Details for: SLC22A8

Gene ID: 9376

Symbol: SLC22A8

Ensembl ID: ENSG00000149452

Description: solute carrier family 22 member 8

Associated with

Other Information

Genular Protein ID: 1530434190

Symbol: S22A8_HUMAN

Name: Organic anion/dicarboxylate exchanger

UniProtKB Accession Codes:

Q8TCC7 B4DPH7 F5GWA8 F5H5J1 O95820 Q59EW9 Q96TC1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CTD 1 ChEBI 46 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 100 DrugCentral 1 EMBL 6 Ensembl 4 ExpressionAtlas 1 GO 12 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 5 RNAct 1 Reactome 2 RefSeq 5 Rhea 23 SAM 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10049739

Title: Molecular cloning and characterization of two novel human renal organic anion transporters (hOAT1 and hOAT3).

PubMed ID: 10049739

DOI: 10.1006/bbrc.1998.9978

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11669456

Title: Characterization of ochratoxin A transport by human organic anion transporters.

PubMed ID: 11669456

DOI: 10.1016/s0024-3205(01)01296-6

PubMed ID: 11306713

Title: Identification and characterization of human organic anion transporter 3 expressing predominantly in the kidney.

PubMed ID: 11306713

DOI: 10.1124/mol.59.5.1277

PubMed ID: 11912245

Title: Gene expression levels and immunolocalization of organic ion transporters in the human kidney.

PubMed ID: 11912245

DOI: 10.1681/asn.v134866

PubMed ID: 11907186

Title: Human organic anion transporters and human organic cation transporters mediate renal transport of prostaglandins.

PubMed ID: 11907186

DOI: 10.1124/jpet.301.1.293

PubMed ID: 14586168

Title: Human organic anion transporter 3 (hOAT3) can operate as an exchanger and mediate secretory urate flux.

PubMed ID: 14586168

DOI: 10.1159/000074539

PubMed ID: 14675047

Title: Characterization of uremic toxin transport by organic anion transporters in the kidney.

PubMed ID: 14675047

DOI: 10.1111/j.1523-1755.2004.00354.x

PubMed ID: 15644426

Title: Transport of the natural sweetener stevioside and its aglycone steviol by human organic anion transporter (hOAT1; SLC22A6) and hOAT3 (SLC22A8).

PubMed ID: 15644426

DOI: 10.1124/jpet.104.080366

PubMed ID: 15846473

Title: Molecular cloning and functional analyses of OAT1 and OAT3 from cynomolgus monkey kidney.

PubMed ID: 15846473

DOI: 10.1007/s11095-005-2503-0

PubMed ID: 15864504

Title: Presence of organic anion transporters 3 (OAT3) and 4 (OAT4) in human adrenocortical cells.

PubMed ID: 15864504

DOI: 10.1007/s00424-004-1373-3

PubMed ID: 16455804

Title: Inhibition of oat3-mediated renal uptake as a mechanism for drug-drug interaction between fexofenadine and probenecid.

PubMed ID: 16455804

DOI: 10.1124/dmd.105.008375

PubMed ID: 22108572

Title: Interaction and transport of kynurenic acid via human organic anion transporters hOAT1 and hOAT3.

PubMed ID: 22108572

DOI: 10.1016/j.phrs.2011.11.003

PubMed ID: 23832370

Title: Transport of xanthurenic acid by rat/human organic anion transporters OAT1 and OAT3.

PubMed ID: 23832370

DOI: 10.1271/bbb.130178

PubMed ID: 26377792

Title: Human organic anion transporter 2 is distinct from organic anion transporters 1 and 3 with respect to transport function.

PubMed ID: 26377792

DOI: 10.1152/ajprenal.00140.2015

PubMed ID: 28534121

Title: Organic anion transporters, OAT1 and OAT3, are crucial biopterin transporters involved in bodily distribution of tetrahydrobiopterin and exclusion of its excess.

PubMed ID: 28534121

DOI: 10.1007/s11010-017-3060-7

PubMed ID: 31553721

Title: Unraveling the functional role of the orphan solute carrier, SLC22A24 in the transport of steroid conjugates through metabolomic and genome-wide association studies.

