CD28 | ENSG00000178562 | NCBI 940

Details for: CD28

Gene ID: 940

Symbol: CD28

Ensembl ID: ENSG00000178562

Description: CD28 molecule

Associated with

Adaptive immune system
(R-HSA-1280218)
Cd28 co-stimulation
(R-HSA-389356)
Cd28 dependent pi3k/akt signaling
(R-HSA-389357)
Cd28 dependent vav1 pathway
(R-HSA-389359)
Constitutive signaling by aberrant pi3k in cancer
(R-HSA-2219530)
Costimulation by the cd28 family
(R-HSA-388841)
Disease
(R-HSA-1643685)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Hiv infection
(R-HSA-162906)
Host interactions of hiv factors
(R-HSA-162909)
Immune system
(R-HSA-168256)
Infectious disease
(R-HSA-5663205)
Intracellular signaling by second messengers
(R-HSA-9006925)
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters
(R-HSA-164938)
Nef mediated downregulation of cd28 cell surface expression
(R-HSA-164939)
Negative regulation of the pi3k/akt network
(R-HSA-199418)
Pi3k/akt signaling in cancer
(R-HSA-2219528)
Pi5p, pp2a and ier3 regulate pi3k/akt signaling
(R-HSA-6811558)
Pip3 activates akt signaling
(R-HSA-1257604)
Signal transduction
(R-HSA-162582)
The role of nef in hiv-1 replication and disease pathogenesis
(R-HSA-164952)
Viral infection pathways
(R-HSA-9824446)
Apoptotic signaling pathway
(GO:0097190)
Cd4-positive, alpha-beta t cell proliferation
(GO:0035739)
Cell surface
(GO:0009986)
Cell surface receptor signaling pathway
(GO:0007166)
Coreceptor activity
(GO:0015026)
Cytosol
(GO:0005829)
External side of plasma membrane
(GO:0009897)
Humoral immune response
(GO:0006959)
Identical protein binding
(GO:0042802)
Immunological synapse
(GO:0001772)
Negative regulation of apoptotic process
(GO:0043066)
Negative regulation of gene expression
(GO:0010629)
Negative thymic t cell selection
(GO:0045060)
Phosphatidylinositol 3-kinase/protein kinase b signal transduction
(GO:0043491)
Plasma membrane
(GO:0005886)
Positive regulation of cd4-positive, alpha-beta t cell proliferation
(GO:2000563)
Positive regulation of cytokine production
(GO:0001819)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of inflammatory response to antigenic stimulus
(GO:0002863)
Positive regulation of interleukin-2 production
(GO:0032743)
Positive regulation of interleukin-4 production
(GO:0032753)
Positive regulation of interleukin-10 production
(GO:0032733)
Positive regulation of isotype switching to igg isotypes
(GO:0048304)
Positive regulation of mitotic nuclear division
(GO:0045840)
Positive regulation of phosphatidylinositol 3-kinase/protein kinase b signal transduction
(GO:0051897)
Positive regulation of t cell proliferation
(GO:0042102)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Positive regulation of translation
(GO:0045727)
Positive regulation of viral genome replication
(GO:0045070)
Protease binding
(GO:0002020)
Protein binding
(GO:0005515)
Protein complex involved in cell adhesion
(GO:0098636)
Protein kinase binding
(GO:0019901)
Regulation of regulatory t cell differentiation
(GO:0045589)
Regulatory t cell differentiation
(GO:0045066)
T cell activation
(GO:0042110)
T cell costimulation
(GO:0031295)
T cell receptor signaling pathway
(GO:0050852)
Transcription by rna polymerase ii
(GO:0006366)

Other Information

Proteins

T-cell-specific surface glycoprotein CD28
B4E0L1_HUMAN

Genular Protein ID: 2651458518

Symbol: CD28_HUMAN

Name: T-cell-specific surface glycoprotein CD28

UniProtKB Accession Codes:

P10747 A8KAC1 Q13964 Q52M23 Q70WG0 Q8NI54 Q8NI55 Q8NI56 Q8WXJ2 Q9BYV0

Database IDs:

Citations:

PubMed ID: 2825196

Title: Molecular cloning of a CD28 cDNA by a high-efficiency COS cell expression system.

PubMed ID: 2825196

DOI: 10.1073/pnas.84.23.8573

PubMed ID: 2162892

Title: The genomic organization of the CD28 gene. Implications for the regulation of CD28 mRNA expression and heterogeneity.

