Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: 3.3448
Cell Significance Index: 51.7500 - Cell Name: DN3 thymocyte (CL0000807)
Fold Change: 3.0907
Cell Significance Index: 30.9900 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 2.7773
Cell Significance Index: -7.4400 - Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 2.5425
Cell Significance Index: 74.6700 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 1.7473
Cell Significance Index: 46.7400 - Cell Name: Hofbauer cell (CL3000001)
Fold Change: 1.6089
Cell Significance Index: 13.1200 - Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 1.2274
Cell Significance Index: -3.7700 - Cell Name: DN1 thymic pro-T cell (CL0000894)
Fold Change: 0.9452
Cell Significance Index: 9.8000 - Cell Name: T-helper 22 cell (CL0001042)
Fold Change: 0.5972
Cell Significance Index: 1.8200 - Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: 0.3834
Cell Significance Index: 5.4900 - Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
Fold Change: 0.2584
Cell Significance Index: 2.2600 - Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
Fold Change: 0.0603
Cell Significance Index: 0.5800 - Cell Name: mature alpha-beta T cell (CL0000791)
Fold Change: 0.0128
Cell Significance Index: 0.0700 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.0085
Cell Significance Index: 1.6900 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0033
Cell Significance Index: -6.2200 - Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0062
Cell Significance Index: -11.4700 - Cell Name: hematopoietic cell (CL0000988)
Fold Change: -0.0068
Cell Significance Index: -0.1000 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0072
Cell Significance Index: -11.0500 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0084
Cell Significance Index: -11.4100 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0091
Cell Significance Index: -6.9000 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0094
Cell Significance Index: -6.9400 - Cell Name: pro-T cell (CL0000827)
Fold Change: -0.0110
Cell Significance Index: -0.2800 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0113
Cell Significance Index: -7.0700 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0117
Cell Significance Index: -7.4200 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0124
Cell Significance Index: -6.9800 - Cell Name: cell in vitro (CL0001034)
Fold Change: -0.0134
Cell Significance Index: -7.3200 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: -0.0182
Cell Significance Index: -6.5200 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0186
Cell Significance Index: -8.4200 - Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
Fold Change: -0.0203
Cell Significance Index: -0.1900 - Cell Name: odontoblast (CL0000060)
Fold Change: -0.0212
Cell Significance Index: -2.7200 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0260
Cell Significance Index: -7.4900 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: -0.0311
Cell Significance Index: -6.2400 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.0328
Cell Significance Index: -3.8700 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0333
Cell Significance Index: -7.0100 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: -0.0353
Cell Significance Index: -6.3600 - Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
Fold Change: -0.0421
Cell Significance Index: -0.3800 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0426
Cell Significance Index: -7.2700 - Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
Fold Change: -0.0487
Cell Significance Index: -0.8400 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0494
Cell Significance Index: -7.1900 - Cell Name: leukocyte (CL0000738)
Fold Change: -0.0506
Cell Significance Index: -0.8600 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.0523
Cell Significance Index: -7.1800 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.0581
Cell Significance Index: -7.1500 - Cell Name: lactocyte (CL0002325)
Fold Change: -0.0581
Cell Significance Index: -7.5100 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0595
Cell Significance Index: -6.8200 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0599
Cell Significance Index: -6.1200 - Cell Name: eukaryotic cell (CL0000255)
Fold Change: -0.0630
Cell Significance Index: -2.7400 - Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.0659
Cell Significance Index: -3.3300 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.0703
Cell Significance Index: -7.3200 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.0777
Cell Significance Index: -3.6500 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.1012
Cell Significance Index: -7.5400 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.1026
Cell Significance Index: -6.9000 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.1043
Cell Significance Index: -8.0100 - Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.1158
