Details for: CD80

Gene ID: 941

Symbol: CD80

Ensembl ID: ENSG00000121594

Description: CD80 molecule

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 16.3242
    Cell Significance Index: 252.5600
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 9.0829
    Cell Significance Index: -3.6900
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 3.0282
    Cell Significance Index: 43.4000
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: 1.5459
    Cell Significance Index: 13.9800
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.6902
    Cell Significance Index: 8.1200
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.3078
    Cell Significance Index: 3.4900
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.2676
    Cell Significance Index: 7.8600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.2390
    Cell Significance Index: 28.1800
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1689
    Cell Significance Index: 116.7900
  • Cell Name: helper T cell (CL0000912)
    Fold Change: 0.0774
    Cell Significance Index: 1.1000
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.0662
    Cell Significance Index: 1.4200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0087
    Cell Significance Index: 1.7500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0011
    Cell Significance Index: -2.0900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0032
    Cell Significance Index: -0.6300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0034
    Cell Significance Index: -5.2500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0035
    Cell Significance Index: -6.4700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0044
    Cell Significance Index: -5.9700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0044
    Cell Significance Index: -0.5700
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.0045
    Cell Significance Index: -0.0600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0047
    Cell Significance Index: -2.9900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0054
    Cell Significance Index: -3.9600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0056
    Cell Significance Index: -0.8100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0063
    Cell Significance Index: -4.7000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0065
    Cell Significance Index: -4.9500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0075
    Cell Significance Index: -2.7000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0082
    Cell Significance Index: -1.4800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0084
    Cell Significance Index: -4.7200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0089
    Cell Significance Index: -2.5800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0090
    Cell Significance Index: -4.1000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0135
    Cell Significance Index: -2.3100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0205
    Cell Significance Index: -2.0900
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0244
    Cell Significance Index: -0.3500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0256
    Cell Significance Index: -5.3900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0264
    Cell Significance Index: -3.2500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0306
    Cell Significance Index: -3.5100
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0340
    Cell Significance Index: -1.4800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0345
    Cell Significance Index: -4.4600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0351
    Cell Significance Index: -0.9800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0361
    Cell Significance Index: -4.9600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0407
    Cell Significance Index: -4.7500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0429
    Cell Significance Index: -3.2900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0430
    Cell Significance Index: -4.4800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0479
    Cell Significance Index: -1.2300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0609
    Cell Significance Index: -4.5400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0676
    Cell Significance Index: -1.8400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0692
    Cell Significance Index: -3.2500
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.0696
    Cell Significance Index: -1.0100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0698
    Cell Significance Index: -4.5000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0703
    Cell Significance Index: -3.6600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0735
    Cell Significance Index: -4.5200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0744
    Cell Significance Index: -5.0000
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.0822
    Cell Significance Index: -0.6700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0850
    Cell Significance Index: -5.2100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0859
    Cell Significance Index: -3.8000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0864
    Cell Significance Index: -2.3100
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0868
    Cell Significance Index: -1.2700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0871
    Cell Significance Index: -4.8900
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0876
    Cell Significance Index: -1.1500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0879
    Cell Significance Index: -4.1000
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.0940
    Cell Significance Index: -1.3700
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0968
    Cell Significance Index: -3.3900
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.0984
    Cell Significance Index: -1.1600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0991
    Cell Significance Index: -2.0800
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0998
    Cell Significance Index: -1.7200
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.1011
