Details for: ADIPOQ

Gene ID: 9370

Symbol: ADIPOQ

Ensembl ID: ENSG00000181092

Description: adiponectin, C1Q and collagen domain containing

Associated with

  • Ampk inhibits chrebp transcriptional activation activity
    (R-HSA-163680)
  • Developmental biology
    (R-HSA-1266738)
  • Integration of energy metabolism
    (R-HSA-163685)
  • Metabolism
    (R-HSA-1430728)
  • Transcriptional regulation of white adipocyte differentiation
    (R-HSA-381340)
  • Brown fat cell differentiation
    (GO:0050873)
  • Cell surface
    (GO:0009986)
  • Cellular response to camp
    (GO:0071320)
  • Cellular response to epinephrine stimulus
    (GO:0071872)
  • Cellular response to insulin stimulus
    (GO:0032869)
  • Cellular response to xenobiotic stimulus
    (GO:0071466)
  • Circadian rhythm
    (GO:0007623)
  • Collagen-containing extracellular matrix
    (GO:0062023)
  • Collagen trimer
    (GO:0005581)
  • Cytokine activity
    (GO:0005125)
  • Detection of oxidative stress
    (GO:0070994)
  • Endoplasmic reticulum
    (GO:0005783)
  • Extracellular matrix structural constituent
    (GO:0005201)
  • Extracellular region
    (GO:0005576)
  • Extracellular space
    (GO:0005615)
  • Fatty acid beta-oxidation
    (GO:0006635)
  • Fatty acid oxidation
    (GO:0019395)
  • Gene expression
    (GO:0010467)
  • Generation of precursor metabolites and energy
    (GO:0006091)
  • Glucose homeostasis
    (GO:0042593)
  • Glucose metabolic process
    (GO:0006006)
  • Hormone activity
    (GO:0005179)
  • Low-density lipoprotein particle clearance
    (GO:0034383)
  • Negative regulation of blood pressure
    (GO:0045776)
  • Negative regulation of canonical nf-kappab signal transduction
    (GO:0043124)
  • Negative regulation of cell migration
    (GO:0030336)
  • Negative regulation of cold-induced thermogenesis
    (GO:0120163)
  • Negative regulation of dna-templated transcription
    (GO:0045892)
  • Negative regulation of dna biosynthetic process
    (GO:2000279)
  • Negative regulation of erk1 and erk2 cascade
    (GO:0070373)
  • Negative regulation of fat cell differentiation
    (GO:0045599)
  • Negative regulation of gluconeogenesis
    (GO:0045721)
  • Negative regulation of granulocyte differentiation
    (GO:0030853)
  • Negative regulation of heterotypic cell-cell adhesion
    (GO:0034115)
  • Negative regulation of hormone secretion
    (GO:0046888)
  • Negative regulation of inflammatory response
    (GO:0050728)
  • Negative regulation of intracellular protein transport
    (GO:0090317)
  • Negative regulation of low-density lipoprotein receptor activity
    (GO:1905598)
  • Negative regulation of macrophage derived foam cell differentiation
    (GO:0010745)
  • Negative regulation of macrophage differentiation
    (GO:0045650)
  • Negative regulation of map kinase activity
    (GO:0043407)
  • Negative regulation of metanephric mesenchymal cell migration
    (GO:2000590)
  • Negative regulation of phagocytosis
    (GO:0050765)
  • Negative regulation of platelet-derived growth factor receptor-alpha signaling pathway
    (GO:2000584)
  • Negative regulation of platelet-derived growth factor receptor signaling pathway
    (GO:0010642)
  • Negative regulation of protein autophosphorylation
    (GO:0031953)
  • Negative regulation of receptor binding
    (GO:1900121)
  • Negative regulation of synaptic transmission
    (GO:0050805)
  • Negative regulation of tumor necrosis factor-mediated signaling pathway
    (GO:0010804)
  • Negative regulation of tumor necrosis factor production
    (GO:0032720)
  • Negative regulation of vascular associated smooth muscle cell migration
    (GO:1904753)
  • Negative regulation of vascular associated smooth muscle cell proliferation
    (GO:1904706)
  • Positive regulation of camp-dependent protein kinase activity
    (GO:2000481)
  • Positive regulation of canonical nf-kappab signal transduction
    (GO:0043123)
  • Positive regulation of cholesterol efflux
    (GO:0010875)
  • Positive regulation of cold-induced thermogenesis
    (GO:0120162)
  • Positive regulation of fatty acid metabolic process
    (GO:0045923)
  • Positive regulation of glucose import
    (GO:0046326)
  • Positive regulation of glycogen (starch) synthase activity
    (GO:2000467)
  • Positive regulation of interleukin-8 production
    (GO:0032757)
  • Positive regulation of lipid transporter activity
    (GO:0110113)
  • Positive regulation of metanephric podocyte development
    (GO:2000478)
  • Positive regulation of monocyte chemotactic protein-1 production
    (GO:0071639)
  • Positive regulation of myeloid cell apoptotic process
    (GO:0033034)
  • Positive regulation of peptidyl-tyrosine phosphorylation
    (GO:0050731)
  • Positive regulation of protein kinase a signaling
    (GO:0010739)
  • Positive regulation of protein phosphorylation
    (GO:0001934)
  • Positive regulation of renal albumin absorption
    (GO:2000534)
  • Positive regulation of signal transduction
    (GO:0009967)
  • Protein binding
    (GO:0005515)
  • Protein homodimerization activity
    (GO:0042803)
  • Protein localization to plasma membrane
    (GO:0072659)
  • Protein serine/threonine kinase activator activity
    (GO:0043539)
  • Regulation of glucose metabolic process
    (GO:0010906)
  • Response to activity
    (GO:0014823)
  • Response to bacterium
    (GO:0009617)
  • Response to ethanol
    (GO:0045471)
  • Response to glucocorticoid
    (GO:0051384)
  • Response to glucose
    (GO:0009749)
  • Response to hypoxia
    (GO:0001666)
  • Response to linoleic acid
    (GO:0070543)
  • Response to nutrient
    (GO:0007584)
  • Response to sucrose
    (GO:0009744)
  • Response to tumor necrosis factor
    (GO:0034612)
  • Sialic acid binding
    (GO:0033691)
  • Signaling receptor binding
    (GO:0005102)
  • Signal transduction
    (GO:0007165)