Cell Significance Index: -7.4700 - Cell Name: alpha-beta T cell (CL0000789)
Fold Change: -0.1280
Cell Significance Index: -1.0900 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.1284
Cell Significance Index: -7.8900 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.1355
Cell Significance Index: -8.3100 - Cell Name: CD4-positive helper T cell (CL0000492)
Fold Change: -0.1425
Cell Significance Index: -1.4400 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.1435
Cell Significance Index: -4.0100 - Cell Name: lymphocyte (CL0000542)
Fold Change: -0.1500
Cell Significance Index: -2.0400 - Cell Name: neuron associated cell (CL0000095)
Fold Change: -0.1516
Cell Significance Index: -6.2100 - Cell Name: T cell (CL0000084)
Fold Change: -0.1584
Cell Significance Index: -1.8700 - Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: -0.1594
Cell Significance Index: -3.8600 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.1599
Cell Significance Index: -4.1100 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.1675
Cell Significance Index: -9.4000 - Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
Fold Change: -0.1687
Cell Significance Index: -1.7500 - Cell Name: myeloid leukocyte (CL0000766)
Fold Change: -0.1734
Cell Significance Index: -1.4100 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.1738
Cell Significance Index: -9.0300 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.1764
Cell Significance Index: -4.7100 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.1813
Cell Significance Index: -8.0200 - Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
Fold Change: -0.1889
Cell Significance Index: -1.6300 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.1893
Cell Significance Index: -7.1700 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -0.1997
Cell Significance Index: -4.1800 - Cell Name: mature T cell (CL0002419)
Fold Change: -0.2001
Cell Significance Index: -1.4400 - Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
Fold Change: -0.2057
Cell Significance Index: -5.1300 - Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: -0.2086
Cell Significance Index: -2.5800 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.2087
Cell Significance Index: -9.7300 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.2155
Cell Significance Index: -7.5500 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.2176
Cell Significance Index: -7.1300 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -0.2221
Cell Significance Index: -5.9500 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.2286
Cell Significance Index: -7.2800 - Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.2318
Cell Significance Index: -8.5100 - Cell Name: T follicular helper cell (CL0002038)
Fold Change: -0.2452
Cell Significance Index: -2.6000 - Cell Name: monocyte-derived dendritic cell (CL0011031)
Fold Change: -0.2503
Cell Significance Index: -4.3000 - Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -0.2523
Cell Significance Index: -7.2000 - Cell Name: type I NK T cell (CL0000921)
Fold Change: -0.2544
Cell Significance Index: -2.4800 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.2613
Cell Significance Index: -7.4900 - Cell Name: granulosa cell (CL0000501)
Fold Change: -0.2628
Cell Significance Index: -6.9100 - Cell Name: regulatory T cell (CL0000815)
Fold Change: -0.2647
Cell Significance Index: -3.0700 - Cell Name: naive regulatory T cell (CL0002677)
Fold Change: -0.2729
Cell Significance Index: -2.4600 - Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.2752
Cell Significance Index: -8.1100 - Cell Name: thymocyte (CL0000893)
Fold Change: -0.2794
Cell Significance Index: -3.5300 - Cell Name: erythrocyte (CL0000232)
Fold Change: -0.2861
Cell Significance Index: -7.2900 - Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: -0.2916
Cell Significance Index: -5.3900 - Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: -0.2922
Cell Significance Index: -7.2900 - Cell Name: stromal cell of endometrium (CL0002255)
Fold Change: -0.2925
Cell Significance Index: -4.1600 - Cell Name: naive T cell (CL0000898)
Fold Change: -0.2928
Cell Significance Index: -2.6600 - Cell Name: keratinocyte (CL0000312)
Fold Change: -0.3015
Cell Significance Index: -7.5300 - Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
Fold Change: -0.3135
Cell Significance Index: -2.9000 - Cell Name: exhausted T cell (CL0011025)
Fold Change: -0.3239
Cell Significance Index: -2.6400 - Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: -0.3278
Cell Significance Index: -6.6700
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 2651458518
Symbol: CD28_HUMAN
Name: T-cell-specific surface glycoprotein CD28
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 2825196
Title: Molecular cloning of a CD28 cDNA by a high-efficiency COS cell expression system.
PubMed ID: 2825196
PubMed ID: 2162892
Title: The genomic organization of the CD28 gene. Implications for the regulation of CD28 mRNA expression and heterogeneity.
