Details for: CYTH3

Gene ID: 9265

Symbol: CYTH3

Ensembl ID: ENSG00000008256

Description: cytohesin 3

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 2.51
    Marker Score: 2,885
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 2.29
    Marker Score: 45,582
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 2.22
    Marker Score: 81,837
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 2.03
    Marker Score: 1,102
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 1.93
    Marker Score: 1,270
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.88
    Marker Score: 28,075
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 1.87
    Marker Score: 3,592
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.84
    Marker Score: 17,442
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.78
    Marker Score: 7,400
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 1.78
    Marker Score: 2,219
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.75
    Marker Score: 13,416
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.7
    Marker Score: 14,625
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.67
    Marker Score: 102,961
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 1.59
    Marker Score: 1,308
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.56
    Marker Score: 27,736
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 1.56
    Marker Score: 1,887
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.53
    Marker Score: 58,173
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.51
    Marker Score: 2,334
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.5
    Marker Score: 14,109
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.47
    Marker Score: 6,003
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 1.45
    Marker Score: 1,382
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 1.35
    Marker Score: 565
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 1.34
    Marker Score: 748
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.34
    Marker Score: 5,181
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 1.25
    Marker Score: 5,799
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 1.21
    Marker Score: 707
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 1.21
    Marker Score: 385
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.19
    Marker Score: 12,316
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 1.18
    Marker Score: 707
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.18
    Marker Score: 18,421
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.1
    Marker Score: 2,425
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.1
    Marker Score: 1,923
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.09
    Marker Score: 340
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.08
    Marker Score: 1,197
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 1.07
    Marker Score: 529
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 1.06
    Marker Score: 1,787
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.06
    Marker Score: 289
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 1.05
    Marker Score: 2,993
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 1.04
    Marker Score: 391
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,765
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47,990
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.99
    Marker Score: 5,954
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,401
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.96
    Marker Score: 721
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.96
    Marker Score: 475
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.95
    Marker Score: 490
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,406
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.94
    Marker Score: 1,269
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.94
    Marker Score: 444
  • Cell Name: fat cell (CL0000136)
    Fold Change: 0.92
    Marker Score: 512
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 0.91
    Marker Score: 20,322
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,723
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.9
    Marker Score: 430
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.9
    Marker Score: 289
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.88
    Marker Score: 5,006
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.87
    Marker Score: 313
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,262
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.86
    Marker Score: 1,400
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.86
    Marker Score: 1,749
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.84
    Marker Score: 17,846
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.83
    Marker Score: 501
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.83
    Marker Score: 28,295
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.82
    Marker Score: 988
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.8
    Marker Score: 421
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.79
    Marker Score: 606
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.78
    Marker Score: 313
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.77
    Marker Score: 25,995
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.77
    Marker Score: 591
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.76
    Marker Score: 1,796
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 0.75
    Marker Score: 2,669
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 0.75
    Marker Score: 271
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.74
    Marker Score: 432
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.74
    Marker Score: 381
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.73
    Marker Score: 3,067
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.72
    Marker Score: 659
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 0.72
    Marker Score: 242
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.7
    Marker Score: 220
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.68
    Marker Score: 330
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 173
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.67
    Marker Score: 721
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.67
    Marker Score: 10,789
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.67
    Marker Score: 3,984
  • Cell Name: trophoblast giant cell (CL0002488)
    Fold Change: 0.65
    Marker Score: 211
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.65
    Marker Score: 316
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.64
    Marker Score: 622
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.64
    Marker Score: 375
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.64
    Marker Score: 2,678
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.64
    Marker Score: 147
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 0.63
    Marker Score: 165
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.63
    Marker Score: 886
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.62
    Marker Score: 541
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 0.6
    Marker Score: 871
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 0.59
    Marker Score: 152
  • Cell Name: mural cell (CL0008034)
    Fold Change: 0.59
    Marker Score: 67,210
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 0.58
    Marker Score: 802
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.58
    Marker Score: 235
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.58
    Marker Score: 167
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 0.57
    Marker Score: 156
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.56
    Marker Score: 285
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 0.56
    Marker Score: 353

