CD19 | ENSG00000177455 | NCBI 930

Details for: CD19

Gene ID: 930

Symbol: CD19

Ensembl ID: ENSG00000177455

Description: CD19 molecule

Associated with

Adaptive immune system
(R-HSA-1280218)
Antigen activates b cell receptor (bcr) leading to generation of second messengers
(R-HSA-983695)
Complement cascade
(R-HSA-166658)
Constitutive signaling by aberrant pi3k in cancer
(R-HSA-2219530)
Disease
(R-HSA-1643685)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Immune system
(R-HSA-168256)
Immunoregulatory interactions between a lymphoid and a non-lymphoid cell
(R-HSA-198933)
Innate immune system
(R-HSA-168249)
Intracellular signaling by second messengers
(R-HSA-9006925)
Negative regulation of the pi3k/akt network
(R-HSA-199418)
Pi3k/akt signaling in cancer
(R-HSA-2219528)
Pi5p, pp2a and ier3 regulate pi3k/akt signaling
(R-HSA-6811558)
Pip3 activates akt signaling
(R-HSA-1257604)
Regulation of complement cascade
(R-HSA-977606)
Signaling by the b cell receptor (bcr)
(R-HSA-983705)
Signal transduction
(R-HSA-162582)
Antigen receptor-mediated signaling pathway
(GO:0050851)
B-1 b cell differentiation
(GO:0001923)
B cell proliferation involved in immune response
(GO:0002322)
B cell receptor signaling pathway
(GO:0050853)
External side of plasma membrane
(GO:0009897)
Extracellular exosome
(GO:0070062)
Immunoglobulin mediated immune response
(GO:0016064)
Membrane raft
(GO:0045121)
Plasma membrane
(GO:0005886)
Positive regulation of phosphatidylinositol 3-kinase/protein kinase b signal transduction
(GO:0051897)
Positive regulation of release of sequestered calcium ion into cytosol
(GO:0051281)
Protein-containing complex
(GO:0032991)
Regulation of b cell activation
(GO:0050864)
Regulation of b cell receptor signaling pathway
(GO:0050855)

Other Information

Proteins

B-lymphocyte antigen CD19

Genular Protein ID: 101508303

Symbol: CD19_HUMAN

Name: B-lymphocyte antigen CD19

UniProtKB Accession Codes:

P15391 A0N0P9 F5H635 Q96S68 Q9BRD6

Database IDs:

Citations:

PubMed ID: 2459292

Title: CD19, the earliest differentiation antigen of the B cell lineage, bears three extracellular immunoglobulin-like domains and an Epstein-Barr virus-related cytoplasmic tail.

PubMed ID: 2459292

DOI: 10.1084/jem.168.3.1205

PubMed ID: 2472450

Title: Isolation of cDNAs encoding the CD19 antigen of human and mouse B lymphocytes. A new member of the immunoglobulin superfamily.

PubMed ID: 2472450

PubMed ID: 1375324

Title: The promoter of the CD19 gene is a target for the B-cell-specific transcription factor BSAP.

PubMed ID: 1375324

DOI: 10.1128/mcb.12.6.2662-2672.1992

PubMed ID: 1370948

Title: Structure of the genes encoding the CD19 antigen of human and mouse B lymphocytes.

PubMed ID: 1370948

DOI: 10.1007/bf00189519

PubMed ID: 12215898

Title: Polymorphisms of human CD19 gene: possible association with susceptibility to systemic lupus erythematosus in Japanese.

PubMed ID: 12215898

DOI: 10.1038/sj.gene.6363906

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15616553

Title: The sequence and analysis of duplication-rich human chromosome 16.

PubMed ID: 15616553

DOI: 10.1038/nature03187

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2463100

Title: Regulatory role of CD19 molecules in B-cell activation and differentiation.

PubMed ID: 2463100

DOI: 10.1016/0008-8749(89)90385-7

PubMed ID: 1702139

Title: Intersection of the complement and immune systems: a signal transduction complex of the B lymphocyte-containing complement receptor type 2 and CD19.

PubMed ID: 1702139

DOI: 10.1084/jem.173.1.55

PubMed ID: 1383329

Title: The CD19/CD21 signal transducing complex of human B lymphocytes includes the target of antiproliferative antibody-1 and Leu-13 molecules.

PubMed ID: 1383329

PubMed ID: 1373518

Title: CD19: lowering the threshold for antigen receptor stimulation of B lymphocytes.

PubMed ID: 1373518

DOI: 10.1126/science.1373518

PubMed ID: 7687428

Title: CD19 is a substrate of the antigen receptor-associated protein tyrosine kinase in human B cells.

PubMed ID: 7687428

DOI: 10.1006/bbrc.1993.1807

PubMed ID: 7687539

Title: Tyrosine phosphorylation of CD19 in pre-B and mature B cells.

PubMed ID: 7687539

DOI: 10.1002/j.1460-2075.1993.tb05930.x

PubMed ID: 7684160

Title: CD19 of B cells as a surrogate kinase insert region to bind phosphatidylinositol 3-kinase.

PubMed ID: 7684160

DOI: 10.1126/science.7684160

PubMed ID: 9382888

Title: Qualitative regulation of B cell antigen receptor signaling by CD19: selective requirement for PI3-kinase activation, inositol-1,4,5-trisphosphate production and Ca2+ mobilization.

PubMed ID: 9382888

DOI: 10.1084/jem.186.11.1897

PubMed ID: 9317126

Title: Regulation of B lymphocyte development and activation by the CD19/CD21/CD81/Leu 13 complex requires the cytoplasmic domain of CD19.

