Details for: KCNB2

Gene ID: 9312

Symbol: KCNB2

Ensembl ID: ENSG00000182674

Description: potassium voltage-gated channel subfamily B member 2

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 5.62
    Marker Score: 4,229
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 4.38
    Marker Score: 6,166
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 4.04
    Marker Score: 2,089
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 4
    Marker Score: 5,381
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 3.21
    Marker Score: 1,864
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 3.04
    Marker Score: 102,828
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 3.04
    Marker Score: 6,298
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 2.74
    Marker Score: 1,601
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 2.63
    Marker Score: 3,279
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 2.49
    Marker Score: 13,366
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 2.47
    Marker Score: 49,231
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 2.45
    Marker Score: 2,966
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 2.44
    Marker Score: 18,723
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 2.36
    Marker Score: 906
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 2.32
    Marker Score: 6,628
  • Cell Name: ganglion interneuron (CL0000397)
    Fold Change: 2.21
    Marker Score: 670
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 2.19
    Marker Score: 20,554
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.05
    Marker Score: 126,302
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.99
    Marker Score: 1,982
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.99
    Marker Score: 3,764
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 1.97
    Marker Score: 3,313
  • Cell Name: interneuron (CL0000099)
    Fold Change: 1.94
    Marker Score: 887
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.93
    Marker Score: 19,886
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.87
    Marker Score: 71,018
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.84
    Marker Score: 15,844
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.77
    Marker Score: 26,520
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.77
    Marker Score: 6,847
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.69
    Marker Score: 6,878
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 1.64
    Marker Score: 7,580
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.6
    Marker Score: 1,164
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 1.56
    Marker Score: 873
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.55
    Marker Score: 2,386
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.48
    Marker Score: 6,204
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.45
    Marker Score: 166,677
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.45
    Marker Score: 2,941
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 1.41
    Marker Score: 4,732
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.41
    Marker Score: 13,359
  • Cell Name: CNS interneuron (CL0000402)
    Fold Change: 1.38
    Marker Score: 664
  • Cell Name: bipolar neuron (CL0000103)
    Fold Change: 1.33
    Marker Score: 446
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.26
    Marker Score: 851
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.17
    Marker Score: 702
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.14
    Marker Score: 4,790
  • Cell Name: glial cell (CL0000125)
    Fold Change: 1.09
    Marker Score: 1,204
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 1.09
    Marker Score: 4,548
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.09
    Marker Score: 500
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.04
    Marker Score: 38,184
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.01
    Marker Score: 15,875
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.01
    Marker Score: 417
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,783
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,008
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 506
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,405
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 459
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,413
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 0.93
    Marker Score: 4,884
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5,312
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.93
    Marker Score: 371
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2,743
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.91
    Marker Score: 408
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 324
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.9
    Marker Score: 444
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,280
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.86
    Marker Score: 3,561
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.86
    Marker Score: 292
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.83
    Marker Score: 1,815
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,260
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 699
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 394
  • Cell Name: granule cell (CL0000120)
    Fold Change: 0.76
    Marker Score: 5,705
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.76
    Marker Score: 1,781
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.72
    Marker Score: 459
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.71
    Marker Score: 341
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.71
    Marker Score: 1,298
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.69
    Marker Score: 217
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.68
    Marker Score: 218
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.67
    Marker Score: 355
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.67
    Marker Score: 212
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 0.67
    Marker Score: 1,542
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.64
    Marker Score: 795
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.63
    Marker Score: 708
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.63
    Marker Score: 548
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 0.62
    Marker Score: 6,288
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.6
    Marker Score: 1,442
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.57
    Marker Score: 616
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.56
    Marker Score: 195
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.56
    Marker Score: 144
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 441
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.53
    Marker Score: 458
  • Cell Name: meningeal macrophage (CL0000879)
    Fold Change: 0.53
    Marker Score: 148
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.52
    Marker Score: 166
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.52
    Marker Score: 357
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.51
    Marker Score: 161
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.51
    Marker Score: 224
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.5
    Marker Score: 551
  • Cell Name: starburst amacrine cell (CL0004232)
    Fold Change: 0.49
    Marker Score: 139
  • Cell Name: sympathetic neuron (CL0011103)
    Fold Change: 0.49
    Marker Score: 161
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 0.49
    Marker Score: 252
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.48
    Marker Score: 621
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 0.46
    Marker Score: 170
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.46
    Marker Score: 524

