Details for: CD9

Gene ID: 928

Symbol: CD9

Ensembl ID: ENSG00000010278

Description: CD9 molecule

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 4.34
    Marker Score: 5,226
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 4.17
    Marker Score: 10,526
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 4.07
    Marker Score: 9,936
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 3.97
    Marker Score: 29,551
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 3.96
    Marker Score: 3,097
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 3.89
    Marker Score: 2,197
  • Cell Name: renal intercalated cell (CL0005010)
    Fold Change: 3.88
    Marker Score: 2,070
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 3.72
    Marker Score: 24,226
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 3.51
    Marker Score: 11,015
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 3.5
    Marker Score: 5,797
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 3.49
    Marker Score: 18,351
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 3.42
    Marker Score: 2,692
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 3.41
    Marker Score: 5,432
  • Cell Name: basophil (CL0000767)
    Fold Change: 3.39
    Marker Score: 1,610
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 3.38
    Marker Score: 4,210
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 3.38
    Marker Score: 26,360
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 3.35
    Marker Score: 2,283
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 3.34
    Marker Score: 8,940
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 3.2
    Marker Score: 27,837
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 3.19
    Marker Score: 12,290
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 3.14
    Marker Score: 108,664
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 3.13
    Marker Score: 5,706
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 3.12
    Marker Score: 26,919
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 3.07
    Marker Score: 1,790
  • Cell Name: basal cell (CL0000646)
    Fold Change: 3.02
    Marker Score: 3,894
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 3
    Marker Score: 3,156
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 2.98
    Marker Score: 1,009
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 2.98
    Marker Score: 14,618
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 2.93
    Marker Score: 4,711
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 2.92
    Marker Score: 6,649
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: 2.89
    Marker Score: 3,405
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 2.87
    Marker Score: 4,066
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 2.86
    Marker Score: 6,027
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 2.83
    Marker Score: 896
  • Cell Name: club cell (CL0000158)
    Fold Change: 2.82
    Marker Score: 3,288
  • Cell Name: tracheobronchial goblet cell (CL0019003)
    Fold Change: 2.79
    Marker Score: 765
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 2.79
    Marker Score: 4,035
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 2.78
    Marker Score: 2,648
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 2.77
    Marker Score: 645
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 2.77
    Marker Score: 70,875
  • Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
    Fold Change: 2.74
    Marker Score: 662
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 2.73
    Marker Score: 1,275
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 2.71
    Marker Score: 2,599
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 2.69
    Marker Score: 2,319
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 2.67
    Marker Score: 5,341
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 2.66
    Marker Score: 1,146
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 2.66
    Marker Score: 2,375
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 2.66
    Marker Score: 1,890
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 2.64
    Marker Score: 1,796
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 2.61
    Marker Score: 3,399
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 2.61
    Marker Score: 3,613
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 2.57
    Marker Score: 4,561
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 2.57
    Marker Score: 4,215
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 2.53
    Marker Score: 2,685
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 2.53
    Marker Score: 40,616
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 2.52
    Marker Score: 2,828
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 2.52
    Marker Score: 894
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.51
    Marker Score: 3,700
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 2.49
    Marker Score: 2,657
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 2.48
    Marker Score: 1,114
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 2.47
    Marker Score: 4,640
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 2.44
    Marker Score: 6,213
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 2.42
    Marker Score: 699
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: 2.41
    Marker Score: 962
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 2.39
    Marker Score: 21,020
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 2.39
    Marker Score: 1,999
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 2.34
    Marker Score: 886
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 2.33
    Marker Score: 1,536
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 2.33
    Marker Score: 1,151
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 2.31
    Marker Score: 5,242
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 2.31
    Marker Score: 11,082
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 2.3
    Marker Score: 5,505
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 2.29
    Marker Score: 4,344
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 2.27
    Marker Score: 764
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 2.26
    Marker Score: 3,283
  • Cell Name: stem cell (CL0000034)
    Fold Change: 2.26
    Marker Score: 5,361
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 2.23
    Marker Score: 2,259
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 2.23
    Marker Score: 1,488
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 2.22
    Marker Score: 809
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 2.2
    Marker Score: 5,977
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 2.19
    Marker Score: 7,528
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 2.19
    Marker Score: 1,866
  • Cell Name: pulmonary ionocyte (CL0017000)
    Fold Change: 2.11
    Marker Score: 1,295
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 2.11
    Marker Score: 1,250
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 2.07
    Marker Score: 2,055
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 2.06
    Marker Score: 799
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 2.06
    Marker Score: 415
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 2.03
    Marker Score: 762
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 2.02
    Marker Score: 572
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 2.02
    Marker Score: 958
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 2
    Marker Score: 587
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 2
    Marker Score: 3,377
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 1.97
    Marker Score: 819
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 1.95
    Marker Score: 5,109
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 1.94
    Marker Score: 918
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.92
    Marker Score: 1,992
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.91
    Marker Score: 1,906
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 1.89
    Marker Score: 1,698
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 1.89
    Marker Score: 971
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 1.86
    Marker Score: 4,813

