Details for: MS4A1

Gene ID: 931

Symbol: MS4A1

Ensembl ID: ENSG00000156738

Description: membrane spanning 4-domains A1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: centroblast (CL0009112)
    Fold Change: 40.5690
    Cell Significance Index: 94.6500
  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 29.2519
    Cell Significance Index: -4.5500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 19.5944
    Cell Significance Index: -4.9700
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 18.3874
    Cell Significance Index: -7.4700
  • Cell Name: centrocyte (CL0009111)
    Fold Change: 15.7773
    Cell Significance Index: 48.6500
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 7.8265
    Cell Significance Index: 35.0000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 7.8216
    Cell Significance Index: 922.4000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 3.6335
    Cell Significance Index: -4.4800
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 3.4208
    Cell Significance Index: 20.6600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 2.7064
    Cell Significance Index: -7.2500
  • Cell Name: B-1b B cell (CL0000821)
    Fold Change: 2.5898
    Cell Significance Index: 12.9900
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 2.3378
    Cell Significance Index: 36.1700
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: 1.9691
    Cell Significance Index: 9.8500
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 1.5497
    Cell Significance Index: 13.6200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 1.2671
    Cell Significance Index: -5.0000
  • Cell Name: B-1a B cell (CL0000820)
    Fold Change: 1.0934
    Cell Significance Index: 5.8100
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.8848
    Cell Significance Index: 5.8700
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: 0.7065
    Cell Significance Index: 4.5100
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 0.0940
    Cell Significance Index: 1.0000
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 0.0744
    Cell Significance Index: 0.7900
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 0.0465
    Cell Significance Index: 0.4400
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 0.0285
    Cell Significance Index: 0.3000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0136
    Cell Significance Index: 1.7500
  • Cell Name: lymphocyte of B lineage (CL0000945)
    Fold Change: 0.0013
    Cell Significance Index: 0.0100
  • Cell Name: mature B cell (CL0000785)
    Fold Change: -0.0015
    Cell Significance Index: -0.0100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0025
    Cell Significance Index: -4.6700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0026
    Cell Significance Index: -1.4600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0030
    Cell Significance Index: -5.5800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0041
    Cell Significance Index: -5.6100
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0051
    Cell Significance Index: -0.0600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0058
    Cell Significance Index: -4.4100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0067
    Cell Significance Index: -4.9800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0095
    Cell Significance Index: -6.9500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0107
    Cell Significance Index: -6.8100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0123
    Cell Significance Index: -5.5900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0139
    Cell Significance Index: -5.0000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0184
    Cell Significance Index: -5.2800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0233
    Cell Significance Index: -1.1800
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0248
    Cell Significance Index: -1.0800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0250
    Cell Significance Index: -5.0100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0255
    Cell Significance Index: -5.0600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0263
    Cell Significance Index: -4.5000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0312
    Cell Significance Index: -5.6300
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0317
    Cell Significance Index: -0.8100
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0369
    Cell Significance Index: -0.5400
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0382
    Cell Significance Index: -1.5700
  • Cell Name: myelocyte (CL0002193)
    Fold Change: -0.0407
    Cell Significance Index: -0.4400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0410
    Cell Significance Index: -5.3000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0425
    Cell Significance Index: -5.8300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0434
    Cell Significance Index: -4.9700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0462
    Cell Significance Index: -6.7200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0512
    Cell Significance Index: -6.2900
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0530
    Cell Significance Index: -0.9000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0565
    Cell Significance Index: -1.5800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0643
    Cell Significance Index: -6.5700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0665
    Cell Significance Index: -1.7100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0711
    Cell Significance Index: -3.3400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0716
    Cell Significance Index: -5.3400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0773
    Cell Significance Index: -5.9300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0804
    Cell Significance Index: -2.1500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0811
    Cell Significance Index: -5.4500
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0864