Other Information

Genular Protein ID: 917839427

Symbol: ADIPO_HUMAN

Name: Adiponectin

UniProtKB Accession Codes:

Q15848 Q58EX9

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CPTAC 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 9 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 84 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 5 PDBsum 3 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 2 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8619847

Title: cDNA cloning and expression of a novel adipose specific collagen-like factor, apM1 (AdiPose Most abundant Gene transcript 1).

PubMed ID: 8619847

DOI: 10.1006/bbrc.1996.0587

PubMed ID: 10095105

Title: Organization of the gene for gelatin-binding protein (GBP28).

PubMed ID: 10095105

DOI: 10.1016/s0378-1119(99)00041-4

PubMed ID: 10403784

Title: The human apM-1, an adipocyte-specific gene linked to the family of TNF's and to genes expressed in activated T cells, is mapped to chromosome 1q21.3-q23, a susceptibility locus identified for familial combined hyperlipidemia (FCH).

PubMed ID: 10403784

DOI: 10.1006/bbrc.1999.0865

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15340161

Title: Signal peptide prediction based on analysis of experimentally verified cleavage sites.

PubMed ID: 15340161

DOI: 10.1110/ps.04682504

PubMed ID: 8947845

Title: Isolation and characterization of GBP28, a novel gelatin-binding protein purified from human plasma.

PubMed ID: 8947845

DOI: 10.1093/oxfordjournals.jbchem.a021483

PubMed ID: 10961870

Title: Adiponectin, a new member of the family of soluble defense collagens, negatively regulates the growth of myelomonocytic progenitors and the functions of macrophages.

PubMed ID: 10961870

PubMed ID: 10982546

Title: Adiponectin, an adipocyte-derived plasma protein, inhibits endothelial NF-kappaB signaling through a cAMP-dependent pathway.

PubMed ID: 10982546

DOI: 10.1161/01.cir.102.11.1296

PubMed ID: 11479627

Title: The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity.

PubMed ID: 11479627

DOI: 10.1038/90984

PubMed ID: 12878598

Title: Impaired multimerization of human adiponectin mutants associated with diabetes. Molecular structure and multimer formation of adiponectin.

