Details for: ACVR2B

Gene ID: 93

Symbol: ACVR2B

Ensembl ID: ENSG00000114739

Description: activin A receptor type 2B

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 1.65
    Marker Score: 2326
  • Cell Name: gut endothelial cell (CL0000131)
    Fold Change: 1.65
    Marker Score: 590
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.3
    Marker Score: 3063.5
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.16
    Marker Score: 4724
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 1.13
    Marker Score: 1205
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.06
    Marker Score: 40271
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.05
    Marker Score: 64583
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 1.05
    Marker Score: 1175
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.02
    Marker Score: 3960
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 1.02
    Marker Score: 342
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 1.02
    Marker Score: 934
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.01
    Marker Score: 37432
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71789
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48014
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.99
    Marker Score: 19658
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.98
    Marker Score: 9337
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30405
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.97
    Marker Score: 8363
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.96
    Marker Score: 496
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.95
    Marker Score: 450
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2410
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.93
    Marker Score: 7150
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.92
    Marker Score: 14329
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2731
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.9
    Marker Score: 5127
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.89
    Marker Score: 1379
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.89
    Marker Score: 3694
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 0.89
    Marker Score: 668
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.88
    Marker Score: 316
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 0.87
    Marker Score: 822
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5295
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.84
    Marker Score: 8718
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.84
    Marker Score: 3509
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 0.84
    Marker Score: 471
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.83
    Marker Score: 7826
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 0.83
    Marker Score: 492
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.79
    Marker Score: 1605
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1268
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 0.78
    Marker Score: 490
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.76
    Marker Score: 11385
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.75
    Marker Score: 570
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.75
    Marker Score: 386
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 0.74
    Marker Score: 351
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: 0.74
    Marker Score: 565
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.74
    Marker Score: 3110
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.73
    Marker Score: 294.5
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 0.72
    Marker Score: 2411
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.7
    Marker Score: 218
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.7
    Marker Score: 635
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.68
    Marker Score: 263
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 0.68
    Marker Score: 3564
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.68
    Marker Score: 14499
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 173
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.67
    Marker Score: 708
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.62
    Marker Score: 753
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.62
    Marker Score: 20971
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.62
    Marker Score: 282
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 0.62
    Marker Score: 203
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.62
    Marker Score: 1286
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.61
    Marker Score: 707
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.59
    Marker Score: 32898.5
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.58
    Marker Score: 830
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.57
    Marker Score: 1346
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.57
    Marker Score: 239
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.56
    Marker Score: 132
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.56
    Marker Score: 307
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 0.56
    Marker Score: 7353
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.55
    Marker Score: 369
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.54
    Marker Score: 434
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.54
    Marker Score: 676.5
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.53
    Marker Score: 897
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.52
    Marker Score: 452
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 0.52
    Marker Score: 2176
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.52
    Marker Score: 149
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 0.51
    Marker Score: 272
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.51
    Marker Score: 550.5
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.51
    Marker Score: 164
  • Cell Name: CNS interneuron (CL0000402)
    Fold Change: 0.51
    Marker Score: 244
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.5
    Marker Score: 2325
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.5
    Marker Score: 3002.5
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.48
    Marker Score: 310
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.48
    Marker Score: 1094
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.48
    Marker Score: 1772
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 0.47
    Marker Score: 246.5
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.47
    Marker Score: 2028
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.47
    Marker Score: 1118.5
  • Cell Name: sympathetic neuron (CL0011103)
    Fold Change: 0.46
    Marker Score: 153
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 0.46
    Marker Score: 239
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.46
    Marker Score: 275
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.46
    Marker Score: 322
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.45
    Marker Score: 480
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.45
    Marker Score: 2889
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.45
    Marker Score: 133
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.45
    Marker Score: 1581
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 0.44
    Marker Score: 167
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.44
    Marker Score: 416
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 0.44
    Marker Score: 2372
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.43
    Marker Score: 537
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.43
    Marker Score: 371
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.42
    Marker Score: 202

