Details for: MS4A3

Gene ID: 932

Symbol: MS4A3

Ensembl ID: ENSG00000149516

Description: membrane spanning 4-domains A3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 5.3602
    Cell Significance Index: 35.5600
  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 5.2075
    Cell Significance Index: -0.8100
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: 3.4479
    Cell Significance Index: 22.0100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 2.6809
    Cell Significance Index: -0.6800
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 2.4369
    Cell Significance Index: -0.9900
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.0909
    Cell Significance Index: 26.4300
  • Cell Name: basophil mast progenitor cell (CL0002028)
    Fold Change: 0.8075
    Cell Significance Index: 6.8200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 0.6407
    Cell Significance Index: -0.7900
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.3914
    Cell Significance Index: 5.7100
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 0.1804
    Cell Significance Index: 3.1100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.1776
    Cell Significance Index: 4.5700
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 0.0913
    Cell Significance Index: 0.4400
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.0898
    Cell Significance Index: 1.1400
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.0455
    Cell Significance Index: 0.4500
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0450
    Cell Significance Index: 0.6500
  • Cell Name: promonocyte (CL0000559)
    Fold Change: 0.0440
    Cell Significance Index: 0.4700
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.0409
    Cell Significance Index: 1.0200
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: 0.0346
    Cell Significance Index: 0.3200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0242
    Cell Significance Index: 0.5300
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.0177
    Cell Significance Index: 0.1200
  • Cell Name: immature neutrophil (CL0000776)
    Fold Change: 0.0131
    Cell Significance Index: 0.1000
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.0116
    Cell Significance Index: 0.1500
  • Cell Name: sebaceous gland cell (CL2000021)
    Fold Change: 0.0109
    Cell Significance Index: 0.0100
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.0103
    Cell Significance Index: 0.1500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0044
    Cell Significance Index: 0.8900
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.0032
    Cell Significance Index: 0.1000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0030
    Cell Significance Index: 0.6000
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.0014
    Cell Significance Index: 0.0200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0004
    Cell Significance Index: 0.5200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0002
    Cell Significance Index: 0.4600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0001
    Cell Significance Index: 0.2300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0001
    Cell Significance Index: 0.0900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0003
    Cell Significance Index: -0.2100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0005
    Cell Significance Index: -0.1700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0005
    Cell Significance Index: -0.3000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0010
    Cell Significance Index: -0.2800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0015
    Cell Significance Index: -0.6800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0015
    Cell Significance Index: -1.1000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0016
    Cell Significance Index: -1.0500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0021
    Cell Significance Index: -0.3600
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: -0.0034
    Cell Significance Index: -0.0300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0035
    Cell Significance Index: -0.1000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0038
    Cell Significance Index: -0.1900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0043
    Cell Significance Index: -0.6300
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0044
    Cell Significance Index: -0.1800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0046
    Cell Significance Index: -0.8300
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0046
    Cell Significance Index: -0.0900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0050
    Cell Significance Index: -0.5700
  • Cell Name: L5/6 near-projecting glutamatergic neuron (CL4030067)
    Fold Change: -0.0054
    Cell Significance Index: -0.0300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0067
    Cell Significance Index: -0.7000
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.0084
    Cell Significance Index: -0.1200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0088
    Cell Significance Index: -1.0900
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: -0.0089
    Cell Significance Index: -0.1000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0089
    Cell Significance Index: -0.6800
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.0095
    Cell Significance Index: -0.1200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0106
    Cell Significance Index: -0.2300
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0113
    Cell Significance Index: -0.1900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0114
    Cell Significance Index: -0.5100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0116
    Cell Significance Index: -0.6500
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0123
    Cell Significance Index: -0.1500
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0138
    Cell Significance Index: -0.2700
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.0145
    Cell Significance Index: -0.1500
  • Cell Name: eosinophil (CL0000771)
    Fold Change: -0.0147
    Cell Significance Index: -0.1300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0150
    Cell Significance Index: -0.5300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0154
    Cell Significance Index: -0.5400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0156
    Cell Significance Index: -0.5900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0163
    Cell Significance Index: -0.5200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0166
    Cell Significance Index: -0.5500
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0174
    Cell Significance Index: -0.3500
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.0174
    Cell Significance Index: -0.4300
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0176
    Cell Significance Index: -0.2400
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0178
    Cell Significance Index: -0.2400
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: -0.0178
    Cell Significance Index: -0.2300
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.0186
    Cell Significance Index: -0.2300
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.0194
    Cell Significance Index: -0.2900
  • Cell Name: erythroblast (CL0000765)
    Fold Change: -0.0201
    Cell Significance Index: -0.2400
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.0204
    Cell Significance Index: -0.2900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0210
    Cell Significance Index: -1.3600
  • Cell Name: granulocyte (CL0000094)
    Fold Change: -0.0216
    Cell Significance Index: -0.2600
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.0218
    Cell Significance Index: -0.3500
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0225
    Cell Significance Index: -0.2600
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.0228
    Cell Significance Index: -0.2500
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0229
    Cell Significance Index: -0.5700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0232
    Cell Significance Index: -1.2100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0235
    Cell Significance Index: -0.6300
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0240
    Cell Significance Index: -0.5100
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.0246
    Cell Significance Index: -0.2900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0260
    Cell Significance Index: -1.1800
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0260
    Cell Significance Index: -0.5400
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0282
    Cell Significance Index: -0.6100
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0283
    Cell Significance Index: -0.5600
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0284
    Cell Significance Index: -0.3900
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0287
    Cell Significance Index: -0.7300
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: -0.0288
    Cell Significance Index: -0.2700
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0293
    Cell Significance Index: -0.3900
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0298
    Cell Significance Index: -0.4400
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.0299
    Cell Significance Index: -0.4100
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0316
    Cell Significance Index: -0.6600
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0317
    Cell Significance Index: -0.4500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0322
    Cell Significance Index: -0.4400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** MS4A3 is a transmembrane protein with four distinct domains, which are thought to be involved in protein-protein interactions and binding. The protein is expressed in various cell types, including blood vessel endothelial cells, myelocytes, promonocytes, goblet cells, granulocyte-monocyte progenitor cells, and stem cells. The gene is highly expressed in the immune system, suggesting its importance in immune cell development and function. **Pathways and Functions:** MS4A3 is involved in several cellular pathways, including: 1. **Immune System:** MS4A3 is expressed in immune cells, such as myelocytes and promonocytes, and is involved in the regulation of immune responses. 2. **Neutrophil Degranulation:** MS4A3 is involved in the degranulation of neutrophils, which is a critical process in the innate immune response. 3. **Protein Binding:** The protein domains of MS4A3 are thought to be involved in protein-protein interactions, which are essential for regulating cellular processes. 4. **Perinuclear Region of Cytoplasm:** MS4A3 is localized to the perinuclear region of the cytoplasm, where it is thought to regulate cellular processes, such as protein trafficking and signaling. **Clinical Significance:** Recent studies have highlighted the clinical significance of MS4A3, revealing its potential role in several diseases, including: 1. **Autoimmune Disorders:** MS4A3 has been implicated in the development of autoimmune disorders, such as rheumatoid arthritis and lupus, where it is thought to regulate immune responses. 2. **Neurological Disorders:** MS4A3 has been linked to neurological disorders, such as multiple sclerosis and Alzheimer's disease, where it is thought to regulate immune responses and inflammation. 3. **Cancer:** MS4A3 has been implicated in cancer, where it is thought to regulate cell signaling and proliferation. 4. **Infectious Diseases:** MS4A3 has been linked to infectious diseases, such as tuberculosis and malaria, where it is thought to regulate immune responses. In conclusion, MS4A3 is a multifunctional protein that plays a critical role in various cellular processes, including immune system development and function. Its clinical significance has been highlighted in several diseases, including autoimmune disorders, neurological disorders, cancer, and infectious diseases. Further research is needed to fully understand the function and clinical significance of MS4A3.

