CD22 | ENSG00000012124 | NCBI 933

Details for: CD22

Gene ID: 933

Symbol: CD22

Ensembl ID: ENSG00000012124

Description: CD22 molecule

Associated with

Adaptive immune system
(R-HSA-1280218)
Antigen activates b cell receptor (bcr) leading to generation of second messengers
(R-HSA-983695)
Cd22 mediated bcr regulation
(R-HSA-5690714)
Immune system
(R-HSA-168256)
Immunoregulatory interactions between a lymphoid and a non-lymphoid cell
(R-HSA-198933)
Signaling by the b cell receptor (bcr)
(R-HSA-983705)
B cell activation
(GO:0042113)
Carbohydrate binding
(GO:0030246)
Cd4 receptor binding
(GO:0042609)
Cell adhesion
(GO:0007155)
Cell surface
(GO:0009986)
Cytoplasm
(GO:0005737)
Early endosome
(GO:0005769)
External side of plasma membrane
(GO:0009897)
Extracellular exosome
(GO:0070062)
Igm binding
(GO:0001791)
Membrane
(GO:0016020)
Negative regulation of b cell receptor signaling pathway
(GO:0050859)
Negative regulation of calcium-mediated signaling
(GO:0050849)
Negative regulation of immunoglobulin production
(GO:0002638)
Neuronal cell body membrane
(GO:0032809)
Plasma membrane
(GO:0005886)
Protein binding
(GO:0005515)
Protein phosphatase binding
(GO:0019903)
Recycling endosome
(GO:0055037)
Regulation of b cell proliferation
(GO:0030888)
Regulation of endocytosis
(GO:0030100)
Regulation of immune response
(GO:0050776)
Sialic acid binding
(GO:0033691)
Signaling receptor binding
(GO:0005102)

Other Information

Proteins

B-lymphocyte cell adhesion molecule

Genular Protein ID: 366550295

Symbol: CD22_HUMAN

Name: B-lymphocyte cell adhesion molecule

UniProtKB Accession Codes:

P20273 F5GYU4 F5H7U3 O95699 O95701 O95702 O95703 Q01665 Q32M46 Q92872 Q92873 Q9UQA6 Q9UQA7 Q9UQA8 Q9UQA9 Q9UQB0 Q9Y2A6

Database IDs:

Citations:

PubMed ID: 1691828

Title: The B-cell antigen CD22 mediates monocyte and erythrocyte adhesion.

PubMed ID: 1691828

DOI: 10.1038/345074a0

PubMed ID: 1985119

Title: cDNA cloning of the B cell membrane protein CD22: a mediator of B-B cell interactions.

PubMed ID: 1985119

DOI: 10.1084/jem.173.1.137

PubMed ID: 8496602

Title: Genomic structure and chromosomal mapping of the human CD22 gene.

PubMed ID: 8496602

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10079291

Title: Identification of the gene variations in human CD22.

PubMed ID: 10079291

DOI: 10.1007/s002510050494

PubMed ID: 8463235

Title: Natural ligands of the B cell adhesion molecule CD22 beta carry N-linked oligosaccharides with alpha-2,6-linked sialic acids that are required for recognition.

PubMed ID: 8463235

DOI: 10.1016/s0021-9258(18)53140-9

PubMed ID: 7618087

Title: A role in B cell activation for CD22 and the protein tyrosine phosphatase SHP.

PubMed ID: 7618087

DOI: 10.1126/science.7618087

PubMed ID: 8647200

Title: Involvement of p72syk kinase, p53/56lyn kinase and phosphatidyl inositol-3 kinase in signal transduction via the human B lymphocyte antigen CD22.

PubMed ID: 8647200

DOI: 10.1002/eji.1830260610

PubMed ID: 8627166

Title: CD22 associates with protein tyrosine phosphatase 1C, Syk, and phospholipase C-gamma(1) upon B cell activation.

PubMed ID: 8627166

DOI: 10.1084/jem.183.2.547

PubMed ID: 9143697

Title: CD22, a B lymphocyte-specific adhesion molecule that regulates antigen receptor signaling.

PubMed ID: 9143697

DOI: 10.1146/annurev.immunol.15.1.481

Sequence Information:

Length: 847
Mass: 95348
Checksum: 38EB0BE4220ACA2D
Sequence:

MHLLGPWLLL LVLEYLAFSD SSKWVFEHPE TLYAWEGACV WIPCTYRALD GDLESFILFH 
NPEYNKNTSK FDGTRLYEST KDGKVPSEQK RVQFLGDKNK NCTLSIHPVH LNDSGQLGLR 
MESKTEKWME RIHLNVSERP FPPHIQLPPE IQESQEVTLT CLLNFSCYGY PIQLQWLLEG 
VPMRQAAVTS TSLTIKSVFT RSELKFSPQW SHHGKIVTCQ LQDADGKFLS NDTVQLNVKH 
TPKLEIKVTP SDAIVREGDS VTMTCEVSSS NPEYTTVSWL KDGTSLKKQN TFTLNLREVT 
KDQSGKYCCQ VSNDVGPGRS EEVFLQVQYA PEPSTVQILH SPAVEGSQVE FLCMSLANPL 
PTNYTWYHNG KEMQGRTEEK VHIPKILPWH AGTYSCVAEN ILGTGQRGPG AELDVQYPPK 
KVTTVIQNPM PIREGDTVTL SCNYNSSNPS VTRYEWKPHG AWEEPSLGVL KIQNVGWDNT 
TIACAACNSW CSWASPVALN VQYAPRDVRV RKIKPLSEIH SGNSVSLQCD FSSSHPKEVQ 
FFWEKNGRLL GKESQLNFDS ISPEDAGSYS CWVNNSIGQT ASKAWTLEVL YAPRRLRVSM 
SPGDQVMEGK SATLTCESDA NPPVSHYTWF DWNNQSLPYH SQKLRLEPVK VQHSGAYWCQ 
GTNSVGKGRS PLSTLTVYYS PETIGRRVAV GLGSCLAILI LAICGLKLQR RWKRTQSQQG 
LQENSSGQSF FVRNKKVRRA PLSEGPHSLG CYNPMMEDGI SYTTLRFPEM NIPRTGDAES 
SEMQRPPPDC DDTVTYSALH KRQVGDYENV IPDFPEDEGI HYSELIQFGV GERPQAQENV 
DYVILKH

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: CD22

Associated with

Other Information

The B-cell antigen CD22 mediates monocyte and erythrocyte adhesion. PubMed ID: 1691828

cDNA cloning of the B cell membrane protein CD22: a mediator of B-B cell interactions. PubMed ID: 1985119

Genomic structure and chromosomal mapping of the human CD22 gene. PubMed ID: 8496602

The DNA sequence and biology of human chromosome 19. PubMed ID: 15057824

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Identification of the gene variations in human CD22. PubMed ID: 10079291

Natural ligands of the B cell adhesion molecule CD22 beta carry N-linked oligosaccharides with alpha-2,6-linked sialic acids that are required for recognition. PubMed ID: 8463235

A role in B cell activation for CD22 and the protein tyrosine phosphatase SHP. PubMed ID: 7618087

Involvement of p72syk kinase, p53/56lyn kinase and phosphatidyl inositol-3 kinase in signal transduction via the human B lymphocyte antigen CD22. PubMed ID: 8647200

CD22 associates with protein tyrosine phosphatase 1C, Syk, and phospholipase C-gamma(1) upon B cell activation. PubMed ID: 8627166

CD22, a B lymphocyte-specific adhesion molecule that regulates antigen receptor signaling. PubMed ID: 9143697