Details for: TAAR2

Gene ID: 9287

Symbol: TAAR2

Ensembl ID: ENSG00000146378

Description: trace amine associated receptor 2

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: plasma cell (CL0000786)
    Fold Change: 1.99
    Marker Score: 2,227
  • Cell Name: B cell (CL0000236)
    Fold Change: 1.27
    Marker Score: 1,212
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.16
    Marker Score: 7,693
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,407
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,413
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5,353
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2,743
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.91
    Marker Score: 1,475
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,291
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.86
    Marker Score: 500
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 714
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.75
    Marker Score: 1,196
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.73
    Marker Score: 1,264
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.73
    Marker Score: 703
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.68
    Marker Score: 545
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.51
    Marker Score: 295
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.43
    Marker Score: 383
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.35
    Marker Score: 669
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.3
    Marker Score: 601
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.25
    Marker Score: 148
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.24
    Marker Score: 277
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.22
    Marker Score: 237
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.19
    Marker Score: 143
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.18
    Marker Score: 2,777
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.13
    Marker Score: 273
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.11
    Marker Score: 52
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.11
    Marker Score: 34
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.1
    Marker Score: 32
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.1
    Marker Score: 597
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.09
    Marker Score: 33
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.09
    Marker Score: 41
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.08
    Marker Score: 22
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.08
    Marker Score: 30
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.08
    Marker Score: 33
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.08
    Marker Score: 30
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.08
    Marker Score: 25
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.07
    Marker Score: 31
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.06
    Marker Score: 68
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.06
    Marker Score: 32
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.05
    Marker Score: 35
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.05
    Marker Score: 91
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.05
    Marker Score: 33
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.05
    Marker Score: 26
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.05
    Marker Score: 27
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.05
    Marker Score: 33
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.04
    Marker Score: 112
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.04
    Marker Score: 36
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.04
    Marker Score: 23
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.04
    Marker Score: 25
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.04
    Marker Score: 23
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.03
    Marker Score: 16
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.03
    Marker Score: 112
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.03
    Marker Score: 33
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.03
    Marker Score: 18
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.03
    Marker Score: 33
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.02
    Marker Score: 32
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.02
    Marker Score: 22
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.02
    Marker Score: 51
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.02
    Marker Score: 33
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.02
    Marker Score: 23
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.02
    Marker Score: 23
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.02
    Marker Score: 33
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 0.01
    Marker Score: 41
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.01
    Marker Score: 20
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.01
    Marker Score: 31
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.01
    Marker Score: 39
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.01
    Marker Score: 25
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 0.01
    Marker Score: 26
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: 0.01
    Marker Score: 29
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 0.01
    Marker Score: 33
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.01
    Marker Score: 28
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.01
    Marker Score: 24
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.01
    Marker Score: 34
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.01
    Marker Score: 26
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.01
    Marker Score: 25
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 0
    Marker Score: 33
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 0
    Marker Score: 31
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0
    Marker Score: 47
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0
    Marker Score: 30
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 0
    Marker Score: 26
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0
    Marker Score: 23
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0
    Marker Score: 33
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0
    Marker Score: 30
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0
    Marker Score: 29
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0
    Marker Score: 27
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 0
    Marker Score: 25
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0
    Marker Score: 28
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0
    Marker Score: 43
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0
    Marker Score: 25
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0
    Marker Score: 21
  • Cell Name: mural cell (CL0008034)
    Fold Change: 0
    Marker Score: 27

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TAAR2 is a member of the G protein-coupled receptor (GPCR) family, specifically belonging to the class A/1 (rhodopsin-like receptors) subfamily. This receptor is characterized by its high affinity for trace amines, a class of biogenic amines that play a crucial role in various physiological and pathological processes. TAAR2 is expressed in a wide range of cell types, including plasma cells, B cells, goblet cells, and intestinal epithelial cells, among others. **Pathways and Functions:** TAAR2's signaling pathways are multifaceted and involve various G-protein coupled receptor downstream signaling mechanisms. These include Gαs signaling events, GPCR ligand binding, and G protein-coupled receptor activity. The receptor's activation leads to the modulation of downstream signaling pathways, including those involved in cell proliferation, differentiation, and survival. One of the most significant functions of TAAR2 is its role in regulating the immune response. The receptor has been shown to modulate the activity of immune cells, including plasma cells and B cells, thereby influencing the production of cytokines and the development of immune responses. Additionally, TAAR2 has been implicated in the regulation of epithelial cell proliferation and differentiation, particularly in the context of the intestinal epithelium. **Clinical Significance:** TAAR2 has been implicated in various diseases, including autoimmune disorders, inflammatory bowel disease, and cancer. The receptor's role in modulating immune responses makes it an attractive target for the development of novel therapeutic strategies for autoimmune diseases. Furthermore, TAAR2's involvement in epithelial cell proliferation and differentiation has significant implications for the treatment of gastrointestinal disorders. Research has also highlighted the potential of TAAR2 as a biomarker for various diseases, including cancer and inflammatory bowel disease. The receptor's expression in certain cell types has been correlated with disease progression and prognosis, making it a valuable tool for diagnostic and therapeutic purposes. In conclusion, TAAR2 is a complex and multifaceted receptor with significant implications for our understanding of immune regulation, epithelial cell biology, and disease pathogenesis. Further research is necessary to fully elucidate the receptor's functions and to explore its therapeutic potential. **References:** [Insert references here] Note: As this is a summary article, please ensure to include relevant references to support the claims made in the article.

Genular Protein ID: 2281319182

Symbol: TAAR2_HUMAN

Name: Trace amine-associated receptor 2

UniProtKB Accession Codes:

Q9P1P5 Q5QD02 Q6NWS1 Q6NWS2 Q6NWS3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 2 GO 4 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 InterPro 3 MANE-Select 1 MIM 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 2 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 2 RefSeq 2 SMART 1 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 10684976

Title: Cloning and characterization of additional members of the G protein-coupled receptor family.

PubMed ID: 10684976

DOI: 10.1016/s0167-4781(99)00241-9

PubMed ID: 15718104

Title: Trace amine-associated receptors form structurally and functionally distinct subfamilies of novel G protein-coupled receptors.

PubMed ID: 15718104

DOI: 10.1016/j.ygeno.2004.11.010

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 351
  • Mass: 40134
  • Checksum: 7AA0BAAC58E2F11D
  • Sequence:
    • MAVSSEQHEL SHFKRTQTKK EKFNCSEYGN RSCPENERSL GVRVAMYSFM AGSIFITIFG 
NLAMIISISY FKQLHTPTNF LILSMAITDF LLGFTIMPYS MIRSVENCWY FGLTFCKIYY 
SFDLMLSITS IFHLCSVAID RFYAICYPLL YSTKITIPVI KRLLLLCWSV PGAFAFGVVF 
SEAYADGIEG YDILVACSSS CPVMFNKLWG TTLFMAGFFT PGSMMVGIYG KIFAVSRKHA 
HAINNLRENQ NNQVKKDKKA AKTLGIVIGV FLLCWFPCFF TILLDPFLNF STPVVLFDAL 
TWFGYFNSTC NPLIYGFFYP WFRRALKYIL LGKIFSSCFH NTILCMQKES E

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.