Details for: CD9

Gene ID: 928

Symbol: CD9

Ensembl ID: ENSG00000010278

Description: CD9 molecule

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 4.34
    Marker Score: 5226
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 4.17
    Marker Score: 10526
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 4.07
    Marker Score: 9936
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 3.97
    Marker Score: 29551
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 3.96
    Marker Score: 3097
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 3.89
    Marker Score: 2197
  • Cell Name: renal intercalated cell (CL0005010)
    Fold Change: 3.88
    Marker Score: 2070
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 3.72
    Marker Score: 24226
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 3.51
    Marker Score: 11015
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 3.5
    Marker Score: 5797
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 3.49
    Marker Score: 18351
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 3.42
    Marker Score: 2692
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 3.41
    Marker Score: 5431.5
  • Cell Name: basophil (CL0000767)
    Fold Change: 3.39
    Marker Score: 1610
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 3.38
    Marker Score: 4210
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 3.38
    Marker Score: 26360
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 3.35
    Marker Score: 2283
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 3.34
    Marker Score: 8940
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 3.2
    Marker Score: 27837
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 3.19
    Marker Score: 12290
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 3.14
    Marker Score: 108664
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 3.13
    Marker Score: 5706
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 3.12
    Marker Score: 26919
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 3.07
    Marker Score: 1790
  • Cell Name: basal cell (CL0000646)
    Fold Change: 3.02
    Marker Score: 3894
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 3
    Marker Score: 3156
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 2.98
    Marker Score: 1009
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 2.98
    Marker Score: 14618
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 2.93
    Marker Score: 4711
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 2.92
    Marker Score: 6649
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: 2.89
    Marker Score: 3405
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 2.87
    Marker Score: 4066
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 2.86
    Marker Score: 6027
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 2.83
    Marker Score: 896
  • Cell Name: club cell (CL0000158)
    Fold Change: 2.82
    Marker Score: 3288
  • Cell Name: tracheobronchial goblet cell (CL0019003)
    Fold Change: 2.79
    Marker Score: 765
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 2.79
    Marker Score: 4035
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 2.78
    Marker Score: 2648
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 2.77
    Marker Score: 645
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 2.77
    Marker Score: 70875
  • Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
    Fold Change: 2.74
    Marker Score: 662
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 2.73
    Marker Score: 1275
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 2.71
    Marker Score: 2599
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 2.69
    Marker Score: 2319
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 2.67
    Marker Score: 5341
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 2.66
    Marker Score: 1146
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 2.66
    Marker Score: 2375
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 2.66
    Marker Score: 1890
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 2.64
    Marker Score: 1796
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 2.61
    Marker Score: 3399
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 2.61
    Marker Score: 3613
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 2.57
    Marker Score: 4561
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 2.57
    Marker Score: 4215
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 2.53
    Marker Score: 2685
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 2.53
    Marker Score: 40616
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 2.52
    Marker Score: 2828
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 2.52
    Marker Score: 894
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.51
    Marker Score: 3700
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 2.49
    Marker Score: 2657
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 2.48
    Marker Score: 1114
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 2.47
    Marker Score: 4640
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 2.44
    Marker Score: 6213
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 2.42
    Marker Score: 699
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: 2.41
    Marker Score: 962
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 2.39
    Marker Score: 21020
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 2.39
    Marker Score: 1999
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 2.34
    Marker Score: 886
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 2.33
    Marker Score: 1536
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 2.33
    Marker Score: 1151
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 2.31
    Marker Score: 5242
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 2.31
    Marker Score: 11082
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 2.3
    Marker Score: 5505
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 2.29
    Marker Score: 4344
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 2.27
    Marker Score: 764
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 2.26
    Marker Score: 3283
  • Cell Name: stem cell (CL0000034)
    Fold Change: 2.26
    Marker Score: 5361
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 2.23
    Marker Score: 2259
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 2.23
    Marker Score: 1488
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 2.22
    Marker Score: 809
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 2.2
    Marker Score: 5977
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 2.19
    Marker Score: 7528
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 2.19
    Marker Score: 1866
  • Cell Name: pulmonary ionocyte (CL0017000)
    Fold Change: 2.11
    Marker Score: 1295
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 2.11
    Marker Score: 1250
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 2.07
    Marker Score: 2055
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 2.06
    Marker Score: 799
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 2.06
    Marker Score: 415
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 2.03
    Marker Score: 762
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 2.02
    Marker Score: 572
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 2.02
    Marker Score: 958
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 2
    Marker Score: 587
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 2
    Marker Score: 3377
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 1.97
    Marker Score: 819
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 1.95
    Marker Score: 5109
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 1.94
    Marker Score: 918
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.92
    Marker Score: 1992
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.91
    Marker Score: 1906
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 1.89
    Marker Score: 1698
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 1.89
    Marker Score: 971
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 1.86
    Marker Score: 4813

