COX5A | ENSG00000178741 | NCBI 9377

Details for: COX5A

Gene ID: 9377

Symbol: COX5A

Ensembl ID: ENSG00000178741

Description: cytochrome c oxidase subunit 5A

Associated with

Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular response to chemical stress
(R-HSA-9711123)
Cytoprotection by hmox1
(R-HSA-9707564)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Metabolism
(R-HSA-1430728)
Metabolism of proteins
(R-HSA-392499)
Mitochondrial protein degradation
(R-HSA-9837999)
Respiratory electron transport
(R-HSA-611105)
Respiratory electron transport, atp synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
(R-HSA-163200)
Rna polymerase ii transcription
(R-HSA-73857)
The citric acid (tca) cycle and respiratory electron transport
(R-HSA-1428517)
Tp53 regulates metabolic genes
(R-HSA-5628897)
Transcriptional regulation by tp53
(R-HSA-3700989)
Cellular respiration
(GO:0045333)
Cytochrome-c oxidase activity
(GO:0004129)
Electron transfer activity
(GO:0009055)
Metal ion binding
(GO:0046872)
Mitochondrial electron transport, cytochrome c to oxygen
(GO:0006123)
Mitochondrial inner membrane
(GO:0005743)
Mitochondrial membrane
(GO:0031966)
Mitochondrial respiratory chain complex iv
(GO:0005751)
Protein binding
(GO:0005515)
Proton transmembrane transport
(GO:1902600)

Other Information

Proteins

Cytochrome c oxidase subunit 5A, mitochondrial

Genular Protein ID: 2511923171

Symbol: COX5A_HUMAN

Name: Cytochrome c oxidase subunit 5A, mitochondrial

UniProtKB Accession Codes:

P20674 P30045 Q8TB65

Database IDs:

Citations:

PubMed ID: 2853101

Title: Subunit Va of human and bovine cytochrome c oxidase is highly conserved.

PubMed ID: 2853101

DOI: 10.1016/0378-1119(88)90435-0

PubMed ID: 18197981

Title: Molecular evolution of the cytochrome c oxidase subunit 5A gene in primates.

PubMed ID: 18197981

DOI: 10.1186/1471-2148-8-8

PubMed ID: 16572171

Title: Analysis of the DNA sequence and duplication history of human chromosome 15.

PubMed ID: 16572171

DOI: 10.1038/nature04601

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8313870

Title: Human liver protein map: update 1993.

PubMed ID: 8313870

DOI: 10.1002/elps.11501401181

PubMed ID: 7498159

Title: The major protein expression profile and two-dimensional protein database of human heart.

PubMed ID: 7498159

DOI: 10.1002/elps.11501601192

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 26759378

Title: The mammalian homologue of yeast Afg1 ATPase (lactation elevated 1) mediates degradation of nuclear-encoded complex IV subunits.

PubMed ID: 26759378

DOI: 10.1042/bj20151029

PubMed ID: 31536960

Title: Rewiring of the Human Mitochondrial Interactome during Neuronal Reprogramming Reveals Regulators of the Respirasome and Neurogenesis.

PubMed ID: 31536960

DOI: 10.1016/j.isci.2019.08.057

PubMed ID: 28844695

Title: Architecture of human mitochondrial respiratory megacomplex I2III2IV2.

PubMed ID: 28844695

DOI: 10.1016/j.cell.2017.07.050

PubMed ID: 30030519

Title: Structure of the intact 14-subunit human cytochrome c oxidase.

PubMed ID: 30030519

DOI: 10.1038/s41422-018-0071-1

PubMed ID: 28247525

Title: Mutation in mitochondrial complex IV subunit COX5A causes pulmonary arterial hypertension, lactic acidemia and failure to thrive.

PubMed ID: 28247525

DOI: 10.1002/humu.23210

Sequence Information:

Length: 150
Mass: 16762
Checksum: 104DAF468BD302FC
Sequence:

MLGAALRRCA VAATTRADPR GLLHSARTPG PAVAIQSVRC YSHGSQETDE EFDARWVTYF 
NKPDIDAWEL RKGINTLVTY DMVPEPKIID AALRACRRLN DFASTVRILE VVKDKAGPHK 
EIYPYVIQEL RPTLNELGIS TPEELGLDKV

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: COX5A

Associated with

Other Information

Subunit Va of human and bovine cytochrome c oxidase is highly conserved. PubMed ID: 2853101

Molecular evolution of the cytochrome c oxidase subunit 5A gene in primates. PubMed ID: 18197981

Analysis of the DNA sequence and duplication history of human chromosome 15. PubMed ID: 16572171

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Human liver protein map: update 1993. PubMed ID: 8313870

The major protein expression profile and two-dimensional protein database of human heart. PubMed ID: 7498159

Initial characterization of the human central proteome. PubMed ID: 21269460

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712

The mammalian homologue of yeast Afg1 ATPase (lactation elevated 1) mediates degradation of nuclear-encoded complex IV subunits. PubMed ID: 26759378

Rewiring of the Human Mitochondrial Interactome during Neuronal Reprogramming Reveals Regulators of the Respirasome and Neurogenesis. PubMed ID: 31536960

Architecture of human mitochondrial respiratory megacomplex I2III2IV2. PubMed ID: 28844695

Structure of the intact 14-subunit human cytochrome c oxidase. PubMed ID: 30030519

Mutation in mitochondrial complex IV subunit COX5A causes pulmonary arterial hypertension, lactic acidemia and failure to thrive. PubMed ID: 28247525