Genular: Defining Cellular Identity and Function

Details for: MAPKAPK2

Gene ID: 9261

Symbol: MAPKAPK2

Ensembl ID: ENSG00000162889

Description: MAPK activated protein kinase 2

Associated with

Activated tak1 mediates p38 mapk activation
(R-HSA-450302)
Arachidonic acid metabolism
(R-HSA-2142753)
Butyrate response factor 1 (brf1) binds and destabilizes mrna
(R-HSA-450385)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular response to heat stress
(R-HSA-3371556)
Cellular senescence
(R-HSA-2559583)
Creb phosphorylation
(R-HSA-199920)
Cytokine signaling in immune system
(R-HSA-1280215)
Death receptor signaling
(R-HSA-73887)
Fatty acid metabolism
(R-HSA-8978868)
Immune system
(R-HSA-168256)
Innate immune system
(R-HSA-168249)
Interleukin-17 signaling
(R-HSA-448424)
Map kinase activation
(R-HSA-450294)
Mapk targets/ nuclear events mediated by map kinases
(R-HSA-450282)
Metabolism
(R-HSA-1430728)
Metabolism of lipids
(R-HSA-556833)
Metabolism of rna
(R-HSA-8953854)
Myd88 cascade initiated on plasma membrane
(R-HSA-975871)
Myd88 dependent cascade initiated on endosome
(R-HSA-975155)
Myd88-independent tlr4 cascade
(R-HSA-166166)
Myd88:mal(tirap) cascade initiated on plasma membrane
(R-HSA-166058)
Nuclear events (kinase and transcription factor activation)
(R-HSA-198725)
Oxidative stress induced senescence
(R-HSA-2559580)
P38mapk events
(R-HSA-171007)
Regulation of hsf1-mediated heat shock response
(R-HSA-3371453)
Regulation of mrna stability by proteins that bind au-rich elements
(R-HSA-450531)
Regulation of tnfr1 signaling
(R-HSA-5357905)
Signaling by interleukins
(R-HSA-449147)
Signaling by ntrk1 (trka)
(R-HSA-187037)
Signaling by ntrks
(R-HSA-166520)
Signaling by receptor tyrosine kinases
(R-HSA-9006934)
Signaling by vegf
(R-HSA-194138)
Signalling to erks
(R-HSA-187687)
Signalling to ras
(R-HSA-167044)
Signal transduction
(R-HSA-162582)
Synthesis of leukotrienes (lt) and eoxins (ex)
(R-HSA-2142691)
Tnf signaling
(R-HSA-75893)
Toll-like receptor cascades
(R-HSA-168898)
Toll like receptor 2 (tlr2) cascade
(R-HSA-181438)
Toll like receptor 3 (tlr3) cascade
(R-HSA-168164)
Toll like receptor 4 (tlr4) cascade
(R-HSA-166016)
Toll like receptor 5 (tlr5) cascade
(R-HSA-168176)
Toll like receptor 7/8 (tlr7/8) cascade
(R-HSA-168181)
Toll like receptor 9 (tlr9) cascade
(R-HSA-168138)
Toll like receptor 10 (tlr10) cascade
(R-HSA-168142)
Toll like receptor tlr1:tlr2 cascade
(R-HSA-168179)
Toll like receptor tlr6:tlr2 cascade
(R-HSA-168188)
Traf6 mediated induction of nfkb and map kinases upon tlr7/8 or 9 activation
(R-HSA-975138)
Trif(ticam1)-mediated tlr4 signaling
(R-HSA-937061)
Tristetraprolin (ttp, zfp36) binds and destabilizes mrna
(R-HSA-450513)
Vegfa-vegfr2 pathway
(R-HSA-4420097)
3'-utr-mediated mrna stabilization
(GO:0070935)
Atp binding
(GO:0005524)
Calcium-dependent protein serine/threonine kinase activity
(GO:0009931)
Calmodulin-dependent protein kinase activity
(GO:0004683)
Calmodulin binding
(GO:0005516)
Cellular response to vascular endothelial growth factor stimulus
(GO:0035924)
Centrosome
(GO:0005813)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Dna damage response
(GO:0006974)
Extracellular exosome
(GO:0070062)
Inflammatory response
(GO:0006954)
Inner ear development
(GO:0048839)
Intracellular signal transduction
(GO:0035556)
Leukotriene metabolic process
(GO:0006691)
Macropinocytosis
(GO:0044351)
Mapk cascade
(GO:0000165)
Mitogen-activated protein kinase binding
(GO:0051019)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
P38mapk cascade
(GO:0038066)
Peptidyl-serine phosphorylation
(GO:0018105)
Positive regulation of macrophage cytokine production
(GO:0060907)
Positive regulation of tumor necrosis factor production
(GO:0032760)
Protein autophosphorylation
(GO:0046777)
Protein binding
(GO:0005515)
Protein kinase activity
(GO:0004672)
Protein phosphorylation
(GO:0006468)
Protein serine/threonine kinase activity
(GO:0004674)
Protein serine kinase activity
(GO:0106310)
Regulation of cellular response to heat
(GO:1900034)
Regulation of interleukin-6 production
(GO:0032675)
Regulation of mrna stability
(GO:0043488)
Regulation of tumor necrosis factor-mediated signaling pathway
(GO:0010803)
Regulation of tumor necrosis factor production
(GO:0032680)
Response to cytokine
(GO:0034097)
Response to lipopolysaccharide
(GO:0032496)
Toll-like receptor signaling pathway
(GO:0002224)
Vascular endothelial growth factor receptor signaling pathway
(GO:0048010)

