Details for: NHERF1

Gene ID: 9368

Symbol: NHERF1

Ensembl ID: ENSG00000109062

Description: NHERF family PDZ scaffold protein 1

Associated with

Other Information

Genular Protein ID: 3805701671

Symbol: NHRF1_HUMAN

Name: Ezrin-radixin-moesin-binding phosphoprotein 50

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 9314537

Title: Identification of EBP50: a PDZ-containing phosphoprotein that associates with members of the ezrin-radixin-moesin family.

PubMed ID: 9314537

DOI: 10.1083/jcb.139.1.169

PubMed ID: 9430655

Title: NHE-RF, a regulatory cofactor for Na(+)-H+ exchange, is a common interactor for merlin and ERM (MERM) proteins.

PubMed ID: 9430655

DOI: 10.1074/jbc.273.3.1273

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12665801

Title: Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.

PubMed ID: 12665801

DOI: 10.1038/nbt810

PubMed ID: 9096337

Title: cAMP-mediated inhibition of the epithelial brush border Na+/H+ exchanger, NHE3, requires an associated regulatory protein.

PubMed ID: 9096337

DOI: 10.1073/pnas.94.7.3010

PubMed ID: 10499588

Title: A kinase-regulated PDZ-domain interaction controls endocytic sorting of the beta2-adrenergic receptor.

PubMed ID: 10499588

DOI: 10.1038/45816

PubMed ID: 11684085

Title: Interaction between two adapter proteins, PAG and EBP50: a possible link between membrane rafts and actin cytoskeleton.

PubMed ID: 11684085

DOI: 10.1016/s0014-5793(01)02955-6

PubMed ID: 11285285

Title: Identification of EPI64, a TBC/rabGAP domain-containing microvillar protein that binds to the first PDZ domain of EBP50 and E3KARP.

PubMed ID: 11285285

DOI: 10.1083/jcb.153.1.191

PubMed ID: 11956211

Title: Protein kinase C epsilon-dependent regulation of cystic fibrosis transmembrane regulator involves binding to a receptor for activated C kinase (RACK1) and RACK1 binding to Na+/H+ exchange regulatory factor.

PubMed ID: 11956211

DOI: 10.1074/jbc.m201917200

PubMed ID: 12004055

Title: Ezrin-radixin-moesin-binding phosphoprotein-50/Na+/H+ exchanger regulatory factor (EBP50/NHERF) blocks U50,488H-induced down-regulation of the human kappa opioid receptor by enhancing its recycling rate.

PubMed ID: 12004055

DOI: 10.1074/jbc.m200058200

PubMed ID: 12080081

Title: Epithelial inducible nitric-oxide synthase is an apical EBP50-binding protein that directs vectorial nitric oxide output.

PubMed ID: 12080081

DOI: 10.1074/jbc.m205764200

PubMed ID: 12193606

Title: Regulation of GTP-binding protein alpha q (Galpha q) signaling by the ezrin-radixin-moesin-binding phosphoprotein-50 (EBP50).

PubMed ID: 12193606

DOI: 10.1074/jbc.m207910200

PubMed ID: 12403779

Title: The cystic fibrosis transmembrane conductance regulator interacts with and regulates the activity of the HCO3- salvage transporter human Na+-HCO3-cotransport isoform 3.

PubMed ID: 12403779

DOI: 10.1074/jbc.m201862200

PubMed ID: 12154080

Title: The PDZ-interacting domain of TRPC4 controls its localization and surface expression in HEK293 cells.

PubMed ID: 12154080

DOI: 10.1242/jcs.115.17.3497

PubMed ID: 12145337

Title: Estrogen receptor inducibility of the human Na+/H+ exchanger regulatory factor/ezrin-radixin-moesin binding protein 50 (NHE-RF/EBP50) gene involving multiple half-estrogen response elements.

PubMed ID: 12145337

DOI: 10.1210/me.2001-0290

PubMed ID: 12444018

Title: The COOH termini of NBC3 and the 56-kDa H+-ATPase subunit are PDZ motifs involved in their interaction.

