CD80 | ENSG00000121594 | NCBI 941

Details for: CD80

Gene ID: 941

Symbol: CD80

Ensembl ID: ENSG00000121594

Description: CD80 molecule

Associated with

Adaptive immune system
(R-HSA-1280218)
Cd28 co-stimulation
(R-HSA-389356)
Cd28 dependent pi3k/akt signaling
(R-HSA-389357)
Cd28 dependent vav1 pathway
(R-HSA-389359)
Constitutive signaling by aberrant pi3k in cancer
(R-HSA-2219530)
Costimulation by the cd28 family
(R-HSA-388841)
Ctla4 inhibitory signaling
(R-HSA-389513)
Cytokine signaling in immune system
(R-HSA-1280215)
Disease
(R-HSA-1643685)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Immune system
(R-HSA-168256)
Interleukin-10 signaling
(R-HSA-6783783)
Intracellular signaling by second messengers
(R-HSA-9006925)
Negative regulation of the pi3k/akt network
(R-HSA-199418)
Pi3k/akt signaling in cancer
(R-HSA-2219528)
Pi5p, pp2a and ier3 regulate pi3k/akt signaling
(R-HSA-6811558)
Pip3 activates akt signaling
(R-HSA-1257604)
Signaling by interleukins
(R-HSA-449147)
Signal transduction
(R-HSA-162582)
Cell surface
(GO:0009986)
Cell surface receptor signaling pathway
(GO:0007166)
Cellular response to lipopolysaccharide
(GO:0071222)
Coreceptor activity
(GO:0015026)
External side of plasma membrane
(GO:0009897)
Immune response
(GO:0006955)
Intracellular signal transduction
(GO:0035556)
Negative regulation of t cell mediated immunity
(GO:0002710)
Negative regulation of t cell proliferation
(GO:0042130)
Plasma membrane
(GO:0005886)
Positive regulation of dna-templated transcription
(GO:0045893)
Positive regulation of granulocyte macrophage colony-stimulating factor production
(GO:0032725)
Positive regulation of interleukin-2 production
(GO:0032743)
Positive regulation of peptidyl-tyrosine phosphorylation
(GO:0050731)
Positive regulation of signal transduction
(GO:0009967)
Positive regulation of t-helper 1 cell differentiation
(GO:0045627)
Positive regulation of t cell proliferation
(GO:0042102)
Protein binding
(GO:0005515)
Protein complex involved in cell adhesion
(GO:0098636)
Receptor ligand activity
(GO:0048018)
Symbiont entry into host cell
(GO:0046718)
T cell activation
(GO:0042110)
T cell costimulation
(GO:0031295)
Virus receptor activity
(GO:0001618)

Other Information

Proteins

T-lymphocyte activation antigen CD80

Genular Protein ID: 1595606794

Symbol: CD80_HUMAN

Name: T-lymphocyte activation antigen CD80

UniProtKB Accession Codes:

P33681 Q5DTA9 Q5DTB0

Database IDs:

Citations:

PubMed ID: 2794510

Title: B7, a new member of the Ig superfamily with unique expression on activated and neoplastic B cells.

PubMed ID: 2794510

PubMed ID: 1377173

Title: Genomic organization and chromosomal location of the human gene encoding the B-lymphocyte activation antigen B7.

PubMed ID: 1377173

DOI: 10.1007/bf00661094

PubMed ID: 17953528

Title: Human Soluble CD80 is generated by alternative splicing, and recombinant soluble CD80 binds to CD28 and CD152 influencing T-cell activation.

PubMed ID: 17953528

DOI: 10.1111/j.1365-3083.2007.02009.x

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1714935

Title: Structure, expression, and T cell costimulatory activity of the murine homologue of the human B lymphocyte activation antigen B7.

PubMed ID: 1714935

DOI: 10.1084/jem.174.3.625

PubMed ID: 7527824

Title: CD80 (B7) and CD86 (B70) provide similar costimulatory signals for T cell proliferation, cytokine production, and generation of CTL.

PubMed ID: 7527824

PubMed ID: 10583602

Title: Interaction of CTLA-4 (CD152) with CD80 or CD86 inhibits human T-cell activation.

PubMed ID: 10583602

DOI: 10.1046/j.1365-2567.1999.00888.x

PubMed ID: 16920215

Title: Members of adenovirus species B utilize CD80 and CD86 as cellular attachment receptors.

PubMed ID: 16920215

DOI: 10.1016/j.virusres.2006.07.009

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 30918073

Title: By Binding CD80 and CD86, the Vaccinia Virus M2 Protein Blocks Their Interactions with both CD28 and CTLA4 and Potentiates CD80 Binding to PD-L1.

PubMed ID: 30918073

DOI: 10.1128/jvi.00207-19

PubMed ID: 10661405

Title: Structure and dimerization of a soluble form of B7-1.

PubMed ID: 10661405

DOI: 10.1016/s1074-7613(00)80158-2

PubMed ID: 11279502

Title: Crystal structure of the B7-1/CTLA-4 complex that inhibits human immune responses.

PubMed ID: 11279502

DOI: 10.1038/35069118

Sequence Information:

Length: 288
Mass: 33048
Checksum: BA453EE34528B1F4
Sequence:

MGHTRRQGTS PSKCPYLNFF QLLVLAGLSH FCSGVIHVTK EVKEVATLSC GHNVSVEELA 
QTRIYWQKEK KMVLTMMSGD MNIWPEYKNR TIFDITNNLS IVILALRPSD EGTYECVVLK 
YEKDAFKREH LAEVTLSVKA DFPTPSISDF EIPTSNIRRI ICSTSGGFPE PHLSWLENGE 
ELNAINTTVS QDPETELYAV SSKLDFNMTT NHSFMCLIKY GHLRVNQTFN WNTTKQEHFP 
DNLLPSWAIT LISVNGIFVI CCLTYCFAPR CRERRRNERL RRESVRPV

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: CD80

Associated with

Other Information

B7, a new member of the Ig superfamily with unique expression on activated and neoplastic B cells. PubMed ID: 2794510

Genomic organization and chromosomal location of the human gene encoding the B-lymphocyte activation antigen B7. PubMed ID: 1377173

Human Soluble CD80 is generated by alternative splicing, and recombinant soluble CD80 binds to CD28 and CD152 influencing T-cell activation. PubMed ID: 17953528

The DNA sequence, annotation and analysis of human chromosome 3. PubMed ID: 16641997

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Structure, expression, and T cell costimulatory activity of the murine homologue of the human B lymphocyte activation antigen B7. PubMed ID: 1714935

CD80 (B7) and CD86 (B70) provide similar costimulatory signals for T cell proliferation, cytokine production, and generation of CTL. PubMed ID: 7527824

Interaction of CTLA-4 (CD152) with CD80 or CD86 inhibits human T-cell activation. PubMed ID: 10583602

Members of adenovirus species B utilize CD80 and CD86 as cellular attachment receptors. PubMed ID: 16920215

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

By Binding CD80 and CD86, the Vaccinia Virus M2 Protein Blocks Their Interactions with both CD28 and CTLA4 and Potentiates CD80 Binding to PD-L1. PubMed ID: 30918073

Structure and dimerization of a soluble form of B7-1. PubMed ID: 10661405

Crystal structure of the B7-1/CTLA-4 complex that inhibits human immune responses. PubMed ID: 11279502