SLIT2 | ENSG00000145147 | NCBI 9353

Details for: SLIT2

Gene ID: 9353

Symbol: SLIT2

Ensembl ID: ENSG00000145147

Description: slit guidance ligand 2

Associated with

Activation of rac1
(R-HSA-428540)
Developmental biology
(R-HSA-1266738)
Formation of the ureteric bud
(R-HSA-9830674)
Inactivation of cdc42 and rac1
(R-HSA-428543)
Kidney development
(R-HSA-9830369)
Nervous system development
(R-HSA-9675108)
Netrin-1 signaling
(R-HSA-373752)
Regulation of commissural axon pathfinding by slit and robo
(R-HSA-428542)
Regulation of expression of slits and robos
(R-HSA-9010553)
Role of abl in robo-slit signaling
(R-HSA-428890)
Signaling by robo receptors
(R-HSA-376176)
Slit2:robo1 increases rhoa activity
(R-HSA-8985586)
Aortic valve morphogenesis
(GO:0003180)
Apoptotic process involved in luteolysis
(GO:0061364)
Axon extension involved in axon guidance
(GO:0048846)
Axon guidance
(GO:0007411)
Branching morphogenesis of an epithelial tube
(GO:0048754)
Calcium ion binding
(GO:0005509)
Cell migration involved in sprouting angiogenesis
(GO:0002042)
Cellular response to heparin
(GO:0071504)
Cellular response to hormone stimulus
(GO:0032870)
Chemorepulsion involved in embryonic olfactory bulb interneuron precursor migration
(GO:0021834)
Chemorepulsion involved in postnatal olfactory bulb interneuron migration
(GO:0021836)
Corticospinal neuron axon guidance through spinal cord
(GO:0021972)
Cytoplasm
(GO:0005737)
Extracellular exosome
(GO:0070062)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Gtpase inhibitor activity
(GO:0005095)
Heparin binding
(GO:0008201)
Identical protein binding
(GO:0042802)
Induction of negative chemotaxis
(GO:0050929)
Laminin-1 binding
(GO:0043237)
Membrane
(GO:0016020)
Motor neuron axon guidance
(GO:0008045)
Negative chemotaxis
(GO:0050919)
Negative regulation of actin filament polymerization
(GO:0030837)
Negative regulation of cell growth
(GO:0030308)
Negative regulation of cell migration
(GO:0030336)
Negative regulation of cellular response to growth factor stimulus
(GO:0090288)
Negative regulation of chemokine-mediated signaling pathway
(GO:0070100)
Negative regulation of endothelial cell migration
(GO:0010596)
Negative regulation of lamellipodium assembly
(GO:0010593)
Negative regulation of leukocyte chemotaxis
(GO:0002689)
Negative regulation of monocyte chemotaxis
(GO:0090027)
Negative regulation of mononuclear cell migration
(GO:0071676)
Negative regulation of neutrophil chemotaxis
(GO:0090024)
Negative regulation of protein phosphorylation
(GO:0001933)
Negative regulation of retinal ganglion cell axon guidance
(GO:0090260)
Negative regulation of small gtpase mediated signal transduction
(GO:0051058)
Negative regulation of smooth muscle cell chemotaxis
(GO:0071672)
Negative regulation of smooth muscle cell migration
(GO:0014912)
Negative regulation of vascular permeability
(GO:0043116)
Positive regulation of apoptotic process
(GO:0043065)
Positive regulation of axonogenesis
(GO:0050772)
Protein binding
(GO:0005515)
Protein homodimerization activity
(GO:0042803)
Proteoglycan binding
(GO:0043394)
Pulmonary valve morphogenesis
(GO:0003184)
Response to cortisol
(GO:0051414)
Retinal ganglion cell axon guidance
(GO:0031290)
Roundabout binding
(GO:0048495)
Roundabout signaling pathway
(GO:0035385)
Ureteric bud development
(GO:0001657)
Ventricular septum morphogenesis
(GO:0060412)

Other Information

Proteins

Slit homolog 2 protein

Genular Protein ID: 2489001890

Symbol: SLIT2_HUMAN

Name: Slit homolog 2 protein

UniProtKB Accession Codes:

O94813 A0A0A6YYB8 B7ZLR5 O95710 Q17RU3 Q9Y5Q7

Database IDs:

Citations:

PubMed ID: 9813312

Title: Cloning and expressions of three mammalian homologues of Drosophila slit suggest possible roles for Slit in the formation and maintenance of the nervous system.

