Gene CD80 - ENSG00000121594 | NCBI Gene ID: 941

Details for: CD80

Gene ID: 941

Symbol: CD80

Ensembl ID: ENSG00000121594

Description: CD80 molecule

Associated with

Adaptive immune system
(R-HSA-1280218)
Cd28 co-stimulation
(R-HSA-389356)
Cd28 dependent pi3k/akt signaling
(R-HSA-389357)
Cd28 dependent vav1 pathway
(R-HSA-389359)
Constitutive signaling by aberrant pi3k in cancer
(R-HSA-2219530)
Costimulation by the cd28 family
(R-HSA-388841)
Ctla4 inhibitory signaling
(R-HSA-389513)
Cytokine signaling in immune system
(R-HSA-1280215)
Disease
(R-HSA-1643685)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Immune system
(R-HSA-168256)
Interleukin-10 signaling
(R-HSA-6783783)
Intracellular signaling by second messengers
(R-HSA-9006925)
Negative regulation of the pi3k/akt network
(R-HSA-199418)
Pi3k/akt signaling in cancer
(R-HSA-2219528)
Pi5p, pp2a and ier3 regulate pi3k/akt signaling
(R-HSA-6811558)
Pip3 activates akt signaling
(R-HSA-1257604)
Signaling by interleukins
(R-HSA-449147)
Signal transduction
(R-HSA-162582)
Cell surface
(GO:0009986)
Cell surface receptor signaling pathway
(GO:0007166)
Cellular response to lipopolysaccharide
(GO:0071222)
Coreceptor activity
(GO:0015026)
External side of plasma membrane
(GO:0009897)
Immune response
(GO:0006955)
Intracellular signal transduction
(GO:0035556)
Negative regulation of t cell mediated immunity
(GO:0002710)
Negative regulation of t cell proliferation
(GO:0042130)
Plasma membrane
(GO:0005886)
Positive regulation of dna-templated transcription
(GO:0045893)
Positive regulation of granulocyte macrophage colony-stimulating factor production
(GO:0032725)
Positive regulation of interleukin-2 production
(GO:0032743)
Positive regulation of peptidyl-tyrosine phosphorylation
(GO:0050731)
Positive regulation of signal transduction
(GO:0009967)
Positive regulation of t-helper 1 cell differentiation
(GO:0045627)
Positive regulation of t cell proliferation
(GO:0042102)
Protein binding
(GO:0005515)
Protein complex involved in cell adhesion
(GO:0098636)
Receptor ligand activity
(GO:0048018)
Symbiont entry into host cell
(GO:0046718)
T cell activation
(GO:0042110)
T cell costimulation
(GO:0031295)
Virus receptor activity
(GO:0001618)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: retina horizontal cell (CL0000745)
Fold Change: 2.32
Marker Score: 2223
Cell Name: T-helper 17 cell (CL0000899)
Fold Change: 2.12
Marker Score: 1389
Cell Name: mural cell (CL0008034)
Fold Change: 1.48
Marker Score: 170116
Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: 1.37
Marker Score: 868
Cell Name: amacrine cell (CL0000561)
Fold Change: 1.17
Marker Score: 3752
Cell Name: goblet cell (CL0000160)
Fold Change: 1.14
Marker Score: 7560
Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
Fold Change: 1.04
Marker Score: 2157
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 1.02
Marker Score: 2073
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71825
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 48049
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30409
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.96
Marker Score: 2449
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.94
Marker Score: 5346
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.92
Marker Score: 2741
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5290
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.78
Marker Score: 1259
Cell Name: brush cell (CL0002204)
Fold Change: 0.77
Marker Score: 706
Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.76
Marker Score: 394
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.75
Marker Score: 574
Cell Name: ON-bipolar cell (CL0000749)
Fold Change: 0.7
Marker Score: 2040.5
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.69
Marker Score: 176
Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 0.67
Marker Score: 1272.5
Cell Name: retinal cone cell (CL0000573)
Fold Change: 0.6
Marker Score: 1726.5
Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: 0.56
Marker Score: 234
Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.56
Marker Score: 444
Cell Name: precursor B cell (CL0000817)
Fold Change: 0.56
Marker Score: 367
Cell Name: common myeloid progenitor (CL0000049)
Fold Change: 0.55
Marker Score: 146
Cell Name: mononuclear cell (CL0000842)
Fold Change: 0.54
Marker Score: 173
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.53
Marker Score: 8279
Cell Name: hematopoietic stem cell (CL0000037)
Fold Change: 0.53
Marker Score: 277
Cell Name: IgG memory B cell (CL0000979)
Fold Change: 0.51
Marker Score: 307
Cell Name: centrocyte (CL0009111)
Fold Change: 0.49
Marker Score: 117
Cell Name: pro-B cell (CL0000826)
Fold Change: 0.49
Marker Score: 472
Cell Name: OFF-bipolar cell (CL0000750)
Fold Change: 0.42
Marker Score: 1233
Cell Name: megakaryocyte (CL0000556)
Fold Change: 0.41
Marker Score: 234
Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
Fold Change: 0.4
Marker Score: 1036
Cell Name: class switched memory B cell (CL0000972)
