Details for: CD8B2

Gene ID: 927

Symbol: CD8B2

Ensembl ID: ENSG00000254126

Description: CD8B family member 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 3.7426
    Cell Significance Index: 93.5600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 3.2647
    Cell Significance Index: 200.1600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 2.2853
    Cell Significance Index: 49.5100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 2.1776
    Cell Significance Index: 69.7500
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 1.9167
    Cell Significance Index: 18.0300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.2278
    Cell Significance Index: 55.6500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.9338
    Cell Significance Index: 177.7100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.7183
    Cell Significance Index: 71.0600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.6196
    Cell Significance Index: 13.2000
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 0.6043
    Cell Significance Index: 3.8000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5481
    Cell Significance Index: 494.8700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3906
    Cell Significance Index: 42.4900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3765
    Cell Significance Index: 61.2400
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.3342
    Cell Significance Index: 3.9500
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.2921
    Cell Significance Index: 4.0100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.2877
    Cell Significance Index: 17.2700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2108
    Cell Significance Index: 14.5800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.1630
    Cell Significance Index: 4.8000
  • Cell Name: duodenum glandular cell (CL1001589)
    Fold Change: 0.1577
    Cell Significance Index: 1.1300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.0843
    Cell Significance Index: 2.3000
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.0594
    Cell Significance Index: 0.7400
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.0447
    Cell Significance Index: 0.3800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0444
    Cell Significance Index: 1.5600
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.0284
    Cell Significance Index: 0.2900
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.0247
    Cell Significance Index: 0.4100
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.0223
    Cell Significance Index: 0.2800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.0189
    Cell Significance Index: 0.5100
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.0176
    Cell Significance Index: 0.4400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0164
    Cell Significance Index: 3.2600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0132
    Cell Significance Index: 0.3800
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.0087
    Cell Significance Index: 0.0900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0067
    Cell Significance Index: 0.3500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0064
    Cell Significance Index: 0.1100
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.0047
    Cell Significance Index: 0.0600
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: 0.0047
    Cell Significance Index: 0.1900
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.0010
    Cell Significance Index: 0.0200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0004
    Cell Significance Index: 0.0800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.0002
    Cell Significance Index: 0.1100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0000
    Cell Significance Index: -0.0700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.0000
    Cell Significance Index: 0.0100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0002
    Cell Significance Index: -0.4000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0003
    Cell Significance Index: -0.4000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0006
    Cell Significance Index: -0.8300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0011
    Cell Significance Index: -0.8500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0013
    Cell Significance Index: -0.4600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0017
    Cell Significance Index: -1.1000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0018
    Cell Significance Index: -1.3000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0023
    Cell Significance Index: -1.0400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0030
    Cell Significance Index: -0.5200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0038
    Cell Significance Index: -0.6900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0045
    Cell Significance Index: -0.5300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0045
    Cell Significance Index: -0.2300
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.0049
    Cell Significance Index: -0.1000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0055
    Cell Significance Index: -0.6500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0063
    Cell Significance Index: -0.9200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0071
    Cell Significance Index: -0.8100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0076
    Cell Significance Index: -0.9300
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0084
    Cell Significance Index: -0.2100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0086
    Cell Significance Index: -0.3000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0088
    Cell Significance Index: -0.9200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0103
    Cell Significance Index: -1.3300
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0119
    Cell Significance Index: -0.1800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0138
    Cell Significance Index: -0.9300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0143
    Cell Significance Index: -0.8800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0145
    Cell Significance Index: -0.3800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0148
    Cell Significance Index: -0.4900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0164
    Cell Significance Index: -1.3000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0165
    Cell Significance Index: -0.7800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0165
    Cell Significance Index: -0.7300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0169
    Cell Significance Index: -0.9500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0181
    Cell Significance Index: -1.3500
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: -0.0187
    Cell Significance Index: -0.0500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0190
    Cell Significance Index: -0.5500
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: -0.0194
    Cell Significance Index: -0.1800
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.0199
    Cell Significance Index: -0.2000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0211
    Cell Significance Index: -1.3600
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.0216
    Cell Significance Index: -0.3600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0219
    Cell Significance Index: -0.8300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0220
    Cell Significance Index: -0.4600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0223
    Cell Significance Index: -0.7100
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0231
    Cell Significance Index: -0.5600
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0240
    Cell Significance Index: -0.7600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0270
    Cell Significance Index: -0.7200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0296
    Cell Significance Index: -0.7600
  • Cell Name: M cell of gut (CL0000682)
    Fold Change: -0.0304
    Cell Significance Index: -0.2500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0308
    Cell Significance Index: -0.4200
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0314
    Cell Significance Index: -0.6600
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0319
    Cell Significance Index: -0.6900
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0325
    Cell Significance Index: -0.6900
  • Cell Name: ionocyte (CL0005006)
    Fold Change: -0.0325
    Cell Significance Index: -0.3400
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.0329
    Cell Significance Index: -0.3400
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0336
    Cell Significance Index: -0.9600
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.0351
    Cell Significance Index: -0.5000
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: -0.0351
    Cell Significance Index: -0.2900
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: -0.0360
    Cell Significance Index: -0.3600
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.0367
    Cell Significance Index: -0.3900
  • Cell Name: paneth cell (CL0000510)
    Fold Change: -0.0387
    Cell Significance Index: -0.4000
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0403
    Cell Significance Index: -0.8100
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.0404
    Cell Significance Index: -0.4800
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0404
    Cell Significance Index: -1.0100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** CD8B2 is a coreceptor that is structurally and functionally related to CD8B, with similarities in their extracellular and transmembrane domains. However, the intracellular domain of CD8B2 exhibits distinct characteristics, including a unique cytoplasmic region that interacts with signaling molecules. The expression of CD8B2 is widespread, with notable presence in enterocytes, goblet cells, granulocyte-monocyte progenitor cells, and other epithelial cells. **Pathways and Functions:** The CD8B2 gene is involved in several key signaling pathways, including: 1. **Adaptive Immune Response:** CD8B2 interacts with MHC class I proteins, facilitating the activation and regulation of T cells, which are essential for adaptive immune responses. 2. **Coreceptor Activity:** CD8B2 acts as a coreceptor, modulating the binding of T cells to MHC class I proteins, thereby influencing the efficiency of antigen presentation. 3. **Regulation of Immune Response:** CD8B2 modulates the expression of immune-related genes, influencing the expression of cytokines and chemokines that regulate immune responses. **Clinical Significance:** The dysregulation of CD8B2 has significant implications for various immune-mediated disorders, including: 1. **Inflammatory Bowel Disease (IBD):** Alterations in CD8B2 expression have been linked to IBD, with potential therapeutic applications for modulating immune responses. 2. **Autoimmune Diseases:** CD8B2 dysfunction may contribute to autoimmune diseases, such as multiple sclerosis, where immune responses are dysregulated. 3. **Cancer:** CD8B2 expression has been observed in various types of cancer, suggesting its potential role in cancer immunology and therapy. In conclusion, CD8B2 is a vital gene that plays a critical role in regulating the adaptive immune response, particularly through its interactions with MHC class I proteins. Further research is necessary to elucidate the full extent of its clinical significance and potential therapeutic applications in immune-mediated disorders.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.