ACVR2B | ENSG00000114739 | NCBI 93

Details for: ACVR2B

Gene ID: 93

Symbol: ACVR2B

Ensembl ID: ENSG00000114739

Description: activin A receptor type 2B

Associated with

Developmental biology
(R-HSA-1266738)
Regulation of signaling by nodal
(R-HSA-1433617)
Signaling by activin
(R-HSA-1502540)
Signaling by bmp
(R-HSA-201451)
Signaling by nodal
(R-HSA-1181150)
Signaling by tgfb family members
(R-HSA-9006936)
Activin binding
(GO:0048185)
Activin receptor activity
(GO:0017002)
Activin receptor activity, type ii
(GO:0016362)
Activin receptor complex
(GO:0048179)
Activin receptor signaling pathway
(GO:0032924)
Anterior/posterior pattern specification
(GO:0009952)
Artery development
(GO:0060840)
Atp binding
(GO:0005524)
Blood vessel remodeling
(GO:0001974)
Bmp signaling pathway
(GO:0030509)
Cellular response to growth factor stimulus
(GO:0071363)
Cytoplasm
(GO:0005737)
Determination of left/right symmetry
(GO:0007368)
Embryonic foregut morphogenesis
(GO:0048617)
Gastrulation with mouth forming second
(GO:0001702)
Growth factor binding
(GO:0019838)
Heart development
(GO:0007507)
Insulin secretion
(GO:0030073)
Kidney development
(GO:0001822)
Kinase activator activity
(GO:0019209)
Lung development
(GO:0030324)
Lymphangiogenesis
(GO:0001946)
Lymphatic endothelial cell differentiation
(GO:0060836)
Mesoderm development
(GO:0007498)
Metal ion binding
(GO:0046872)
Negative regulation of cold-induced thermogenesis
(GO:0120163)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Odontogenesis of dentin-containing tooth
(GO:0042475)
Organ growth
(GO:0035265)
Pancreas development
(GO:0031016)
Phosphorylation
(GO:0016310)
Plasma membrane
(GO:0005886)
Positive regulation of activin receptor signaling pathway
(GO:0032927)
Positive regulation of bone mineralization
(GO:0030501)
Positive regulation of osteoblast differentiation
(GO:0045669)
Post-embryonic development
(GO:0009791)
Protein-containing complex
(GO:0032991)
Protein binding
(GO:0005515)
Protein phosphorylation
(GO:0006468)
Protein serine/threonine/tyrosine kinase activity
(GO:0004712)
Protein serine/threonine kinase activity
(GO:0004674)
Receptor complex
(GO:0043235)
Regulation of dna-templated transcription
(GO:0006355)
Response to glucose
(GO:0009749)
Retina vasculature development in camera-type eye
(GO:0061298)
Roof of mouth development
(GO:0060021)
Signal transduction
(GO:0007165)
Skeletal system morphogenesis
(GO:0048705)
Transmembrane receptor protein serine/threonine kinase signaling pathway
(GO:0007178)
Venous blood vessel development
(GO:0060841)

Other Information

Proteins

Activin receptor type-2B

Genular Protein ID: 3795705460

Symbol: AVR2B_HUMAN

Name: Activin receptor type-2B

UniProtKB Accession Codes:

Q13705 Q4VAV0

Database IDs:

Citations:

PubMed ID: 8161782

Title: Expression of type II activin receptor genes during differentiation of human K562 cells and cDNA cloning of the human type IIB activin receptor.

PubMed ID: 8161782

PubMed ID: 9621519

Title: Genomic organization and mapping of the human activin receptor type IIB (hActR-IIB) gene.

PubMed ID: 9621519

DOI: 10.1007/s100380050054

PubMed ID: 9916847

Title: Left-right axis malformations associated with mutations in ACVR2B, the gene for human activin receptor type IIB.

PubMed ID: 9916847

DOI: 10.1002/(sici)1096-8628(19990101)82:1<70::aid-ajmg14>3.0.co;2-y

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8622651

Title: Activation of signalling by the activin receptor complex.

