Details for: KLF4

Gene ID: 9314

Symbol: KLF4

Ensembl ID: ENSG00000136826

Description: KLF transcription factor 4

Associated with

  • Developmental biology
    (R-HSA-1266738)
  • Foxo-mediated transcription
    (R-HSA-9614085)
  • Foxo-mediated transcription of cell cycle genes
    (R-HSA-9617828)
  • Gene expression (transcription)
    (R-HSA-74160)
  • Generic transcription pathway
    (R-HSA-212436)
  • Metabolism of proteins
    (R-HSA-392499)
  • Peptide hormone metabolism
    (R-HSA-2980736)
  • Rna polymerase ii transcription
    (R-HSA-73857)
  • Synthesis, secretion, and deacylation of ghrelin
    (R-HSA-422085)
  • Transcriptional regulation of pluripotent stem cells
    (R-HSA-452723)
  • Transcriptional regulation of white adipocyte differentiation
    (R-HSA-381340)
  • Beta-catenin binding
    (GO:0008013)
  • Canonical wnt signaling pathway
    (GO:0060070)
  • Cellular response to cycloheximide
    (GO:0071409)
  • Cellular response to growth factor stimulus
    (GO:0071363)
  • Cellular response to hydrogen peroxide
    (GO:0070301)
  • Cellular response to laminar fluid shear stress
    (GO:0071499)
  • Cellular response to leukemia inhibitory factor
    (GO:1990830)
  • Cellular response to peptide
    (GO:1901653)
  • Cellular response to retinoic acid
    (GO:0071300)
  • Chromatin
    (GO:0000785)
  • Chromatin dna binding
    (GO:0031490)
  • Cytosol
    (GO:0005829)
  • Defense response to tumor cell
    (GO:0002357)
  • Dna-binding transcription activator activity, rna polymerase ii-specific
    (GO:0001228)
  • Dna-binding transcription factor activity
    (GO:0003700)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Epidermal cell differentiation
    (GO:0009913)
  • Epidermis morphogenesis
    (GO:0048730)
  • Establishment of skin barrier
    (GO:0061436)
  • Euchromatin
    (GO:0000791)
  • Fat cell differentiation
    (GO:0045444)
  • Glandular epithelial cell differentiation
    (GO:0002067)
  • Histone deacetylase binding
    (GO:0042826)
  • Mesodermal cell fate determination
    (GO:0007500)
  • Microtubule cytoskeleton
    (GO:0015630)
  • Negative regulation of angiogenesis
    (GO:0016525)
  • Negative regulation of cell migration involved in sprouting angiogenesis
    (GO:0090051)
  • Negative regulation of cell population proliferation
    (GO:0008285)
  • Negative regulation of chemokine (c-x-c motif) ligand 2 production
    (GO:2000342)
  • Negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
    (GO:0043154)
  • Negative regulation of dna-templated transcription
    (GO:0045892)
  • Negative regulation of g1/s transition of mitotic cell cycle
    (GO:2000134)
  • Negative regulation of gene expression
    (GO:0010629)
  • Negative regulation of heterotypic cell-cell adhesion
    (GO:0034115)
  • Negative regulation of inflammatory response
    (GO:0050728)
  • Negative regulation of interleukin-8 production
    (GO:0032717)
  • Negative regulation of leukocyte adhesion to arterial endothelial cell
    (GO:1904998)
  • Negative regulation of nf-kappab transcription factor activity
    (GO:0032088)
  • Negative regulation of response to cytokine stimulus
    (GO:0060761)
  • Negative regulation of smooth muscle cell proliferation
    (GO:0048662)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Nucleoplasm
    (GO:0005654)
  • Positive regulation of dna-templated transcription
    (GO:0045893)
  • Positive regulation of gene expression
    (GO:0010628)
  • Positive regulation of hemoglobin biosynthetic process
    (GO:0046985)
  • Positive regulation of mirna transcription
    (GO:1902895)
  • Positive regulation of nitric oxide biosynthetic process
    (GO:0045429)
  • Positive regulation of protein metabolic process
    (GO:0051247)
  • Positive regulation of sprouting angiogenesis
    (GO:1903672)
  • Positive regulation of telomerase activity
    (GO:0051973)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Post-embryonic camera-type eye development
    (GO:0031077)
  • Post-embryonic hemopoiesis
    (GO:0035166)
  • Promoter-specific chromatin binding
    (GO:1990841)
  • Protein binding
    (GO:0005515)
  • Regulation of axon regeneration
    (GO:0048679)
  • Regulation of blastocyst development
    (GO:0120222)
  • Regulation of cell differentiation
    (GO:0045595)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna polymerase ii-specific dna-binding transcription factor binding
    (GO:0061629)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Rna polymerase ii sequence-specific dna-binding transcription factor recruiting activity
    (GO:0001010)
  • Sequence-specific double-stranded dna binding
    (GO:1990837)
  • Somatic stem cell population maintenance
    (GO:0035019)
  • Stem cell population maintenance
    (GO:0019827)
  • Transcription by rna polymerase ii
    (GO:0006366)
  • Transcription cis-regulatory region binding
    (GO:0000976)
  • Transcription coregulator binding
    (GO:0001221)
  • Transcription regulator complex
    (GO:0005667)
  • Zinc ion binding
    (GO:0008270)