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Other Information

**Key characteristics:** - Protein type: transmembrane protein - Ensembl ID: ENSG00000114739 - Pathway: Activin binding, Activin receptor activity, Activin receptor activity, type ii, Atp binding, Developmental biology, Growth factor binding, Kinase activator activity, Metal ion binding, Negative regulation of transcription by rna polymerase ii, Protein binding, Protein serine/threonine/tyrosine kinase activity, Protein serine/threonine kinase activity, Regulation of signaling by nodal, Signaling by bmp, Signaling by nodal, Signaling by tgfb family members, Signal transduction **Pathways and functions:** - Activin binds to various extracellular matrix proteins and signaling molecules, including type I and type II receptors for TGF-beta. - It is involved in cell migration, proliferation, and differentiation. - It plays a crucial role in the development and maintenance of the cardiovascular system, including the heart, blood vessels, and smooth muscle. - It is also involved in the regulation of epithelial cell function, cell adhesion, and angiogenesis. **Clinical significance:** - Mutations in the ACVR2B gene have been linked to various human diseases, including cardiovascular disease, cancer, and developmental disorders. - ACVR2B inhibitors are being investigated as potential therapeutic agents for these diseases. **Additional notes:** - The ACVR2B gene is highly expressed in cells of the cardiovascular system, including endothelial cells, cardiomyocytes, and vascular smooth muscle cells. - It is also expressed in other cell types, such as neurons, epithelial cells, and cancer cells. - The expression of ACVR2B is often upregulated in tumor cells, indicating its potential role in cancer progression and metastasis.

Genular Protein ID: 3795705460

Symbol: AVR2B_HUMAN

Name: Activin receptor type-2B

UniProtKB Accession Codes:

Q13705 Q4VAV0

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 14 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugCentral 1 EC 3 EMBL 9 EPD 1 Ensembl 1 EvolutionaryTrace 1 GO 47 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 11 PDBsum 7 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 4 RefSeq 1 Rhea 6 SIGNOR 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8161782

Title: Expression of type II activin receptor genes during differentiation of human K562 cells and cDNA cloning of the human type IIB activin receptor.

PubMed ID: 8161782

PubMed ID: 9621519

Title: Genomic organization and mapping of the human activin receptor type IIB (hActR-IIB) gene.

PubMed ID: 9621519

DOI: 10.1007/s100380050054

PubMed ID: 9916847

Title: Left-right axis malformations associated with mutations in ACVR2B, the gene for human activin receptor type IIB.

PubMed ID: 9916847

DOI: 10.1002/(sici)1096-8628(19990101)82:1<70::aid-ajmg14>3.0.co;2-y

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8622651

Title: Activation of signalling by the activin receptor complex.

PubMed ID: 8622651

DOI: 10.1128/mcb.16.3.1066

PubMed ID: 12941698

Title: TLP, a novel modulator of TGF-beta signaling, has opposite effects on Smad2- and Smad3-dependent signaling.

PubMed ID: 12941698

DOI: 10.1093/emboj/cdg428

PubMed ID: 18070108

Title: Type I receptor binding of bone morphogenetic protein 6 is dependent on N-glycosylation of the ligand.

PubMed ID: 18070108

DOI: 10.1111/j.1742-4658.2007.06187.x

PubMed ID: 31665064

Title: BMP3 suppresses colon tumorigenesis via ActRIIB/SMAD2-dependent and TAK1/JNK signaling pathways.

PubMed ID: 31665064

DOI: 10.1186/s13046-019-1435-1

PubMed ID: 17295905

Title: A silent H-bond can be mutationally activated for high-affinity interaction of BMP-2 and activin type IIB receptor.

PubMed ID: 17295905

DOI: 10.1186/1472-6807-7-6

PubMed ID: 22718755

Title: Specificity and structure of a high affinity activin receptor-like kinase 1 (ALK1) signaling complex.

PubMed ID: 22718755

DOI: 10.1074/jbc.m112.377960

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

  • Length: 512
  • Mass: 57724
  • Checksum: B377FEF92EF74937
  • Sequence:
    • MTAPWVALAL LWGSLCAGSG RGEAETRECI YYNANWELER TNQSGLERCE GEQDKRLHCY 
ASWRNSSGTI ELVKKGCWLD DFNCYDRQEC VATEENPQVY FCCCEGNFCN ERFTHLPEAG 
GPEVTYEPPP TAPTLLTVLA YSLLPIGGLS LIVLLAFWMY RHRKPPYGHV DIHEDPGPPP 
PSPLVGLKPL QLLEIKARGR FGCVWKAQLM NDFVAVKIFP LQDKQSWQSE REIFSTPGMK 
HENLLQFIAA EKRGSNLEVE LWLITAFHDK GSLTDYLKGN IITWNELCHV AETMSRGLSY 
LHEDVPWCRG EGHKPSIAHR DFKSKNVLLK SDLTAVLADF GLAVRFEPGK PPGDTHGQVG 
TRRYMAPEVL EGAINFQRDA FLRIDMYAMG LVLWELVSRC KAADGPVDEY MLPFEEEIGQ 
HPSLEELQEV VVHKKMRPTI KDHWLKHPGL AQLCVTIEEC WDHDAEARLS AGCVEERVSL 
IRRSVNGTTS DCLVSLVTSV TNVDLPPKES SI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.