PubMed ID: 9813312

DOI: 10.1016/s0169-328x(98)00224-1

PubMed ID: 10349621

Title: Distinct but overlapping expression patterns of two vertebrate slit homologs implies functional roles in CNS development and organogenesis.

PubMed ID: 10349621

DOI: 10.1016/s0925-4773(98)00174-9

PubMed ID: 10102268

Title: Slit proteins bind Robo receptors and have an evolutionarily conserved role in repulsive axon guidance.

PubMed ID: 10102268

DOI: 10.1016/s0092-8674(00)80590-5

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10975526

Title: Squeezing axons out of the gray matter: a role for slit and semaphorin proteins from midline and ventral spinal cord.

PubMed ID: 10975526

DOI: 10.1016/s0092-8674(00)00041-6

PubMed ID: 10864954

Title: Slit2 is a repellent for retinal ganglion cell axons.

PubMed ID: 10864954

DOI: 10.1523/jneurosci.20-13-04962.2000

PubMed ID: 11309622

Title: The neuronal repellent Slit inhibits leukocyte chemotaxis induced by chemotactic factors.

PubMed ID: 11309622

DOI: 10.1038/35073616

PubMed ID: 11222645

Title: The N-terminal leucine-rich regions in Slit are sufficient to repel olfactory bulb axons and subventricular zone neurons.

PubMed ID: 11222645

DOI: 10.1523/jneurosci.21-05-01548.2001

PubMed ID: 11404413

Title: Diversity and specificity of actions of Slit2 proteolytic fragments in axon guidance.

PubMed ID: 11404413

DOI: 10.1523/jneurosci.21-12-04281.2001

PubMed ID: 11239147

Title: Hierarchical organization of guidance receptors: silencing of netrin attraction by slit through a Robo/DCC receptor complex.

PubMed ID: 11239147

DOI: 10.1126/science.1058445

PubMed ID: 12200164

Title: Slit proteins: molecular guidance cues for cells ranging from neurons to leukocytes.

PubMed ID: 12200164

DOI: 10.1016/s0959-437x(02)00343-x

PubMed ID: 17704564

Title: Production of Slit2 LRR domains in mammalian cells for structural studies and the structure of human Slit2 domain 3.

PubMed ID: 17704564

DOI: 10.1107/s0907444907035470

PubMed ID: 17848514

Title: Structural insights into the Slit-Robo complex.

PubMed ID: 17848514

DOI: 10.1073/pnas.0705310104

PubMed ID: 19498462

Title: Structure and functional relevance of the Slit2 homodimerization domain.

PubMed ID: 19498462

DOI: 10.1038/embor.2009.95

Sequence Information:

Length: 1529
Mass: 169870
Checksum: 5D19CC5E7FD461BA
Sequence:

