KL | ENSG00000133116 | NCBI 9365

Details for: KL

Gene ID: 9365

Symbol: KL

Ensembl ID: ENSG00000133116

Description: klotho

Associated with

Constitutive signaling by aberrant pi3k in cancer
(R-HSA-2219530)
Disease
(R-HSA-1643685)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Downstream signaling of activated fgfr1
(R-HSA-5654687)
Fgfr1 ligand binding and activation
(R-HSA-190242)
Fgfr1c and klotho ligand binding and activation
(R-HSA-190374)
Frs-mediated fgfr1 signaling
(R-HSA-5654693)
Igf1r signaling cascade
(R-HSA-2428924)
Insulin receptor signalling cascade
(R-HSA-74751)
Intracellular signaling by second messengers
(R-HSA-9006925)
Irs-mediated signalling
(R-HSA-112399)
Irs-related events triggered by igf1r
(R-HSA-2428928)
Mapk1/mapk3 signaling
(R-HSA-5684996)
Mapk family signaling cascades
(R-HSA-5683057)
Negative regulation of fgfr1 signaling
(R-HSA-5654726)
Negative regulation of the pi3k/akt network
(R-HSA-199418)
Phospholipase c-mediated cascade: fgfr1
(R-HSA-5654219)
Pi-3k cascade:fgfr1
(R-HSA-5654689)
Pi3k/akt signaling in cancer
(R-HSA-2219528)
Pi3k cascade
(R-HSA-109704)
Pi5p, pp2a and ier3 regulate pi3k/akt signaling
(R-HSA-6811558)
Pip3 activates akt signaling
(R-HSA-1257604)
Raf/map kinase cascade
(R-HSA-5673001)
Shc-mediated cascade:fgfr1
(R-HSA-5654688)
Signaling by fgfr
(R-HSA-190236)
Signaling by fgfr1
(R-HSA-5654736)
Signaling by insulin receptor
(R-HSA-74752)
Signaling by receptor tyrosine kinases
(R-HSA-9006934)
Signaling by type 1 insulin-like growth factor 1 receptor (igf1r)
(R-HSA-2404192)
Signal transduction
(R-HSA-162582)
Apical plasma membrane
(GO:0016324)
Beta-glucosidase activity
(GO:0008422)
Beta-glucuronidase activity
(GO:0004566)
Calcium ion homeostasis
(GO:0055074)
Carbohydrate metabolic process
(GO:0005975)
Determination of adult lifespan
(GO:0008340)
Energy reserve metabolic process
(GO:0006112)
Extracellular exosome
(GO:0070062)
Extracellular region
(GO:0005576)
Fibroblast growth factor binding
(GO:0017134)
Fibroblast growth factor receptor binding
(GO:0005104)
Fibroblast growth factor receptor signaling pathway
(GO:0008543)
Hormone activity
(GO:0005179)
Negative regulation of systemic arterial blood pressure
(GO:0003085)
Norepinephrine biosynthetic process
(GO:0042421)
Plasma membrane
(GO:0005886)
Positive regulation of bone mineralization
(GO:0030501)
Positive regulation of mapkkk cascade by fibroblast growth factor receptor signaling pathway
(GO:0090080)
Response to activity
(GO:0014823)
Response to angiotensin
(GO:1990776)
Response to vitamin d
(GO:0033280)
Vitamin d binding
(GO:0005499)

Other Information

Proteins

Klotho

Genular Protein ID: 826003125

Symbol: KLOT_HUMAN

Name: Klotho

UniProtKB Accession Codes:

Q9UEF7 Q5VZ95 Q96KV5 Q96KW5 Q9UEI9 Q9Y4F0

Database IDs:

Citations:

PubMed ID: 9363890

Title: Mutation of the mouse klotho gene leads to a syndrome resembling ageing.

PubMed ID: 9363890

DOI: 10.1038/36285

PubMed ID: 9464267

Title: Identification of the human klotho gene and its two transcripts encoding membrane and secreted klotho protein.

PubMed ID: 9464267

DOI: 10.1006/bbrc.1997.8019

PubMed ID: 15057823

Title: The DNA sequence and analysis of human chromosome 13.

PubMed ID: 15057823

DOI: 10.1038/nature02379

PubMed ID: 10631108

Title: Establishment of the anti-Klotho monoclonal antibodies and detection of Klotho protein in kidneys.

PubMed ID: 10631108

DOI: 10.1006/bbrc.1999.2009

PubMed ID: 11043382

Title: Molecular cloning and expression of a novel klotho-related protein.

PubMed ID: 11043382

DOI: 10.1007/s001090000131

PubMed ID: 11162628

Title: Severely reduced production of klotho in human chronic renal failure kidney.

