Details for: CD19

Gene ID: 930

Symbol: CD19

Ensembl ID: ENSG00000177455

Description: CD19 molecule

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: 2.67
    Marker Score: 3207
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 2.64
    Marker Score: 7822
  • Cell Name: centroblast (CL0009112)
    Fold Change: 2.54
    Marker Score: 1250
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 2.42
    Marker Score: 2162
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 2.25
    Marker Score: 1372
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 2.13
    Marker Score: 3718
  • Cell Name: centrocyte (CL0009111)
    Fold Change: 1.94
    Marker Score: 461
  • Cell Name: B-1b B cell (CL0000821)
    Fold Change: 1.92
    Marker Score: 442
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 1.81
    Marker Score: 4910
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 1.67
    Marker Score: 3504
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.61
    Marker Score: 1172
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 1.58
    Marker Score: 1481.5
  • Cell Name: pre-B-I cell (CL0000956)
    Fold Change: 1.48
    Marker Score: 378
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.46
    Marker Score: 1457
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 1.4
    Marker Score: 494
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.32
    Marker Score: 13396
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 1.29
    Marker Score: 778
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 1.29
    Marker Score: 976
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 1.27
    Marker Score: 1255
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: 1.24
    Marker Score: 1464.5
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4817
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251812
  • Cell Name: mature B cell (CL0000785)
    Fold Change: 1.04
    Marker Score: 759
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71829
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48054
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: 1
    Marker Score: 1081
  • Cell Name: B-1a B cell (CL0000820)
    Fold Change: 0.99
    Marker Score: 237
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 510
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.99
    Marker Score: 939
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 463
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.98
    Marker Score: 662
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.95
    Marker Score: 604
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.94
    Marker Score: 375
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5332
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2741
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.91
    Marker Score: 326
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.9
    Marker Score: 1194
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5291
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 0.85
    Marker Score: 566
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.84
    Marker Score: 1596
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.8
    Marker Score: 609
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 0.79
    Marker Score: 463
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1263
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 709
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.78
    Marker Score: 782
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 397
  • Cell Name: IgM plasma cell (CL0000986)
    Fold Change: 0.77
    Marker Score: 267
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.72
    Marker Score: 463
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.7
    Marker Score: 250
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 178
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 0.68
    Marker Score: 333
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.67
    Marker Score: 1354
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.66
    Marker Score: 1161
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.58
    Marker Score: 460
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.55
    Marker Score: 173
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.49
    Marker Score: 7729
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.49
    Marker Score: 5684.5
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 278
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 0.42
    Marker Score: 360
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.42
    Marker Score: 135
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.41
    Marker Score: 425
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.4
    Marker Score: 581
  • Cell Name: IgG plasmablast (CL0000982)
    Fold Change: 0.4
    Marker Score: 111
  • Cell Name: IgA plasmablast (CL0000984)
    Fold Change: 0.38
    Marker Score: 101
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: 0.37
    Marker Score: 161
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.35
    Marker Score: 231
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 0.34
    Marker Score: 116.5
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.32
    Marker Score: 182
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.3
    Marker Score: 144
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.3
    Marker Score: 375.5
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.29
    Marker Score: 121.5
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.29
    Marker Score: 77
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.28
    Marker Score: 1890
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.28
    Marker Score: 580
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.27
    Marker Score: 124
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.26
    Marker Score: 291
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: 0.24
    Marker Score: 195
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.24
    Marker Score: 137
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.23
    Marker Score: 138
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 64
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.22
    Marker Score: 111
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 74
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.2
    Marker Score: 192
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.19
    Marker Score: 102
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.18
    Marker Score: 81
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.17
    Marker Score: 114
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.17
    Marker Score: 42
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.17
    Marker Score: 53
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.16
    Marker Score: 65
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 0.15
    Marker Score: 154.5
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.14
    Marker Score: 152
  • Cell Name: promonocyte (CL0000559)
    Fold Change: 0.14
    Marker Score: 89
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.14
    Marker Score: 39
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.14
    Marker Score: 66
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.12
    Marker Score: 57
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.12
    Marker Score: 254
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 0.12
    Marker Score: 82
  • Cell Name: B-2 B cell (CL0000822)
    Fold Change: 0.12
    Marker Score: 142