PubMed ID: 9317126

PubMed ID: 10706702

Title: Systematic analysis of the role of CD19 cytoplasmic tyrosines in enhancement of activation in Daudi human B cells: clustering of phospholipase C and Vav and of Grb2 and Sos with different CD19 tyrosines.

PubMed ID: 10706702

DOI: 10.4049/jimmunol.164.6.3123

PubMed ID: 12387743

Title: The physiologic role of CD19 cytoplasmic tyrosines.

PubMed ID: 12387743

DOI: 10.1016/s1074-7613(02)00426-0

PubMed ID: 16449649

Title: Building of the tetraspanin web: distinct structural domains of CD81 function in different cellular compartments.

PubMed ID: 16449649

DOI: 10.1128/mcb.26.4.1373-1385.2006

PubMed ID: 16672701

Title: An antibody-deficiency syndrome due to mutations in the CD19 gene.

PubMed ID: 16672701

DOI: 10.1056/nejmoa051568

PubMed ID: 17525332

Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

PubMed ID: 17525332

DOI: 10.1126/science.1140321

PubMed ID: 29490423

Title: Crystal structure of B-cell co-receptor CD19 in complex with antibody B43 reveals an unexpected fold.

PubMed ID: 29490423

DOI: 10.1002/prot.25485

Sequence Information:

Length: 556
Mass: 61128
Checksum: A0E08DD628B69E51
Sequence:

MPPPRLLFFL LFLTPMEVRP EEPLVVKVEE GDNAVLQCLK GTSDGPTQQL TWSRESPLKP 
FLKLSLGLPG LGIHMRPLAI WLFIFNVSQQ MGGFYLCQPG PPSEKAWQPG WTVNVEGSGE 
LFRWNVSDLG GLGCGLKNRS SEGPSSPSGK LMSPKLYVWA KDRPEIWEGE PPCLPPRDSL 
NQSLSQDLTM APGSTLWLSC GVPPDSVSRG PLSWTHVHPK GPKSLLSLEL KDDRPARDMW 
VMETGLLLPR ATAQDAGKYY CHRGNLTMSF HLEITARPVL WHWLLRTGGW KVSAVTLAYL 
IFCLCSLVGI LHLQRALVLR RKRKRMTDPT RRFFKVTPPP GSGPQNQYGN VLSLPTPTSG 
LGRAQRWAAG LGGTAPSYGN PSSDVQADGA LGSRSPPGVG PEEEEGEGYE EPDSEEDSEF 
YENDSNLGQD QLSQDGSGYE NPEDEPLGPE DEDSFSNAES YENEDEELTQ PVARTMDFLS 
PHGSAWDPSR EATSLGSQSY EDMRGILYAA PQLRSIRGQP GPNHEEDADS YENMDNPDGP 
DPAWGGGGRM GTWSTR

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: CD19

Associated with

Other Information

CD19, the earliest differentiation antigen of the B cell lineage, bears three extracellular immunoglobulin-like domains and an Epstein-Barr virus-related cytoplasmic tail. PubMed ID: 2459292

Isolation of cDNAs encoding the CD19 antigen of human and mouse B lymphocytes. A new member of the immunoglobulin superfamily. PubMed ID: 2472450

The promoter of the CD19 gene is a target for the B-cell-specific transcription factor BSAP. PubMed ID: 1375324

Structure of the genes encoding the CD19 antigen of human and mouse B lymphocytes. PubMed ID: 1370948

Polymorphisms of human CD19 gene: possible association with susceptibility to systemic lupus erythematosus in Japanese. PubMed ID: 12215898

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The sequence and analysis of duplication-rich human chromosome 16. PubMed ID: 15616553

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Regulatory role of CD19 molecules in B-cell activation and differentiation. PubMed ID: 2463100

Intersection of the complement and immune systems: a signal transduction complex of the B lymphocyte-containing complement receptor type 2 and CD19. PubMed ID: 1702139

The CD19/CD21 signal transducing complex of human B lymphocytes includes the target of antiproliferative antibody-1 and Leu-13 molecules. PubMed ID: 1383329

CD19: lowering the threshold for antigen receptor stimulation of B lymphocytes. PubMed ID: 1373518

CD19 is a substrate of the antigen receptor-associated protein tyrosine kinase in human B cells. PubMed ID: 7687428

Tyrosine phosphorylation of CD19 in pre-B and mature B cells. PubMed ID: 7687539

CD19 of B cells as a surrogate kinase insert region to bind phosphatidylinositol 3-kinase. PubMed ID: 7684160

Qualitative regulation of B cell antigen receptor signaling by CD19: selective requirement for PI3-kinase activation, inositol-1,4,5-trisphosphate production and Ca2+ mobilization. PubMed ID: 9382888

Regulation of B lymphocyte development and activation by the CD19/CD21/CD81/Leu 13 complex requires the cytoplasmic domain of CD19. PubMed ID: 9317126

Systematic analysis of the role of CD19 cytoplasmic tyrosines in enhancement of activation in Daudi human B cells: clustering of phospholipase C and Vav and of Grb2 and Sos with different CD19 tyrosines. PubMed ID: 10706702

The physiologic role of CD19 cytoplasmic tyrosines. PubMed ID: 12387743

Building of the tetraspanin web: distinct structural domains of CD81 function in different cellular compartments. PubMed ID: 16449649

An antibody-deficiency syndrome due to mutations in the CD19 gene. PubMed ID: 16672701

ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. PubMed ID: 17525332

Crystal structure of B-cell co-receptor CD19 in complex with antibody B43 reveals an unexpected fold. PubMed ID: 29490423