Fold Change: 0.4
Marker Score: 373
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.39
Marker Score: 1147
Cell Name: Kupffer cell (CL0000091)
Fold Change: 0.37
Marker Score: 374
Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: 0.37
Marker Score: 369
Cell Name: retinal bipolar neuron (CL0000748)
Fold Change: 0.34
Marker Score: 2914.5
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 0.34
Marker Score: 2162
Cell Name: alveolar macrophage (CL0000583)
Fold Change: 0.27
Marker Score: 6900
Cell Name: alternatively activated macrophage (CL0000890)
Fold Change: 0.27
Marker Score: 112
Cell Name: transitional stage B cell (CL0000818)
Fold Change: 0.26
Marker Score: 93
Cell Name: glial cell (CL0000125)
Fold Change: 0.26
Marker Score: 287
Cell Name: retinal rod cell (CL0000604)
Fold Change: 0.25
Marker Score: 700
Cell Name: centroblast (CL0009112)
Fold Change: 0.24
Marker Score: 120
Cell Name: myeloid cell (CL0000763)
Fold Change: 0.24
Marker Score: 389
Cell Name: Mueller cell (CL0000636)
Fold Change: 0.23
Marker Score: 322
Cell Name: renal beta-intercalated cell (CL0002201)
Fold Change: 0.21
Marker Score: 67
Cell Name: macrophage (CL0000235)
Fold Change: 0.21
Marker Score: 229
Cell Name: smooth muscle myoblast (CL0000514)
Fold Change: 0.19
Marker Score: 92
Cell Name: dendritic cell (CL0000451)
Fold Change: 0.19
Marker Score: 130
Cell Name: unswitched memory B cell (CL0000970)
Fold Change: 0.19
Marker Score: 111
Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 0.19
Marker Score: 113
Cell Name: B cell (CL0000236)
Fold Change: 0.19
Marker Score: 178
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 0.18
Marker Score: 111
Cell Name: renal alpha-intercalated cell (CL0005011)
Fold Change: 0.18
Marker Score: 96
Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: 0.18
Marker Score: 55
Cell Name: endothelial cell (CL0000115)
Fold Change: 0.17
Marker Score: 152
Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 0.17
Marker Score: 394
Cell Name: hepatocyte (CL0000182)
Fold Change: 0.17
Marker Score: 113
Cell Name: hematopoietic cell (CL0000988)
Fold Change: 0.17
Marker Score: 110
Cell Name: conventional dendritic cell (CL0000990)
Fold Change: 0.16
Marker Score: 111
Cell Name: monocyte (CL0000576)
Fold Change: 0.16
Marker Score: 204
Cell Name: memory B cell (CL0000787)
Fold Change: 0.15
Marker Score: 114
Cell Name: connective tissue cell (CL0002320)
Fold Change: 0.15
Marker Score: 38
Cell Name: leptomeningeal cell (CL0000708)
Fold Change: 0.14
Marker Score: 70
Cell Name: renal principal cell (CL0005009)
Fold Change: 0.13
Marker Score: 98
Cell Name: pulmonary interstitial fibroblast (CL0002241)
Fold Change: 0.13
Marker Score: 101
Cell Name: microglial cell (CL0000129)
Fold Change: 0.13
Marker Score: 228
Cell Name: plasmacytoid dendritic cell (CL0000784)
Fold Change: 0.12
Marker Score: 67
Cell Name: parietal epithelial cell (CL1000452)
Fold Change: 0.12
Marker Score: 43
Cell Name: mononuclear phagocyte (CL0000113)
Fold Change: 0.12
Marker Score: 118
Cell Name: elicited macrophage (CL0000861)
Fold Change: 0.12
Marker Score: 714
Cell Name: myeloid dendritic cell, human (CL0001057)
Fold Change: 0.12
Marker Score: 42
Cell Name: epithelial cell of alveolus of lung (CL0010003)
Fold Change: 0.12
Marker Score: 52
Cell Name: plasmablast (CL0000980)
Fold Change: 0.11
Marker Score: 152
Cell Name: germinal center B cell (CL0000844)
Fold Change: 0.11
Marker Score: 67
Cell Name: myeloid leukocyte (CL0000766)
Fold Change: 0.11
Marker Score: 132
Cell Name: lung macrophage (CL1001603)
Fold Change: 0.11
Marker Score: 125
Cell Name: erythrocyte (CL0000232)
Fold Change: 0.11
Marker Score: 60
Cell Name: leukocyte (CL0000738)
Fold Change: 0.11
Marker Score: 62
Cell Name: T cell (CL0000084)
Fold Change: 0.11
Marker Score: 185
Cell Name: choroid plexus epithelial cell (CL0000706)
Fold Change: 0.11
Marker Score: 98
Cell Name: myeloid dendritic cell (CL0000782)
Fold Change: 0.1
Marker Score: 63
Cell Name: late promyelocyte (CL0002151)
Fold Change: 0.1
Marker Score: 26
Cell Name: proerythroblast (CL0000547)
Fold Change: 0.1
Marker Score: 70
Cell Name: IgG plasma cell (CL0000985)
Fold Change: 0.1
Marker Score: 45
Cell Name: mature NK T cell (CL0000814)
Fold Change: 0.1
Marker Score: 47
Cell Name: pericyte (CL0000669)
Fold Change: 0.1
Marker Score: 59
Cell Name: plasmacytoid dendritic cell, human (CL0001058)
Fold Change: 0.1
Marker Score: 26
Cell Name: skin fibroblast (CL0002620)
Fold Change: 0.1
Marker Score: 25
Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
Fold Change: 0.09
Marker Score: 25
Cell Name: neuronal receptor cell (CL0000006)
Fold Change: 0.09
Marker Score: 42
Cell Name: IgG plasmablast (CL0000982)
Fold Change: 0.09
Marker Score: 26
Cell Name: CD4-positive, CD25-positive, alpha-beta regulatory T cell (CL0000792)
Fold Change: 0.09
Marker Score: 25
Cell Name: follicular B cell (CL0000843)
Fold Change: 0.09
Marker Score: 101
Cell Name: exhausted T cell (CL0011025)
Fold Change: 0.09
Marker Score: 53

