ZFYVE9 | ENSG00000157077 | NCBI 9372

Details for: ZFYVE9

Gene ID: 9372

Symbol: ZFYVE9

Ensembl ID: ENSG00000157077

Description: zinc finger FYVE-type containing 9

Associated with

Disease
(R-HSA-1643685)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Downregulation of tgf-beta receptor signaling
(R-HSA-2173788)
Loss of function of smad2/3 in cancer
(R-HSA-3304349)
Loss of function of tgfbr1 in cancer
(R-HSA-3656534)
Signaling by tgf-beta receptor complex
(R-HSA-170834)
Signaling by tgf-beta receptor complex in cancer
(R-HSA-3304351)
Signaling by tgfb family members
(R-HSA-9006936)
Signal transduction
(R-HSA-162582)
Smad2/3 phosphorylation motif mutants in cancer
(R-HSA-3304356)
Tgf-beta receptor signaling activates smads
(R-HSA-2173789)
Tgfbr1 kd mutants in cancer
(R-HSA-3656532)
1-phosphatidylinositol binding
(GO:0005545)
Cytosol
(GO:0005829)
Early endosome
(GO:0005769)
Early endosome membrane
(GO:0031901)
Endocytosis
(GO:0006897)
Endosomal transport
(GO:0016197)
Intracellular membrane-bounded organelle
(GO:0043231)
Metal ion binding
(GO:0046872)
Protein-containing complex
(GO:0032991)
Protein binding
(GO:0005515)
Protein domain specific binding
(GO:0019904)
Transforming growth factor beta receptor signaling pathway
(GO:0007179)

Other Information

Proteins

Zinc finger FYVE domain-containing protein 9

Genular Protein ID: 4215074373

Symbol: ZFYV9_HUMAN

Name: Zinc finger FYVE domain-containing protein 9

UniProtKB Accession Codes:

O95405 Q5T0F6 Q5T0F7 Q9UNE1 Q9Y5R7

Database IDs:

Citations:

PubMed ID: 9865696

Title: SARA, a FYVE domain protein that recruits Smad2 to the TGFbeta receptor.

PubMed ID: 9865696

DOI: 10.1016/s0092-8674(00)81701-8

PubMed ID: 9582421

Title: Identification of a novel serine protease-like molecule in human brain.

PubMed ID: 9582421

DOI: 10.1016/s0169-328x(97)00366-5

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11877415

Title: Early endosomal regulation of Smad-dependent signaling in endothelial cells.

PubMed ID: 11877415

DOI: 10.1074/jbc.m107983200

PubMed ID: 14759258

Title: An unappreciated role for RNA surveillance.

PubMed ID: 14759258

DOI: 10.1186/gb-2004-5-2-r8

PubMed ID: 15356634

Title: Cytoplasmic PML function in TGF-beta signalling.

PubMed ID: 15356634

DOI: 10.1038/nature02783

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 10615055

Title: Structural basis of Smad2 recognition by the Smad anchor for receptor activation.

PubMed ID: 10615055

DOI: 10.1126/science.287.5450.92

PubMed ID: 12154125

Title: Smad3 allostery links TGF-beta receptor kinase activation to transcriptional control.

PubMed ID: 12154125

DOI: 10.1101/gad.1002002

Sequence Information:

Length: 1425
Mass: 156403
Checksum: ADE5CB530C1272C6
Sequence:

MENYFQAEAY NLDKVLDEFE QNEDETVSST LLDTKWNKIL DPPSHRLSFN PTLASVNESA 
VSNESQPQLK VFSLAHSAPL TTEEEDHCAN GQDCNLNPEI ATMWIDENAV AEDQLIKRNY 
SWDDQCSAVE VGEKKCGNLA CLPDEKNVLV VAVMHNCDKR TLQNDLQDCN NYNSQSLMDA 
FSCSLDNENR QTDQFSFSIN ESTEKDMNSE KQMDPLNRPK TEGRSVNHLC PTSSDSLASV 
CSPSQLKDDG SIGRDPSMSA ITSLTVDSVI SSQGTDGCPA VKKQENYIPD EDLTGKISSP 
RTDLGSPNSF SHMSEGILMK KEPAEESTTE ESLRSGLPLL LKPDMPNGSG RNNDCERCSD 
CLVPNEVRAD ENEGYEHEET LGTTEFLNMT EHFSESQDMT NWKLTKLNEM NDSQVNEEKE 
KFLQISQPED TNGDSGGQCV GLADAGLDLK GTCISESEEC DFSTVIDTPA ANYLSNGCDS 
YGMQDPGVSF VPKTLPSKED SVTEEKEIEE SKSECYSNIY EQRGNEATEG SGLLLNSTGD 
LMKKNYLHNF CSQVPSVLGQ SSPKVVASLP SISVPFGGAR PKQPSNLKLQ IPKPLSDHLQ 
NDFPANSGNN TKNKNDILGK AKLGENSATN VCSPSLGNIS NVDTNGEHLE SYEAEISTRP 
CLALAPDSPD NDLRAGQFGI SARKPFTTLG EVAPVWVPDS QAPNCMKCEA RFTFTKRRHH 
CRACGKVFCA SCCSLKCKLL YMDRKEARVC VICHSVLMNA QAWENMMSAS SQSPNPNNPA 
EYCSTIPPLQ QAQASGALSS PPPTVMVPVG VLKHPGAEVA QPREQRRVWF ADGILPNGEV 
ADAAKLTMNG TSSAGTLAVS HDPVKPVTTS PLPAETDICL FSGSITQVGS PVGSAMNLIP 
EDGLPPILIS TGVKGDYAVE EKPSQISVMQ QLEDGGPDPL VFVLNANLLS MVKIVNYVNR 
KCWCFTTKGM HAVGQSEIVI LLQCLPDEKC LPKDIFNHFV QLYRDALAGN VVSNLGHSFF 
SQSFLGSKEH GGFLYVTSTY QSLQDLVLPT PPYLFGILIQ KWETPWAKVF PIRLMLRLGA 
EYRLYPCPLF SVRFRKPLFG ETGHTIMNLL ADFRNYQYTL PVVQGLVVDM EVRKTSIKIP 
SNRYNEMMKA MNKSNEHVLA GGACFNEKAD SHLVCVQNDD GNYQTQAISI HNQPRKVTGA 
SFFVFSGALK SSSGYLAKSS IVEDGVMVQI TAENMDSLRQ ALREMKDFTI TCGKADAEEP 
QEHIHIQWVD DDKNVSKGVV SPIDGKSMET ITNVKIFHGS EYKANGKVIR WTEVFFLEND 
DQHNCLSDPA DHSRLTEHVA KAFCLALCPH LKLLKEDGMT KLGLRVTLDS DQVGYQAGSN 
GQPLPSQYMN DLDSALVPVI HGGACQLSEG PVVMELIFYI LENIV

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: ZFYVE9

Associated with

Other Information

SARA, a FYVE domain protein that recruits Smad2 to the TGFbeta receptor. PubMed ID: 9865696

Identification of a novel serine protease-like molecule in human brain. PubMed ID: 9582421

The DNA sequence and biological annotation of human chromosome 1. PubMed ID: 16710414

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Early endosomal regulation of Smad-dependent signaling in endothelial cells. PubMed ID: 11877415

An unappreciated role for RNA surveillance. PubMed ID: 14759258

Cytoplasmic PML function in TGF-beta signalling. PubMed ID: 15356634

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

Structural basis of Smad2 recognition by the Smad anchor for receptor activation. PubMed ID: 10615055

Smad3 allostery links TGF-beta receptor kinase activation to transcriptional control. PubMed ID: 12154125