Gene CD86 - ENSG00000114013 | NCBI Gene ID: 942

Details for: CD86

Gene ID: 942

Symbol: CD86

Ensembl ID: ENSG00000114013

Description: CD86 molecule

Associated with

Adaptive immune system
(R-HSA-1280218)
Cd28 co-stimulation
(R-HSA-389356)
Cd28 dependent pi3k/akt signaling
(R-HSA-389357)
Cd28 dependent vav1 pathway
(R-HSA-389359)
Constitutive signaling by aberrant pi3k in cancer
(R-HSA-2219530)
Costimulation by the cd28 family
(R-HSA-388841)
Ctla4 inhibitory signaling
(R-HSA-389513)
Cytokine signaling in immune system
(R-HSA-1280215)
Disease
(R-HSA-1643685)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Immune system
(R-HSA-168256)
Interleukin-10 signaling
(R-HSA-6783783)
Intracellular signaling by second messengers
(R-HSA-9006925)
Negative regulation of the pi3k/akt network
(R-HSA-199418)
Pi3k/akt signaling in cancer
(R-HSA-2219528)
Pi5p, pp2a and ier3 regulate pi3k/akt signaling
(R-HSA-6811558)
Pip3 activates akt signaling
(R-HSA-1257604)
Signaling by interleukins
(R-HSA-449147)
Signal transduction
(R-HSA-162582)
Activation of phospholipase c activity
(GO:0007202)
Activation of protein kinase c activity
(GO:1990051)
Adaptive immune response
(GO:0002250)
B cell activation
(GO:0042113)
Cd40 signaling pathway
(GO:0023035)
Cell surface
(GO:0009986)
Cell surface receptor signaling pathway
(GO:0007166)
Cellular response to lipopolysaccharide
(GO:0071222)
Centriolar satellite
(GO:0034451)
Coreceptor activity
(GO:0015026)
External side of plasma membrane
(GO:0009897)
Extracellular exosome
(GO:0070062)
Immune response
(GO:0006955)
Negative regulation of t cell proliferation
(GO:0042130)
Plasma membrane
(GO:0005886)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of dna-templated transcription
(GO:0045893)
Positive regulation of immunoglobulin production
(GO:0002639)
Positive regulation of interleukin-2 production
(GO:0032743)
Positive regulation of interleukin-4 production
(GO:0032753)
Positive regulation of lymphotoxin a production
(GO:0032761)
Positive regulation of non-canonical nf-kappab signal transduction
(GO:1901224)
Positive regulation of t-helper 2 cell differentiation
(GO:0045630)
Positive regulation of t cell proliferation
(GO:0042102)
Protein binding
(GO:0005515)
Receptor ligand activity
(GO:0048018)
Signaling receptor activity
(GO:0038023)
Symbiont entry into host cell
(GO:0046718)
T cell activation
(GO:0042110)
T cell costimulation
(GO:0031295)
Virus receptor activity
(GO:0001618)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: T-helper 17 cell (CL0000899)
Fold Change: 3.94
Marker Score: 2586
Cell Name: Kupffer cell (CL0000091)
Fold Change: 2.77
Marker Score: 2775
Cell Name: non-classical monocyte (CL0000875)
Fold Change: 2.2
Marker Score: 5322
Cell Name: central nervous system macrophage (CL0000878)
Fold Change: 2.1
Marker Score: 1042
Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
Fold Change: 1.97
Marker Score: 3838
Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
Fold Change: 1.71
Marker Score: 4438
Cell Name: eurydendroid cell (CL0000253)
Fold Change: 1.65
Marker Score: 672
Cell Name: lung macrophage (CL1001603)
Fold Change: 1.64
Marker Score: 1880
Cell Name: myelocyte (CL0002193)
Fold Change: 1.63
Marker Score: 705
Cell Name: Hofbauer cell (CL3000001)
Fold Change: 1.63
Marker Score: 895
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 1.62
Marker Score: 90702
Cell Name: myeloid leukocyte (CL0000766)
Fold Change: 1.61
Marker Score: 1947
Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: 1.59
Marker Score: 3966
Cell Name: mature microglial cell (CL0002629)
Fold Change: 1.59
Marker Score: 575
Cell Name: mural cell (CL0008034)
Fold Change: 1.48
Marker Score: 169911
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 1.42
Marker Score: 2883
Cell Name: alveolar macrophage (CL0000583)
Fold Change: 1.33
Marker Score: 34016
Cell Name: microglial cell (CL0000129)
Fold Change: 1.18
Marker Score: 2157.5
Cell Name: mononuclear cell (CL0000842)
