COPS2 | ENSG00000166200 | NCBI 9318

Details for: COPS2

Gene ID: 9318

Symbol: COPS2

Ensembl ID: ENSG00000166200

Description: COP9 signalosome subunit 2

Associated with

Cargo recognition for clathrin-mediated endocytosis
(R-HSA-8856825)
Clathrin-mediated endocytosis
(R-HSA-8856828)
Dna damage recognition in gg-ner
(R-HSA-5696394)
Dna repair
(R-HSA-73894)
Formation of tc-ner pre-incision complex
(R-HSA-6781823)
Global genome nucleotide excision repair (gg-ner)
(R-HSA-5696399)
Membrane trafficking
(R-HSA-199991)
Metabolism of proteins
(R-HSA-392499)
Neddylation
(R-HSA-8951664)
Nucleotide excision repair
(R-HSA-5696398)
Post-translational protein modification
(R-HSA-597592)
Rhobtb1 gtpase cycle
(R-HSA-9013422)
Rhobtb gtpase cycle
(R-HSA-9706574)
Rho gtpase cycle
(R-HSA-9012999)
Signaling by rho gtpases
(R-HSA-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-HSA-9716542)
Transcription-coupled nucleotide excision repair (tc-ner)
(R-HSA-6781827)
Vesicle-mediated transport
(R-HSA-5653656)
Cop9 signalosome
(GO:0008180)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Inner cell mass cell proliferation
(GO:0001833)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Neuron differentiation
(GO:0030182)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Protein binding
(GO:0005515)
Protein deneddylation
(GO:0000338)
Protein neddylation
(GO:0045116)
Protein phosphorylation
(GO:0006468)
Regulation of protein neddylation
(GO:2000434)
Signal transduction
(GO:0007165)
Skeletal muscle cell differentiation
(GO:0035914)
Transcription by rna polymerase ii
(GO:0006366)
Transcription corepressor activity
(GO:0003714)
Trophectodermal cell proliferation
(GO:0001834)

Other Information

Proteins

COP9 signalosome complex subunit 2
Q59EL2_HUMAN

Genular Protein ID: 1757568119

Symbol: CSN2_HUMAN

Name: COP9 signalosome complex subunit 2

UniProtKB Accession Codes:

P61201 O88950 Q15647 Q6FGP4 Q9BY54 Q9R249 Q9UNI2 Q9UNQ5

Database IDs:

Citations:

PubMed ID: 10931946

Title: Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning.

PubMed ID: 10931946

DOI: 10.1073/pnas.160270997

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7776974

Title: Two classes of proteins dependent on either the presence or absence of thyroid hormone for interaction with the thyroid hormone receptor.

PubMed ID: 7776974

DOI: 10.1210/mend.9.2.7776974

PubMed ID: 10207062

Title: Alien, a highly conserved protein with characteristics of a corepressor for members of the nuclear hormone receptor superfamily.

PubMed ID: 10207062

DOI: 10.1128/mcb.19.5.3383

PubMed ID: 9535219

Title: A novel protein complex involved in signal transduction possessing similarities to 26S proteasome subunits.

PubMed ID: 9535219

DOI: 10.1096/fasebj.12.6.469

PubMed ID: 10713076

Title: Interaction of the corepressor Alien with DAX-1 is abrogated by mutations of DAX-1 involved in adrenal hypoplasia congenita.

PubMed ID: 10713076

DOI: 10.1074/jbc.275.11.7662

PubMed ID: 10991940

Title: Interaction between interferon consensus sequence-binding protein and COP9/signalosome subunit CSN2 (Trip15). A possible link between interferon regulatory factor signaling and the COP9/signalosome.

PubMed ID: 10991940

DOI: 10.1074/jbc.m004900200

PubMed ID: 11285227

Title: COP9 signalosome-specific phosphorylation targets p53 to degradation by the ubiquitin system.

PubMed ID: 11285227

DOI: 10.1093/emboj/20.7.1630

PubMed ID: 11337588

Title: Promotion of NEDD-CUL1 conjugate cleavage by COP9 signalosome.

PubMed ID: 11337588

DOI: 10.1126/science.1059780

PubMed ID: 12732143

Title: The ubiquitin ligase activity in the DDB2 and CSA complexes is differentially regulated by the COP9 signalosome in response to DNA damage.

PubMed ID: 12732143

DOI: 10.1016/s0092-8674(03)00316-7

PubMed ID: 12628923

Title: Protein kinase CK2 and protein kinase D are associated with the COP9 signalosome.