PubMed ID: 11162628

DOI: 10.1006/bbrc.2000.4226

PubMed ID: 15135068

Title: Secreted Klotho protein in sera and CSF: implication for post-translational cleavage in release of Klotho protein from cell membrane.

PubMed ID: 15135068

DOI: 10.1016/j.febslet.2004.03.090

PubMed ID: 11792841

Title: Association of human aging with a functional variant of klotho.

PubMed ID: 11792841

DOI: 10.1073/pnas.022484299

PubMed ID: 15677572

Title: Association between a functional variant of the KLOTHO gene and high-density lipoprotein cholesterol, blood pressure, stroke, and longevity.

PubMed ID: 15677572

DOI: 10.1161/01.res.0000157171.04054.30

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

PubMed ID: 17710231

Title: A homozygous missense mutation in human KLOTHO causes severe tumoral calcinosis.

PubMed ID: 17710231

DOI: 10.1172/jci31330

Sequence Information:

Length: 1012
Mass: 116181
Checksum: 62031BD73E322E63
Sequence:

MPASAPPRRP RPPPPSLSLL LVLLGLGGRR LRAEPGDGAQ TWARFSRPPA PEAAGLFQGT 
FPDGFLWAVG SAAYQTEGGW QQHGKGASIW DTFTHHPLAP PGDSRNASLP LGAPSPLQPA 
TGDVASDSYN NVFRDTEALR ELGVTHYRFS ISWARVLPNG SAGVPNREGL RYYRRLLERL 
RELGVQPVVT LYHWDLPQRL QDAYGGWANR ALADHFRDYA ELCFRHFGGQ VKYWITIDNP 
YVVAWHGYAT GRLAPGIRGS PRLGYLVAHN LLLAHAKVWH LYNTSFRPTQ GGQVSIALSS 
HWINPRRMTD HSIKECQKSL DFVLGWFAKP VFIDGDYPES MKNNLSSILP DFTESEKKFI 
KGTADFFALC FGPTLSFQLL DPHMKFRQLE SPNLRQLLSW IDLEFNHPQI FIVENGWFVS 
GTTKRDDAKY MYYLKKFIME TLKAIKLDGV DVIGYTAWSL MDGFEWHRGY SIRRGLFYVD 
FLSQDKMLLP KSSALFYQKL IEKNGFPPLP ENQPLEGTFP CDFAWGVVDN YIQVDTTLSQ 
FTDLNVYLWD VHHSKRLIKV DGVVTKKRKS YCVDFAAIQP QIALLQEMHV THFRFSLDWA 
LILPLGNQSQ VNHTILQYYR CMASELVRVN ITPVVALWQP MAPNQGLPRL LARQGAWENP 
YTALAFAEYA RLCFQELGHH VKLWITMNEP YTRNMTYSAG HNLLKAHALA WHVYNEKFRH 
AQNGKISIAL QADWIEPACP FSQKDKEVAE RVLEFDIGWL AEPIFGSGDY PWVMRDWLNQ 
RNNFLLPYFT EDEKKLIQGT FDFLALSHYT TILVDSEKED PIKYNDYLEV QEMTDITWLN 
SPSQVAVVPW GLRKVLNWLK FKYGDLPMYI ISNGIDDGLH AEDDQLRVYY MQNYINEALK 
AHILDGINLC GYFAYSFNDR TAPRFGLYRY AADQFEPKAS MKHYRKIIDS NGFPGPETLE 
RFCPEEFTVC TECSFFHTRK SLLAFIAFLF FASIISLSLI FYYSKKGRRS YK

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: KL

Associated with

Other Information

Mutation of the mouse klotho gene leads to a syndrome resembling ageing. PubMed ID: 9363890

Identification of the human klotho gene and its two transcripts encoding membrane and secreted klotho protein. PubMed ID: 9464267

The DNA sequence and analysis of human chromosome 13. PubMed ID: 15057823

Establishment of the anti-Klotho monoclonal antibodies and detection of Klotho protein in kidneys. PubMed ID: 10631108

Molecular cloning and expression of a novel klotho-related protein. PubMed ID: 11043382

Severely reduced production of klotho in human chronic renal failure kidney. PubMed ID: 11162628

Secreted Klotho protein in sera and CSF: implication for post-translational cleavage in release of Klotho protein from cell membrane. PubMed ID: 15135068

Association of human aging with a functional variant of klotho. PubMed ID: 11792841

Association between a functional variant of the KLOTHO gene and high-density lipoprotein cholesterol, blood pressure, stroke, and longevity. PubMed ID: 15677572

The consensus coding sequences of human breast and colorectal cancers. PubMed ID: 16959974

A homozygous missense mutation in human KLOTHO causes severe tumoral calcinosis. PubMed ID: 17710231