Details for: CD27

Gene ID: 939

Symbol: CD27

Ensembl ID: ENSG00000139193

Description: CD27 molecule

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 56.3180
    Cell Significance Index: -8.7600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 37.1782
    Cell Significance Index: -9.4300
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 22.4942
    Cell Significance Index: -10.6200
  • Cell Name: centroblast (CL0009112)
    Fold Change: 19.8709
    Cell Significance Index: 46.3600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 6.9589
    Cell Significance Index: -8.5800
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 3.5644
    Cell Significance Index: 35.7400
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 3.2925
    Cell Significance Index: 50.9400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 3.1337
    Cell Significance Index: 67.8900
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 2.4353
    Cell Significance Index: -7.4800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 2.4049
    Cell Significance Index: -9.4900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 2.0851
    Cell Significance Index: 245.9000
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.5254
    Cell Significance Index: 44.8000
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 1.1615
    Cell Significance Index: 3.5400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 1.1012
    Cell Significance Index: -2.9500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.0097
    Cell Significance Index: 45.7700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.9564
    Cell Significance Index: 182.0100
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 0.5469
    Cell Significance Index: 5.6700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.5456
    Cell Significance Index: 11.6200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4669
    Cell Significance Index: 46.1900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4021
    Cell Significance Index: 363.0800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.3753
    Cell Significance Index: 22.5300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3415
    Cell Significance Index: 37.1500
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: 0.3080
    Cell Significance Index: 0.8300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2755
    Cell Significance Index: 44.8100
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.2628
    Cell Significance Index: 3.3200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1844
    Cell Significance Index: 12.7500
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.1504
    Cell Significance Index: 0.8200
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 0.0846
    Cell Significance Index: 0.7400
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 0.0418
    Cell Significance Index: 0.7200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0003
    Cell Significance Index: 0.0100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0006
    Cell Significance Index: -0.0200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0021
    Cell Significance Index: -3.9400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0027
    Cell Significance Index: -4.8900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0032
    Cell Significance Index: -4.8900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0052
    Cell Significance Index: -7.0500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0080
    Cell Significance Index: -0.2000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0101
    Cell Significance Index: -5.5400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0116
    Cell Significance Index: -8.8000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0142
    Cell Significance Index: -6.2900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0153
    Cell Significance Index: -11.3700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0159
    Cell Significance Index: -9.9400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0197
    Cell Significance Index: -5.6800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0198
    Cell Significance Index: -11.1700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0205
    Cell Significance Index: -7.3700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0225
    Cell Significance Index: -16.4700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0249
    Cell Significance Index: -15.8000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0270
    Cell Significance Index: -5.3500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0279
    Cell Significance Index: -5.6000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0295
    Cell Significance Index: -13.3900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0380
    Cell Significance Index: -1.9200
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0382
    Cell Significance Index: -1.6600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0393
    Cell Significance Index: -2.4100
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0458
    Cell Significance Index: -0.6900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0553
    Cell Significance Index: -1.7700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0608
    Cell Significance Index: -12.8100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0631
    Cell Significance Index: -8.0900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0644
    Cell Significance Index: -7.5100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0652
    Cell Significance Index: -11.1300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0666
    Cell Significance Index: -9.1400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0679
    Cell Significance Index: -12.2400
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0742
    Cell Significance Index: -1.5400
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0814
    Cell Significance Index: -3.3400
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0899
    Cell Significance Index: -1.3200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0904
    Cell Significance Index: -9.4100
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0913
    Cell Significance Index: -1.5500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0976
    Cell Significance Index: -14.1900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1000
    Cell Significance Index: -11.4600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1035
    Cell Significance Index: -7.3200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.1110
    Cell Significance Index: -13.6500
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.1132
    Cell Significance Index: -1.5400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1146
    Cell Significance Index: -14.8100
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1178
    Cell Significance Index: -3.0100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1179
    Cell Significance Index: -7.4300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1190
    Cell Significance Index: -12.1600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1265
    Cell Significance Index: -9.7100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1300
    Cell Significance Index: -6.1100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1434
    Cell Significance Index: -9.6400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1682
    Cell Significance Index: -4.5000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1735
    Cell Significance Index: -8.0900
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.1793
    Cell Significance Index: -1.8600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1804
    Cell Significance Index: -7.9800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1860
    Cell Significance Index: -10.4400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1889
    Cell Significance Index: -9.9200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2003
    Cell Significance Index: -14.9300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2123
    Cell Significance Index: -8.0400
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.2138
    Cell Significance Index: -2.0000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.2231
    Cell Significance Index: -11.5900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2284
    Cell Significance Index: -14.0400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.2345
    Cell Significance Index: -15.1300
  • Cell Name: mature T cell (CL0002419)
    Fold Change: -0.2404
    Cell Significance Index: -1.7300
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: -0.2460
    Cell Significance Index: -1.8300
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.2516
    Cell Significance Index: -2.9700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2601
    Cell Significance Index: -7.2700
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2626
    Cell Significance Index: -9.2000
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.2788
    Cell Significance Index: -2.6800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2857
    Cell Significance Index: -9.3600
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2969
    Cell Significance Index: -10.9000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.3001
    Cell Significance Index: -8.0400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3014
    Cell Significance Index: -9.6000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3046
    Cell Significance Index: -7.8300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Transmembrane Receptor:** CD27 is a transmembrane receptor that interacts with its ligands to regulate immune responses. 2. **Apoptosis Regulation:** CD27 is involved in the regulation of apoptosis in T cells and B cells, promoting cell survival and preventing autoimmune responses. 3. **Cell Differentiation:** CD27 plays a crucial role in the differentiation of T cells and B cells, influencing the development of regulatory T cells and plasma cells. 4. **Immune Response Modulation:** CD27 modulates immune responses by interacting with its ligands, influencing the production of cytokines and the activation of immune cells. **Pathways and Functions:** 1. **Apoptotic Pathway:** CD27 interacts with its ligands to regulate apoptosis in T cells and B cells, promoting cell survival and preventing autoimmune responses. 2. **Cytokine Signaling:** CD27 modulates cytokine signaling in immune cells, influencing the production of cytokines and the activation of immune cells. 3. **Non-Canonical NF-κB Signaling:** CD27 activates non-canonical NF-κB signaling, which regulates the expression of genes involved in immune responses. 4. **JNK Cascade Activation:** CD27 activates the JNK cascade, a signaling pathway involved in the regulation of immune responses and cell differentiation. 5. **T-Cell Differentiation:** CD27 is involved in the differentiation of T cells, influencing the development of regulatory T cells and effector T cells. **Clinical Significance:** 1. **Autoimmune Diseases:** Dysregulation of CD27 signaling has been implicated in autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. 2. **Tumor Immunology:** CD27 is involved in the regulation of tumor immunity, influencing the recognition and elimination of cancer cells. 3. **Infectious Diseases:** CD27 modulates immune responses to infections, influencing the clearance of pathogens and the development of immune tolerance. 4. **Cancer Immunotherapy:** CD27 is a potential target for cancer immunotherapy, as it can be used to enhance the activity of T cells and B cells against cancer cells. In conclusion, the CD27 gene is a critical regulator of immune cell differentiation, apoptosis, and immune responses. Its dysregulation has been implicated in various diseases, making it a promising target for therapeutic interventions. Further research is needed to fully understand the mechanisms of CD27 signaling and its clinical applications.