Genular Protein ID: 3500524401

Symbol: MS4A3_HUMAN

Name: Membrane-spanning 4-domains subfamily A member 3

UniProtKB Accession Codes:

Q96HJ5 A8MTP8 Q8NHW2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 6 ExpressionAtlas 1 GO 3 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 1 RefSeq 3 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 7524084

Title: Cloning of the cDNA for a hematopoietic cell-specific protein related to CD20 and the beta subunit of the high-affinity IgE receptor: evidence for a family of proteins with four membrane-spanning regions.

PubMed ID: 7524084

DOI: 10.1073/pnas.91.21.10178

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11781350

Title: Human HTm4 is a hematopoietic cell cycle regulator.

PubMed ID: 11781350

DOI: 10.1172/jci14025

PubMed ID: 15671017

Title: Binding of HTm4 to cyclin-dependent kinase (Cdk)-associated phosphatase (KAP).Cdk2.cyclin A complex enhances the phosphatase activity of KAP, dissociates cyclin A, and facilitates KAP dephosphorylation of Cdk2.

PubMed ID: 15671017

DOI: 10.1074/jbc.m413437200

Sequence Information:

  • Length: 214
  • Mass: 22933
  • Checksum: D30C276213DB8F3D
  • Sequence:
    • MASHEVDNAE LGSASAHGTP GSEAGPEELN TSVYQPIDGS PDYQKAKLQV LGAIQILNAA 
MILALGVFLG SLQYPYHFQK HFFFFTFYTG YPIWGAVFFC SSGTLSVVAG IKPTRTWIQN 
SFGMNIASAT IALVGTAFLS LNIAVNIQSL RSCHSSSESP DLCNYMGSIS NGMVSLLLIL 
TLLELCVTIS TIAMWCNANC CNSREEISSP PNSV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.