Other Information

Genular Protein ID: 2029294322

Symbol: KLF4_HUMAN

Name: Krueppel-like factor 4

UniProtKB Accession Codes:

O43474 B2R8S4 B3KT79 L0R3I6 L0R4N5 P78338 Q5T3J8 Q5T3J9 Q8N717 Q9UNP3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DIP 1 DNASU 1 DisGeNET 1 DisProt 1 EMBL 13 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 69 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 4 RefSeq 2 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9422764

Title: Human EZF, a Kruppel-like zinc finger protein, is expressed in vascular endothelial cells and contains transcriptional activation and repression domains.

PubMed ID: 9422764

DOI: 10.1074/jbc.273.2.1026

PubMed ID: 10392904

Title: Oncogene expression cloning by retroviral transduction of adenovirus E1A-immortalized rat kidney RK3E cells: transformation of a host with epithelial features by c-MYC and the zinc finger protein GKLF.

PubMed ID: 10392904

PubMed ID: 23134681

Title: Shaking the family tree: Identification of novel and biologically active alternatively spliced isoforms across the KLF family of transcription factors.

PubMed ID: 23134681

DOI: 10.1096/fj.12-220319

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17308127

Title: Human mucin 1 oncoprotein represses transcription of the p53 tumor suppressor gene.

PubMed ID: 17308127

DOI: 10.1158/0008-5472.can-06-3063

PubMed ID: 18035408

Title: Induction of pluripotent stem cells from adult human fibroblasts by defined factors.

PubMed ID: 18035408

DOI: 10.1016/j.cell.2007.11.019

PubMed ID: 17467953

Title: Nine-amino-acid transactivation domain: establishment and prediction utilities.

PubMed ID: 17467953

DOI: 10.1016/j.ygeno.2007.02.003

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 18655026

Title: Proteomic analysis of ubiquitinated proteins in normal hepatocyte cell line Chang liver cells.

PubMed ID: 18655026

DOI: 10.1002/pmic.200700887

PubMed ID: 20071344

Title: Kruppel-like factor 4 (Klf4) prevents embryonic stem (ES) cell differentiation by regulating Nanog gene expression.

PubMed ID: 20071344

DOI: 10.1074/jbc.m109.077958

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21746878

Title: Cooperative transcriptional activation by Klf4, Meis2, and Pbx1.

PubMed ID: 21746878

DOI: 10.1128/mcb.01456-10

PubMed ID: 21654807

Title: Direct reprogramming of somatic cells is promoted by maternal transcription factor Glis1.

PubMed ID: 21654807

DOI: 10.1038/nature10106

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 29593216

Title: Klf4 glutamylation is required for cell reprogramming and early embryonic development in mice.

PubMed ID: 29593216

DOI: 10.1038/s41467-018-03008-2

PubMed ID: 31375868

Title: The evolution of the 9aaTAD domain in Sp2 proteins: inactivation with valines and intron reservoirs.

PubMed ID: 31375868

DOI: 10.1007/s00018-019-03251-w

Sequence Information:

  • Length: 513
  • Mass: 54671
  • Checksum: 3B6113A3EF333935
  • Sequence:
    • MRQPPGESDM AVSDALLPSF STFASGPAGR EKTLRQAGAP NNRWREELSH MKRLPPVLPG 
RPYDLAAATV ATDLESGGAG AACGGSNLAP LPRRETEEFN DLLDLDFILS NSLTHPPESV 
AATVSSSASA SSSSSPSSSG PASAPSTCSF TYPIRAGNDP GVAPGGTGGG LLYGRESAPP 
PTAPFNLADI NDVSPSGGFV AELLRPELDP VYIPPQQPQP PGGGLMGKFV LKASLSAPGS 
EYGSPSVISV SKGSPDGSHP VVVAPYNGGP PRTCPKIKQE AVSSCTHLGA GPPLSNGHRP 
AAHDFPLGRQ LPSRTTPTLG LEEVLSSRDC HPALPLPPGF HPHPGPNYPS FLPDQMQPQV 
PPLHYQGQSR GFVARAGEPC VCWPHFGTHG MMLTPPSSPL ELMPPGSCMP EEPKPKRGRR 
SWPRKRTATH TCDYAGCGKT YTKSSHLKAH LRTHTGEKPY HCDWDGCGWK FARSDELTRH 
YRKHTGHRPF QCQKCDRAFS RSDHLALHMK RHF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.