CD14 | ENSG00000170458 | NCBI 929

Details for: CD14

Gene ID: 929

Symbol: CD14

Ensembl ID: ENSG00000170458

Description: CD14 molecule

Associated with

Activation of irf3, irf7 mediated by tbk1, ikbke
(R-HSA-936964)
Adaptive immune system
(R-HSA-1280218)
Antigen processing-cross presentation
(R-HSA-1236975)
Apoptosis
(R-HSA-109581)
Caspase activation via death receptors in the presence of ligand
(R-HSA-140534)
Caspase activation via extrinsic apoptotic signalling pathway
(R-HSA-5357769)
Class i mhc mediated antigen processing & presentation
(R-HSA-983169)
Disease
(R-HSA-1643685)
Diseases associated with the tlr signaling cascade
(R-HSA-5602358)
Diseases of immune system
(R-HSA-5260271)
Er-phagosome pathway
(R-HSA-1236974)
Ikk complex recruitment mediated by rip1
(R-HSA-937041)
Immune system
(R-HSA-168256)
Infectious disease
(R-HSA-5663205)
Innate immune system
(R-HSA-168249)
Irak2 mediated activation of tak1 complex upon tlr7/8 or 9 stimulation
(R-HSA-975163)
Irak4 deficiency (tlr2/4)
(R-HSA-5603041)
Myd88 deficiency (tlr2/4)
(R-HSA-5602498)
Myd88 dependent cascade initiated on endosome
(R-HSA-975155)
Myd88-independent tlr4 cascade
(R-HSA-166166)
Myd88:mal(tirap) cascade initiated on plasma membrane
(R-HSA-166058)
Neutrophil degranulation
(R-HSA-6798695)
Programmed cell death
(R-HSA-5357801)
Regulation of tlr by endogenous ligand
(R-HSA-5686938)
Respiratory syncytial virus (rsv) attachment and entry
(R-HSA-9820960)
Respiratory syncytial virus infection pathway
(R-HSA-9820952)
Rsv-host interactions
(R-HSA-9833110)
Toll-like receptor cascades
(R-HSA-168898)
Toll like receptor 2 (tlr2) cascade
(R-HSA-181438)
Toll like receptor 4 (tlr4) cascade
(R-HSA-166016)
Toll like receptor 7/8 (tlr7/8) cascade
(R-HSA-168181)
Toll like receptor 9 (tlr9) cascade
(R-HSA-168138)
Toll like receptor tlr1:tlr2 cascade
(R-HSA-168179)
Toll like receptor tlr6:tlr2 cascade
(R-HSA-168188)
Traf6 mediated induction of nfkb and map kinases upon tlr7/8 or 9 activation
(R-HSA-975138)
Traf6-mediated induction of tak1 complex within tlr4 complex
(R-HSA-937072)
Transfer of lps from lbp carrier to cd14
(R-HSA-166020)
Trif(ticam1)-mediated tlr4 signaling
(R-HSA-937061)
Trif-mediated programmed cell death
(R-HSA-2562578)
Viral infection pathways
(R-HSA-9824446)
Apoptotic process
(GO:0006915)
Cell surface pattern recognition receptor signaling pathway
(GO:0002752)
Cell surface receptor signaling pathway
(GO:0007166)
Cellular response to diacyl bacterial lipopeptide
(GO:0071726)
Cellular response to lipopolysaccharide
(GO:0071222)
Cellular response to lipoteichoic acid
(GO:0071223)
Cellular response to molecule of bacterial origin
(GO:0071219)
Cellular response to triacyl bacterial lipopeptide
(GO:0071727)
Endosome membrane
(GO:0010008)
External side of plasma membrane
(GO:0009897)
Extracellular exosome
(GO:0070062)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Golgi apparatus
(GO:0005794)
Inflammatory response
(GO:0006954)
Innate immune response
(GO:0045087)
Lipopolysaccharide-mediated signaling pathway
(GO:0031663)
Lipopolysaccharide binding
(GO:0001530)
Lipopolysaccharide immune receptor activity
(GO:0001875)
Lipopolysaccharide receptor complex
(GO:0046696)
Lipoteichoic acid binding
(GO:0070891)
Membrane raft
(GO:0045121)
Opsonin receptor activity
(GO:0001847)
Peptidoglycan immune receptor activity
(GO:0016019)
Phagocytosis
(GO:0006909)
Plasma membrane
(GO:0005886)
Positive regulation of cytokine production
(GO:0001819)
Positive regulation of endocytosis
(GO:0045807)
Positive regulation of interleukin-8 production
(GO:0032757)
Positive regulation of lipopolysaccharide-mediated signaling pathway
(GO:0031666)
Positive regulation of toll-like receptor 4 signaling pathway
(GO:0034145)
Positive regulation of tumor necrosis factor production
(GO:0032760)
Positive regulation of type ii interferon production
(GO:0032729)
Positive regulation of type i interferon production
(GO:0032481)
Protein binding
(GO:0005515)
Receptor-mediated endocytosis
(GO:0006898)
Response to electrical stimulus
(GO:0051602)
Response to ethanol
(GO:0045471)
Response to magnesium ion
(GO:0032026)
Response to tumor necrosis factor
(GO:0034612)
Secretory granule membrane
(GO:0030667)
Toll-like receptor 4 signaling pathway
(GO:0034142)