PubMed ID: 31553721

DOI: 10.1371/journal.pgen.1008208

PubMed ID: 12811365

Title: Polymorphisms of OATP-C (SLC21A6) and OAT3 (SLC22A8) genes: consequences for pravastatin pharmacokinetics.

PubMed ID: 12811365

DOI: 10.1016/s0009-9236(03)00060-2

PubMed ID: 16291576

Title: The human organic anion transporter 3 (OAT3; SLC22A8): genetic variation and functional genomics.

PubMed ID: 16291576

DOI: 10.1152/ajprenal.00272.2005

Sequence Information:

  • Length: 542
  • Mass: 59856
  • Checksum: 22799360D91B4CCF
  • Sequence:
    • MTFSEILDRV GSMGHFQFLH VAILGLPILN MANHNLLQIF TAATPVHHCR PPHNASTGPW 
VLPMGPNGKP ERCLRFVHPP NASLPNDTQR AMEPCLDGWV YNSTKDSIVT EWDLVCNSNK 
LKEMAQSIFM AGILIGGLVL GDLSDRFGRR PILTCSYLLL AASGSGAAFS PTFPIYMVFR 
FLCGFGISGI TLSTVILNVE WVPTRMRAIM STALGYCYTF GQFILPGLAY AIPQWRWLQL 
TVSIPFFVFF LSSWWTPESI RWLVLSGKSS KALKILRRVA VFNGKKEEGE RLSLEELKLN 
LQKEISLAKA KYTASDLFRI PMLRRMTFCL SLAWFATGFA YYSLAMGVEE FGVNLYILQI 
IFGGVDVPAK FITILSLSYL GRHTTQAAAL LLAGGAILAL TFVPLDLQTV RTVLAVFGKG 
CLSSSFSCLF LYTSELYPTV IRQTGMGVSN LWTRVGSMVS PLVKITGEVQ PFIPNIIYGI 
TALLGGSAAL FLPETLNQPL PETIEDLENW SLRAKKPKQE PEVEKASQRI PLQPHGPGLG 
SS

Genular Protein ID: 642205151

Symbol: B2R807_HUMAN

Name: N/A

UniProtKB Accession Codes:

B2R807

Database IDs:

ARBA 37 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChEBI 46 DNASU 1 EMBL 2 GO 5 Gene3D 1 Genevisible 1 GenomeRNAi 1 InterPro 5 KEGG 1 NCBI Taxonomy 1 NCBIfam 1 OrthoDB 1 PANTHER 2 PROSITE 3 PeptideAtlas 1 Pfam 1 RefSeq 1 Rhea 23 SAM 2 SUPFAM 1

Sequence Information:

  • Length: 542
  • Mass: 59909
  • Checksum: 31AF4769A565EF1E
  • Sequence:
    • MTFSEILDRV GSMGHFQFLH VAILGLPILN MANHNLLQIF TAATPVHHCR PPHNASTGPW 
VLPMGPNGKP ERCLRFVHPP NASLPNDTQR AMEPRLDGWV YNSTKDSIVT EWDLVCNSNK 
LKEMAQSIFM AGILIGGLVL GDLSDRFGRR PILTCSYLLL AASGSGAAFS PTFPIYMVFR 
FLCGFGISGI TLSTVILNVE WVPTRMRAIM STALGYCYTF GQFILPGLAY AIPQWRWLQL 
TVSIPFFVFF LSSWWTPESI RWLVLSGKSS KALKILRRVA VFNGKKEEGE RLSLEELKLN 
LQKEISLAKA KYTASDLFRI PMLRRMTFCL SLAWFATGFA YYSLAMGVEE FGVNLYILQI 
IFGGVDVPAK FITILSLSYL GRHTTQAAAL LLAGGAILAL TFVPLDLQTV RTVLAVFGKG 
CLSSSFSCLF LYTSELYPTV IRQTGMGVSN LWTRVGSMVS PLVKITGEVQ PFIPNIIYGI 
TALLGGSAAL FLPETLNQPL PETIEDLENW SLRAKKPKQE PEVEKASQRI PLQPHGPGLG 
SS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.