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Expression Pattern**: CYTH3 is widely expressed in various cell types, including vascular leptomeningeal cells, GABAergic cortical interneurons, and cardiac neurons. 2. **Function**: CYTH3 regulates epithelial cell polarity and cell adhesion, processes that are critical for maintaining tissue integrity and function. 3. **Pathways**: CYTH3 is involved in various signaling pathways, including adherens junction, bicellular tight junction, and Golgi membrane trafficking. 4. **Protein Binding**: CYTH3 interacts with other proteins, such as ARF and RAB, to regulate their activity and function. **Pathways and Functions** 1. **Establishment of Epithelial Cell Polarity**: CYTH3 plays a crucial role in establishing epithelial cell polarity, a process that involves the regulation of the cytoskeleton, tight junctions, and adherens junctions. 2. **Cell Adhesion**: CYTH3 regulates cell adhesion by interacting with other proteins, such as cadherins and catenins, to maintain tissue integrity and function. 3. **Golgi Membrane Trafficking**: CYTH3 is involved in the regulation of Golgi membrane trafficking, a process that is critical for the proper functioning of various cellular processes, including protein synthesis and secretion. 4. **Vesicle-Mediated Transport**: CYTH3 regulates vesicle-mediated transport, a process that involves the movement of vesicles between the Golgi apparatus and the plasma membrane. **Clinical Significance** 1. **Epithelial Disorders**: Abnormalities in CYTH3 expression have been implicated in various epithelial disorders, including cancer and inflammatory diseases. 2. **Neurological Disorders**: CYTH3 has been implicated in various neurological disorders, including epilepsy and neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. 3. **Cardiovascular Diseases**: CYTH3 has been implicated in various cardiovascular diseases, including atherosclerosis and cardiac arrhythmias. In conclusion, CYTH3 is a critical regulator of epithelial cell polarity and cell adhesion, processes that are essential for maintaining tissue integrity and function. Further research is needed to fully elucidate the role of CYTH3 in various diseases and to explore its potential as a therapeutic target.

Genular Protein ID: 2702161611

Symbol: CYH3_HUMAN

Name: Cytohesin-3

UniProtKB Accession Codes:

O43739 A4D2N8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CORUM 1 CTD 1 ChEBI 5 ChEMBL 1 ChiTaRS 1 DIP 1 DNASU 1 DisGeNET 1 DrugBank 2 EMBL 5 EMDB 2 EPD 1 Ensembl 1 GO 13 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 3 PRO 1 PROSITE 2 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9742223

Title: Nerve growth factor- and epidermal growth factor-stimulated translocation of the ADP-ribosylation factor-exchange factor GRP1 to the plasma membrane of PC12 cells requires activation of phosphatidylinositol 3-kinase and the GRP1 pleckstrin homology domain.

PubMed ID: 9742223

DOI: 10.1042/bj3350139

PubMed ID: 9707577

Title: ARNO3, a Sec7-domain guanine nucleotide exchange factor for ADP ribosylation factor 1, is involved in the control of Golgi structure and function.

PubMed ID: 9707577

DOI: 10.1073/pnas.95.17.9926

PubMed ID: 12690205

Title: Human chromosome 7: DNA sequence and biology.

PubMed ID: 12690205

DOI: 10.1126/science.1083423

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10652308

Title: Similarities in function and gene structure of cytohesin-4 and cytohesin-1, guanine nucleotide-exchange proteins for ADP-ribosylation factors.

PubMed ID: 10652308

DOI: 10.1074/jbc.275.5.3221

PubMed ID: 17398095

Title: The Arl4 family of small G proteins can recruit the cytohesin Arf6 exchange factors to the plasma membrane.

PubMed ID: 17398095

DOI: 10.1016/j.cub.2007.03.007

PubMed ID: 23940353

Title: Structural basis for membrane recruitment and allosteric activation of cytohesin family Arf GTPase exchange factors.

PubMed ID: 23940353

DOI: 10.1073/pnas.1301883110

Sequence Information:

  • Length: 400
  • Mass: 46349
  • Checksum: 87FB917899EE957D
  • Sequence:
    • MDEDGGGEGG GVPEDLSLEE REELLDIRRR KKELIDDIER LKYEIAEVMT EIDNLTSVEE 
SKTTQRNKQI AMGRKKFNMD PKKGIQFLIE NDLLQSSPED VAQFLYKGEG LNKTVIGDYL 
GERDEFNIKV LQAFVELHEF ADLNLVQALR QFLWSFRLPG EAQKIDRMME AFASRYCLCN 
PGVFQSTDTC YVLSFAIIML NTSLHNHNVR DKPTAERFIA MNRGINEGGD LPEELLRNLY 
ESIKNEPFKI PEDDGNDLTH TFFNPDREGW LLKLGGGRVK TWKRRWFILT DNCLYYFEYT 
TDKEPRGIIP LENLSIREVE DPRKPNCFEL YNPSHKGQVI KACKTEADGR VVEGNHVVYR 
ISAPSPEEKE EWMKSIKASI SRDPFYDMLA TRKRRIANKK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.