GPR37L1 | ENSG00000170075 | NCBI 9283

Details for: GPR37L1

Gene ID: 9283

Symbol: GPR37L1

Ensembl ID: ENSG00000170075

Description: G protein-coupled receptor 37 like 1

Associated with

Class a/1 (rhodopsin-like receptors)
(R-HSA-373076)
G alpha (i) signalling events
(R-HSA-418594)
Gpcr downstream signalling
(R-HSA-388396)
Gpcr ligand binding
(R-HSA-500792)
Peptide ligand-binding receptors
(R-HSA-375276)
Signaling by gpcr
(R-HSA-372790)
Signal transduction
(R-HSA-162582)
Adenylate cyclase-inhibiting g protein-coupled receptor signaling pathway
(GO:0007193)
Bergmann glial cell differentiation
(GO:0060020)
Cellular response to reactive oxygen species
(GO:0034614)
Ciliary membrane
(GO:0060170)
G protein-coupled peptide receptor activity
(GO:0008528)
G protein-coupled receptor activity
(GO:0004930)
Membrane
(GO:0016020)
Negative regulation of astrocyte differentiation
(GO:0048712)
Negative regulation of neuron differentiation
(GO:0045665)
Negative regulation of smoothened signaling pathway
(GO:0045879)
Negative regulation of systemic arterial blood pressure
(GO:0003085)
Peptide binding
(GO:0042277)
Plasma membrane
(GO:0005886)
Positive regulation of cerebellar granule cell precursor proliferation
(GO:0021940)
Positive regulation of mapk cascade
(GO:0043410)
Prosaposin receptor activity
(GO:0036505)
Protein binding
(GO:0005515)
Receptor complex
(GO:0043235)
Smoothened signaling pathway
(GO:0007224)

Other Information

Proteins

G-protein coupled receptor 37-like 1

Genular Protein ID: 3915395808

Symbol: G37L1_HUMAN

Name: G-protein coupled receptor 37-like 1

UniProtKB Accession Codes:

O60883 B2R7M9 Q5SXP7 Q86VP7

Database IDs:

Citations:

PubMed ID: 9539149

Title: A new family of orphan G protein-coupled receptors predominantly expressed in the brain.

PubMed ID: 9539149

DOI: 10.1016/s0014-5793(98)00170-7

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 23234360

Title: LC-MS/MS characterization of O-glycosylation sites and glycan structures of human cerebrospinal fluid glycoproteins.

PubMed ID: 23234360

DOI: 10.1021/pr300963h

PubMed ID: 23690594

Title: GPR37 and GPR37L1 are receptors for the neuroprotective and glioprotective factors prosaptide and prosaposin.

PubMed ID: 23690594

DOI: 10.1073/pnas.1219004110

PubMed ID: 27072655

Title: Metalloprotease cleavage of the N terminus of the orphan G protein-coupled receptor GPR37L1 reduces its constitutive activity.

PubMed ID: 27072655

DOI: 10.1126/scisignal.aad1089

PubMed ID: 28688853

Title: GPR37L1 modulates seizure susceptibility: Evidence from mouse studies and analyses of a human GPR37L1 variant.

PubMed ID: 28688853

DOI: 10.1016/j.nbd.2017.07.006

Sequence Information:

Length: 481
Mass: 52771
Checksum: EE9DFE0446E3AF24
Sequence:

MRWLWPLAVS LAVILAVGLS RVSGGAPLHL GRHRAETQEQ QSRSKRGTED EEAKGVQQYV 
PEEWAEYPRP IHPAGLQPTK PLVATSPNPG KDGGTPDSGQ ELRGNLTGAP GQRLQIQNPL 
YPVTESSYSA YAIMLLALVV FAVGIVGNLS VMCIVWHSYY LKSAWNSILA SLALWDFLVL 
FFCLPIVIFN EITKQRLLGD VSCRAVPFME VSSLGVTTFS LCALGIDRFH VATSTLPKVR 
PIERCQSILA KLAVIWVGSM TLAVPELLLW QLAQEPAPTM GTLDSCIMKP SASLPESLYS 
LVMTYQNARM WWYFGCYFCL PILFTVTCQL VTWRVRGPPG RKSECRASKH EQCESQLNST 
VVGLTVVYAF CTLPENVCNI VVAYLSTELT RQTLDLLGLI NQFSTFFKGA ITPVLLLCIC 
RPLGQAFLDC CCCCCCEECG GASEASAANG SDNKLKTEVS SSIYFHKPRE SPPLLPLGTP 
C

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: GPR37L1

Associated with

Other Information

A new family of orphan G protein-coupled receptors predominantly expressed in the brain. PubMed ID: 9539149

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence and biological annotation of human chromosome 1. PubMed ID: 16710414

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

LC-MS/MS characterization of O-glycosylation sites and glycan structures of human cerebrospinal fluid glycoproteins. PubMed ID: 23234360

GPR37 and GPR37L1 are receptors for the neuroprotective and glioprotective factors prosaptide and prosaposin. PubMed ID: 23690594

Metalloprotease cleavage of the N terminus of the orphan G protein-coupled receptor GPR37L1 reduces its constitutive activity. PubMed ID: 27072655

GPR37L1 modulates seizure susceptibility: Evidence from mouse studies and analyses of a human GPR37L1 variant. PubMed ID: 28688853