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Other Information

**Key characteristics:** - CD19 is a glycoprotein with a molecular weight of approximately 110 kDa. - It is expressed on the surface of B cells, but not on other cell types. - CD19 is a homophilic molecule, meaning that it binds to other CD19 molecules. - CD19 is a key receptor for B cell activation. **Pathways and functions:** - CD19 binds to the B-cell receptor (BCR) on the surface of antigen-presenting cells. - This binding triggers the activation of the BCR signaling pathway. - The BCR pathway is a central pathway in adaptive immune response. - Activated CD19 leads to the generation of second messengers, including phosphatidylinositol 3-kinase (PI3K) and Akt. - PI3K/Akt signaling is a major pathway in B cell activation and differentiation. - CD19 also regulates the complement cascade, which is a pathway that is involved in inflammation and immune responses. **Clinical significance:** - CD19 is a target for cancer immunotherapy. - Antibodies against CD19 can block B cell activation and inhibit tumor growth. - CD19 is also a target for autoimmune disorders. - Dysregulation of CD19 signaling has been linked to several human diseases, including cancer and autoimmune disorders. **Additional information:** - CD19 is expressed on all mature B cell subsets, including naive B cells, germinal center B cells, and B-1 B cells. - CD19 is also expressed on activated T cells and natural killer cells. - CD19 is a highly conserved protein, with a similar protein found in mice and other mammals.

Genular Protein ID: 101508303

Symbol: CD19_HUMAN

Name: B-lymphocyte antigen CD19

UniProtKB Accession Codes:

P15391 A0N0P9 F5H635 Q96S68 Q9BRD6

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 DrugBank 10 DrugCentral 1 ELM 1 EMBL 16 EMDB 3 Ensembl 2 GO 14 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 7 PDBsum 4 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 6 RefSeq 2 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 2459292

Title: CD19, the earliest differentiation antigen of the B cell lineage, bears three extracellular immunoglobulin-like domains and an Epstein-Barr virus-related cytoplasmic tail.

PubMed ID: 2459292

DOI: 10.1084/jem.168.3.1205

PubMed ID: 2472450

Title: Isolation of cDNAs encoding the CD19 antigen of human and mouse B lymphocytes. A new member of the immunoglobulin superfamily.

PubMed ID: 2472450

PubMed ID: 1375324

Title: The promoter of the CD19 gene is a target for the B-cell-specific transcription factor BSAP.

PubMed ID: 1375324

DOI: 10.1128/mcb.12.6.2662-2672.1992

PubMed ID: 1370948

Title: Structure of the genes encoding the CD19 antigen of human and mouse B lymphocytes.

PubMed ID: 1370948

DOI: 10.1007/bf00189519

PubMed ID: 12215898

Title: Polymorphisms of human CD19 gene: possible association with susceptibility to systemic lupus erythematosus in Japanese.

PubMed ID: 12215898

DOI: 10.1038/sj.gene.6363906

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15616553

Title: The sequence and analysis of duplication-rich human chromosome 16.

PubMed ID: 15616553

DOI: 10.1038/nature03187

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2463100

Title: Regulatory role of CD19 molecules in B-cell activation and differentiation.

PubMed ID: 2463100

DOI: 10.1016/0008-8749(89)90385-7

PubMed ID: 1702139

Title: Intersection of the complement and immune systems: a signal transduction complex of the B lymphocyte-containing complement receptor type 2 and CD19.

PubMed ID: 1702139

DOI: 10.1084/jem.173.1.55

PubMed ID: 1383329

Title: The CD19/CD21 signal transducing complex of human B lymphocytes includes the target of antiproliferative antibody-1 and Leu-13 molecules.

PubMed ID: 1383329

PubMed ID: 1373518

Title: CD19: lowering the threshold for antigen receptor stimulation of B lymphocytes.

