ITGB1BP1 | ENSG00000119185 | NCBI 9270

Details for: ITGB1BP1

Gene ID: 9270

Symbol: ITGB1BP1

Ensembl ID: ENSG00000119185

Description: integrin subunit beta 1 binding protein 1

Associated with

Activation of protein kinase b activity
(GO:0032148)
Biomineral tissue development
(GO:0031214)
Blood vessel diameter maintenance
(GO:0097746)
Blood vessel endothelial cell proliferation involved in sprouting angiogenesis
(GO:0002043)
Cell-matrix adhesion
(GO:0007160)
Cell differentiation
(GO:0030154)
Cell migration
(GO:0016477)
Cell periphery
(GO:0071944)
Cellular response to fibroblast growth factor stimulus
(GO:0044344)
Cellular response to vascular endothelial growth factor stimulus
(GO:0035924)
Centriolar satellite
(GO:0034451)
Cytoplasm
(GO:0005737)
Cytoskeleton
(GO:0005856)
Cytosol
(GO:0005829)
Focal adhesion
(GO:0005925)
Gdp-dissociation inhibitor activity
(GO:0005092)
Integrin-mediated signaling pathway
(GO:0007229)
Integrin activation
(GO:0033622)
Integrin binding
(GO:0005178)
Intracellular signal transduction
(GO:0035556)
Lamellipodium
(GO:0030027)
Membrane
(GO:0016020)
Myoblast migration
(GO:0051451)
Negative regulation of cell adhesion involved in substrate-bound cell migration
(GO:0006933)
Negative regulation of cell migration involved in sprouting angiogenesis
(GO:0090051)
Negative regulation of cell population proliferation
(GO:0008285)
Negative regulation of erk1 and erk2 cascade
(GO:0070373)
Negative regulation of fibroblast migration
(GO:0010764)
Negative regulation of focal adhesion assembly
(GO:0051895)
Negative regulation of protein binding
(GO:0032091)
Negative regulation of protein kinase activity
(GO:0006469)
Negative regulation of protein targeting to membrane
(GO:0090315)
Negative regulation of substrate adhesion-dependent cell spreading
(GO:1900025)
Notch signaling pathway
(GO:0007219)
Nuclear body
(GO:0016604)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Perinuclear region of cytoplasm
(GO:0048471)
Plasma membrane
(GO:0005886)
Positive regulation of cell division
(GO:0051781)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of endothelial cell migration
(GO:0010595)
Positive regulation of focal adhesion assembly
(GO:0051894)
Positive regulation of notch signaling pathway
(GO:0045747)
Positive regulation of phosphatidylinositol 3-kinase/protein kinase b signal transduction
(GO:0051897)
Positive regulation of protein targeting to membrane
(GO:0090314)
Positive regulation of stress fiber assembly
(GO:0051496)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Protein binding
(GO:0005515)
Protein kinase binding
(GO:0019901)
Protein localization to plasma membrane
(GO:0072659)
Receptor clustering
(GO:0043113)
Regulation of cell adhesion mediated by integrin
(GO:0033628)
Regulation of gtpase activity
(GO:0043087)
Regulation of integrin-mediated signaling pathway
(GO:2001044)
Ruffle
(GO:0001726)
Tube formation
(GO:0035148)

Other Information

Proteins

Integrin beta-1-binding protein 1
B4DQY5_HUMAN

Genular Protein ID: 907124972

Symbol: ITBP1_HUMAN

Name: Integrin beta-1-binding protein 1

UniProtKB Accession Codes:

O14713 D6W4Y9 O14714 Q53RS0

Database IDs:

Citations:

PubMed ID: 9281591

Title: ICAP-1, a novel beta1 integrin cytoplasmic domain-associated protein, binds to a conserved and functionally important NPXY sequence motif of beta1 integrin.

PubMed ID: 9281591

DOI: 10.1083/jcb.138.5.1149

PubMed ID: 9867804

Title: Interaction of the integrin beta1 cytoplasmic domain with ICAP-1 protein.

PubMed ID: 9867804

DOI: 10.1074/jbc.274.1.11

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9813144

Title: Calcium/calmodulin-dependent protein kinase II controls integrin alpha5beta1-mediated cell adhesion through the integrin cytoplasmic domain associated protein-1alpha.

PubMed ID: 9813144

DOI: 10.1006/bbrc.1998.9592

PubMed ID: 11741838

Title: Interaction between krit1 and icap1alpha infers perturbation of integrin beta1-mediated angiogenesis in the pathogenesis of cerebral cavernous malformation.

PubMed ID: 11741838

DOI: 10.1093/hmg/10.25.2953

PubMed ID: 11854171

Title: KRIT1 association with the integrin-binding protein ICAP-1: a new direction in the elucidation of cerebral cavernous malformations (CCM1) pathogenesis.

PubMed ID: 11854171

DOI: 10.1093/hmg/11.4.389

PubMed ID: 11741908

Title: Molecular basis for interaction between Icap1alpha PTB domain and beta 1 integrin.

PubMed ID: 11741908

DOI: 10.1074/jbc.m109031200

PubMed ID: 11919189

Title: Integrin cytoplasmic domain-associated protein 1alpha (ICAP-1alpha) interacts directly with the metastasis suppressor nm23-H2, and both proteins are targeted to newly formed cell adhesion sites upon integrin engagement.

