Details for: CNOT8

Gene ID: 9337

Symbol: CNOT8

Ensembl ID: ENSG00000155508

Description: CCR4-NOT transcription complex subunit 8

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 2.41
    Marker Score: 1,928
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 1.85
    Marker Score: 1,103
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.39
    Marker Score: 5,976
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 1.36
    Marker Score: 3,691
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 1.31
    Marker Score: 1,316
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: 1.28
    Marker Score: 1,539
  • Cell Name: blood cell (CL0000081)
    Fold Change: 1.24
    Marker Score: 14,390
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: 1.21
    Marker Score: 1,429
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 1.16
    Marker Score: 1,640
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 1.12
    Marker Score: 318
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 1.1
    Marker Score: 2,311
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 1.09
    Marker Score: 573
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.05
    Marker Score: 16,430
  • Cell Name: Unknown (CL0000548)
    Fold Change: 1.03
    Marker Score: 751
  • Cell Name: Unknown (CL0002371)
    Fold Change: 1.02
    Marker Score: 1,081
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 1.02
    Marker Score: 234
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 1.01
    Marker Score: 53,414
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 1.01
    Marker Score: 1,977
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 1
    Marker Score: 349
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,640
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 0.99
    Marker Score: 47,864
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.99
    Marker Score: 2,064
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,381
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.97
    Marker Score: 937
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.96
    Marker Score: 2,399
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.96
    Marker Score: 9,694
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.95
    Marker Score: 33,058
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 0.95
    Marker Score: 305
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.95
    Marker Score: 234
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.94
    Marker Score: 1,606
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 0.94
    Marker Score: 326
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.94
    Marker Score: 1,017
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.94
    Marker Score: 8,275
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2,386
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.93
    Marker Score: 273
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 0.93
    Marker Score: 919
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.93
    Marker Score: 57,077
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.92
    Marker Score: 1,276
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.92
    Marker Score: 5,894
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.92
    Marker Score: 475
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 0.92
    Marker Score: 555
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.92
    Marker Score: 434
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.92
    Marker Score: 51,266
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 0.92
    Marker Score: 5,974
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.92
    Marker Score: 3,750
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.92
    Marker Score: 624
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.92
    Marker Score: 7,869
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.91
    Marker Score: 503
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.91
    Marker Score: 9,181
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.91
    Marker Score: 964
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.91
    Marker Score: 2,471
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.91
    Marker Score: 284
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 0.91
    Marker Score: 876
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.9
    Marker Score: 574
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 0.9
    Marker Score: 1,452
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.9
    Marker Score: 829
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.9
    Marker Score: 2,681
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.88
    Marker Score: 5,020
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 0.88
    Marker Score: 1,532
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 0.88
    Marker Score: 821
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 0.87
    Marker Score: 3,745
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,291
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 0.87
    Marker Score: 937
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 0.87
    Marker Score: 2,734
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.87
    Marker Score: 776
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.86
    Marker Score: 2,563
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.86
    Marker Score: 813
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 0.86
    Marker Score: 1,537
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.86
    Marker Score: 300
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.86
    Marker Score: 583
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.86
    Marker Score: 309
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 0.86
    Marker Score: 808
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.85
    Marker Score: 566
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 0.85
    Marker Score: 415
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 0.84
    Marker Score: 575
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.84
    Marker Score: 3,316
  • Cell Name: B-1b B cell (CL0000821)
    Fold Change: 0.84
    Marker Score: 194
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.83
    Marker Score: 742
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.83
    Marker Score: 519
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.83
    Marker Score: 267
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.83
    Marker Score: 198
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: 0.83
    Marker Score: 251
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 0.83
    Marker Score: 342
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 0.82
    Marker Score: 1,992
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.82
    Marker Score: 4,836
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.81
    Marker Score: 326
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.81
    Marker Score: 13,061
  • Cell Name: osteoblast (CL0000062)
    Fold Change: 0.81
    Marker Score: 435
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.81
    Marker Score: 813
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 0.81
    Marker Score: 823
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.8
    Marker Score: 1,239
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.8
    Marker Score: 231
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.8
    Marker Score: 899
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.79
    Marker Score: 386
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.79
    Marker Score: 607
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 0.79
    Marker Score: 2,222
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 0.79
    Marker Score: 694
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.79
    Marker Score: 527
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.79
    Marker Score: 5,121
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 0.79
    Marker Score: 856

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** The CNOT8 gene is a member of the CCR4-NOT transcription complex, which is composed of seven subunits, including CNOT8. The CNOT8 subunit is a catalytic component of the complex, responsible for the degradation of mRNA through the action of a 3'-5' exonuclease. The CNOT8 subunit is also involved in the regulation of translation, where it interacts with ribosomal proteins and other factors to control the initiation of translation. The CNOT8 subunit exhibits metal ion binding activity, which is essential for its catalytic function. Additionally, CNOT8 interacts with various proteins, including TP53, to regulate cell cycle genes and apoptosis. **Pathways and Functions** The CNOT8 gene is involved in several cellular pathways, including: 1. **Deadenylation-dependent mRNA decay**: The CNOT8 subunit is a key component of the CCR4-NOT complex, which is responsible for the degradation of mRNA through the action of a 3'-5' exonuclease. 2. **Regulation of translation**: CNOT8 interacts with ribosomal proteins and other factors to control the initiation of translation, modulating protein synthesis in response to changes in cellular conditions. 3. **Cell cycle regulation**: CNOT8 interacts with TP53 to regulate cell cycle genes, influencing cell proliferation and apoptosis. 4. **Apoptosis regulation**: The CNOT8 subunit is involved in the regulation of apoptosis, modulating the expression of pro-apoptotic and anti-apoptotic genes. 5. **Developmental biology**: CNOT8 is involved in the development of specific cell types, including pulmonary interstitial fibroblasts and cerebral cortex endothelial cells. **Clinical Significance** Dysregulation of the CNOT8 gene has been implicated in various diseases, including: 1. **Cancer**: Overexpression of CNOT8 has been observed in certain types of cancer, including leukemia and lymphoma, where it contributes to oncogenesis by promoting cell proliferation and inhibiting apoptosis. 2. **Neurodegenerative diseases**: Mutations in the CNOT8 gene have been associated with neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease, where it contributes to the degradation of mRNA and the regulation of translation. 3. **Immune disorders**: Dysregulation of CNOT8 has been implicated in immune disorders, including autoimmune diseases and immunodeficiency disorders, where it influences the regulation of translation and the function of immune cells. In conclusion, the CNOT8 gene plays a critical role in the regulation of gene expression, particularly in the decay of mRNA and the regulation of translation. Its dysregulation has been implicated in various diseases, highlighting the importance of this gene in maintaining cellular homeostasis and preventing disease.