PubMed ID: 12444018

DOI: 10.1152/ajpcell.00225.2002

PubMed ID: 12444019

Title: Isoforms of SLC26A6 mediate anion transport and have functional PDZ interaction domains.

PubMed ID: 12444019

DOI: 10.1152/ajpcell.00270.2002

PubMed ID: 12830000

Title: EBP50, a beta-catenin-associating protein, enhances Wnt signaling and is over-expressed in hepatocellular carcinoma.

PubMed ID: 12830000

DOI: 10.1053/jhep.2003.50270

PubMed ID: 12471024

Title: The PDZ-binding chloride channel ClC-3B localizes to the Golgi and associates with cystic fibrosis transmembrane conductance regulator-interacting PDZ proteins.

PubMed ID: 12471024

DOI: 10.1074/jbc.m211050200

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 17924679

Title: Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra.

PubMed ID: 17924679

DOI: 10.1021/pr070152u

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 19367720

Title: Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment.

PubMed ID: 19367720

DOI: 10.1021/pr800500r

PubMed ID: 18088087

Title: Phosphoproteome of resting human platelets.

PubMed ID: 18088087

DOI: 10.1021/pr0704130

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19555689

Title: MCC, a new interacting protein for Scrib, is required for cell migration in epithelial cells.

PubMed ID: 19555689

DOI: 10.1016/j.febslet.2009.06.034

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 22506049

Title: A new human NHERF1 mutation decreases renal phosphate transporter NPT2a expression by a PTH-independent mechanism.

PubMed ID: 22506049

DOI: 10.1371/journal.pone.0034764

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 34189428

Title: ACE2 interaction with cytoplasmic PDZ protein enhances SARS-CoV-2 invasion.

PubMed ID: 34189428

DOI: 10.1016/j.isci.2021.102770

PubMed ID: 11304524

Title: Structural basis of the Na+/H+ exchanger regulatory factor PDZ1 interaction with the carboxyl-terminal region of the cystic fibrosis transmembrane conductance regulator.

PubMed ID: 11304524

DOI: 10.1074/jbc.c100154200

PubMed ID: 11352585

Title: Crystal structure of the PDZ1 domain of human Na(+)/H(+) exchanger regulatory factor provides insights into the mechanism of carboxyl-terminal leucine recognition by class I PDZ domains.

PubMed ID: 11352585

DOI: 10.1006/jmbi.2001.4634

PubMed ID: 11882663

Title: Structural determinants of the Na+/H+ exchanger regulatory factor interaction with the beta 2 adrenergic and platelet-derived growth factor receptors.

PubMed ID: 11882663

DOI: 10.1074/jbc.m201507200

PubMed ID: 15020681

Title: The EBP50-moesin interaction involves a binding site regulated by direct masking on the FERM domain.

PubMed ID: 15020681

DOI: 10.1242/jcs.01038

PubMed ID: 16615918

Title: Structural basis for NHERF recognition by ERM proteins.

PubMed ID: 16615918

DOI: 10.1016/j.str.2006.01.015

PubMed ID: 18784102

Title: NHERF1 mutations and responsiveness of renal parathyroid hormone.

PubMed ID: 18784102

DOI: 10.1056/nejmoa0802836

Sequence Information:

  • Length: 358
  • Mass: 38868
  • Checksum: E33AF87016D37A65
  • Sequence:
  • MSADAAAGAP LPRLCCLEKG PNGYGFHLHG EKGKLGQYIR LVEPGSPAEK AGLLAGDRLV 
    EVNGENVEKE THQQVVSRIR AALNAVRLLV VDPETDEQLQ KLGVQVREEL LRAQEAPGQA 
    EPPAAAEVQG AGNENEPREA DKSHPEQREL RPRLCTMKKG PSGYGFNLHS DKSKPGQFIR 
    SVDPDSPAEA SGLRAQDRIV EVNGVCMEGK QHGDVVSAIR AGGDETKLLV VDRETDEFFK 
    KCRVIPSQEH LNGPLPVPFT NGEIQKENSR EALAEAALES PRPALVRSAS SDTSEELNSQ 
    DSPPKQDSTA PSSTSSSDPI LDFNISLAMA KERAHQKRSS KRAPQMDWSK KNELFSNL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.