MED21 | ENSG00000152944 | NCBI 9412

Details for: MED21

Gene ID: 9412

Symbol: MED21

Ensembl ID: ENSG00000152944

Description: mediator complex subunit 21

Associated with

Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Infectious disease
(R-HSA-5663205)
Metabolism
(R-HSA-1430728)
Metabolism of lipids
(R-HSA-556833)
Ppara activates gene expression
(R-HSA-1989781)
Regulation of lipid metabolism by pparalpha
(R-HSA-400206)
Respiratory syncytial virus infection pathway
(R-HSA-9820952)
Rsv-host interactions
(R-HSA-9833110)
Transcriptional regulation of white adipocyte differentiation
(R-HSA-381340)
Viral infection pathways
(R-HSA-9824446)
Blastocyst development
(GO:0001824)
Core mediator complex
(GO:0070847)
Dna-directed 5'-3' rna polymerase activity
(GO:0003899)
Mediator complex
(GO:0016592)
Nucleus
(GO:0005634)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Positive regulation of transcription elongation by rna polymerase ii
(GO:0032968)
Positive regulation of transcription initiation by rna polymerase ii
(GO:0060261)
Protein binding
(GO:0005515)
Protein ubiquitination
(GO:0016567)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Rna polymerase ii preinitiation complex assembly
(GO:0051123)
Somatic stem cell population maintenance
(GO:0035019)
Transcription coactivator activity
(GO:0003713)
Transcription coregulator activity
(GO:0003712)
Ubiquitin ligase complex
(GO:0000151)
Ubiquitin protein ligase activity
(GO:0061630)

Other Information

Proteins

Mediator of RNA polymerase II transcription subunit 21

Genular Protein ID: 2023441924

Symbol: MED21_HUMAN

Name: Mediator of RNA polymerase II transcription subunit 21

UniProtKB Accession Codes:

Q13503 B2R4I3 Q6IB05 Q92811

Database IDs:

Citations:

PubMed ID: 8598913

Title: A mammalian SRB protein associated with an RNA polymerase II holoenzyme.

PubMed ID: 8598913

DOI: 10.1038/380082a0

PubMed ID: 8609996

Title: A human RNA polymerase II complex associated with SRB and DNA-repair proteins.

PubMed ID: 8609996

DOI: 10.1038/381086a0

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9660976

Title: Transcription activation via enhanced preinitiation complex assembly in a human cell-free system lacking TAFIIs.

PubMed ID: 9660976

DOI: 10.1016/s1097-2765(00)80092-1

PubMed ID: 9734358

Title: NAT, a human complex containing Srb polypeptides that functions as a negative regulator of activated transcription.

PubMed ID: 9734358

DOI: 10.1016/s1097-2765(00)80131-8

PubMed ID: 9933582

Title: The human homologue of Drosophila TRF-proximal protein is associated with an RNA polymerase II-SRB complex.

PubMed ID: 9933582

DOI: 10.1074/jbc.274.7.3937

PubMed ID: 10024883

Title: A novel human SRB/MED-containing cofactor complex, SMCC, involved in transcription regulation.

PubMed ID: 10024883

DOI: 10.1016/s1097-2765(00)80178-1

PubMed ID: 15175163

Title: A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology.

PubMed ID: 15175163

DOI: 10.1016/j.molcel.2004.05.006

PubMed ID: 15249124

Title: hSrb7, an essential human Mediator component, acts as a coactivator for the thyroid hormone receptor.

PubMed ID: 15249124

DOI: 10.1016/j.mce.2004.05.003

PubMed ID: 15989967

Title: MED1/TRAP220 exists predominantly in a TRAP/Mediator subpopulation enriched in RNA polymerase II and is required for ER-mediated transcription.

PubMed ID: 15989967

DOI: 10.1016/j.molcel.2005.05.015

Sequence Information:

Length: 144
Mass: 15564
Checksum: F786169620EDC126
Sequence:

MADRLTQLQD AVNSLADQFC NAIGVLQQCG PPASFNNIQT AINKDQPANP TEEYAQLFAA 
LIARTAKDID VLIDSLPSEE STAALQAASL YKLEEENHEA ATCLEDVVYR GDMLLEKIQS 
ALADIAQSQL KTRSGTHSQS LPDS

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: MED21

Associated with

Other Information

A mammalian SRB protein associated with an RNA polymerase II holoenzyme. PubMed ID: 8598913

A human RNA polymerase II complex associated with SRB and DNA-repair proteins. PubMed ID: 8609996

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Transcription activation via enhanced preinitiation complex assembly in a human cell-free system lacking TAFIIs. PubMed ID: 9660976

NAT, a human complex containing Srb polypeptides that functions as a negative regulator of activated transcription. PubMed ID: 9734358

The human homologue of Drosophila TRF-proximal protein is associated with an RNA polymerase II-SRB complex. PubMed ID: 9933582

A novel human SRB/MED-containing cofactor complex, SMCC, involved in transcription regulation. PubMed ID: 10024883

A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology. PubMed ID: 15175163

hSrb7, an essential human Mediator component, acts as a coactivator for the thyroid hormone receptor. PubMed ID: 15249124

MED1/TRAP220 exists predominantly in a TRAP/Mediator subpopulation enriched in RNA polymerase II and is required for ER-mediated transcription. PubMed ID: 15989967