Genular Protein ID: 1286431993

Symbol: CNOT8_HUMAN

Name: CCR4-NOT transcription complex subunit 8

UniProtKB Accession Codes:

Q9UFF9 B0AZS3 B2RAR8 B7Z8R1 D3DQI8 O95709 Q7Z521 Q9H6Y1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CORUM 1 CTD 1 ChEBI 5 ChiTaRS 1 ComplexPortal 2 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EC 2 EMBL 18 EPD 1 Ensembl 8 ExpressionAtlas 1 GO 14 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 3 RefSeq 22 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10036195

Title: The human POP2 gene: identification, sequencing, and mapping to the critical region of the 5q- syndrome.

PubMed ID: 10036195

DOI: 10.1006/geno.1998.5687

PubMed ID: 10637334

Title: Isolation and characterization of human orthologs of yeast CCR4-NOT complex subunits.

PubMed ID: 10637334

DOI: 10.1093/nar/28.3.809

PubMed ID: 11230166

Title: Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.

PubMed ID: 11230166

DOI: 10.1101/gr.gr1547r

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11136725

Title: Relationships of the antiproliferative proteins BTG1 and BTG2 with CAF1, the human homolog of a component of the yeast CCR4 transcriptional complex: involvement in estrogen receptor alpha signaling pathway.

PubMed ID: 11136725

DOI: 10.1074/jbc.m008201200

PubMed ID: 12771185

Title: BTG2 antiproliferative protein interacts with the human CCR4 complex existing in vivo in three cell-cycle-regulated forms.

PubMed ID: 12771185

DOI: 10.1242/jcs.00480

PubMed ID: 15769875

Title: Conservation of the deadenylase activity of proteins of the Caf1 family in human.

PubMed ID: 15769875

DOI: 10.1261/rna.7135305

PubMed ID: 19558367

Title: Human Ccr4-Not complexes contain variable deadenylase subunits.

PubMed ID: 19558367

DOI: 10.1042/bj20090500

PubMed ID: 19605561

Title: The Ccr4-NOT deadenylase subunits CNOT7 and CNOT8 have overlapping roles and modulate cell proliferation.

PubMed ID: 19605561

DOI: 10.1091/mbc.e09-02-0146

PubMed ID: 20065043

Title: CCR4-NOT deadenylates mRNA associated with complexes in human cells.

PubMed ID: 20065043

DOI: 10.1128/mcb.01481-09

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23236473

Title: The anti-proliferative activity of BTG/TOB proteins is mediated via the Caf1a (CNOT7) and Caf1b (CNOT8) deadenylase subunits of the Ccr4-not complex.

PubMed ID: 23236473

DOI: 10.1371/journal.pone.0051331

Sequence Information:

  • Length: 292
  • Mass: 33540
  • Checksum: 81027A966E51AFDB
  • Sequence:
    • MPAALVENSQ VICEVWASNL EEEMRKIREI VLSYSYIAMD TEFPGVVVRP IGEFRSSIDY 
QYQLLRCNVD LLKIIQLGLT FTNEKGEYPS GINTWQFNFK FNLTEDMYSQ DSIDLLANSG 
LQFQKHEEEG IDTLHFAELL MTSGVVLCDN VKWLSFHSGY DFGYMVKLLT DSRLPEEEHE 
FFHILNLFFP SIYDVKYLMK SCKNLKGGLQ EVADQLDLQR IGRQHQAGSD SLLTGMAFFR 
MKELFFEDSI DDAKYCGRLY GLGTGVAQKQ NEDVDSAQEK MSILAIINNM QQ

Genular Protein ID: 1259304596

Symbol: B7Z9U0_HUMAN

Name: N/A

UniProtKB Accession Codes:

B7Z9U0

Database IDs:

Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 3 EPD 1 Ensembl 2 GO 3 Gene3D 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 InterPro 3 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 Proteomes 2 ProteomicsDB 1 RefSeq 2 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

Sequence Information:

  • Length: 128
  • Mass: 14656
  • Checksum: 17A1511AD2B7921B
  • Sequence:
    • MVKLLTDSRL PEEEHEFFHI LNLFFPSIYD VKYLMKSCKN LKGGLQEVAD QLDLQRIGRQ 
HQAGSDSLLT GMAFFRMKEL FFEDSIDDAK YCGRLYGLGT GVAQKQNEDV DSAQEKMSIL 
AIINNMQQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.