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Other Information

**Key characteristics:** - CD9 is a glycoprotein with a molecular weight of approximately 120 kDa. - It is a type I transmembrane protein that is expressed on the surface of endothelial cells, epithelial cells, and immune cells. - CD9 is a member of the immunoglobulin superfamily. - It is involved in the regulation of platelet activation and aggregation. **Pathways and functions:** - CD9 is involved in cell adhesion by binding to its ligand, ICAM-1 (intercellular adhesion molecule-1). - It is also involved in the regulation of the immune response by binding to CD28, a cell surface protein that is expressed on activated T cells. - CD9 is also involved in the regulation of cell population proliferation by binding to the EGF receptor, which is expressed on proliferating cells. - It is also involved in the regulation of fertilization by binding to the sperm surface protein SRY (sex-determining region Y). **Clinical significance:** - Mutations in the CD9 gene have been linked to a number of human diseases, including cancer, autoimmune disorders, and infectious diseases. - In cancer, CD9 mutations can lead to the uncontrolled growth of cancer cells. - In autoimmune disorders, CD9 mutations can lead to the immune response attacking healthy cells. - In infectious diseases, CD9 mutations can make cells more susceptible to infection.

Genular Protein ID: 1218206090

Symbol: CD9_HUMAN

Name: 5H9 antigen

UniProtKB Accession Codes:

P21926 D3DUQ9 Q5J7W6 Q96ES4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EMBL 25 EPD 1 Ensembl 3 ExpressionAtlas 1 GO 25 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 7 PDBsum 5 PIR 1 PIRSF 1 PRIDE 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 3 RefSeq 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1840589

Title: Molecular cloning of the CD9 antigen. A new family of cell surface proteins.

PubMed ID: 1840589

DOI: 10.1016/s0021-9258(18)52410-8

PubMed ID: 2037603

Title: cDNA cloning and expression of platelet p24/CD9. Evidence for a new family of multiple membrane-spanning proteins.

PubMed ID: 2037603

DOI: 10.1016/s0021-9258(18)99271-9

PubMed ID: 1720807

Title: Identification of the motility-related protein (MRP-1), recognized by monoclonal antibody M31-15, which inhibits cell motility.

PubMed ID: 1720807

DOI: 10.1084/jem.174.6.1347

PubMed ID: 8486348

Title: Organization of the human CD9 gene.

PubMed ID: 8486348

DOI: 10.1006/geno.1993.1150

PubMed ID: 15196249

Title: The tetraspanin CD9 is preferentially expressed on the human CD4(+)CD45RA+ naive T cell population and is involved in T cell activation.

PubMed ID: 15196249

DOI: 10.1111/j.1365-2249.2004.02494.x

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2358073

Title: Purification and partial characterization of CD9 antigen of human platelets.

PubMed ID: 2358073

DOI: 10.1016/0014-5793(90)80265-k

PubMed ID: 8478605

Title: Suppression of cell motility and metastasis by transfection with human motility-related protein (MRP-1/CD9) DNA.

PubMed ID: 8478605

DOI: 10.1084/jem.177.5.1231

PubMed ID: 7511626

Title: CD9-regulated adhesion. Anti-CD9 monoclonal antibody induce pre-B cell adhesion to bone marrow fibroblasts through de novo recognition of fibronectin.

PubMed ID: 7511626

PubMed ID: 14575715

Title: Structural requirements for the inhibitory action of the CD9 large extracellular domain in sperm/oocyte binding and fusion.

PubMed ID: 14575715

DOI: 10.1016/j.bbrc.2003.09.196

PubMed ID: 12796480

Title: Tetraspanins CD9 and CD81 function to prevent the fusion of mononuclear phagocytes.

PubMed ID: 12796480

DOI: 10.1083/jcb.200212031

PubMed ID: 14556650

Title: Evidence for specific tetraspanin homodimers: inhibition of palmitoylation makes cysteine residues available for cross-linking.

PubMed ID: 14556650

DOI: 10.1042/bj20031037

PubMed ID: 11959120

Title: Differential stability of tetraspanin/tetraspanin interactions: role of palmitoylation.

PubMed ID: 11959120

DOI: 10.1016/s0014-5793(02)02522-x

PubMed ID: 11278880

Title: The major CD9 and CD81 molecular partner. Identification and characterization of the complexes.