    Cell Significance Index: -1.1800
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0918
    Cell Significance Index: -2.2900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0938
    Cell Significance Index: -6.0500
  • Cell Name: megakaryocyte progenitor cell (CL0000553)
    Fold Change: -0.0946
    Cell Significance Index: -0.6800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0970
    Cell Significance Index: -5.9500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0980
    Cell Significance Index: -4.5700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1108
    Cell Significance Index: -6.2200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1152
    Cell Significance Index: -5.9900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1253
    Cell Significance Index: -6.5300
  • Cell Name: B-2 B cell (CL0000822)
    Fold Change: -0.1298
    Cell Significance Index: -1.1500
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1305
    Cell Significance Index: -4.7900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1330
    Cell Significance Index: -4.6600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1379
    Cell Significance Index: -6.1000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1414
    Cell Significance Index: -8.9100
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.1504
    Cell Significance Index: -2.0800
  • Cell Name: PP cell (CL0000696)
    Fold Change: -0.1505
    Cell Significance Index: -1.5300
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.1570
    Cell Significance Index: -2.2800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1573
    Cell Significance Index: -5.1500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1617
    Cell Significance Index: -5.1500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1624
    Cell Significance Index: -6.1500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1688
    Cell Significance Index: -5.9300
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.1738
    Cell Significance Index: -4.3400
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.1774
    Cell Significance Index: -5.6100
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.1777
    Cell Significance Index: -2.3000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1779
    Cell Significance Index: -5.1000
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: -0.1811
    Cell Significance Index: -1.2800
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: -0.1839
    Cell Significance Index: -1.6400
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.1884
    Cell Significance Index: -2.3300
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1913
    Cell Significance Index: -5.4600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1967
    Cell Significance Index: -5.2700
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.2048
    Cell Significance Index: -2.6000
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.2061
    Cell Significance Index: -5.1400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.2142
    Cell Significance Index: -5.7200
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.2155
    Cell Significance Index: -1.8100
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.2183
    Cell Significance Index: -4.2600
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: -0.2185
    Cell Significance Index: -2.6000
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.2254
    Cell Significance Index: -4.8700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2257
    Cell Significance Index: -7.2300
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.2257
    Cell Significance Index: -4.5000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** MS4A1 is a membrane-spanning 4-domains A1 protein, comprising four extracellular domains and a single transmembrane domain. The protein is highly expressed on the surface of B cells, where it serves as a key component of the B-cell receptor complex. The gene's expression is restricted to B cells, with minimal or no expression in other cell types. Notably, MS4A1 is the only gene among the CD20 family members that is restricted to B cells, making it a unique marker for B-cell identification. **Pathways and Functions:** MS4A1 is involved in multiple signaling pathways, including: 1. **B-cell activation**: MS4A1 is required for the activation of B cells in response to antigens, facilitating the initiation of the humoral immune response. 2. **B-cell receptor signaling pathway**: The protein plays a crucial role in the signaling cascade initiated by the B-cell receptor, regulating downstream events such as calcium influx and gene expression. 3. **Calcium ion import into cytosol**: MS4A1 is involved in the regulation of calcium ion influx into the cytosol, which is essential for B-cell activation and function. 4. **Protein tetramerization**: The protein can form tetramers with other B-cell surface receptors, such as CD19 and CD21, modulating their signaling properties. **Clinical Significance:** Dysregulation of MS4A1 has been implicated in various B-cell-related disorders, including: 1. **Non-Hodgkin lymphoma**: MS4A1 expression is often reduced or lost in non-Hodgkin lymphoma cells, making it a potential target for therapeutic interventions. 2. **Autoimmune diseases**: MS4A1 has been shown to play a role in the regulation of B-cell responses in autoimmune diseases, such as rheumatoid arthritis and systemic lupus erythematosus. 3. **Infectious diseases**: The protein's involvement in B-cell activation and function makes it a potential target for the development of vaccines and immunotherapies against infectious diseases. In conclusion, MS4A1 is a critical component of the B-cell receptor complex, playing a pivotal role in the development, activation, and function of B lymphocytes. Its dysregulation has been implicated in various B-cell-related disorders, highlighting the importance of further research into the gene's function and potential therapeutic applications.