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: cardiac muscle cell (CL0000746)
Fold Change: 5.29
Marker Score: 70,416
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 2.23
Marker Score: 75,933
Cell Name: regular ventricular cardiac myocyte (CL0002131)
Fold Change: 1.92
Marker Score: 43,012
Cell Name: regular atrial cardiac myocyte (CL0002129)
Fold Change: 1.85
Marker Score: 6,589
Cell Name: myeloid leukocyte (CL0000766)
Fold Change: 1.77
Marker Score: 2,132
Cell Name: squamous epithelial cell (CL0000076)
Fold Change: 1.52
Marker Score: 1,034
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 1.39
Marker Score: 1,465
Cell Name: skeletal muscle satellite stem cell (CL0008011)
Fold Change: 1.39
Marker Score: 1,485
Cell Name: pancreatic stellate cell (CL0002410)
Fold Change: 1.39
Marker Score: 877
Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
Fold Change: 1.39
Marker Score: 1,178
Cell Name: epicardial adipocyte (CL1000309)
Fold Change: 1.38
Marker Score: 672
Cell Name: myoepithelial cell of mammary gland (CL0002324)
Fold Change: 1.38
Marker Score: 6,781
Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 1.37
Marker Score: 3,228
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 1.36
Marker Score: 2,005
Cell Name: vascular leptomeningeal cell (CL4023051)
Fold Change: 1.33
Marker Score: 1,533
Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
Fold Change: 1.32
Marker Score: 550
Cell Name: cortical thymic epithelial cell (CL0002364)
Fold Change: 1.32
Marker Score: 4,889
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: 1.32
Marker Score: 1,305
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 1.29
Marker Score: 20,221
Cell Name: classical monocyte (CL0000860)
Fold Change: 1.28
Marker Score: 5,323
Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
Fold Change: 1.28
Marker Score: 1,087
Cell Name: retinal ganglion cell (CL0000740)
Fold Change: 1.22
Marker Score: 1,525
Cell Name: glandular epithelial cell (CL0000150)
Fold Change: 1.22
Marker Score: 2,988
Cell Name: hematopoietic cell (CL0000988)
Fold Change: 1.21
Marker Score: 805
Cell Name: luminal epithelial cell of mammary gland (CL0002326)
Fold Change: 1.14
Marker Score: 2,020
Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
Fold Change: 1.13
Marker Score: 254
Cell Name: renal interstitial pericyte (CL1001318)
Fold Change: 1.13
Marker Score: 1,075
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 1.12
Marker Score: 672
Cell Name: kidney collecting duct principal cell (CL1001431)
Fold Change: 1.11
Marker Score: 2,788
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: 1.1
Marker Score: 1,140
Cell Name: fibroblast of breast (CL4006000)
Fold Change: 1.1
Marker Score: 626
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 1.05
Marker Score: 2,392
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 1.04
Marker Score: 304
Cell Name: IgG plasmablast (CL0000982)
Fold Change: 1.04
Marker Score: 286
Cell Name: renal principal cell (CL0005009)
Fold Change: 1.04
Marker Score: 798
Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
Fold Change: 1.03
Marker Score: 1,095
Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: 1.03
Marker Score: 728
Cell Name: kidney connecting tubule epithelial cell (CL1000768)
Fold Change: 1.03
Marker Score: 1,459
Cell Name: epithelial cell of lung (CL0000082)
Fold Change: 1.02
Marker Score: 5,337
Cell Name: kidney collecting duct intercalated cell (CL1001432)
Fold Change: 1.01
Marker Score: 1,682
Cell Name: intermediate monocyte (CL0002393)
Fold Change: 1.01
Marker Score: 350
Cell Name: epithelial cell of urethra (CL1000296)
Fold Change: 1
Marker Score: 790
Cell Name: renal alpha-intercalated cell (CL0005011)
Fold Change: 1
Marker Score: 526
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71,634
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 0.99
Marker Score: 47,859
Cell Name: mammary gland epithelial cell (CL0002327)
Fold Change: 0.98
Marker Score: 349
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30,378
Cell Name: kidney interstitial fibroblast (CL1000692)
Fold Change: 0.98
Marker Score: 1,880
Cell Name: IgG memory B cell (CL0000979)
Fold Change: 0.96
