PIWIL1 | ENSG00000125207 | NCBI 9271

Details for: PIWIL1

Gene ID: 9271

Symbol: PIWIL1

Ensembl ID: ENSG00000125207

Description: piwi like RNA-mediated gene silencing 1

Associated with

Gene expression (transcription)
(R-HSA-74160)
Gene silencing by rna
(R-HSA-211000)
Piwi-interacting rna (pirna) biogenesis
(R-HSA-5601884)
Chromatoid body
(GO:0033391)
Cytoplasm
(GO:0005737)
Dense body
(GO:0097433)
Meiotic cell cycle
(GO:0051321)
Metal ion binding
(GO:0046872)
Mrna binding
(GO:0003729)
Mrna cap binding complex binding
(GO:0140262)
Nucleus
(GO:0005634)
P granule
(GO:0043186)
Pirna-mediated retrotransposon silencing by heterochromatin formation
(GO:0141006)
Pirna binding
(GO:0034584)
Pirna processing
(GO:0034587)
Polysome binding
(GO:1905538)
Primary pirna processing
(GO:0140990)
Protein binding
(GO:0005515)
Protein kinase binding
(GO:0019901)
Regulation of translation
(GO:0006417)
Regulatory ncrna-mediated gene silencing
(GO:0031047)
Rna endonuclease activity
(GO:0004521)
Single-stranded rna binding
(GO:0003727)
Spermatid development
(GO:0007286)
Spermatogenesis
(GO:0007283)
Sperm dna condensation
(GO:0035092)

Other Information

Proteins

Piwi-like protein 1

Genular Protein ID: 1388207674

Symbol: PIWL1_HUMAN

Name: Piwi-like protein 1

UniProtKB Accession Codes:

Q96J94 A4F266 O95404 Q8NA60 Q8TBY5 Q96JD5

Database IDs:

Citations:

PubMed ID: 11154219

Title: Human CD34+ stem cells express the hiwi gene, a human homologue of the Drosophila gene piwi.

PubMed ID: 11154219

DOI: 10.1182/blood.v97.2.426

PubMed ID: 12037681

Title: Molecular characterization of hiwi, a human member of the piwi gene family whose overexpression is correlated to seminomas.

PubMed ID: 12037681

DOI: 10.1038/sj.onc.1205505

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17544373

Title: The induction of H3K9 methylation by PIWIL4 at the p16Ink4a locus.

PubMed ID: 17544373

DOI: 10.1016/j.bbrc.2007.05.136

PubMed ID: 12906857

Title: Identification of eight members of the Argonaute family in the human genome.

PubMed ID: 12906857

DOI: 10.1016/s0888-7543(03)00129-0

PubMed ID: 14749716

Title: Characterization of the interactions between mammalian PAZ PIWI domain proteins and Dicer.

PubMed ID: 14749716

DOI: 10.1038/sj.embor.7400070

PubMed ID: 16287078

Title: Expression of hiwi gene in human gastric cancer was associated with proliferation of cancer cells.

PubMed ID: 16287078

DOI: 10.1002/ijc.21575

PubMed ID: 23436708

Title: Scanning of novel cancer/testis proteins by human testis proteomic analysis.

PubMed ID: 23436708

DOI: 10.1002/pmic.201200489

PubMed ID: 21193640

Title: Structural basis for piRNA 2'-O-methylated 3'-end recognition by Piwi PAZ (Piwi/Argonaute/Zwille) domains.

PubMed ID: 21193640

DOI: 10.1073/pnas.1017762108

PubMed ID: 21465557

Title: Structural insights into piRNA recognition by the human PIWI-like 1 PAZ domain.

PubMed ID: 21465557

DOI: 10.1002/prot.23003

PubMed ID: 28552346

Title: Ubiquitination-deficient mutations in human Piwi cause male infertility by impairing histone-to-protamine exchange during spermiogenesis.

PubMed ID: 28552346

DOI: 10.1016/j.cell.2017.04.034

Sequence Information:

Length: 861
Mass: 98603
Checksum: 58D7F6C7321DEFA4
Sequence:

MTGRARARAR GRARGQETAQ LVGSTASQQP GYIQPRPQPP PAEGELFGRG RQRGTAGGTA 
KSQGLQISAG FQELSLAERG GRRRDFHDLG VNTRQNLDHV KESKTGSSGI IVRLSTNHFR 
LTSRPQWALY QYHIDYNPLM EARRLRSALL FQHEDLIGKC HAFDGTILFL PKRLQQKVTE 
VFSKTRNGED VRITITLTNE LPPTSPTCLQ FYNIIFRRLL KIMNLQQIGR NYYNPNDPID 
IPSHRLVIWP GFTTSILQYE NSIMLCTDVS HKVLRSETVL DFMFNFYHQT EEHKFQEQVS 
KELIGLVVLT KYNNKTYRVD DIDWDQNPKS TFKKADGSEV SFLEYYRKQY NQEITDLKQP 
VLVSQPKRRR GPGGTLPGPA MLIPELCYLT GLTDKMRNDF NVMKDLAVHT RLTPEQRQRE 
VGRLIDYIHK NDNVQRELRD WGLSFDSNLL SFSGRILQTE KIHQGGKTFD YNPQFADWSK 
ETRGAPLISV KPLDNWLLIY TRRNYEAANS LIQNLFKVTP AMGMQMRKAI MIEVDDRTEA 
YLRVLQQKVT ADTQIVVCLL SSNRKDKYDA IKKYLCTDCP TPSQCVVART LGKQQTVMAI 
ATKIALQMNC KMGGELWRVD IPLKLVMIVG IDCYHDMTAG RRSIAGFVAS INEGMTRWFS 
RCIFQDRGQE LVDGLKVCLQ AALRAWNSCN EYMPSRIIVY RDGVGDGQLK TLVNYEVPQF 
LDCLKSIGRG YNPRLTVIVV KKRVNTRFFA QSGGRLQNPL PGTVIDVEVT RPEWYDFFIV 
SQAVRSGSVS PTHYNVIYDN SGLKPDHIQR LTYKLCHIYY NWPGVIRVPA PCQYAHKLAF 
LVGQSIHREP NLSLSNRLYY L

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: PIWIL1

Associated with

Other Information

Human CD34+ stem cells express the hiwi gene, a human homologue of the Drosophila gene piwi. PubMed ID: 11154219

Molecular characterization of hiwi, a human member of the piwi gene family whose overexpression is correlated to seminomas. PubMed ID: 12037681

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

The induction of H3K9 methylation by PIWIL4 at the p16Ink4a locus. PubMed ID: 17544373

Identification of eight members of the Argonaute family in the human genome. PubMed ID: 12906857

Characterization of the interactions between mammalian PAZ PIWI domain proteins and Dicer. PubMed ID: 14749716

Expression of hiwi gene in human gastric cancer was associated with proliferation of cancer cells. PubMed ID: 16287078

Scanning of novel cancer/testis proteins by human testis proteomic analysis. PubMed ID: 23436708

Structural basis for piRNA 2'-O-methylated 3'-end recognition by Piwi PAZ (Piwi/Argonaute/Zwille) domains. PubMed ID: 21193640

Structural insights into piRNA recognition by the human PIWI-like 1 PAZ domain. PubMed ID: 21465557

Ubiquitination-deficient mutations in human Piwi cause male infertility by impairing histone-to-protamine exchange during spermiogenesis. PubMed ID: 28552346