Details for: ACVR2B

Gene ID: 93

Symbol: ACVR2B

Ensembl ID: ENSG00000114739

Description: activin A receptor type 2B

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 111.3503
    Cell Significance Index: -17.3200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 69.5070
    Cell Significance Index: -17.6300
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 40.8116
    Cell Significance Index: -16.5800
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 17.3764
    Cell Significance Index: -16.5900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 15.3452
    Cell Significance Index: -18.9200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 4.8251
    Cell Significance Index: -19.0400
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 2.6136
    Cell Significance Index: -5.7200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 1.3116
    Cell Significance Index: 73.6000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.9416
    Cell Significance Index: 93.1500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.8202
    Cell Significance Index: 740.6000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.7406
    Cell Significance Index: 148.5600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.6289
    Cell Significance Index: 124.8100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.5469
    Cell Significance Index: 34.4700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.5312
    Cell Significance Index: 57.7800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.5124
    Cell Significance Index: 183.7900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5085
    Cell Significance Index: 82.7100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.4432
    Cell Significance Index: 26.6100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.3892
    Cell Significance Index: 23.9200
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.3665
    Cell Significance Index: 8.7900
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.3480
    Cell Significance Index: 7.6200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.3221
    Cell Significance Index: 16.7300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2643
    Cell Significance Index: 18.2800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2541
    Cell Significance Index: 7.3200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2010
    Cell Significance Index: 36.2400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1408
    Cell Significance Index: 19.3400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1348
    Cell Significance Index: 2.9200
  • Cell Name: sensory neuron (CL0000101)
    Fold Change: 0.1311
    Cell Significance Index: 0.7400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1267
    Cell Significance Index: 69.2000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1245
    Cell Significance Index: 86.1400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1216
    Cell Significance Index: 5.5100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0933
    Cell Significance Index: 2.5000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0877
    Cell Significance Index: 10.7800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0834
    Cell Significance Index: 2.9300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0683
    Cell Significance Index: 13.0000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0574
    Cell Significance Index: 25.3700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0525
    Cell Significance Index: 2.4500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.0259
    Cell Significance Index: 0.9000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0228
    Cell Significance Index: 0.3900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0183
    Cell Significance Index: 34.4300
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.0159
    Cell Significance Index: 0.1900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0024
    Cell Significance Index: 1.5000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0001
    Cell Significance Index: 0.0900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0028
    Cell Significance Index: -5.1100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0069
    Cell Significance Index: -1.0000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0082
    Cell Significance Index: -0.2200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0085
    Cell Significance Index: -11.5700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0109
    Cell Significance Index: -7.9800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0128
    Cell Significance Index: -0.9800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0134
    Cell Significance Index: -6.1000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0149
    Cell Significance Index: -2.5400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0227
    Cell Significance Index: -17.2100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0235
    Cell Significance Index: -17.4200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0328
    Cell Significance Index: -18.5100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0343
    Cell Significance Index: -21.4500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0371
    Cell Significance Index: -4.7600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0487
    Cell Significance Index: -1.3600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0492
    Cell Significance Index: -14.1700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0718
    Cell Significance Index: -1.5300
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0887
    Cell Significance Index: -1.8400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0922
    Cell Significance Index: -10.7400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0978
    Cell Significance Index: -4.3300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1021
    Cell Significance Index: -10.4300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1022
    Cell Significance Index: -21.5300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1100
    Cell Significance Index: -4.1700
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: -0.1143
    Cell Significance Index: -1.6100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1149
    Cell Significance Index: -13.1600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1256
    Cell Significance Index: -16.2300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1288