Marker Score: 579
Cell Name: common dendritic progenitor (CL0001029)
Fold Change: 0.96
Marker Score: 332
Cell Name: plasmacytoid dendritic cell, human (CL0001058)
Fold Change: 0.96
Marker Score: 252
Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
Fold Change: 0.96
Marker Score: 2,562
Cell Name: prostate gland microvascular endothelial cell (CL2000059)
Fold Change: 0.95
Marker Score: 371
Cell Name: osteoclast (CL0000092)
Fold Change: 0.95
Marker Score: 475
Cell Name: late promyelocyte (CL0002151)
Fold Change: 0.95
Marker Score: 239
Cell Name: lung macrophage (CL1001603)
Fold Change: 0.95
Marker Score: 1,087
Cell Name: luminal cell of prostate epithelium (CL0002340)
Fold Change: 0.95
Marker Score: 553
Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.95
Marker Score: 9,607
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.95
Marker Score: 2,076
Cell Name: ependymal cell (CL0000065)
Fold Change: 0.94
Marker Score: 329
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.94
Marker Score: 2,384
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 0.94
Marker Score: 2,287
Cell Name: fibroblast of connective tissue of prostate (CL1000299)
Fold Change: 0.93
Marker Score: 232
Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
Fold Change: 0.93
Marker Score: 780
Cell Name: prostate stromal cell (CL0002622)
Fold Change: 0.92
Marker Score: 232
Cell Name: corneal epithelial cell (CL0000575)
Fold Change: 0.92
Marker Score: 1,015
Cell Name: DN1 thymic pro-T cell (CL0000894)
Fold Change: 0.92
Marker Score: 284
Cell Name: type II pneumocyte (CL0002063)
Fold Change: 0.92
Marker Score: 5,966
Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
Fold Change: 0.91
Marker Score: 986
Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
Fold Change: 0.91
Marker Score: 855
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.91
Marker Score: 467
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.91
Marker Score: 2,711
Cell Name: nasal mucosa goblet cell (CL0002480)
Fold Change: 0.9
Marker Score: 601
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 0.9
Marker Score: 3,461
Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.9
Marker Score: 423
Cell Name: foveolar cell of stomach (CL0002179)
Fold Change: 0.89
Marker Score: 5,699
Cell Name: megakaryocyte (CL0000556)
Fold Change: 0.89
Marker Score: 506
Cell Name: mononuclear cell (CL0000842)
Fold Change: 0.89
Marker Score: 286
Cell Name: podocyte (CL0000653)
Fold Change: 0.89
Marker Score: 328
Cell Name: IgA plasmablast (CL0000984)
Fold Change: 0.89
Marker Score: 233
Cell Name: plasmacytoid dendritic cell (CL0000784)
Fold Change: 0.89
Marker Score: 476
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5,291
Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: 0.87
Marker Score: 18,624
Cell Name: cholangiocyte (CL1000488)
Fold Change: 0.87
Marker Score: 326
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.87
Marker Score: 9,811
Cell Name: group 3 innate lymphoid cell (CL0001071)
Fold Change: 0.87
Marker Score: 365
Cell Name: mucous neck cell (CL0000651)
Fold Change: 0.87
Marker Score: 1,970
Cell Name: common lymphoid progenitor (CL0000051)
Fold Change: 0.86
Marker Score: 588
Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: 0.86
Marker Score: 270
Cell Name: PP cell (CL0000696)
Fold Change: 0.86
Marker Score: 194
Cell Name: neutrophil (CL0000775)
Fold Change: 0.86
Marker Score: 524
Cell Name: hepatic stellate cell (CL0000632)
Fold Change: 0.86
Marker Score: 324
Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
Fold Change: 0.86
Marker Score: 871
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.86
Marker Score: 205
Cell Name: IgG-negative class switched memory B cell (CL0002117)
Fold Change: 0.85
Marker Score: 838
Cell Name: stem cell of epidermis (CL1000428)
Fold Change: 0.85
Marker Score: 288
Cell Name: choroid plexus epithelial cell (CL0000706)
Fold Change: 0.85
Marker Score: 778
Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
Fold Change: 0.85
Marker Score: 365
Cell Name: cardiac mesenchymal cell (CL0000569)
Fold Change: 0.85
Marker Score: 208
Cell Name: lung endothelial cell (CL1001567)
Fold Change: 0.84
Marker Score: 7,406