Hover over a box to see details here...

**Key characteristics:** - CD80 is a glycoprotein with a molecular weight of approximately 40-50 kDa. - It is expressed on the surface of activated T cells and some other immune cells. - CD80 binds to CD86 on the surface of antigen-presenting cells, triggering the activation of T cells. **Pathways and functions:** - CD80 signaling is a critical pathway for T cell activation. - It is involved in the early stages of T cell activation, promoting the formation of the T cell receptor complex and the subsequent signal transduction pathway. - CD80 signaling is also involved in the regulation of immune responses, as it can inhibit the activation of T cells in anergic conditions. **Clinical significance:** - Mutations in the CD80 gene have been linked to several human cancers. - Targeting CD80 signaling has emerged as a promising therapeutic strategy for cancer immunotherapy. - By blocking CD80-CD86 interactions, anti-CD80 antibodies can inhibit T cell activation and prevent cancer growth. **Other important points:** - CD80 is also expressed on activated B cells and macrophages. - It is involved in the regulation of immune responses to viral infection. - CD80 signaling is a complex and multifaceted pathway that is still being fully understood.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

T-lymphocyte activation antigen CD80

Genular Protein ID: 1595606794

Symbol: CD80_HUMAN

Name: T-lymphocyte activation antigen CD80

UniProtKB Accession Codes:

P33681 Q5DTA9 Q5DTB0

Database IDs:

Citations:

PubMed ID: 2794510

Title: B7, a new member of the Ig superfamily with unique expression on activated and neoplastic B cells.