PubMed ID: 1373518

DOI: 10.1126/science.1373518

PubMed ID: 7687428

Title: CD19 is a substrate of the antigen receptor-associated protein tyrosine kinase in human B cells.

PubMed ID: 7687428

DOI: 10.1006/bbrc.1993.1807

PubMed ID: 7687539

Title: Tyrosine phosphorylation of CD19 in pre-B and mature B cells.

PubMed ID: 7687539

DOI: 10.1002/j.1460-2075.1993.tb05930.x

PubMed ID: 7684160

Title: CD19 of B cells as a surrogate kinase insert region to bind phosphatidylinositol 3-kinase.

PubMed ID: 7684160

DOI: 10.1126/science.7684160

PubMed ID: 9382888

Title: Qualitative regulation of B cell antigen receptor signaling by CD19: selective requirement for PI3-kinase activation, inositol-1,4,5-trisphosphate production and Ca2+ mobilization.

PubMed ID: 9382888

DOI: 10.1084/jem.186.11.1897

PubMed ID: 9317126

Title: Regulation of B lymphocyte development and activation by the CD19/CD21/CD81/Leu 13 complex requires the cytoplasmic domain of CD19.

PubMed ID: 9317126

PubMed ID: 10706702

Title: Systematic analysis of the role of CD19 cytoplasmic tyrosines in enhancement of activation in Daudi human B cells: clustering of phospholipase C and Vav and of Grb2 and Sos with different CD19 tyrosines.

PubMed ID: 10706702

DOI: 10.4049/jimmunol.164.6.3123

PubMed ID: 12387743

Title: The physiologic role of CD19 cytoplasmic tyrosines.

PubMed ID: 12387743

DOI: 10.1016/s1074-7613(02)00426-0

PubMed ID: 16449649

Title: Building of the tetraspanin web: distinct structural domains of CD81 function in different cellular compartments.

PubMed ID: 16449649

DOI: 10.1128/mcb.26.4.1373-1385.2006

PubMed ID: 16672701

Title: An antibody-deficiency syndrome due to mutations in the CD19 gene.

PubMed ID: 16672701

DOI: 10.1056/nejmoa051568

PubMed ID: 17525332

Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

PubMed ID: 17525332

DOI: 10.1126/science.1140321

PubMed ID: 29490423

Title: Crystal structure of B-cell co-receptor CD19 in complex with antibody B43 reveals an unexpected fold.

PubMed ID: 29490423

DOI: 10.1002/prot.25485

Sequence Information:

  • Length: 556
  • Mass: 61128
  • Checksum: A0E08DD628B69E51
  • Sequence:
    • MPPPRLLFFL LFLTPMEVRP EEPLVVKVEE GDNAVLQCLK GTSDGPTQQL TWSRESPLKP 
FLKLSLGLPG LGIHMRPLAI WLFIFNVSQQ MGGFYLCQPG PPSEKAWQPG WTVNVEGSGE 
LFRWNVSDLG GLGCGLKNRS SEGPSSPSGK LMSPKLYVWA KDRPEIWEGE PPCLPPRDSL 
NQSLSQDLTM APGSTLWLSC GVPPDSVSRG PLSWTHVHPK GPKSLLSLEL KDDRPARDMW 
VMETGLLLPR ATAQDAGKYY CHRGNLTMSF HLEITARPVL WHWLLRTGGW KVSAVTLAYL 
IFCLCSLVGI LHLQRALVLR RKRKRMTDPT RRFFKVTPPP GSGPQNQYGN VLSLPTPTSG 
LGRAQRWAAG LGGTAPSYGN PSSDVQADGA LGSRSPPGVG PEEEEGEGYE EPDSEEDSEF 
YENDSNLGQD QLSQDGSGYE NPEDEPLGPE DEDSFSNAES YENEDEELTQ PVARTMDFLS 
PHGSAWDPSR EATSLGSQSY EDMRGILYAA PQLRSIRGQP GPNHEEDADS YENMDNPDGP 
DPAWGGGGRM GTWSTR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.