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

**Key Characteristics** MAPKAPK2 is a serine/threonine kinase that exhibits the following characteristics: 1. **Phosphorylation activity**: MAPKAPK2 is capable of phosphorylating specific serine and threonine residues on target proteins, modulating their activity and function. 2. **MAPK binding**: MAPKAPK2 interacts with various MAPKs, including p38MAPK, JNK, and ERK, to regulate their activity and downstream signaling. 3. **Stress response**: MAPKAPK2 is activated in response to various stress stimuli, such as heat shock, oxidative stress, and cytokine exposure, leading to the activation of transcription factors and gene expression. 4. **Inflammation regulation**: MAPKAPK2 plays a role in regulating inflammatory responses by phosphorylating and modulating the activity of inflammatory mediators and signaling molecules. **Pathways and Functions** MAPKAPK2 is involved in several signaling pathways, including: 1. **Activated Tak1 mediates p38 MAPK activation**: MAPKAPK2 interacts with activated Tak1, leading to the activation of p38 MAPK and subsequent signaling cascades. 2. **Arachidonic acid metabolism**: MAPKAPK2 regulates the metabolism of arachidonic acid, a key lipid mediator involved in inflammation and immune responses. 3. **Butyrate response factor 1 (BRF1) binding and mRNA destabilization**: MAPKAPK2 interacts with BRF1, leading to the destabilization of target mRNAs and regulation of gene expression. 4. **Calcium-dependent protein serine/threonine kinase activity**: MAPKAPK2 exhibits calcium-dependent kinase activity, modulating the activity of downstream targets. 5. **P38 MAPK cascade**: MAPKAPK2 is involved in the activation of p38 MAPK, a key signaling molecule in stress response and inflammation. **Clinical Significance** MAPKAPK2 has been implicated in various diseases and disorders, including: 1. **Cardiovascular diseases**: MAPKAPK2 plays a role in the regulation of cardiac function and remodeling in response to stress and injury. 2. **Cancer**: MAPKAPK2 is involved in the regulation of cell growth, differentiation, and apoptosis in various cancer types. 3. **Neurological disorders**: MAPKAPK2 is implicated in the pathogenesis of neurodegenerative diseases, such as Alzheimer's and Parkinson's disease. 4. **Immune system dysregulation**: MAPKAPK2 plays a role in regulating immune responses and inflammation in autoimmune and inflammatory disorders. In conclusion, MAPKAPK2 is a key regulator of cellular processes, including stress response, inflammation, and immune system regulation. Its dysregulation has been implicated in various diseases and disorders, highlighting the importance of further research into its role in human health and disease.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

MAP kinase-activated protein kinase 2

Genular Protein ID: 1315984950

Symbol: MAPK2_HUMAN

Name: MAP kinase-activated protein kinase 2

UniProtKB Accession Codes:

P49137 Q5SY30 Q5SY41 Q8IYD6

Database IDs:

Citations:

PubMed ID: 8179591

Title: The primary structure of a human MAP kinase activated protein kinase 2.