PubMed ID: 11278880

DOI: 10.1074/jbc.m011297200

PubMed ID: 11504738

Title: EWI-2 is a major CD9 and CD81 partner and member of a novel Ig protein subfamily.

PubMed ID: 11504738

DOI: 10.1074/jbc.m107338200

PubMed ID: 18541721

Title: Tetraspanin family member CD9 inhibits Aggrus/podoplanin-induced platelet aggregation and suppresses pulmonary metastasis.

PubMed ID: 18541721

DOI: 10.1182/blood-2007-11-124693

PubMed ID: 18508921

Title: DHHC2 affects palmitoylation, stability, and functions of tetraspanins CD9 and CD151.

PubMed ID: 18508921

DOI: 10.1091/mbc.e07-11-1164

PubMed ID: 19640571

Title: Palmitoylation supports the association of tetraspanin CD63 with CD9 and integrin alphaIIbbeta3 in activated platelets.

PubMed ID: 19640571

DOI: 10.1016/j.thromres.2009.07.005

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23858057

Title: CD81 controls sustained T cell activation signaling and defines the maturation stages of cognate immunological synapses.

PubMed ID: 23858057

DOI: 10.1128/mcb.00302-13

PubMed ID: 25551757

Title: Distinct regions of the large extracellular domain of tetraspanin CD9 are involved in the control of human multinucleated giant cell formation.

PubMed ID: 25551757

DOI: 10.1371/journal.pone.0116289

PubMed ID: 27993971

Title: The CD9, CD81, and CD151 EC2 domains bind to the classical RGD-binding site of integrin alphavbeta3.

PubMed ID: 27993971

DOI: 10.1042/bcj20160998

Sequence Information:

  • Length: 228
  • Mass: 25416
  • Checksum: F68333E0C20611D8
  • Sequence:
    • MPVKGGTKCI KYLLFGFNFI FWLAGIAVLA IGLWLRFDSQ TKSIFEQETN NNNSSFYTGV 
YILIGAGALM MLVGFLGCCG AVQESQCMLG LFFGFLLVIF AIEIAAAIWG YSHKDEVIKE 
VQEFYKDTYN KLKTKDEPQR ETLKAIHYAL NCCGLAGGVE QFISDICPKK DVLETFTVKS 
CPDAIKEVFD NKFHIIGAVG IGIAVVMIFG MIFSMILCCA IRRNREMV

Genular Protein ID: 86971999

Symbol: B4DK09_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DK09

Database IDs:

ARBA 6 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 EMBL 2 GO 1 Gene3D 1 GenomeRNAi 1 InterPro 3 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 1 PeptideAtlas 1 Pfam 1 RefSeq 1 SAM 1 SMR 1 SUPFAM 1

Sequence Information:

  • Length: 249
  • Mass: 28193
  • Checksum: EE10994261F76A7B
  • Sequence:
    • MPVKGGTKCI KYLLFGFNFI FWLAGIAVLA IGLWLRFDSQ TKSIFEQETN NNNSSFYTGV 
YILIGAGALM MLVGFLGCCG AVQESQCMLG LFFGFLLVIF AIEIAAAIWG YSHKDEVIKE 
VQEFYKDTYN KLKTKDEPQR ETLKAIHYAV CRLGKDTLLR FLRIVSAHRV LTAPDQCKHS 
NRLLTICFSH PHPCLLAVVE LLWFGWGRGT VYLRHLPQEG RTRNLHREGK LRPGSWCPCP 
HCSGQTLQA

Genular Protein ID: 645160075

Symbol: A6NNI4_HUMAN

Name: N/A

UniProtKB Accession Codes:

A6NNI4

Database IDs:

ARBA 4 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 1 EPD 1 Ensembl 5 GO 1 Gene3D 1 GeneTree 1 GenomeRNAi 1 HGNC 1 InterPro 3 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PRINTS 1 Pfam 1 Proteomes 2 ProteomicsDB 1 RefSeq 1 SAM 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

Sequence Information:

  • Length: 159
  • Mass: 17764
  • Checksum: FF482FA2AF4C6ACF
  • Sequence:
    • MMLVGFLGCC GAVQESQCML GLFFGFLLVI FAIEIAAAIW GYSHKDEVIK EVQEFYKDTY 
NKLKTKDEPQ RETLKAIHYA LNCCGLAGGV EQFISDICPK KDVLETFTVK SCPDAIKEVF 
DNKFHIIGAV GIGIAVVMIF GMIFSMILCC AIRRNREMV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.