Details for: CD27

Gene ID: 939

Symbol: CD27

Ensembl ID: ENSG00000139193

Description: CD27 molecule

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mature T cell (CL0002419)
    Fold Change: 2.79
    Marker Score: 27673
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 2.75
    Marker Score: 3894
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 2.51
    Marker Score: 1252
  • Cell Name: centroblast (CL0009112)
    Fold Change: 2.5
    Marker Score: 1231
  • Cell Name: CD4-positive, CD25-positive, alpha-beta regulatory T cell (CL0000792)
    Fold Change: 2.43
    Marker Score: 644
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 2.41
    Marker Score: 2049
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 2.33
    Marker Score: 1415
  • Cell Name: memory regulatory T cell (CL0002678)
    Fold Change: 2.18
    Marker Score: 762
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 2.06
    Marker Score: 1186
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 1.99
    Marker Score: 105242
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: 1.91
    Marker Score: 579
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 1.83
    Marker Score: 3269
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.8
    Marker Score: 5346
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: 1.8
    Marker Score: 1986
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 1.78
    Marker Score: 5001
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 1.78
    Marker Score: 7629.5
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 1.78
    Marker Score: 1719
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 1.67
    Marker Score: 3277
  • Cell Name: naive T cell (CL0000898)
    Fold Change: 1.64
    Marker Score: 1055
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.59
    Marker Score: 1158
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: 1.57
    Marker Score: 1852.5
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 1.55
    Marker Score: 1490
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: 1.53
    Marker Score: 668
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 1.53
    Marker Score: 474
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 1.5
    Marker Score: 2575
  • Cell Name: IgM plasma cell (CL0000986)
    Fold Change: 1.48
    Marker Score: 514
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 1.46
    Marker Score: 1366
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 1.46
    Marker Score: 1212
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 1.43
    Marker Score: 1047
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 1.42
    Marker Score: 1073
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.39
    Marker Score: 1387
  • Cell Name: blood cell (CL0000081)
    Fold Change: 1.36
    Marker Score: 15759
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 1.34
    Marker Score: 1130
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 1.29
    Marker Score: 1213
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.25
    Marker Score: 846
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 1.18
    Marker Score: 1050
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 1.15
    Marker Score: 695
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 1.14
    Marker Score: 3592
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: 1.13
    Marker Score: 819
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251775
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 1.04
    Marker Score: 608
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 1.03
    Marker Score: 577
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.03
    Marker Score: 6601
  • Cell Name: T follicular regulatory cell (CL0009113)
    Fold Change: 1.03
    Marker Score: 279
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 1.01
    Marker Score: 1337
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71795
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48020
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30405
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 504
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.97
    Marker Score: 6473
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 0.97
    Marker Score: 1046
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 457
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 0.97
    Marker Score: 566
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2409
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 0.95
    Marker Score: 335
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.94
    Marker Score: 431.5
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: 0.94
    Marker Score: 481
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 0.92
    Marker Score: 671
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.92
    Marker Score: 370
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.92
    Marker Score: 5242
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2732
  • Cell Name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell (CL0000802)
    Fold Change: 0.91
    Marker Score: 295
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 323
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.89
    Marker Score: 753
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5279
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.87
    Marker Score: 969
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.85
    Marker Score: 810
  • Cell Name: CD56-positive, CD161-positive immature natural killer cell, human (CL0002338)
    Fold Change: 0.85
    Marker Score: 279
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.84
    Marker Score: 614
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 0.83
    Marker Score: 510
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.82
    Marker Score: 629
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1253
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 0.77
    Marker Score: 2129
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 392
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.75
    Marker Score: 3162
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.75
    Marker Score: 1420
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.75
    Marker Score: 683
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 0.74
    Marker Score: 583
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 0.74
    Marker Score: 1287
  • Cell Name: centrocyte (CL0009111)
    Fold Change: 0.71
    Marker Score: 170
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.71
    Marker Score: 457
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 0.71
    Marker Score: 540
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 0.71
    Marker Score: 1604
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 177
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.69
    Marker Score: 217
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 0.68
    Marker Score: 739
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: 0.67
    Marker Score: 590
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.65
    Marker Score: 344
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.65
    Marker Score: 270
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.64
    Marker Score: 10010
  • Cell Name: IgG plasmablast (CL0000982)
    Fold Change: 0.63
    Marker Score: 173
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: 0.63
    Marker Score: 345
  • Cell Name: IgA plasmablast (CL0000984)
    Fold Change: 0.58
    Marker Score: 153
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.57
    Marker Score: 288
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 0.56
    Marker Score: 905
  • Cell Name: T-helper 1 cell (CL0000545)
    Fold Change: 0.55
    Marker Score: 213
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.51
    Marker Score: 1029
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 0.5
    Marker Score: 215
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.48
    Marker Score: 128