PubMed ID: 2794510

PubMed ID: 1377173

Title: Genomic organization and chromosomal location of the human gene encoding the B-lymphocyte activation antigen B7.

PubMed ID: 1377173

DOI: 10.1007/bf00661094

PubMed ID: 17953528

Title: Human Soluble CD80 is generated by alternative splicing, and recombinant soluble CD80 binds to CD28 and CD152 influencing T-cell activation.

PubMed ID: 17953528

DOI: 10.1111/j.1365-3083.2007.02009.x

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1714935

Title: Structure, expression, and T cell costimulatory activity of the murine homologue of the human B lymphocyte activation antigen B7.

PubMed ID: 1714935

DOI: 10.1084/jem.174.3.625

PubMed ID: 7527824

Title: CD80 (B7) and CD86 (B70) provide similar costimulatory signals for T cell proliferation, cytokine production, and generation of CTL.

PubMed ID: 7527824

PubMed ID: 10583602

Title: Interaction of CTLA-4 (CD152) with CD80 or CD86 inhibits human T-cell activation.

PubMed ID: 10583602

DOI: 10.1046/j.1365-2567.1999.00888.x

PubMed ID: 16920215

Title: Members of adenovirus species B utilize CD80 and CD86 as cellular attachment receptors.

PubMed ID: 16920215

DOI: 10.1016/j.virusres.2006.07.009

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 30918073

Title: By Binding CD80 and CD86, the Vaccinia Virus M2 Protein Blocks Their Interactions with both CD28 and CTLA4 and Potentiates CD80 Binding to PD-L1.

PubMed ID: 30918073

DOI: 10.1128/jvi.00207-19

PubMed ID: 10661405

Title: Structure and dimerization of a soluble form of B7-1.

PubMed ID: 10661405

DOI: 10.1016/s1074-7613(00)80158-2

PubMed ID: 11279502

Title: Crystal structure of the B7-1/CTLA-4 complex that inhibits human immune responses.

PubMed ID: 11279502

DOI: 10.1038/35069118

Sequence Information:

Length: 288
Mass: 33048
Checksum: BA453EE34528B1F4
Sequence:

MGHTRRQGTS PSKCPYLNFF QLLVLAGLSH FCSGVIHVTK EVKEVATLSC GHNVSVEELA 
QTRIYWQKEK KMVLTMMSGD MNIWPEYKNR TIFDITNNLS IVILALRPSD EGTYECVVLK 
YEKDAFKREH LAEVTLSVKA DFPTPSISDF EIPTSNIRRI ICSTSGGFPE PHLSWLENGE 
ELNAINTTVS QDPETELYAV SSKLDFNMTT NHSFMCLIKY GHLRVNQTFN WNTTKQEHFP 
DNLLPSWAIT LISVNGIFVI CCLTYCFAPR CRERRRNERL RRESVRPV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: CD80

Associated with

Cells (max top 100)

Other Information

B7, a new member of the Ig superfamily with unique expression on activated and neoplastic B cells. PubMed ID: 2794510

Genomic organization and chromosomal location of the human gene encoding the B-lymphocyte activation antigen B7. PubMed ID: 1377173

Human Soluble CD80 is generated by alternative splicing, and recombinant soluble CD80 binds to CD28 and CD152 influencing T-cell activation. PubMed ID: 17953528

The DNA sequence, annotation and analysis of human chromosome 3. PubMed ID: 16641997

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Structure, expression, and T cell costimulatory activity of the murine homologue of the human B lymphocyte activation antigen B7. PubMed ID: 1714935

CD80 (B7) and CD86 (B70) provide similar costimulatory signals for T cell proliferation, cytokine production, and generation of CTL. PubMed ID: 7527824

Interaction of CTLA-4 (CD152) with CD80 or CD86 inhibits human T-cell activation. PubMed ID: 10583602

Members of adenovirus species B utilize CD80 and CD86 as cellular attachment receptors. PubMed ID: 16920215

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

By Binding CD80 and CD86, the Vaccinia Virus M2 Protein Blocks Their Interactions with both CD28 and CTLA4 and Potentiates CD80 Binding to PD-L1. PubMed ID: 30918073

Structure and dimerization of a soluble form of B7-1. PubMed ID: 10661405

Crystal structure of the B7-1/CTLA-4 complex that inhibits human immune responses. PubMed ID: 11279502