Genular Protein ID: 493113202

Symbol: CD27_HUMAN

Name: CD27L receptor

UniProtKB Accession Codes:

P26842 B2RDZ0

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CPTC 1 CTD 1 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 ELM 1 EMBL 5 Ensembl 1 GO 17 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 5 PDBsum 5 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1655907

Title: The T cell activation antigen CD27 is a member of the nerve growth factor/tumor necrosis factor receptor gene family.

PubMed ID: 1655907

PubMed ID: 1334106

Title: Genomic organization and chromosomal localization of the human CD27 gene.

PubMed ID: 1334106

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15340161

Title: Signal peptide prediction based on analysis of experimentally verified cleavage sites.

PubMed ID: 15340161

DOI: 10.1110/ps.04682504

PubMed ID: 9692890

Title: The TNF receptor family member CD27 signals to Jun N-terminal kinase via Traf-2.

PubMed ID: 9692890

DOI: 10.1002/(sici)1521-4141(199807)28:07<2208::aid-immu2208>3.0.co;2-l

PubMed ID: 9177220

Title: CD27, a member of the tumor necrosis factor receptor family, induces apoptosis and binds to Siva, a proapoptotic protein.

PubMed ID: 9177220

DOI: 10.1073/pnas.94.12.6346

PubMed ID: 22171320

Title: Human urinary glycoproteomics; attachment site specific analysis of N- and O-linked glycosylations by CID and ECD.

PubMed ID: 22171320

DOI: 10.1074/mcp.m111.013649

PubMed ID: 28011863

Title: Inherited CD70 deficiency in humans reveals a critical role for the CD70-CD27 pathway in immunity to Epstein-Barr virus infection.

PubMed ID: 28011863

DOI: 10.1084/jem.20160784

PubMed ID: 38354704

Title: Signaling via a CD27-TRAF2-SHP-1 axis during naive T cell activation promotes memory-associated gene regulatory networks.

PubMed ID: 38354704

DOI: 10.1016/j.immuni.2024.01.011

PubMed ID: 22197273

Title: CD27 deficiency is associated with combined immunodeficiency and persistent symptomatic EBV viremia.

PubMed ID: 22197273

DOI: 10.1016/j.jaci.2011.11.013

PubMed ID: 34419446

Title: Structural delineation and phase-dependent activation of the costimulatory CD27:CD70 complex.

PubMed ID: 34419446

DOI: 10.1016/j.jbc.2021.101102

PubMed ID: 22801960

Title: Combined immunodeficiency with life-threatening EBV-associated lymphoproliferative disorder in patients lacking functional CD27.

PubMed ID: 22801960

DOI: 10.3324/haematol.2012.068791

Sequence Information:

  • Length: 260
  • Mass: 29137
  • Checksum: 43C38B895B2AD4E2
  • Sequence:
    • MARPHPWWLC VLGTLVGLSA TPAPKSCPER HYWAQGKLCC QMCEPGTFLV KDCDQHRKAA 
QCDPCIPGVS FSPDHHTRPH CESCRHCNSG LLVRNCTITA NAECACRNGW QCRDKECTEC 
DPLPNPSLTA RSSQALSPHP QPTHLPYVSE MLEARTAGHM QTLADFRQLP ARTLSTHWPP 
QRSLCSSDFI RILVIFSGMF LVFTLAGALF LHQRRKYRSN KGESPVEPAE PCHYSCPREE 
EGSTIPIQED YRKPEPACSP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.