Other Information

Proteins

Myeloid cell-specific leucine-rich glycoprotein

Genular Protein ID: 3628415192

Symbol: CD14_HUMAN

Name: Myeloid cell-specific leucine-rich glycoprotein

UniProtKB Accession Codes:

P08571 Q53XT5 Q96FR6 Q96L99 Q9UNS3

Database IDs:

Citations:

PubMed ID: 3385210

Title: The monocyte differentiation antigen, CD14, is anchored to the cell membrane by a phosphatidylinositol linkage.

PubMed ID: 3385210

PubMed ID: 2453848

Title: Nucleotide sequence of the gene encoding the monocyte differentiation antigen, CD14.

PubMed ID: 2453848

DOI: 10.1093/nar/16.9.4173

PubMed ID: 2472171

Title: Mouse and human CD14 (myeloid cell-specific leucine-rich glycoprotein) primary structure deduced from cDNA clones.

PubMed ID: 2472171

DOI: 10.1016/0167-4781(80)90012-3

PubMed ID: 2462937

Title: Monocyte antigen CD14 is a phospholipid anchored membrane protein.

PubMed ID: 2462937

PubMed ID: 18810425

Title: Natural selection in the TLR-related genes in the course of primate evolution.

PubMed ID: 18810425

DOI: 10.1007/s00251-008-0332-0

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2779588

Title: Structural relationship between the soluble and membrane-bound forms of human monocyte surface glycoprotein CD14.

PubMed ID: 2779588

DOI: 10.1016/0161-5890(89)90048-5

PubMed ID: 1698311

Title: CD14, a receptor for complexes of lipopolysaccharide (LPS) and LPS binding protein.

PubMed ID: 1698311

DOI: 10.1126/science.1698311

PubMed ID: 8612135

Title: Resistance to endotoxin shock and reduced dissemination of gram-negative bacteria in CD14-deficient mice.

PubMed ID: 8612135

DOI: 10.1016/s1074-7613(00)80254-x

PubMed ID: 11274165

Title: Lipopolysaccharide is in close proximity to each of the proteins in its membrane receptor complex. transfer from CD14 to TLR4 and MD-2.

PubMed ID: 11274165

DOI: 10.1074/jbc.m009164200

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

PubMed ID: 16880211

Title: Membrane sorting of toll-like receptor (TLR)-2/6 and TLR2/1 heterodimers at the cell surface determines heterotypic associations with CD36 and intracellular targeting.

PubMed ID: 16880211

DOI: 10.1074/jbc.m602794200

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 19838169

Title: Enrichment of glycopeptides for glycan structure and attachment site identification.

PubMed ID: 19838169

DOI: 10.1038/nmeth.1392

PubMed ID: 20133493

Title: Lipopolysaccharide-binding protein-mediated Toll-like receptor 4 dimerization enables rapid signal transduction against lipopolysaccharide stimulation on membrane-associated CD14-expressing cells.

PubMed ID: 20133493

DOI: 10.1093/intimm/dxq005

PubMed ID: 22265692

Title: Follistatin-related protein/follistatin-like 1 evokes an innate immune response via CD14 and toll-like receptor 4.

PubMed ID: 22265692

DOI: 10.1016/j.febslet.2012.01.010

PubMed ID: 23880187

Title: CD14 and TLR4 mediate cytokine release promoted by electronegative LDL in monocytes.