PubMed ID: 12628923

DOI: 10.1093/emboj/cdg127

PubMed ID: 18850735

Title: Characterization of the human COP9 signalosome complex using affinity purification and mass spectrometry.

PubMed ID: 18850735

DOI: 10.1021/pr800574c

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 26456823

Title: CSNAP is a stoichiometric subunit of the COP9 signalosome.

PubMed ID: 26456823

DOI: 10.1016/j.celrep.2015.09.021

Sequence Information:

Length: 443
Mass: 51597
Checksum: 1DB6FA774C13BC59
Sequence:

MSDMEDDFMC DDEEDYDLEY SEDSNSEPNV DLENQYYNSK ALKEDDPKAA LSSFQKVLEL 
EGEKGEWGFK ALKQMIKINF KLTNFPEMMN RYKQLLTYIR SAVTRNYSEK SINSILDYIS 
TSKQMDLLQE FYETTLEALK DAKNDRLWFK TNTKLGKLYL EREEYGKLQK ILRQLHQSCQ 
TDDGEDDLKK GTQLLEIYAL EIQMYTAQKN NKKLKALYEQ SLHIKSAIPH PLIMGVIREC 
GGKMHLREGE FEKAHTDFFE AFKNYDESGS PRRTTCLKYL VLANMLMKSG INPFDSQEAK 
PYKNDPEILA MTNLVSAYQN NDITEFEKIL KTNHSNIMDD PFIREHIEEL LRNIRTQVLI 
KLIKPYTRIH IPFISKELNI DVADVESLLV QCILDNTIHG RIDQVNQLLE LDHQKRGGAR 
YTALDKWTNQ LNSLNQAVVS KLA

Genular Protein ID: 1651957696

Symbol: Q59EL2_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q59EL2

Database IDs:

Sequence Information:

Length: 451
Mass: 52533
Checksum: 6797C8758E62B21A
Sequence:

KMSDMEDDFM CDDEEDYDLE YSEDSNSEPN VDLENQYYNS KALKEDDPKA ALSSFQKVLE 
LEGEKGEWGF KALKQMIKIN FKLTNFPEMM NRYKQLLTYI RSAVTRNYSE KSINSILDYI 
STSKQNSDFL CQMDLLQEFY ETTLEALKDA KNDRLWFKTN TKLGKLYLER EEYGKLQKIL 
RQLHQSCQTD DGEDDLKKGT QLLEIYALEI QMYTAQKNNK KLKALYEQSL HIKSAIPHPL 
IMGVIRECGG KMHLREGEFE KAHTDFFEAF KNYDESGSPR RTTCLKYLVL ANMLMKSGIN 
PFDSQEAKPY KNDPEILAMT NLVSAYQNND ITEFEKILKT NHSNIMDDPF IREHIEELLR 
NIRTQVLIKL IKPYTRIHIP FISKELNIDV ADVESLLVQC ILDNTIHGRI DQVNQLLELD 
HQKRGGARYT ALDKWTNQLN SLNQAVVSKL A

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: COPS2

Associated with

Other Information

Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. PubMed ID: 10931946

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Two classes of proteins dependent on either the presence or absence of thyroid hormone for interaction with the thyroid hormone receptor. PubMed ID: 7776974

Alien, a highly conserved protein with characteristics of a corepressor for members of the nuclear hormone receptor superfamily. PubMed ID: 10207062

A novel protein complex involved in signal transduction possessing similarities to 26S proteasome subunits. PubMed ID: 9535219

Interaction of the corepressor Alien with DAX-1 is abrogated by mutations of DAX-1 involved in adrenal hypoplasia congenita. PubMed ID: 10713076

Interaction between interferon consensus sequence-binding protein and COP9/signalosome subunit CSN2 (Trip15). A possible link between interferon regulatory factor signaling and the COP9/signalosome. PubMed ID: 10991940

COP9 signalosome-specific phosphorylation targets p53 to degradation by the ubiquitin system. PubMed ID: 11285227

Promotion of NEDD-CUL1 conjugate cleavage by COP9 signalosome. PubMed ID: 11337588

The ubiquitin ligase activity in the DDB2 and CSA complexes is differentially regulated by the COP9 signalosome in response to DNA damage. PubMed ID: 12732143

Protein kinase CK2 and protein kinase D are associated with the COP9 signalosome. PubMed ID: 12628923

Characterization of the human COP9 signalosome complex using affinity purification and mass spectrometry. PubMed ID: 18850735

Initial characterization of the human central proteome. PubMed ID: 21269460

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

CSNAP is a stoichiometric subunit of the COP9 signalosome. PubMed ID: 26456823