    Cell Significance Index: -8.6600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1463
    Cell Significance Index: -7.6200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1514
    Cell Significance Index: -17.8500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1681
    Cell Significance Index: -17.5000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1772
    Cell Significance Index: -12.5300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1820
    Cell Significance Index: -5.8300
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.1887
    Cell Significance Index: -1.1200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1914
    Cell Significance Index: -14.2700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.2030
    Cell Significance Index: -2.7700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2111
    Cell Significance Index: -16.7200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2115
    Cell Significance Index: -3.5400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2170
    Cell Significance Index: -10.2000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2586
    Cell Significance Index: -6.8000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.2591
    Cell Significance Index: -7.0500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.2706
    Cell Significance Index: -17.4600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2796
    Cell Significance Index: -14.6800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2797
    Cell Significance Index: -7.1900
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.2841
    Cell Significance Index: -6.0300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3076
    Cell Significance Index: -18.8600
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.3127
    Cell Significance Index: -2.4100
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.3244
    Cell Significance Index: -4.6500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3317
    Cell Significance Index: -10.8600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3350
    Cell Significance Index: -10.6700
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.3388
    Cell Significance Index: -6.7000
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.3530
    Cell Significance Index: -5.2100
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.3872
    Cell Significance Index: -11.0500
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.3927
    Cell Significance Index: -6.6200
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.3952
    Cell Significance Index: -9.1300
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.3990
    Cell Significance Index: -8.0100
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.4027
    Cell Significance Index: -2.6200
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.4136
    Cell Significance Index: -14.4900
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.4265
    Cell Significance Index: -4.4200
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.4550
    Cell Significance Index: -8.4100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** ACVR2B is a transmembrane receptor protein serine/threonine kinase that belongs to the transforming growth factor-beta (TGF-β) superfamily. It is characterized by its high degree of sequence similarity to other TGF-β receptors, including ACVR1, ACVR2A, and ACVR2D. ACVR2B is a type II receptor, which means it requires the presence of a type I receptor (e.g., ACVR1) to initiate signaling. The receptor is composed of two distinct domains: an extracellular ligand-binding domain and an intracellular kinase domain. Upon binding to activin A, the receptor undergoes conformational changes, which activate the kinase domain and trigger downstream signaling events. **Pathways and Functions** ACVR2B plays a critical role in various signaling pathways, including: 1. **Activin signaling pathway**: ACVR2B is the primary receptor for activin A, a member of the TGF-β superfamily. Activin A binding to ACVR2B triggers a cascade of intracellular signaling events, influencing cell proliferation, differentiation, and survival. 2. **BMP signaling pathway**: ACVR2B also interacts with bone morphogenetic protein (BMP) signaling pathway, which is involved in embryonic development, tissue growth, and differentiation. 3. **TGF-β signaling pathway**: ACVR2B is a key component of the TGF-β signaling pathway, which regulates cell growth, differentiation, and apoptosis. 4. **Wnt signaling pathway**: ACVR2B has been shown to interact with Wnt signaling pathway, which is involved in embryonic development, tissue growth, and cancer. ACVR2B has been implicated in various biological processes, including: 1. **Embryonic development**: ACVR2B plays a critical role in embryonic development, influencing the formation of the anterior/posterior axis, determination of left/right symmetry, and gastrulation. 2. **Tissue growth and differentiation**: ACVR2B regulates cell proliferation, differentiation, and survival in various tissues, including the nervous system, kidney, and pancreas. 3. **Cancer**: ACVR2B has been implicated in cancer development and progression, particularly in tumors of the nervous system, kidney, and pancreas. 4. **Cardiovascular disease**: ACVR2B has been shown to play a role in cardiovascular disease, influencing blood vessel remodeling and artery development. **Clinical Significance** Dysregulation of ACVR2B has been implicated in various diseases, including: 1. **Cancer**: Overexpression of ACVR2B has been observed in various types of cancer, including medulloblastoma, rhabdomyosarcoma, and pancreatic cancer. 2. **Cardiovascular disease**: ACVR2B has been shown to play a role in cardiovascular disease, influencing blood vessel remodeling and artery development. 3. **Diabetes**: ACVR2B has been implicated in diabetes, influencing insulin secretion and glucose metabolism. 4. **Neurological disorders**: ACVR2B has been implicated in various neurological disorders, including autism, schizophrenia, and Alzheimer's disease. In conclusion, ACVR2B is a critical component of the activin signaling pathway, which plays a pivotal role in various biological processes, including embryonic development, tissue growth, and differentiation. Dysregulation of ACVR2B has been implicated in various diseases, including cancer, cardiovascular disease, and diabetes, highlighting the importance of this gene in human health and disease.