PubMed ID: 23880187

DOI: 10.1016/j.atherosclerosis.2013.05.011

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25497142

Title: 27-Hydroxycholesterol up-regulates CD14 and predisposes monocytic cells to superproduction of CCL2 in response to lipopolysaccharide.

PubMed ID: 25497142

DOI: 10.1016/j.bbadis.2014.12.003

PubMed ID: 25965346

Title: SP-R210 (Myo18A) isoforms as intrinsic modulators of macrophage priming and activation.

PubMed ID: 25965346

DOI: 10.1371/journal.pone.0126576

PubMed ID: 23264655

Title: The crystal structure of human soluble CD14 reveals a bent solenoid with a hydrophobic amino-terminal pocket.

PubMed ID: 23264655

DOI: 10.4049/jimmunol.1202446

Sequence Information:

Length: 375
Mass: 40076
Checksum: 1746CDB41F394F8D
Sequence:

MERASCLLLL LLPLVHVSAT TPEPCELDDE DFRCVCNFSE PQPDWSEAFQ CVSAVEVEIH 
AGGLNLEPFL KRVDADADPR QYADTVKALR VRRLTVGAAQ VPAQLLVGAL RVLAYSRLKE 
LTLEDLKITG TMPPLPLEAT GLALSSLRLR NVSWATGRSW LAELQQWLKP GLKVLSIAQA 
HSPAFSCEQV RAFPALTSLD LSDNPGLGER GLMAALCPHK FPAIQNLALR NTGMETPTGV 
CAALAAAGVQ PHSLDLSHNS LRATVNPSAP RCMWSSALNS LNLSFAGLEQ VPKGLPAKLR 
VLDLSCNRLN RAPQPDELPE VDNLTLDGNP FLVPGTALPH EGSMNSGVVP ACARSTLSVG 
VSGTLVLLQG ARGFA

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: CD14

Associated with

Other Information

The monocyte differentiation antigen, CD14, is anchored to the cell membrane by a phosphatidylinositol linkage. PubMed ID: 3385210

Nucleotide sequence of the gene encoding the monocyte differentiation antigen, CD14. PubMed ID: 2453848

Mouse and human CD14 (myeloid cell-specific leucine-rich glycoprotein) primary structure deduced from cDNA clones. PubMed ID: 2472171

Monocyte antigen CD14 is a phospholipid anchored membrane protein. PubMed ID: 2462937

Natural selection in the TLR-related genes in the course of primate evolution. PubMed ID: 18810425

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Structural relationship between the soluble and membrane-bound forms of human monocyte surface glycoprotein CD14. PubMed ID: 2779588

CD14, a receptor for complexes of lipopolysaccharide (LPS) and LPS binding protein. PubMed ID: 1698311

Resistance to endotoxin shock and reduced dissemination of gram-negative bacteria in CD14-deficient mice. PubMed ID: 8612135

Lipopolysaccharide is in close proximity to each of the proteins in its membrane receptor complex. transfer from CD14 to TLR4 and MD-2. PubMed ID: 11274165

Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. PubMed ID: 16335952

Membrane sorting of toll-like receptor (TLR)-2/6 and TLR2/1 heterodimers at the cell surface determines heterotypic associations with CD36 and intracellular targeting. PubMed ID: 16880211

Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. PubMed ID: 19159218

Enrichment of glycopeptides for glycan structure and attachment site identification. PubMed ID: 19838169

Lipopolysaccharide-binding protein-mediated Toll-like receptor 4 dimerization enables rapid signal transduction against lipopolysaccharide stimulation on membrane-associated CD14-expressing cells. PubMed ID: 20133493

Follistatin-related protein/follistatin-like 1 evokes an innate immune response via CD14 and toll-like receptor 4. PubMed ID: 22265692

CD14 and TLR4 mediate cytokine release promoted by electronegative LDL in monocytes. PubMed ID: 23880187

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

27-Hydroxycholesterol up-regulates CD14 and predisposes monocytic cells to superproduction of CCL2 in response to lipopolysaccharide. PubMed ID: 25497142

SP-R210 (Myo18A) isoforms as intrinsic modulators of macrophage priming and activation. PubMed ID: 25965346

The crystal structure of human soluble CD14 reveals a bent solenoid with a hydrophobic amino-terminal pocket. PubMed ID: 23264655