PubMed ID: 2162892

PubMed ID: 11916166

Title: A novel CD28 mRNA variant and simultaneous presence of various CD28 mRNA isoforms in human T lymphocytes.

PubMed ID: 11916166

DOI: 10.1016/s0198-8859(01)00354-8

PubMed ID: 11877290

Title: A novel costimulatory signaling in human T lymphocytes by a splice variant of CD28.

PubMed ID: 11877290

DOI: 10.1182/blood.v99.6.2138

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11735222

Title: Assembly and annotation of human chromosome 2q33 sequence containing the CD28, CTLA4, and ICOS gene cluster: analysis by computational, comparative, and microarray approaches.

PubMed ID: 11735222

DOI: 10.1006/geno.2001.6655

PubMed ID: 8617933

Title: Cross-linking of the CD40 ligand on human CD4+ T lymphocytes generates a costimulatory signal that up-regulates IL-4 synthesis.

PubMed ID: 8617933

PubMed ID: 15144186

Title: Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry.

PubMed ID: 15144186

DOI: 10.1021/ac035352d

PubMed ID: 15067037

Title: The modulation of CD40 ligand signaling by transmembrane CD28 splice variant in human T cells.

PubMed ID: 15067037

DOI: 10.1084/jem.20031705

PubMed ID: 19349973

Title: Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins.

PubMed ID: 19349973

DOI: 10.1038/nbt.1532

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 15696168

Title: Crystal structure of a soluble CD28-Fab complex.

PubMed ID: 15696168

DOI: 10.1038/ni1170

PubMed ID: 24098653

Title: High resolution crystal structure of the Grb2 SH2 domain with a phosphopeptide derived from CD28.

PubMed ID: 24098653

DOI: 10.1371/journal.pone.0074482

Sequence Information:

Length: 220
Mass: 25066
Checksum: 1D9B6552A5878D0F
Sequence:

MLRLLLALNL FPSIQVTGNK ILVKQSPMLV AYDNAVNLSC KYSYNLFSRE FRASLHKGLD 
SAVEVCVVYG NYSQQLQVYS KTGFNCDGKL GNESVTFYLQ NLYVNQTDIY FCKIEVMYPP 
PYLDNEKSNG TIIHVKGKHL CPSPLFPGPS KPFWVLVVVG GVLACYSLLV TVAFIIFWVR 
SKRSRLLHSD YMNMTPRRPG PTRKHYQPYA PPRDFAAYRS

Genular Protein ID: 3949633715

Symbol: B4E0L1_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4E0L1

Database IDs:

Sequence Information:

Length: 124
Mass: 14072
Checksum: 3A91FF25D56AFB29
Sequence:

MLRLLLALNL FPSIQVTGNK ILVKQSPMLV AYDNAVNLSC KYSYNLFSRE FRASLHKGLD 
SAVEVCVVYG NYSQQLQVYS KTGFNCDGKL GNESVTFYLQ NLYVNHYPCE RETPLSKSPI 
SRTF

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: CD28

Associated with

Other Information

Molecular cloning of a CD28 cDNA by a high-efficiency COS cell expression system. PubMed ID: 2825196

The genomic organization of the CD28 gene. Implications for the regulation of CD28 mRNA expression and heterogeneity. PubMed ID: 2162892

A novel CD28 mRNA variant and simultaneous presence of various CD28 mRNA isoforms in human T lymphocytes. PubMed ID: 11916166

A novel costimulatory signaling in human T lymphocytes by a splice variant of CD28. PubMed ID: 11877290

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

Generation and annotation of the DNA sequences of human chromosomes 2 and 4. PubMed ID: 15815621

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Assembly and annotation of human chromosome 2q33 sequence containing the CD28, CTLA4, and ICOS gene cluster: analysis by computational, comparative, and microarray approaches. PubMed ID: 11735222

Cross-linking of the CD40 ligand on human CD4+ T lymphocytes generates a costimulatory signal that up-regulates IL-4 synthesis. PubMed ID: 8617933

Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry. PubMed ID: 15144186

The modulation of CD40 ligand signaling by transmembrane CD28 splice variant in human T cells. PubMed ID: 15067037

Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins. PubMed ID: 19349973

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. PubMed ID: 19690332

Crystal structure of a soluble CD28-Fab complex. PubMed ID: 15696168

High resolution crystal structure of the Grb2 SH2 domain with a phosphopeptide derived from CD28. PubMed ID: 24098653