Genular Protein ID: 3810168173

Symbol: CD20_HUMAN

Name: B-lymphocyte antigen CD20

UniProtKB Accession Codes:

P11836 A6NMS4 B4DT24 P08984 Q13963

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CPTC 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 12 DrugCentral 1 EMBL 14 EMDB 5 Ensembl 5 EvolutionaryTrace 1 ExpressionAtlas 1 GO 22 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 8 PDBsum 8 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 RefSeq 2 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3260267

Title: Analysis of two cDNA clones encoding the B lymphocyte antigen CD20 (B1, Bp35), a type III integral membrane protein.

PubMed ID: 3260267

DOI: 10.1084/jem.167.6.1975

PubMed ID: 2448768

Title: Isolation and structure of a cDNA encoding the B1 (CD20) cell-surface antigen of human B lymphocytes.

PubMed ID: 2448768

DOI: 10.1073/pnas.85.1.208

PubMed ID: 2456210

Title: Molecular cloning of the human B cell CD20 receptor predicts a hydrophobic protein with multiple transmembrane domains.

PubMed ID: 2456210

DOI: 10.1002/j.1460-2075.1988.tb02867.x

PubMed ID: 2466899

Title: Structure of the gene encoding the human B lymphocyte differentiation antigen CD20 (B1).

PubMed ID: 2466899

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 3925015

Title: The B cell surface molecule B1 is functionally linked with B cell activation and differentiation.

PubMed ID: 3925015

PubMed ID: 2472394

Title: Phosphorylation of the CD20 phosphoprotein in resting B lymphocytes. Regulation by protein kinase C.

PubMed ID: 2472394

DOI: 10.1016/s0021-9258(18)60461-2

PubMed ID: 7684739

Title: Transfection of the CD20 cell surface molecule into ectopic cell types generates a Ca2+ conductance found constitutively in B lymphocytes.

PubMed ID: 7684739

DOI: 10.1083/jcb.121.5.1121

PubMed ID: 12920111

Title: Store-operated cation entry mediated by CD20 in membrane rafts.

PubMed ID: 12920111

DOI: 10.1074/jbc.m308802200

PubMed ID: 16785532

Title: The biological activity of human CD20 monoclonal antibodies is linked to unique epitopes on CD20.

PubMed ID: 16785532

DOI: 10.4049/jimmunol.177.1.362

PubMed ID: 19367720

Title: Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment.

PubMed ID: 19367720

DOI: 10.1021/pr800500r

PubMed ID: 18474602

Title: CD20 homo-oligomers physically associate with the B cell antigen receptor. Dissociation upon receptor engagement and recruitment of phosphoproteins and calmodulin-binding proteins.

PubMed ID: 18474602

DOI: 10.1074/jbc.m800784200

PubMed ID: 20038800

Title: CD20 deficiency in humans results in impaired T cell-independent antibody responses.

PubMed ID: 20038800

DOI: 10.1172/jci40231

PubMed ID: 22615937

Title: Proteomic analysis of S-acylated proteins in human B cells reveals palmitoylation of the immune regulators CD20 and CD23.

PubMed ID: 22615937

DOI: 10.1371/journal.pone.0037187

PubMed ID: 17395584

Title: Structural basis for recognition of CD20 by therapeutic antibody Rituximab.

PubMed ID: 17395584

DOI: 10.1074/jbc.m701654200

PubMed ID: 18346788

Title: Crystal structure of chimeric antibody C2H7 Fab in complex with a CD20 peptide.

PubMed ID: 18346788

DOI: 10.1016/j.molimm.2008.01.034

PubMed ID: 21444918

Title: Epitope characterization and crystal structure of GA101 provide insights into the molecular basis for type I/II distinction of CD20 antibodies.

PubMed ID: 21444918

DOI: 10.1182/blood-2010-09-305847

Sequence Information:

  • Length: 297
  • Mass: 33077
  • Checksum: AC5420F8B626BDD1
  • Sequence:
    • MTTPRNSVNG TFPAEPMKGP IAMQSGPKPL FRRMSSLVGP TQSFFMRESK TLGAVQIMNG 
LFHIALGGLL MIPAGIYAPI CVTVWYPLWG GIMYIISGSL LAATEKNSRK CLVKGKMIMN 
SLSLFAAISG MILSIMDILN IKISHFLKME SLNFIRAHTP YINIYNCEPA NPSEKNSPST 
QYCYSIQSLF LGILSVMLIF AFFQELVIAG IVENEWKRTC SRPKSNIVLL SAEEKKEQTI 
EIKEEVVGLT ETSSQPKNEE DIEIIPIQEE EEEETETNFP EPPQDQESSP IENDSSP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.