Genular Protein ID: 3795705460

Symbol: AVR2B_HUMAN

Name: Activin receptor type-2B

UniProtKB Accession Codes:

Q13705 Q4VAV0

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 14 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugCentral 1 EC 3 EMBL 9 Ensembl 1 EvolutionaryTrace 1 GO 47 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 7 PDBsum 7 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 4 RefSeq 1 Rhea 6 SIGNOR 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8161782

Title: Expression of type II activin receptor genes during differentiation of human K562 cells and cDNA cloning of the human type IIB activin receptor.

PubMed ID: 8161782

PubMed ID: 9621519

Title: Genomic organization and mapping of the human activin receptor type IIB (hActR-IIB) gene.

PubMed ID: 9621519

DOI: 10.1007/s100380050054

PubMed ID: 9916847

Title: Left-right axis malformations associated with mutations in ACVR2B, the gene for human activin receptor type IIB.

PubMed ID: 9916847

DOI: 10.1002/(sici)1096-8628(19990101)82:1<70::aid-ajmg14>3.0.co;2-y

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8622651

Title: Activation of signalling by the activin receptor complex.

PubMed ID: 8622651

DOI: 10.1128/mcb.16.3.1066

PubMed ID: 12941698

Title: TLP, a novel modulator of TGF-beta signaling, has opposite effects on Smad2- and Smad3-dependent signaling.

PubMed ID: 12941698

DOI: 10.1093/emboj/cdg428

PubMed ID: 18070108

Title: Type I receptor binding of bone morphogenetic protein 6 is dependent on N-glycosylation of the ligand.

PubMed ID: 18070108

DOI: 10.1111/j.1742-4658.2007.06187.x

PubMed ID: 31665064

Title: BMP3 suppresses colon tumorigenesis via ActRIIB/SMAD2-dependent and TAK1/JNK signaling pathways.

PubMed ID: 31665064

DOI: 10.1186/s13046-019-1435-1

PubMed ID: 17295905

Title: A silent H-bond can be mutationally activated for high-affinity interaction of BMP-2 and activin type IIB receptor.

PubMed ID: 17295905

DOI: 10.1186/1472-6807-7-6

PubMed ID: 22718755

Title: Specificity and structure of a high affinity activin receptor-like kinase 1 (ALK1) signaling complex.

PubMed ID: 22718755

DOI: 10.1074/jbc.m112.377960

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

  • Length: 512
  • Mass: 57724
  • Checksum: B377FEF92EF74937
  • Sequence:
    • MTAPWVALAL LWGSLCAGSG RGEAETRECI YYNANWELER TNQSGLERCE GEQDKRLHCY 
ASWRNSSGTI ELVKKGCWLD DFNCYDRQEC VATEENPQVY FCCCEGNFCN ERFTHLPEAG 
GPEVTYEPPP TAPTLLTVLA YSLLPIGGLS LIVLLAFWMY RHRKPPYGHV DIHEDPGPPP 
PSPLVGLKPL QLLEIKARGR FGCVWKAQLM NDFVAVKIFP LQDKQSWQSE REIFSTPGMK 
HENLLQFIAA EKRGSNLEVE LWLITAFHDK GSLTDYLKGN IITWNELCHV AETMSRGLSY 
LHEDVPWCRG EGHKPSIAHR DFKSKNVLLK SDLTAVLADF GLAVRFEPGK PPGDTHGQVG 
TRRYMAPEVL EGAINFQRDA FLRIDMYAMG LVLWELVSRC KAADGPVDEY MLPFEEEIGQ 
HPSLEELQEV VVHKKMRPTI KDHWLKHPGL AQLCVTIEEC WDHDAEARLS AGCVEERVSL 
IRRSVNGTTS DCLVSLVTSV TNVDLPPKES SI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.