PubMed ID: 8179591

DOI: 10.1006/bbrc.1994.1566

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8280084

Title: The substrate specificity and structure of mitogen-activated protein (MAP) kinase-activated protein kinase-2.

PubMed ID: 8280084

DOI: 10.1042/bj2960843

PubMed ID: 8093612

Title: Small heat shock proteins are molecular chaperones.

PubMed ID: 8093612

DOI: 10.1016/s0021-9258(18)53882-5

PubMed ID: 8846784

Title: Identification of novel phosphorylation sites required for activation of MAPKAP kinase-2.

PubMed ID: 8846784

DOI: 10.1002/j.1460-2075.1995.tb00280.x

PubMed ID: 8774846

Title: A comparison of the substrate specificity of MAPKAP kinase-2 and MAPKAP kinase-3 and their activation by cytokines and cellular stress.

PubMed ID: 8774846

DOI: 10.1016/0014-5793(96)00816-2

PubMed ID: 10383393

Title: Regulation of Hsp27 oligomerization, chaperone function, and protective activity against oxidative stress/tumor necrosis factor alpha by phosphorylation.

PubMed ID: 10383393

DOI: 10.1074/jbc.274.27.18947

PubMed ID: 12456657

Title: Inhibition of SAPK2a/p38 prevents hnRNP A0 phosphorylation by MAPKAP-K2 and its interaction with cytokine mRNAs.

PubMed ID: 12456657

DOI: 10.1093/emboj/cdf639

PubMed ID: 11844797

Title: Arachidonic acid promotes phosphorylation of 5-lipoxygenase at Ser-271 by MAPK-activated protein kinase 2 (MK2).

PubMed ID: 11844797

DOI: 10.1074/jbc.m111945200

PubMed ID: 12565831

Title: Affinity purification of ARE-binding proteins identifies polyA-binding protein 1 as a potential substrate in MK2-induced mRNA stabilization.

PubMed ID: 12565831

DOI: 10.1016/s0006-291x(03)00015-9

PubMed ID: 14499342

Title: MAPK-activated protein kinase-2 participates in p38 MAPK-dependent and ERK-dependent functions in human neutrophils.

PubMed ID: 14499342

DOI: 10.1016/s0898-6568(03)00074-3

PubMed ID: 14517288

Title: Stabilization of urokinase and urokinase receptor mRNAs by HuR is linked to its cytoplasmic accumulation induced by activated mitogen-activated protein kinase-activated protein kinase 2.

PubMed ID: 14517288

DOI: 10.1128/mcb.23.20.7177-7188.2003

PubMed ID: 15014438

Title: MK2-induced tristetraprolin:14-3-3 complexes prevent stress granule association and ARE-mRNA decay.

PubMed ID: 15014438

DOI: 10.1038/sj.emboj.7600163

PubMed ID: 15094067

Title: P66(ShcA) interacts with MAPKAP kinase 2 and regulates its activity.

PubMed ID: 15094067

DOI: 10.1016/s0014-5793(04)00351-5

PubMed ID: 15629715

Title: MAPKAP kinase-2 is a cell cycle checkpoint kinase that regulates the G2/M transition and S phase progression in response to UV irradiation.

PubMed ID: 15629715

DOI: 10.1016/j.molcel.2004.11.021

PubMed ID: 16456544

Title: MAPKAPK-2-mediated LIM-kinase activation is critical for VEGF-induced actin remodeling and cell migration.

PubMed ID: 16456544

DOI: 10.1038/sj.emboj.7600973

PubMed ID: 16278218

Title: Phosphorylation of HSF1 by MAPK-activated protein kinase 2 on serine 121, inhibits transcriptional activity and promotes HSP90 binding.

PubMed ID: 16278218

DOI: 10.1074/jbc.m505822200

PubMed ID: 17481585

Title: MAPKAPK2-mediated LSP1 phosphorylation and FMLP-induced neutrophil polarization.