PubMed ID: 8622651

DOI: 10.1128/mcb.16.3.1066

PubMed ID: 12941698

Title: TLP, a novel modulator of TGF-beta signaling, has opposite effects on Smad2- and Smad3-dependent signaling.

PubMed ID: 12941698

DOI: 10.1093/emboj/cdg428

PubMed ID: 18070108

Title: Type I receptor binding of bone morphogenetic protein 6 is dependent on N-glycosylation of the ligand.

PubMed ID: 18070108

DOI: 10.1111/j.1742-4658.2007.06187.x

PubMed ID: 31665064

Title: BMP3 suppresses colon tumorigenesis via ActRIIB/SMAD2-dependent and TAK1/JNK signaling pathways.

PubMed ID: 31665064

DOI: 10.1186/s13046-019-1435-1

PubMed ID: 17295905

Title: A silent H-bond can be mutationally activated for high-affinity interaction of BMP-2 and activin type IIB receptor.

PubMed ID: 17295905

DOI: 10.1186/1472-6807-7-6

PubMed ID: 22718755

Title: Specificity and structure of a high affinity activin receptor-like kinase 1 (ALK1) signaling complex.

PubMed ID: 22718755

DOI: 10.1074/jbc.m112.377960

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

Length: 512
Mass: 57724
Checksum: B377FEF92EF74937
Sequence:

MTAPWVALAL LWGSLCAGSG RGEAETRECI YYNANWELER TNQSGLERCE GEQDKRLHCY 
ASWRNSSGTI ELVKKGCWLD DFNCYDRQEC VATEENPQVY FCCCEGNFCN ERFTHLPEAG 
GPEVTYEPPP TAPTLLTVLA YSLLPIGGLS LIVLLAFWMY RHRKPPYGHV DIHEDPGPPP 
PSPLVGLKPL QLLEIKARGR FGCVWKAQLM NDFVAVKIFP LQDKQSWQSE REIFSTPGMK 
HENLLQFIAA EKRGSNLEVE LWLITAFHDK GSLTDYLKGN IITWNELCHV AETMSRGLSY 
LHEDVPWCRG EGHKPSIAHR DFKSKNVLLK SDLTAVLADF GLAVRFEPGK PPGDTHGQVG 
TRRYMAPEVL EGAINFQRDA FLRIDMYAMG LVLWELVSRC KAADGPVDEY MLPFEEEIGQ 
HPSLEELQEV VVHKKMRPTI KDHWLKHPGL AQLCVTIEEC WDHDAEARLS AGCVEERVSL 
IRRSVNGTTS DCLVSLVTSV TNVDLPPKES SI

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: ACVR2B

Associated with

Other Information

Expression of type II activin receptor genes during differentiation of human K562 cells and cDNA cloning of the human type IIB activin receptor. PubMed ID: 8161782

Genomic organization and mapping of the human activin receptor type IIB (hActR-IIB) gene. PubMed ID: 9621519

Left-right axis malformations associated with mutations in ACVR2B, the gene for human activin receptor type IIB. PubMed ID: 9916847

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Activation of signalling by the activin receptor complex. PubMed ID: 8622651

TLP, a novel modulator of TGF-beta signaling, has opposite effects on Smad2- and Smad3-dependent signaling. PubMed ID: 12941698

Type I receptor binding of bone morphogenetic protein 6 is dependent on N-glycosylation of the ligand. PubMed ID: 18070108

BMP3 suppresses colon tumorigenesis via ActRIIB/SMAD2-dependent and TAK1/JNK signaling pathways. PubMed ID: 31665064

A silent H-bond can be mutationally activated for high-affinity interaction of BMP-2 and activin type IIB receptor. PubMed ID: 17295905

Specificity and structure of a high affinity activin receptor-like kinase 1 (ALK1) signaling complex. PubMed ID: 22718755

Patterns of somatic mutation in human cancer genomes. PubMed ID: 17344846