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** CD9 is a member of the tetraspanin family, characterized by its four transmembrane domains. It is a multifunctional protein that can interact with various receptors, adhesion molecules, and signaling proteins, influencing cellular behavior and function. CD9 is also known as the 5H9 antigen and is involved in the recognition of bacterial toxins, such as diphtheria toxin. **Pathways and Functions:** CD9 is involved in numerous cellular processes, including: 1. **Cell Adhesion:** CD9 interacts with integrins, which are essential for cell-cell and cell-extracellular matrix interactions. 2. **Cell Proliferation and Migration:** CD9 regulates cell growth, differentiation, and migration, particularly in epithelial and endothelial cells. 3. **Immune Response:** CD9 is involved in the regulation of immune responses, including the recognition of bacterial toxins and the activation of immune cells. 4. **Sperm-Oocyte Interaction:** CD9 plays a crucial role in the recognition and binding of sperm to the egg plasma membrane during fertilization. 5. **Endocytic Vesicle Membrane:** CD9 is involved in the regulation of endocytic vesicle membrane dynamics and the uptake of bacterial toxins. **Clinical Significance:** CD9 is significantly expressed in various diseases, including: 1. **Cancer:** CD9 is overexpressed in several types of cancer, including breast, lung, and colon cancer, and is associated with poor prognosis. 2. **Infectious Diseases:** CD9 is involved in the recognition and response to bacterial toxins, such as diphtheria toxin, which can cause severe respiratory and cardiovascular complications. 3. **Autoimmune Diseases:** CD9 is also implicated in autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis, where it regulates immune cell function and tissue damage. 4. **Reproductive Disorders:** CD9 plays a crucial role in fertilization and embryonic development, and its dysregulation can lead to reproductive disorders, such as infertility and miscarriage. In conclusion, CD9 is a multifaceted gene that plays a crucial role in various cellular processes, including cell adhesion, proliferation, and migration, as well as in the regulation of immune responses and cellular signaling pathways. Its dysregulation is implicated in various diseases, making it a promising target for therapeutic interventions. **References:** * [Insert relevant references to support the discussion] Note: As an expert immunologist, I would like to emphasize the importance of further research on CD9 and its role in various diseases, particularly in the context of infectious diseases, autoimmune diseases, and reproductive disorders.

Genular Protein ID: 1218206090

Symbol: CD9_HUMAN

Name: 5H9 antigen

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 1840589

Title: Molecular cloning of the CD9 antigen. A new family of cell surface proteins.

PubMed ID: 1840589

DOI: 10.1016/s0021-9258(18)52410-8

PubMed ID: 2037603

Title: cDNA cloning and expression of platelet p24/CD9. Evidence for a new family of multiple membrane-spanning proteins.

PubMed ID: 2037603

DOI: 10.1016/s0021-9258(18)99271-9

PubMed ID: 1720807

Title: Identification of the motility-related protein (MRP-1), recognized by monoclonal antibody M31-15, which inhibits cell motility.

PubMed ID: 1720807

DOI: 10.1084/jem.174.6.1347

PubMed ID: 8486348

Title: Organization of the human CD9 gene.

PubMed ID: 8486348

DOI: 10.1006/geno.1993.1150

PubMed ID: 15196249

Title: The tetraspanin CD9 is preferentially expressed on the human CD4(+)CD45RA+ naive T cell population and is involved in T cell activation.

PubMed ID: 15196249

DOI: 10.1111/j.1365-2249.2004.02494.x

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2358073

Title: Purification and partial characterization of CD9 antigen of human platelets.

PubMed ID: 2358073

DOI: 10.1016/0014-5793(90)80265-k

PubMed ID: 8478605

Title: Suppression of cell motility and metastasis by transfection with human motility-related protein (MRP-1/CD9) DNA.

PubMed ID: 8478605

DOI: 10.1084/jem.177.5.1231

PubMed ID: 7511626

Title: CD9-regulated adhesion. Anti-CD9 monoclonal antibody induce pre-B cell adhesion to bone marrow fibroblasts through de novo recognition of fibronectin.

PubMed ID: 7511626

PubMed ID: 14575715

Title: Structural requirements for the inhibitory action of the CD9 large extracellular domain in sperm/oocyte binding and fusion.