PubMed ID: 17481585

DOI: 10.1016/j.bbrc.2007.04.104

PubMed ID: 18021073

Title: Roles for TAB1 in regulating the IL-1-dependent phosphorylation of the TAB3 regulatory subunit and activity of the TAK1 complex.

PubMed ID: 18021073

DOI: 10.1042/bj20071149

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 20932473

Title: DNA damage activates a spatially distinct late cytoplasmic cell-cycle checkpoint network controlled by MK2-mediated RNA stabilization.

PubMed ID: 20932473

DOI: 10.1016/j.molcel.2010.09.018

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21131586

Title: MK2 SUMOylation regulates actin filament remodeling and subsequent migration in endothelial cells by inhibiting MK2 kinase and HSP27 phosphorylation.

PubMed ID: 21131586

DOI: 10.1182/blood-2010-08-302281

PubMed ID: 18508601

Title: MK2 and MK3--a pair of isoenzymes?

PubMed ID: 18508601

DOI: 10.2741/3095

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 26616734

Title: p38- and MK2-dependent signalling promotes stress-induced centriolar satellite remodelling via 14-3-3-dependent sequestration of CEP131/AZI1.

PubMed ID: 26616734

DOI: 10.1038/ncomms10075

PubMed ID: 12171911

Title: Structure of mitogen-activated protein kinase-activated protein (MAPKAP) kinase 2 suggests a bifunctional switch that couples kinase activation with nuclear export.

PubMed ID: 12171911

DOI: 10.1074/jbc.c200418200

PubMed ID: 12791252

Title: Catalytically active MAP KAP kinase 2 structures in complex with staurosporine and ADP reveal differences with the autoinhibited enzyme.

PubMed ID: 12791252

DOI: 10.1016/s0969-2126(03)00092-3

PubMed ID: 17576063

Title: The discovery of carboline analogs as potent MAPKAP-K2 inhibitors.

PubMed ID: 17576063

DOI: 10.1016/j.bmcl.2007.05.101

PubMed ID: 17255097

Title: Crystal structure of the p38 alpha-MAPKAP kinase 2 heterodimer.

PubMed ID: 17255097

DOI: 10.1074/jbc.m611165200

PubMed ID: 17480064

Title: Pyrrolopyridine inhibitors of mitogen-activated protein kinase-activated protein kinase 2 (MK-2).

PubMed ID: 17480064

DOI: 10.1021/jm0611004

PubMed ID: 17449059

Title: Structural basis for a high affinity inhibitor bound to protein kinase MK2.

PubMed ID: 17449059

DOI: 10.1016/j.jmb.2007.03.004

PubMed ID: 17395714

Title: Molecular basis of MAPK-activated protein kinase 2:p38 assembly.

PubMed ID: 17395714

DOI: 10.1073/pnas.0701679104

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

Length: 400
Mass: 45568
Checksum: E4EFFF11CCF288DC
Sequence:

MLSNSQGQSP PVPFPAPAPP PQPPTPALPH PPAQPPPPPP QQFPQFHVKS GLQIKKNAII 
DDYKVTSQVL GLGINGKVLQ IFNKRTQEKF ALKMLQDCPK ARREVELHWR ASQCPHIVRI 
VDVYENLYAG RKCLLIVMEC LDGGELFSRI QDRGDQAFTE REASEIMKSI GEAIQYLHSI 
NIAHRDVKPE NLLYTSKRPN AILKLTDFGF AKETTSHNSL TTPCYTPYYV APEVLGPEKY 
DKSCDMWSLG VIMYILLCGY PPFYSNHGLA ISPGMKTRIR MGQYEFPNPE WSEVSEEVKM 
LIRNLLKTEP TQRMTITEFM NHPWIMQSTK VPQTPLHTSR VLKEDKERWE DVKEEMTSAL 
ATMRVDYEQI KIKKIEDASN PLLLKRRKKA RALEAAALAH

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: MAPKAPK2

Associated with

Cells (max top 100)

Other Information

The primary structure of a human MAP kinase activated protein kinase 2. PubMed ID: 8179591

The DNA sequence and biological annotation of human chromosome 1. PubMed ID: 16710414