PubMed ID: 12878598

DOI: 10.1074/jbc.m300365200

PubMed ID: 16497731

Title: Adiponectin multimerization is dependent on conserved lysines in the collagenous domain: evidence for regulation of multimerization by alterations in posttranslational modifications.

PubMed ID: 16497731

DOI: 10.1210/me.2005-0390

PubMed ID: 19855092

Title: Sialic acid modification of adiponectin is not required for multimerization or secretion but determines half-life in circulation.

PubMed ID: 19855092

DOI: 10.1210/me.2009-0133

PubMed ID: 22905912

Title: Resveratrol-induced changes of the human adipocyte secretion profile.

PubMed ID: 22905912

DOI: 10.1021/pr300539b

PubMed ID: 22449980

Title: Crystal structure of a single-chain trimer of human adiponectin globular domain.

PubMed ID: 22449980

DOI: 10.1016/j.febslet.2012.02.024

PubMed ID: 10918532

Title: Genomic structure and mutations in adipose-specific gene, adiponectin.

PubMed ID: 10918532

DOI: 10.1038/sj.ijo.0801244

PubMed ID: 11812766

Title: Genetic variation in the gene encoding adiponectin is associated with an increased risk of type 2 diabetes in the Japanese population.

PubMed ID: 11812766

DOI: 10.2337/diabetes.51.2.536

PubMed ID: 12086969

Title: Association of adiponectin mutation with type 2 diabetes: a candidate gene for the insulin resistance syndrome.

PubMed ID: 12086969

DOI: 10.2337/diabetes.51.7.2325

PubMed ID: 12354786

Title: Single-nucleotide polymorphism haplotypes in the both proximal promoter and exon 3 of the APM1 gene modulate adipocyte-secreted adiponectin hormone levels and contribute to the genetic risk for type 2 diabetes in French Caucasians.

PubMed ID: 12354786

DOI: 10.1093/hmg/11.21.2607

PubMed ID: 35869090

Title: A dominant negative ADIPOQ mutation in a diabetic family with renal disease, hypoadiponectinemia, and hyperceramidemia.

PubMed ID: 35869090

DOI: 10.1038/s41525-022-00314-z

Sequence Information:

  • Length: 244
  • Mass: 26414
  • Checksum: 64D8C6C1204B1018
  • Sequence:
    • MLLLGAVLLL LALPGHDQET TTQGPGVLLP LPKGACTGWM AGIPGHPGHN GAPGRDGRDG 
TPGEKGEKGD PGLIGPKGDI GETGVPGAEG PRGFPGIQGR KGEPGEGAYV YRSAFSVGLE 
TYVTIPNMPI RFTKIFYNQQ NHYDGSTGKF HCNIPGLYYF AYHITVYMKD VKVSLFKKDK 
AMLFTYDQYQ ENNVDQASGS VLLHLEVGDQ VWLQVYGEGE RNGLYADNDN DSTFTGFLLY 
HDTN

Genular Protein ID: 2811588379

Symbol: B2R773_HUMAN

Name: N/A

UniProtKB Accession Codes:

B2R773

Database IDs:

ARBA 2 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 EMBL 2 GO 1 Gene3D 1 Genevisible 1 GenomeRNAi 1 InterPro 3 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 2 PeptideAtlas 1 Pfam 2 PharmGKB 1 RefSeq 1 SAM 2 SMART 1 SMR 1 SUPFAM 1

Sequence Information:

  • Length: 244
  • Mass: 26426
  • Checksum: 52AFAAD6076B577F
  • Sequence:
    • MLLLGAVLLL LALPGHDQET TTQGPGVLLP LPKGACTGWM AGIPGHPGHN GAPGRDGRDG 
TPGEKGEKGD PGLIGPKGDI GETGVPGAEG PRGFPGIQGR KGEPGEGAYV YRSAFSVGLE 
TYVTIPNMPI RFTKIFYNQQ NHYDGSTGKF HCNIPGLYYF AYHITVYMKD VKVSPFRKDK 
AMLFTYDQYQ ENNVDQASGS VLLHLEVGDQ VWLQVYGEGE RNGLYADNDN DSTFTGFLLY 
HDTN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.