PubMed ID: 2162892
PubMed ID: 11916166
Title: A novel CD28 mRNA variant and simultaneous presence of various CD28 mRNA isoforms in human T lymphocytes.
PubMed ID: 11916166
PubMed ID: 11877290
Title: A novel costimulatory signaling in human T lymphocytes by a splice variant of CD28.
PubMed ID: 11877290
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 15815621
Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.
PubMed ID: 15815621
DOI: 10.1038/nature03466
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 11735222
Title: Assembly and annotation of human chromosome 2q33 sequence containing the CD28, CTLA4, and ICOS gene cluster: analysis by computational, comparative, and microarray approaches.
PubMed ID: 11735222
PubMed ID: 1650475
Title: B-cell surface antigen B7 provides a costimulatory signal that induces T cells to proliferate and secrete interleukin 2.
PubMed ID: 1650475
PubMed ID: 7568038
Title: p56Lck and p59Fyn regulate CD28 binding to phosphatidylinositol 3-kinase, growth factor receptor-bound protein GRB-2, and T cell-specific protein-tyrosine kinase ITK: implications for T-cell costimulation.
PubMed ID: 7568038
PubMed ID: 8617933
Title: Cross-linking of the CD40 ligand on human CD4+ T lymphocytes generates a costimulatory signal that up-regulates IL-4 synthesis.
PubMed ID: 8617933
PubMed ID: 12196291
Title: The interaction properties of costimulatory molecules revisited.
PubMed ID: 12196291
PubMed ID: 15144186
Title: Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry.
PubMed ID: 15144186
DOI: 10.1021/ac035352d
PubMed ID: 15067037
Title: The modulation of CD40 ligand signaling by transmembrane CD28 splice variant in human T cells.
PubMed ID: 15067037
DOI: 10.1084/jem.20031705
PubMed ID: 19349973
Title: Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins.
PubMed ID: 19349973
DOI: 10.1038/nbt.1532
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 21964608
Title: A motif in the V3 domain of the kinase PKC-theta determines its localization in the immunological synapse and functions in T cells via association with CD28.
PubMed ID: 21964608
DOI: 10.1038/ni.2120
PubMed ID: 24665965
Title: T-cell co-stimulation through the CD2 and CD28 co-receptors induces distinct signalling responses.
PubMed ID: 24665965
DOI: 10.1042/bj20140040
PubMed ID: 15696168
PubMed ID: 24098653
Title: High resolution crystal structure of the Grb2 SH2 domain with a phosphopeptide derived from CD28.
PubMed ID: 24098653
PubMed ID: 36114179
Title: Structural insights into the pSer/pThr dependent regulation of the SHP2 tyrosine phosphatase in insulin and CD28 signaling.
PubMed ID: 36114179
PubMed ID: 35397202
Title: Structural characterization of a dimerization interface in the CD28 transmembrane domain.
PubMed ID: 35397202
Sequence Information:
- Length: 220
- Mass: 25066
- Checksum: 1D9B6552A5878D0F
- Sequence:
MLRLLLALNL FPSIQVTGNK ILVKQSPMLV AYDNAVNLSC KYSYNLFSRE FRASLHKGLD SAVEVCVVYG NYSQQLQVYS KTGFNCDGKL GNESVTFYLQ NLYVNQTDIY FCKIEVMYPP PYLDNEKSNG TIIHVKGKHL CPSPLFPGPS KPFWVLVVVG GVLACYSLLV TVAFIIFWVR SKRSRLLHSD YMNMTPRRPG PTRKHYQPYA PPRDFAAYRS
Genular Protein ID: 3949633715
Symbol: B4E0L1_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Sequence Information:
- Length: 124
- Mass: 14072
- Checksum: 3A91FF25D56AFB29
- Sequence:
MLRLLLALNL FPSIQVTGNK ILVKQSPMLV AYDNAVNLSC KYSYNLFSRE FRASLHKGLD SAVEVCVVYG NYSQQLQVYS KTGFNCDGKL GNESVTFYLQ NLYVNHYPCE RETPLSKSPI SRTF
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.