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Gene Structure and Function:** The KCNB2 gene is a single-copy gene located on chromosome 12q13.13. It encodes for the Voltage-gated potassium channel subunit Kv2.2, a heteromeric channel composed of two subunits (Kv2.2 and Kv2.1). 2. **Expression Patterns:** Kv2.2 is widely expressed in various tissues, including the brain, kidney, and smooth muscle. Notably, it is highly expressed in neurons, particularly in photoreceptor cells, retinal ganglion cells, and Purkinje cells. 3. **Channel Properties:** Kv2.2 channels exhibit characteristics of delayed rectifier potassium channels, including a slow activation time, a prolonged decay phase, and a high density of channels in the plasma membrane. **Pathways and Functions:** 1. **Neuronal Excitability:** Kv2.2 channels play a critical role in regulating neuronal excitability by controlling the outward potassium current. This current helps to terminate action potentials and stabilize resting membrane potential. 2. **Potassium Ion Transport:** Kv2.2 channels contribute to potassium ion transport across the plasma membrane, influencing cellular excitability and maintaining proper ion balance. 3. **Smooth Muscle Contraction:** Kv2.2 channels are also expressed in smooth muscle cells, where they regulate contraction by modulating potassium ion efflux. 4. **Regulation of Smooth Muscle Contraction:** Kv2.2 channels interact with other ion channels and receptors, influencing smooth muscle contraction and relaxation. **Clinical Significance:** 1. **Neurological Disorders:** Mutations in the KCNB2 gene have been associated with various neurological disorders, including epilepsy, myoclonus, and ataxia. 2. **Cardiac Arrhythmias:** Kv2.2 channels contribute to the regulation of cardiac excitability, and alterations in channel function may contribute to the development of cardiac arrhythmias. 3. **Smooth Muscle Contraction:** Kv2.2 channels play a role in regulating smooth muscle contraction, which is essential for maintaining proper blood pressure and cardiovascular function. 4. **Cancer:** Kv2.2 channels have been implicated in cancer development and progression, particularly in the regulation of cell growth and survival. In conclusion, the KCNB2 gene and its encoded protein, Kv2.2, are critical components of potassium voltage-gated channels in neuronal function and regulation. Understanding the key characteristics, pathways, and functions of Kv2.2 is essential for elucidating the molecular mechanisms underlying various diseases and developing novel therapeutic strategies.

Genular Protein ID: 1461810340

Symbol: KCNB2_HUMAN

Name: Voltage-gated potassium channel subunit Kv2.2

UniProtKB Accession Codes:

Q92953 Q7Z7D0 Q9BXD3

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 4 DrugCentral 1 EMBL 3 Ensembl 1 GO 13 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 4 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 UniProtKB 4 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 9612272

Title: Molecular identification of a component of delayed rectifier current in gastrointestinal smooth muscles.

PubMed ID: 9612272

DOI: 10.1152/ajpgi.1998.274.5.g901

PubMed ID: 10414301

Title: Molecular diversity of K+ channels.

PubMed ID: 10414301

DOI: 10.1111/j.1749-6632.1999.tb11293.x

PubMed ID: 33124732

Title: FFAT motif phosphorylation controls formation and lipid transfer function of inter-organelle contacts.

PubMed ID: 33124732

DOI: 10.15252/embj.2019104369

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 911
  • Mass: 102563
  • Checksum: 2261D7D6280CF81A
  • Sequence:
    • MAEKAPPGLN RKTSRSTLSL PPEPVDIIRS KTCSRRVKIN VGGLNHEVLW RTLDRLPRTR 
LGKLRDCNTH ESLLEVCDDY NLNENEYFFD RHPGAFTSIL NFYRTGKLHM MEEMCALSFG 
QELDYWGIDE IYLESCCQAR YHQKKEQMNE ELRREAETMR EREGEEFDNT CCPDKRKKLW 
DLLEKPNSSV AAKILAIVSI LFIVLSTIAL SLNTLPELQE TDEFGQLNDN RQLAHVEAVC 
IAWFTMEYLL RFLSSPNKWK FFKGPLNVID LLAILPYYVT IFLTESNKSV LQFQNVRRVV 
QIFRIMRILR ILKLARHSTG LQSLGFTLRR SYNELGLLIL FLAMGIMIFS SLVFFAEKDE 
DATKFTSIPA SFWWATITMT TVGYGDIYPK TLLGKIVGGL CCIAGVLVIA LPIPIIVNNF 
SEFYKEQKRQ EKAIKRREAL ERAKRNGSIV SMNLKDAFAR SMELIDVAVE KAGESANTKD 
SADDNHLSPS RWKWARKALS ETSSNKSFEN KYQEVSQKDS HEQLNNTSSS SPQHLSAQKL 
EMLYNEITKT QPHSHPNPDC QEKPERPSAY EEEIEMEEVV CPQEQLAVAQ TEVIVDMKST 
SSIDSFTSCA TDFTETERSP LPPPSASHLQ MKFPTDLPGT EEHQRARGPP FLTLSREKGP 
AARDGTLEYA PVDITVNLDA SGSQCGLHSP LQSDNATDSP KSSLKGSNPL KSRSLKVNFK 
ENRGSAPQTP PSTARPLPVT TADFSLTTPQ HISTILLEET PSQGDRPLLG TEVSAPCQGP 
SKGLSPRFPK QKLFPFSSRE RRSFTEIDTG DDEDFLELPG AREEKQVDSS PNCFADKPSD 
GRDPLREEGS VGSSSPQDTG HNCRQDIYHA VSEVKKDSSQ EGCKMENHLF APEIHSNPGD 
TGYCPTRETS M

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.