PubMed ID: 11919189

DOI: 10.1074/jbc.m200200200

PubMed ID: 11807099

Title: The integrin cytoplasmic domain-associated protein ICAP-1 binds and regulates Rho family GTPases during cell spreading.

PubMed ID: 11807099

DOI: 10.1083/jcb.200108030

PubMed ID: 12473654

Title: Disruption of focal adhesions by integrin cytoplasmic domain-associated protein-1 alpha.

PubMed ID: 12473654

DOI: 10.1074/jbc.m211258200

PubMed ID: 14759258

Title: An unappreciated role for RNA surveillance.

PubMed ID: 14759258

DOI: 10.1186/gb-2004-5-2-r8

PubMed ID: 15703214

Title: Nuclear translocation of integrin cytoplasmic domain-associated protein 1 stimulates cellular proliferation.

PubMed ID: 15703214

DOI: 10.1091/mbc.e04-08-0744

PubMed ID: 17916086

Title: Krit 1 interactions with microtubules and membranes are regulated by Rap1 and integrin cytoplasmic domain associated protein-1.

PubMed ID: 17916086

DOI: 10.1111/j.1742-4658.2007.06068.x

PubMed ID: 20616313

Title: Integrin cytoplasmic domain-associated protein-1 attenuates sprouting angiogenesis.

PubMed ID: 20616313

DOI: 10.1161/circresaha.110.217257

PubMed ID: 21768292

Title: Osteoblast mineralization requires beta1 integrin/ICAP-1-dependent fibronectin deposition.

PubMed ID: 21768292

DOI: 10.1083/jcb.201007108

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

Title: Mechanism for KRIT1 release of ICAP1-mediated suppression of integrin activation.

DOI: 10.1016/j.molcel.2012.12.005

Sequence Information:

Length: 200
Mass: 21782
Checksum: 0F041238E68FBE23
Sequence:

MFRKGKKRHS SSSSQSSEIS TKSKSVDSSL GGLSRSSTVA SLDTDSTKSS GQSNNNSDTC 
AEFRIKYVGA IEKLKLSEGK GLEGPLDLIN YIDVAQQDGK LPFVPPEEEF IMGVSKYGIK 
VSTSDQYDVL HRHALYLIIR MVCYDDGLGA GKSLLALKTT DASNEEYSLW VYQCNSLEQA 
QAICKVLSTA FDSVLTSEKP

Genular Protein ID: 3211066163

Symbol: B4DQY5_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DQY5

Database IDs:

Sequence Information:

Length: 156
Mass: 17286
Checksum: ECC51CEDAC9B030A
Sequence:

MGPRLRGQSN NNSDTCAEFR IKYVGAIEKL KLSEGKGLEG PLDLINYIDV AQQDGKLPFV 
PPEEEFIMGV SKYGIKVSTS DQYDVLHRHA LYLIIRMVCY DDGLGAGKSL LALKTTDASN 
EEYSLWVYQC NSLEQAQAIC KVLSTAFDSV LTSEKP

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: ITGB1BP1

Associated with

Other Information

ICAP-1, a novel beta1 integrin cytoplasmic domain-associated protein, binds to a conserved and functionally important NPXY sequence motif of beta1 integrin. PubMed ID: 9281591

Interaction of the integrin beta1 cytoplasmic domain with ICAP-1 protein. PubMed ID: 9867804

Generation and annotation of the DNA sequences of human chromosomes 2 and 4. PubMed ID: 15815621

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Calcium/calmodulin-dependent protein kinase II controls integrin alpha5beta1-mediated cell adhesion through the integrin cytoplasmic domain associated protein-1alpha. PubMed ID: 9813144

Interaction between krit1 and icap1alpha infers perturbation of integrin beta1-mediated angiogenesis in the pathogenesis of cerebral cavernous malformation. PubMed ID: 11741838

KRIT1 association with the integrin-binding protein ICAP-1: a new direction in the elucidation of cerebral cavernous malformations (CCM1) pathogenesis. PubMed ID: 11854171

Molecular basis for interaction between Icap1alpha PTB domain and beta 1 integrin. PubMed ID: 11741908

Integrin cytoplasmic domain-associated protein 1alpha (ICAP-1alpha) interacts directly with the metastasis suppressor nm23-H2, and both proteins are targeted to newly formed cell adhesion sites upon integrin engagement. PubMed ID: 11919189

The integrin cytoplasmic domain-associated protein ICAP-1 binds and regulates Rho family GTPases during cell spreading. PubMed ID: 11807099

Disruption of focal adhesions by integrin cytoplasmic domain-associated protein-1 alpha. PubMed ID: 12473654

An unappreciated role for RNA surveillance. PubMed ID: 14759258

Nuclear translocation of integrin cytoplasmic domain-associated protein 1 stimulates cellular proliferation. PubMed ID: 15703214

Krit 1 interactions with microtubules and membranes are regulated by Rap1 and integrin cytoplasmic domain associated protein-1. PubMed ID: 17916086

Integrin cytoplasmic domain-associated protein-1 attenuates sprouting angiogenesis. PubMed ID: 20616313

Osteoblast mineralization requires beta1 integrin/ICAP-1-dependent fibronectin deposition. PubMed ID: 21768292

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

Mechanism for KRIT1 release of ICAP1-mediated suppression of integrin activation.