    Cell Significance Index: -1.2500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1032
    Cell Significance Index: -5.3600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1035
    Cell Significance Index: -3.9200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.1041
    Cell Significance Index: -2.2800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1053
    Cell Significance Index: -3.3600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1109
    Cell Significance Index: -3.6300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1183
    Cell Significance Index: -4.1100
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.1196
    Cell Significance Index: -2.2100
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: -0.1233
    Cell Significance Index: -1.1800
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.1236
    Cell Significance Index: -2.1000
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.1240
    Cell Significance Index: -1.9900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1258
    Cell Significance Index: -3.3700
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.1260
    Cell Significance Index: -1.7000
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.1299
    Cell Significance Index: -2.5400
  • Cell Name: pulmonary capillary endothelial cell (CL4028001)
    Fold Change: -0.1300
    Cell Significance Index: -1.7800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1301
    Cell Significance Index: -2.2300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1406
    Cell Significance Index: -4.1400
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.1407
    Cell Significance Index: -1.9300
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1423
    Cell Significance Index: -3.0200
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: -0.1434
    Cell Significance Index: -1.2400
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.1437
    Cell Significance Index: -2.9300
  • Cell Name: L6 corticothalamic-projecting glutamatergic cortical neuron (CL4023042)
    Fold Change: -0.1459
    Cell Significance Index: -1.6100
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.1468
    Cell Significance Index: -2.0300
  • Cell Name: stromal cell of endometrium (CL0002255)
    Fold Change: -0.1476
    Cell Significance Index: -2.1000
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1487
    Cell Significance Index: -3.7100
  • Cell Name: centrocyte (CL0009111)
    Fold Change: -0.1492
    Cell Significance Index: -0.4600
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.1498
    Cell Significance Index: -1.3200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1531
    Cell Significance Index: -5.3800
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.1532
    Cell Significance Index: -3.8200
  • Cell Name: neuroplacodal cell (CL0000032)
    Fold Change: -0.1543
    Cell Significance Index: -1.9000
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.1548
    Cell Significance Index: -1.8300
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.1549
    Cell Significance Index: -2.0100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1556
    Cell Significance Index: -4.4600
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1558
    Cell Significance Index: -5.7200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1569
    Cell Significance Index: -4.1900
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.1595
    Cell Significance Index: -2.1200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Expression**: CD80 is primarily expressed on the surface of APCs, but it can also be found on other cell types, such as epithelial cells and some types of immune cells. 2. **Structure**: CD80 is a type II transmembrane glycoprotein composed of two extracellular domains and a transmembrane domain, with an intracellular tail. 3. **Function**: CD80 acts as a co-stimulatory molecule, providing a second signal necessary for T cell activation, proliferation, and differentiation. 4. **Regulation**: CD80 expression can be regulated by various factors, including cytokines, growth factors, and transcription factors. **Pathways and Functions** 1. **CD28 co-stimulation**: CD80 interacts with CD28 on T cells, providing a second signal necessary for full T cell activation. 2. **CD28-dependent PI3K/Akt signaling**: CD80 engagement with CD28 activates the PI3K/Akt signaling pathway, which promotes T cell survival, proliferation, and differentiation. 3. **Vav1 pathway**: CD80 engagement with CD28 also activates the Vav1 pathway, which is involved in T cell activation and proliferation. 4. **Intracellular signaling**: CD80 can also activate intracellular signaling pathways, including the PI3K/Akt and MAPK pathways, which regulate various cellular processes, including cell survival, proliferation, and differentiation. 5. **Costimulation by the CD28 family**: CD80 is a member of the CD28 family, which also includes CD28, CD137, and CTLA-4. CD80 provides a second signal necessary for T cell activation, while CD28 provides the first signal. **Clinical Significance** 1. **Immunotherapy**: CD80 is a target for immunotherapy, as it is involved in the activation and proliferation of T cells, which are essential for the efficacy of immunotherapeutic strategies, including checkpoint inhibitors and cancer vaccines. 2. **Autoimmune diseases**: CD80 has been implicated in various autoimmune diseases, including rheumatoid arthritis, lupus, and multiple sclerosis, where it is thought to contribute to the activation and proliferation of autoreactive T cells. 3. **Cancer**: CD80 has been found to be overexpressed in various types of cancer, including melanoma, lung cancer, and breast cancer, where it may contribute to the immune evasion of cancer cells. 4. **Immunodeficiency**: CD80 has also been implicated in immunodeficiency disorders, such as X-linked lymphoproliferative disease, where it is thought to contribute to the impaired T cell activation and proliferation. In conclusion, CD80 is a critical co-stimulatory molecule that plays a pivotal role in the activation, proliferation, and differentiation of T cells. Its dysregulation has been implicated in various autoimmune and cancer diseases, and it is a target for immunotherapeutic strategies.