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

The substrate specificity and structure of mitogen-activated protein (MAP) kinase-activated protein kinase-2. PubMed ID: 8280084

Small heat shock proteins are molecular chaperones. PubMed ID: 8093612

Identification of novel phosphorylation sites required for activation of MAPKAP kinase-2. PubMed ID: 8846784

A comparison of the substrate specificity of MAPKAP kinase-2 and MAPKAP kinase-3 and their activation by cytokines and cellular stress. PubMed ID: 8774846

Regulation of Hsp27 oligomerization, chaperone function, and protective activity against oxidative stress/tumor necrosis factor alpha by phosphorylation. PubMed ID: 10383393

Inhibition of SAPK2a/p38 prevents hnRNP A0 phosphorylation by MAPKAP-K2 and its interaction with cytokine mRNAs. PubMed ID: 12456657

Arachidonic acid promotes phosphorylation of 5-lipoxygenase at Ser-271 by MAPK-activated protein kinase 2 (MK2). PubMed ID: 11844797

Affinity purification of ARE-binding proteins identifies polyA-binding protein 1 as a potential substrate in MK2-induced mRNA stabilization. PubMed ID: 12565831

MAPK-activated protein kinase-2 participates in p38 MAPK-dependent and ERK-dependent functions in human neutrophils. PubMed ID: 14499342

Stabilization of urokinase and urokinase receptor mRNAs by HuR is linked to its cytoplasmic accumulation induced by activated mitogen-activated protein kinase-activated protein kinase 2. PubMed ID: 14517288

MK2-induced tristetraprolin:14-3-3 complexes prevent stress granule association and ARE-mRNA decay. PubMed ID: 15014438

P66(ShcA) interacts with MAPKAP kinase 2 and regulates its activity. PubMed ID: 15094067

MAPKAP kinase-2 is a cell cycle checkpoint kinase that regulates the G2/M transition and S phase progression in response to UV irradiation. PubMed ID: 15629715

MAPKAPK-2-mediated LIM-kinase activation is critical for VEGF-induced actin remodeling and cell migration. PubMed ID: 16456544

Phosphorylation of HSF1 by MAPK-activated protein kinase 2 on serine 121, inhibits transcriptional activity and promotes HSP90 binding. PubMed ID: 16278218

MAPKAPK2-mediated LSP1 phosphorylation and FMLP-induced neutrophil polarization. PubMed ID: 17481585

Roles for TAB1 in regulating the IL-1-dependent phosphorylation of the TAB3 regulatory subunit and activity of the TAK1 complex. PubMed ID: 18021073

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

DNA damage activates a spatially distinct late cytoplasmic cell-cycle checkpoint network controlled by MK2-mediated RNA stabilization. PubMed ID: 20932473

Initial characterization of the human central proteome. PubMed ID: 21269460

MK2 SUMOylation regulates actin filament remodeling and subsequent migration in endothelial cells by inhibiting MK2 kinase and HSP27 phosphorylation. PubMed ID: 21131586

MK2 and MK3--a pair of isoenzymes? PubMed ID: 18508601

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

p38- and MK2-dependent signalling promotes stress-induced centriolar satellite remodelling via 14-3-3-dependent sequestration of CEP131/AZI1. PubMed ID: 26616734

Structure of mitogen-activated protein kinase-activated protein (MAPKAP) kinase 2 suggests a bifunctional switch that couples kinase activation with nuclear export. PubMed ID: 12171911

Catalytically active MAP KAP kinase 2 structures in complex with staurosporine and ADP reveal differences with the autoinhibited enzyme. PubMed ID: 12791252

The discovery of carboline analogs as potent MAPKAP-K2 inhibitors. PubMed ID: 17576063

Crystal structure of the p38 alpha-MAPKAP kinase 2 heterodimer. PubMed ID: 17255097

Pyrrolopyridine inhibitors of mitogen-activated protein kinase-activated protein kinase 2 (MK-2). PubMed ID: 17480064

Structural basis for a high affinity inhibitor bound to protein kinase MK2. PubMed ID: 17449059

Molecular basis of MAPK-activated protein kinase 2:p38 assembly. PubMed ID: 17395714

Patterns of somatic mutation in human cancer genomes. PubMed ID: 17344846