GRAP2 | ENSG00000100351 | NCBI 9402

Details for: GRAP2

Gene ID: 9402

Symbol: GRAP2

Ensembl ID: ENSG00000100351

Description: GRB2 related adaptor protein 2

Associated with

Adaptive immune system
(R-HSA-1280218)
Cd28 co-stimulation
(R-HSA-389356)
Costimulation by the cd28 family
(R-HSA-388841)
Cytokine signaling in immune system
(R-HSA-1280215)
Dap12 interactions
(R-HSA-2172127)
Dap12 signaling
(R-HSA-2424491)
Fc epsilon receptor (fceri) signaling
(R-HSA-2454202)
Fceri mediated ca+2 mobilization
(R-HSA-2871809)
Fceri mediated mapk activation
(R-HSA-2871796)
Flt3 signaling
(R-HSA-9607240)
Generation of second messenger molecules
(R-HSA-202433)
Immune system
(R-HSA-168256)
Innate immune system
(R-HSA-168249)
Signaling by csf1 (m-csf) in myeloid cells
(R-HSA-9680350)
Signaling by receptor tyrosine kinases
(R-HSA-9006934)
Signaling by scf-kit
(R-HSA-1433557)
Tcr signaling
(R-HSA-202403)
Cell-cell signaling
(GO:0007267)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Endosome
(GO:0005768)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Phosphotyrosine residue binding
(GO:0001784)
Plasma membrane
(GO:0005886)
Protein binding
(GO:0005515)
Ras protein signal transduction
(GO:0007265)
Regulation of mapk cascade
(GO:0043408)
Signal transduction
(GO:0007165)

Other Information

Proteins

GRB2-related adapter protein 2
B7Z8E3_HUMAN

Genular Protein ID: 3490138282

Symbol: GRAP2_HUMAN

Name: GRB2-related adapter protein 2

UniProtKB Accession Codes:

O75791 B7Z8I3 O43726 Q9NRB7

Database IDs:

Citations:

PubMed ID: 9878555

Title: Molecular cloning and expression of human grap-2, a novel leukocyte-specific SH2- and SH3-containing adaptor-like protein that binds to gab-1.

PubMed ID: 9878555

DOI: 10.1006/bbrc.1998.9795

PubMed ID: 10209041

Title: GrpL, a Grb2-related adaptor protein, interacts with SLP-76 to regulate nuclear factor of activated T cell activation.

PubMed ID: 10209041

DOI: 10.1084/jem.189.8.1243

PubMed ID: 10224278

Title: Grf40, A novel Grb2 family member, is involved in T cell signaling through interaction with SLP-76 and LAT.

PubMed ID: 10224278

DOI: 10.1084/jem.189.9.1383

PubMed ID: 10820259

Title: GRID: a novel Grb-2-related adapter protein that interacts with the activated T cell costimulatory receptor CD28.

PubMed ID: 10820259

DOI: 10.4049/jimmunol.164.11.5805

PubMed ID: 12062812

Title: Genomic organization and restricted expression of the human Mona/Gads gene suggests regulation by two specific promoters.

PubMed ID: 12062812

DOI: 10.1016/s0378-1119(02)00555-3

PubMed ID: 15461802

Title: A genome annotation-driven approach to cloning the human ORFeome.

PubMed ID: 15461802

DOI: 10.1186/gb-2004-5-10-r84

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 10591208

Title: The DNA sequence of human chromosome 22.

PubMed ID: 10591208

DOI: 10.1038/990031

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10811803

Title: Association of Grb2, Gads, and phospholipase C-gamma 1 with phosphorylated LAT tyrosine residues. Effect of LAT tyrosine mutations on T cell antigen receptor-mediated signaling.

PubMed ID: 10811803

DOI: 10.1074/jbc.m000404200

PubMed ID: 12084069

Title: Shb links SLP-76 and Vav with the CD3 complex in Jurkat T cells.

PubMed ID: 12084069

DOI: 10.1046/j.1432-1033.2002.03008.x

PubMed ID: 12359715

Title: Molecular cloning of a novel gene encoding a membrane-associated adaptor protein (LAX) in lymphocyte signaling.

PubMed ID: 12359715

DOI: 10.1074/jbc.m208946200

PubMed ID: 12522270

Title: Profiling of tyrosine phosphorylation pathways in human cells using mass spectrometry.

