10383393

DOI: 10.1074/jbc.274.27.18947

PubMed ID: 12456657

Title: Inhibition of SAPK2a/p38 prevents hnRNP A0 phosphorylation by MAPKAP-K2 and its interaction with cytokine mRNAs.

PubMed ID: 12456657

DOI: 10.1093/emboj/cdf639

PubMed ID: 11844797

Title: Arachidonic acid promotes phosphorylation of 5-lipoxygenase at Ser-271 by MAPK-activated protein kinase 2 (MK2).

PubMed ID: 11844797

DOI: 10.1074/jbc.m111945200

PubMed ID: 12565831

Title: Affinity purification of ARE-binding proteins identifies polyA-binding protein 1 as a potential substrate in MK2-induced mRNA stabilization.

PubMed ID: 12565831

DOI: 10.1016/s0006-291x(03)00015-9

PubMed ID: 14499342

Title: MAPK-activated protein kinase-2 participates in p38 MAPK-dependent and ERK-dependent functions in human neutrophils.

PubMed ID: 14499342

DOI: 10.1016/s0898-6568(03)00074-3

PubMed ID: 14517288

Title: Stabilization of urokinase and urokinase receptor mRNAs by HuR is linked to its cytoplasmic accumulation induced by activated mitogen-activated protein kinase-activated protein kinase 2.

PubMed ID: 14517288

DOI: 10.1128/mcb.23.20.7177-7188.2003

PubMed ID: 15014438

Title: MK2-induced tristetraprolin:14-3-3 complexes prevent stress granule association and ARE-mRNA decay.

PubMed ID: 15014438

DOI: 10.1038/sj.emboj.7600163

PubMed ID: 15094067

Title: P66(ShcA) interacts with MAPKAP kinase 2 and regulates its activity.

PubMed ID: 15094067

DOI: 10.1016/s0014-5793(04)00351-5

PubMed ID: 15629715

Title: MAPKAP kinase-2 is a cell cycle checkpoint kinase that regulates the G2/M transition and S phase progression in response to UV irradiation.

PubMed ID: 15629715

DOI: 10.1016/j.molcel.2004.11.021

PubMed ID: 16456544

Title: MAPKAPK-2-mediated LIM-kinase activation is critical for VEGF-induced actin remodeling and cell migration.

PubMed ID: 16456544

DOI: 10.1038/sj.emboj.7600973

PubMed ID: 16278218

Title: Phosphorylation of HSF1 by MAPK-activated protein kinase 2 on serine 121, inhibits transcriptional activity and promotes HSP90 binding.

PubMed ID: 16278218

DOI: 10.1074/jbc.m505822200

PubMed ID: 17481585

Title: MAPKAPK2-mediated LSP1 phosphorylation and FMLP-induced neutrophil polarization.

PubMed ID: 17481585

DOI: 10.1016/j.bbrc.2007.04.104

PubMed ID: 18021073

Title: Roles for TAB1 in regulating the IL-1-dependent phosphorylation of the TAB3 regulatory subunit and activity of the TAK1 complex.

PubMed ID: 18021073

DOI: 10.1042/bj20071149

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 20932473

Title: DNA damage activates a spatially distinct late cytoplasmic cell-cycle checkpoint network controlled by MK2-mediated RNA stabilization.

PubMed ID: 20932473

DOI: 10.1016/j.molcel.2010.09.018

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21131586

Title: MK2 SUMOylation regulates actin filament remodeling and subsequent migration in endothelial cells by inhibiting MK2 kinase and HSP27 phosphorylation.

PubMed ID: 21131586

DOI: 10.1182/blood-2010-08-302281

PubMed ID: 18508601

Title: MK2 and MK3--a pair of isoenzymes?

PubMed ID: 18508601

DOI: 10.2741/3095

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 26616734

Title: p38- and MK2-dependent signalling promotes stress-induced centriolar satellite remodelling via 14-3-3-dependent sequestration of CEP131/AZI1.

PubMed ID: 26616734

DOI: 10.1038/ncomms10075

PubMed ID: 12171911

Title: Structure of mitogen-activated protein kinase-activated protein (MAPKAP) kinase 2 suggests a bifunctional switch that couples kinase activation with nuclear export.

PubMed ID: 12171911

DOI: 10.1074/jbc.c200418200

PubMed ID: 12791252

Title: Catalytically active MAP KAP kinase 2 structures in complex with staurosporine and ADP reveal differences with the autoinhibited enzyme.

PubMed ID: 12791252

DOI: 10.1016/s0969-2126(03)00092-3

PubMed ID: 17576063

Title: The discovery of carboline analogs as potent MAPKAP-K2 inhibitors.

PubMed ID: 17576063

DOI: 10.1016/j.bmcl.2007.05.101

PubMed ID: 17255097

Title: Crystal structure of the p38 alpha-MAPKAP kinase 2 heterodimer.

PubMed ID: 17255097

DOI: 10.1074/jbc.m611165200

PubMed ID: 17480064

Title: Pyrrolopyridine inhibitors of mitogen-activated protein kinase-activated protein kinase 2 (MK-2).

PubMed ID: 17480064

DOI: 10.1021/jm0611004

PubMed ID: 17449059

Title: Structural basis for a high affinity inhibitor bound to protein kinase MK2.

PubMed ID: 17449059

DOI: 10.1016/j.jmb.2007.03.004

PubMed ID: 17395714

Title: Molecular basis of MAPK-activated protein kinase 2:p38 assembly.

PubMed ID: 17395714

DOI: 10.1073/pnas.0701679104

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

  • Length: 400
  • Mass: 45568
  • Checksum: E4EFFF11CCF288DC
  • Sequence:
    • MLSNSQGQSP PVPFPAPAPP PQPPTPALPH PPAQPPPPPP QQFPQFHVKS GLQIKKNAII 
DDYKVTSQVL GLGINGKVLQ IFNKRTQEKF ALKMLQDCPK ARREVELHWR ASQCPHIVRI 
VDVYENLYAG RKCLLIVMEC LDGGELFSRI QDRGDQAFTE REASEIMKSI GEAIQYLHSI 
NIAHRDVKPE NLLYTSKRPN AILKLTDFGF AKETTSHNSL TTPCYTPYYV APEVLGPEKY 
DKSCDMWSLG VIMYILLCGY PPFYSNHGLA ISPGMKTRIR MGQYEFPNPE WSEVSEEVKM 
LIRNLLKTEP TQRMTITEFM NHPWIMQSTK VPQTPLHTSR VLKEDKERWE DVKEEMTSAL 
ATMRVDYEQI KIKKIEDASN PLLLKRRKKA RALEAAALAH

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.