Genular Protein ID: 1595606794

Symbol: CD80_HUMAN

Name: T-lymphocyte activation antigen CD80

UniProtKB Accession Codes:

P33681 Q5DTA9 Q5DTB0

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 3 DrugCentral 1 EMBL 9 EMDB 1 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 21 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 9 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 4 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 RNAct 1 Reactome 8 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 2794510

Title: B7, a new member of the Ig superfamily with unique expression on activated and neoplastic B cells.

PubMed ID: 2794510

PubMed ID: 1377173

Title: Genomic organization and chromosomal location of the human gene encoding the B-lymphocyte activation antigen B7.

PubMed ID: 1377173

DOI: 10.1007/bf00661094

PubMed ID: 17953528

Title: Human Soluble CD80 is generated by alternative splicing, and recombinant soluble CD80 binds to CD28 and CD152 influencing T-cell activation.

PubMed ID: 17953528

DOI: 10.1111/j.1365-3083.2007.02009.x

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1714935

Title: Structure, expression, and T cell costimulatory activity of the murine homologue of the human B lymphocyte activation antigen B7.

PubMed ID: 1714935

DOI: 10.1084/jem.174.3.625

PubMed ID: 7527824

Title: CD80 (B7) and CD86 (B70) provide similar costimulatory signals for T cell proliferation, cytokine production, and generation of CTL.

PubMed ID: 7527824

PubMed ID: 10583602

Title: Interaction of CTLA-4 (CD152) with CD80 or CD86 inhibits human T-cell activation.

PubMed ID: 10583602

DOI: 10.1046/j.1365-2567.1999.00888.x

PubMed ID: 10438913

Title: IL-2-independent activation and proliferation in human T cells induced by CD28.

PubMed ID: 10438913

PubMed ID: 12121659

Title: The CD28 signaling pathway regulates glucose metabolism.

PubMed ID: 12121659

DOI: 10.1016/s1074-7613(02)00323-0

PubMed ID: 12196291

Title: The interaction properties of costimulatory molecules revisited.

PubMed ID: 12196291

DOI: 10.1016/s1074-7613(02)00362-x

PubMed ID: 16920215

Title: Members of adenovirus species B utilize CD80 and CD86 as cellular attachment receptors.

PubMed ID: 16920215

DOI: 10.1016/j.virusres.2006.07.009

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 30918073

Title: By Binding CD80 and CD86, the Vaccinia Virus M2 Protein Blocks Their Interactions with both CD28 and CTLA4 and Potentiates CD80 Binding to PD-L1.

PubMed ID: 30918073

DOI: 10.1128/jvi.00207-19

PubMed ID: 36727298

Title: The CTLA-4 immune checkpoint protein regulates PD-L1:PD-1 interaction via transendocytosis of its ligand CD80.

PubMed ID: 36727298

DOI: 10.15252/embj.2022111556

PubMed ID: 38467718

Title: zDHHC20-driven S-palmitoylation of CD80 is required for its costimulatory function.

PubMed ID: 38467718

DOI: 10.1038/s41401-024-01248-1

PubMed ID: 10661405

Title: Structure and dimerization of a soluble form of B7-1.

PubMed ID: 10661405

DOI: 10.1016/s1074-7613(00)80158-2

PubMed ID: 11279502

Title: Crystal structure of the B7-1/CTLA-4 complex that inhibits human immune responses.

PubMed ID: 11279502

DOI: 10.1038/35069118

Sequence Information:

  • Length: 288
  • Mass: 33048
  • Checksum: BA453EE34528B1F4
  • Sequence:
    • MGHTRRQGTS PSKCPYLNFF QLLVLAGLSH FCSGVIHVTK EVKEVATLSC GHNVSVEELA 
QTRIYWQKEK KMVLTMMSGD MNIWPEYKNR TIFDITNNLS IVILALRPSD EGTYECVVLK 
YEKDAFKREH LAEVTLSVKA DFPTPSISDF EIPTSNIRRI ICSTSGGFPE PHLSWLENGE 
ELNAINTTVS QDPETELYAV SSKLDFNMTT NHSFMCLIKY GHLRVNQTFN WNTTKQEHFP 
DNLLPSWAIT LISVNGIFVI CCLTYCFAPR CRERRRNERL RRESVRPV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.