MRGVGWQMLS LSLGLVLAIL NKVAPQACPA QCSCSGSTVD CHGLALRSVP RNIPRNTERL 
DLNGNNITRI TKTDFAGLRH LRVLQLMENK ISTIERGAFQ DLKELERLRL NRNHLQLFPE 
LLFLGTAKLY RLDLSENQIQ AIPRKAFRGA VDIKNLQLDY NQISCIEDGA FRALRDLEVL 
TLNNNNITRL SVASFNHMPK LRTFRLHSNN LYCDCHLAWL SDWLRQRPRV GLYTQCMGPS 
HLRGHNVAEV QKREFVCSGH QSFMAPSCSV LHCPAACTCS NNIVDCRGKG LTEIPTNLPE 
TITEIRLEQN TIKVIPPGAF SPYKKLRRID LSNNQISELA PDAFQGLRSL NSLVLYGNKI 
TELPKSLFEG LFSLQLLLLN ANKINCLRVD AFQDLHNLNL LSLYDNKLQT IAKGTFSPLR 
AIQTMHLAQN PFICDCHLKW LADYLHTNPI ETSGARCTSP RRLANKRIGQ IKSKKFRCSA 
KEQYFIPGTE DYRSKLSGDC FADLACPEKC RCEGTTVDCS NQKLNKIPEH IPQYTAELRL 
NNNEFTVLEA TGIFKKLPQL RKINFSNNKI TDIEEGAFEG ASGVNEILLT SNRLENVQHK 
MFKGLESLKT LMLRSNRITC VGNDSFIGLS SVRLLSLYDN QITTVAPGAF DTLHSLSTLN 
LLANPFNCNC YLAWLGEWLR KKRIVTGNPR CQKPYFLKEI PIQDVAIQDF TCDDGNDDNS 
CSPLSRCPTE CTCLDTVVRC SNKGLKVLPK GIPRDVTELY LDGNQFTLVP KELSNYKHLT 
LIDLSNNRIS TLSNQSFSNM TQLLTLILSY NRLRCIPPRT FDGLKSLRLL SLHGNDISVV 
PEGAFNDLSA LSHLAIGANP LYCDCNMQWL SDWVKSEYKE PGIARCAGPG EMADKLLLTT 
PSKKFTCQGP VDVNILAKCN PCLSNPCKND GTCNSDPVDF YRCTCPYGFK GQDCDVPIHA 
CISNPCKHGG TCHLKEGEED GFWCICADGF EGENCEVNVD DCEDNDCENN STCVDGINNY 
TCLCPPEYTG ELCEEKLDFC AQDLNPCQHD SKCILTPKGF KCDCTPGYVG EHCDIDFDDC 
QDNKCKNGAH CTDAVNGYTC ICPEGYSGLF CEFSPPMVLP RTSPCDNFDC QNGAQCIVRI 
NEPICQCLPG YQGEKCEKLV SVNFINKESY LQIPSAKVRP QTNITLQIAT DEDSGILLYK 
GDKDHIAVEL YRGRVRASYD TGSHPASAIY SVETINDGNF HIVELLALDQ SLSLSVDGGN 
PKIITNLSKQ STLNFDSPLY VGGMPGKSNV ASLRQAPGQN GTSFHGCIRN LYINSELQDF 
QKVPMQTGIL PGCEPCHKKV CAHGTCQPSS QAGFTCECQE GWMGPLCDQR TNDPCLGNKC 
VHGTCLPINA FSYSCKCLEG HGGVLCDEEE DLFNPCQAIK CKHGKCRLSG LGQPYCECSS 
GYTGDSCDRE ISCRGERIRD YYQKQQGYAA CQTTKKVSRL ECRGGCAGGQ CCGPLRSKRR 
KYSFECTDGS SFVDEVEKVV KCGCTRCVS

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: SLIT2

Associated with

Other Information

Cloning and expressions of three mammalian homologues of Drosophila slit suggest possible roles for Slit in the formation and maintenance of the nervous system. PubMed ID: 9813312

Distinct but overlapping expression patterns of two vertebrate slit homologs implies functional roles in CNS development and organogenesis. PubMed ID: 10349621

Slit proteins bind Robo receptors and have an evolutionarily conserved role in repulsive axon guidance. PubMed ID: 10102268

Generation and annotation of the DNA sequences of human chromosomes 2 and 4. PubMed ID: 15815621

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Squeezing axons out of the gray matter: a role for slit and semaphorin proteins from midline and ventral spinal cord. PubMed ID: 10975526

Slit2 is a repellent for retinal ganglion cell axons. PubMed ID: 10864954

The neuronal repellent Slit inhibits leukocyte chemotaxis induced by chemotactic factors. PubMed ID: 11309622

The N-terminal leucine-rich regions in Slit are sufficient to repel olfactory bulb axons and subventricular zone neurons. PubMed ID: 11222645

Diversity and specificity of actions of Slit2 proteolytic fragments in axon guidance. PubMed ID: 11404413

Hierarchical organization of guidance receptors: silencing of netrin attraction by slit through a Robo/DCC receptor complex. PubMed ID: 11239147

Slit proteins: molecular guidance cues for cells ranging from neurons to leukocytes. PubMed ID: 12200164

Production of Slit2 LRR domains in mammalian cells for structural studies and the structure of human Slit2 domain 3. PubMed ID: 17704564

Structural insights into the Slit-Robo complex. PubMed ID: 17848514

Structure and functional relevance of the Slit2 homodimerization domain. PubMed ID: 19498462