PubMed ID: 14575715

DOI: 10.1016/j.bbrc.2003.09.196

PubMed ID: 12796480

Title: Tetraspanins CD9 and CD81 function to prevent the fusion of mononuclear phagocytes.

PubMed ID: 12796480

DOI: 10.1083/jcb.200212031

PubMed ID: 14556650

Title: Evidence for specific tetraspanin homodimers: inhibition of palmitoylation makes cysteine residues available for cross-linking.

PubMed ID: 14556650

DOI: 10.1042/bj20031037

PubMed ID: 11959120

Title: Differential stability of tetraspanin/tetraspanin interactions: role of palmitoylation.

PubMed ID: 11959120

DOI: 10.1016/s0014-5793(02)02522-x

PubMed ID: 11278880

Title: The major CD9 and CD81 molecular partner. Identification and characterization of the complexes.

PubMed ID: 11278880

DOI: 10.1074/jbc.m011297200

PubMed ID: 11504738

Title: EWI-2 is a major CD9 and CD81 partner and member of a novel Ig protein subfamily.

PubMed ID: 11504738

DOI: 10.1074/jbc.m107338200

PubMed ID: 18541721

Title: Tetraspanin family member CD9 inhibits Aggrus/podoplanin-induced platelet aggregation and suppresses pulmonary metastasis.

PubMed ID: 18541721

DOI: 10.1182/blood-2007-11-124693

PubMed ID: 18508921

Title: DHHC2 affects palmitoylation, stability, and functions of tetraspanins CD9 and CD151.

PubMed ID: 18508921

DOI: 10.1091/mbc.e07-11-1164

PubMed ID: 19640571

Title: Palmitoylation supports the association of tetraspanin CD63 with CD9 and integrin alphaIIbbeta3 in activated platelets.

PubMed ID: 19640571

DOI: 10.1016/j.thromres.2009.07.005

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23858057

Title: CD81 controls sustained T cell activation signaling and defines the maturation stages of cognate immunological synapses.

PubMed ID: 23858057

DOI: 10.1128/mcb.00302-13

PubMed ID: 25551757

Title: Distinct regions of the large extracellular domain of tetraspanin CD9 are involved in the control of human multinucleated giant cell formation.

PubMed ID: 25551757

DOI: 10.1371/journal.pone.0116289

PubMed ID: 27993971

Title: The CD9, CD81, and CD151 EC2 domains bind to the classical RGD-binding site of integrin alphavbeta3.

PubMed ID: 27993971

DOI: 10.1042/bcj20160998

Sequence Information:

  • Length: 228
  • Mass: 25416
  • Checksum: F68333E0C20611D8
  • Sequence:
  • MPVKGGTKCI KYLLFGFNFI FWLAGIAVLA IGLWLRFDSQ TKSIFEQETN NNNSSFYTGV 
    YILIGAGALM MLVGFLGCCG AVQESQCMLG LFFGFLLVIF AIEIAAAIWG YSHKDEVIKE 
    VQEFYKDTYN KLKTKDEPQR ETLKAIHYAL NCCGLAGGVE QFISDICPKK DVLETFTVKS 
    CPDAIKEVFD NKFHIIGAVG IGIAVVMIFG MIFSMILCCA IRRNREMV

Genular Protein ID: 86971999

Symbol: B4DK09_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 249
  • Mass: 28193
  • Checksum: EE10994261F76A7B
  • Sequence:
  • MPVKGGTKCI KYLLFGFNFI FWLAGIAVLA IGLWLRFDSQ TKSIFEQETN NNNSSFYTGV 
    YILIGAGALM MLVGFLGCCG AVQESQCMLG LFFGFLLVIF AIEIAAAIWG YSHKDEVIKE 
    VQEFYKDTYN KLKTKDEPQR ETLKAIHYAV CRLGKDTLLR FLRIVSAHRV LTAPDQCKHS 
    NRLLTICFSH PHPCLLAVVE LLWFGWGRGT VYLRHLPQEG RTRNLHREGK LRPGSWCPCP 
    HCSGQTLQA

Genular Protein ID: 645160075

Symbol: A6NNI4_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

Sequence Information:

  • Length: 159
  • Mass: 17764
  • Checksum: FF482FA2AF4C6ACF
  • Sequence:
  • MMLVGFLGCC GAVQESQCML GLFFGFLLVI FAIEIAAAIW GYSHKDEVIK EVQEFYKDTY 
    NKLKTKDEPQ RETLKAIHYA LNCCGLAGGV EQFISDICPK KDVLETFTVK SCPDAIKEVF 
    DNKFHIIGAV GIGIAVVMIF GMIFSMILCC AIRRNREMV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.