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Other Information

**Key characteristics:** * CD27 is a type I transmembrane receptor belonging to the TNF receptor superfamily. * It is expressed in high levels on the surface of mature T cells and some other immune cells. * Upon ligand binding, CD27 recruits the CD28 protein to the cell surface, triggering the activation of the T cell. * CD27 is also expressed on activated B cells, where it plays a regulatory role. **Pathways and functions:** * **Cell surface receptor signaling pathway:** CD27 binds to its ligand, CD80 or CD86 on the surface of antigen-presenting cells. This binding activates the CD28 protein, leading to the activation of the T cell. * **Cysteine-type endopeptidase inhibitor activity:** CD27 also has a cysteine-type endopeptidase inhibitor activity, which helps to regulate the activity of other cell surface receptors. This activity is involved in the regulation of cell signaling and immune responses. * **Cytokine signaling in immune system:** CD27 is a key regulator of cytokine signaling in the immune system. It interacts with cytokines such as IL-2 and IL-4, which are important for the activation of T cells. * **Extracellular region:** The extracellular region of CD27 is involved in the regulation of T cell activation. It interacts with CD80 and CD86 on the surface of antigen-presenting cells, which are necessary for the activation of T cells. **Clinical significance:** CD27 is a promising target for cancer immunotherapy due to its role in regulating T cell and B cell activation. Inhibition of CD27 signaling has been shown to be effective in promoting the activation of T cells and enhancing anti-tumor immune responses. This has led to the development of CD27-based cancer vaccines and immunotherapies, which are currently being evaluated in clinical trials.

Genular Protein ID: 493113202

Symbol: CD27_HUMAN

Name: CD27 antigen

UniProtKB Accession Codes:

P26842 B2RDZ0

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CPTC 1 CTD 1 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 ELM 1 EMBL 5 EPD 1 Ensembl 1 GO 15 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 7 PDBsum 5 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1655907

Title: The T cell activation antigen CD27 is a member of the nerve growth factor/tumor necrosis factor receptor gene family.

PubMed ID: 1655907

PubMed ID: 1334106

Title: Genomic organization and chromosomal localization of the human CD27 gene.

PubMed ID: 1334106

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15340161

Title: Signal peptide prediction based on analysis of experimentally verified cleavage sites.

PubMed ID: 15340161

DOI: 10.1110/ps.04682504

PubMed ID: 9692890

Title: The TNF receptor family member CD27 signals to Jun N-terminal kinase via Traf-2.

PubMed ID: 9692890

DOI: 10.1002/(sici)1521-4141(199807)28:07<2208::aid-immu2208>3.0.co;2-l

PubMed ID: 9177220

Title: CD27, a member of the tumor necrosis factor receptor family, induces apoptosis and binds to Siva, a proapoptotic protein.

PubMed ID: 9177220

DOI: 10.1073/pnas.94.12.6346

PubMed ID: 22171320

Title: Human urinary glycoproteomics; attachment site specific analysis of N- and O-linked glycosylations by CID and ECD.

PubMed ID: 22171320

DOI: 10.1074/mcp.m111.013649

PubMed ID: 22197273

Title: CD27 deficiency is associated with combined immunodeficiency and persistent symptomatic EBV viremia.

PubMed ID: 22197273

DOI: 10.1016/j.jaci.2011.11.013

PubMed ID: 22801960

Title: Combined immunodeficiency with life-threatening EBV-associated lymphoproliferative disorder in patients lacking functional CD27.

PubMed ID: 22801960

DOI: 10.3324/haematol.2012.068791

Sequence Information:

  • Length: 260
  • Mass: 29137
  • Checksum: 43C38B895B2AD4E2
  • Sequence:
    • MARPHPWWLC VLGTLVGLSA TPAPKSCPER HYWAQGKLCC QMCEPGTFLV KDCDQHRKAA 
QCDPCIPGVS FSPDHHTRPH CESCRHCNSG LLVRNCTITA NAECACRNGW QCRDKECTEC 
DPLPNPSLTA RSSQALSPHP QPTHLPYVSE MLEARTAGHM QTLADFRQLP ARTLSTHWPP 
QRSLCSSDFI RILVIFSGMF LVFTLAGALF LHQRRKYRSN KGESPVEPAE PCHYSCPREE 
EGSTIPIQED YRKPEPACSP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.