PubMed ID: 12522270

DOI: 10.1073/pnas.2436191100

PubMed ID: 15144186

Title: Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry.

PubMed ID: 15144186

DOI: 10.1021/ac035352d

PubMed ID: 18088087

Title: Phosphoproteome of resting human platelets.

PubMed ID: 18088087

DOI: 10.1021/pr0704130

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21179510

Title: Histidine domain-protein tyrosine phosphatase interacts with Grb2 and GrpL.

PubMed ID: 21179510

DOI: 10.1371/journal.pone.0014339

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

Length: 330
Mass: 37909
Checksum: 74F4C8D0EBB56D55
Sequence:

MEAVAKFDFT ASGEDELSFH TGDVLKILSN QEEWFKAELG SQEGYVPKNF IDIQFPKWFH 
EGLSRHQAEN LLMGKEVGFF IIRASQSSPG DFSISVRHED DVQHFKVMRD NKGNYFLWTE 
KFPSLNKLVD YYRTNSISRQ KQIFLRDRTR EDQGHRGNSL DRRSQGGPHL SGAVGEEIRP 
SMNRKLSDHP PTLPLQQHQH QPQPPQYAPA PQQLQQPPQQ RYLQHHHFHQ ERRGGSLDIN 
DGHCGTGLGS EMNAALMHRR HTDPVQLQAA GRVRWARALY DFEALEDDEL GFHSGEVVEV 
LDSSNPSWWT GRLHNKLGLF PANYVAPMTR

Genular Protein ID: 463262006

Symbol: B7Z8E3_HUMAN

Name: N/A

UniProtKB Accession Codes:

B7Z8E3

Database IDs:

Sequence Information:

Length: 258
Mass: 29625
Checksum: D975950B906D36CE
Sequence:

MGKEVGFFII RASQSSPGDF SISVRHEDDV QHFKVMRDNK GNYFLWTEKF PSLNKLVDYY 
RTNSISRQKQ IFLRDRTRED QGHRGNSLDR RSQGGPHLSG AVGEEIRPSM NRKLSDHPPT 
LPLQQHQHQP QPPQYAPAPQ QLQQPPQQRY LQHHHFHQER RGGSLDINDG HCGTGLGSEM 
NAALMHRRHT DPVQLQAAGR VRWARALYDF EALEDDELGF HSGEVVEVLD SSNPSWWTGR 
LHNKLGLFPA NYVAPMTR

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: GRAP2

Associated with

Other Information

Molecular cloning and expression of human grap-2, a novel leukocyte-specific SH2- and SH3-containing adaptor-like protein that binds to gab-1. PubMed ID: 9878555

GrpL, a Grb2-related adaptor protein, interacts with SLP-76 to regulate nuclear factor of activated T cell activation. PubMed ID: 10209041

Grf40, A novel Grb2 family member, is involved in T cell signaling through interaction with SLP-76 and LAT. PubMed ID: 10224278

GRID: a novel Grb-2-related adapter protein that interacts with the activated T cell costimulatory receptor CD28. PubMed ID: 10820259

Genomic organization and restricted expression of the human Mona/Gads gene suggests regulation by two specific promoters. PubMed ID: 12062812

A genome annotation-driven approach to cloning the human ORFeome. PubMed ID: 15461802

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence of human chromosome 22. PubMed ID: 10591208

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Association of Grb2, Gads, and phospholipase C-gamma 1 with phosphorylated LAT tyrosine residues. Effect of LAT tyrosine mutations on T cell antigen receptor-mediated signaling. PubMed ID: 10811803

Shb links SLP-76 and Vav with the CD3 complex in Jurkat T cells. PubMed ID: 12084069

Molecular cloning of a novel gene encoding a membrane-associated adaptor protein (LAX) in lymphocyte signaling. PubMed ID: 12359715

Profiling of tyrosine phosphorylation pathways in human cells using mass spectrometry. PubMed ID: 12522270

Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry. PubMed ID: 15144186

Phosphoproteome of resting human platelets. PubMed ID: 18088087

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. PubMed ID: 19690332

Lysine acetylation targets protein complexes and co-regulates major cellular functions. PubMed ID: 19608861

Histidine domain-protein tyrosine phosphatase interacts with Grb2 and GrpL. PubMed ID: 21179510

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569