Fold Change: 1.13
Marker Score: 365
Cell Name: conventional dendritic cell (CL0000990)
Fold Change: 1.1
Marker Score: 759
Cell Name: classical monocyte (CL0000860)
Fold Change: 1.03
Marker Score: 4289
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71805
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 48030
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30406
Cell Name: elicited macrophage (CL0000861)
Fold Change: 0.97
Marker Score: 5918
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2413
Cell Name: blood cell (CL0000081)
Fold Change: 0.95
Marker Score: 11013
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.93
Marker Score: 5301
Cell Name: professional antigen presenting cell (CL0000145)
Fold Change: 0.92
Marker Score: 477
Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 0.92
Marker Score: 1746
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.91
Marker Score: 2735
Cell Name: macrophage (CL0000235)
Fold Change: 0.91
Marker Score: 1014
Cell Name: alternatively activated macrophage (CL0000890)
Fold Change: 0.89
Marker Score: 369
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5282
Cell Name: class switched memory B cell (CL0000972)
Fold Change: 0.84
Marker Score: 794
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.84
Marker Score: 638
Cell Name: dendritic cell, human (CL0001056)
Fold Change: 0.83
Marker Score: 846
Cell Name: dendritic cell (CL0000451)
Fold Change: 0.79
Marker Score: 543
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.77
Marker Score: 1256
Cell Name: brush cell (CL0002204)
Fold Change: 0.77
Marker Score: 704
Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.76
Marker Score: 392
Cell Name: myeloid cell (CL0000763)
Fold Change: 0.73
Marker Score: 1166
Cell Name: promonocyte (CL0000559)
Fold Change: 0.71
Marker Score: 455
Cell Name: follicular B cell (CL0000843)
Fold Change: 0.7
Marker Score: 754
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.69
Marker Score: 176
Cell Name: IgG memory B cell (CL0000979)
Fold Change: 0.63
Marker Score: 380
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.6
Marker Score: 1781
Cell Name: monocyte (CL0000576)
Fold Change: 0.57
Marker Score: 746
Cell Name: mononuclear phagocyte (CL0000113)
Fold Change: 0.57
Marker Score: 573
Cell Name: centroblast (CL0009112)
Fold Change: 0.57
Marker Score: 281
Cell Name: memory B cell (CL0000787)
Fold Change: 0.57
Marker Score: 429
Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.56
Marker Score: 444
Cell Name: precursor B cell (CL0000817)
Fold Change: 0.55
Marker Score: 364
Cell Name: centrocyte (CL0009111)
Fold Change: 0.52
Marker Score: 124
Cell Name: plasmablast (CL0000980)
Fold Change: 0.52
Marker Score: 687
Cell Name: late promyelocyte (CL0002151)
Fold Change: 0.51
Marker Score: 128
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.49
Marker Score: 7610
Cell Name: myeloid dendritic cell (CL0000782)
Fold Change: 0.48
Marker Score: 294
Cell Name: renal beta-intercalated cell (CL0002201)
Fold Change: 0.48
Marker Score: 152.5
Cell Name: germinal center B cell (CL0000844)
Fold Change: 0.47
Marker Score: 288
Cell Name: osteoclast (CL0000092)
Fold Change: 0.47
Marker Score: 235
Cell Name: pro-B cell (CL0000826)
Fold Change: 0.46
Marker Score: 448
Cell Name: colon macrophage (CL0009038)
Fold Change: 0.46
Marker Score: 128
Cell Name: unswitched memory B cell (CL0000970)
Fold Change: 0.45
Marker Score: 262
Cell Name: transitional stage B cell (CL0000818)
Fold Change: 0.43
Marker Score: 151
Cell Name: common myeloid progenitor (CL0000049)
Fold Change: 0.42
Marker Score: 112
Cell Name: intermediate monocyte (CL0002393)
Fold Change: 0.42
Marker Score: 144
Cell Name: B cell (CL0000236)
Fold Change: 0.42
Marker Score: 396
Cell Name: Langerhans cell (CL0000453)
Fold Change: 0.41
Marker Score: 124
Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: 0.4
Marker Score: 282
Cell Name: pre-conventional dendritic cell (CL0002010)
Fold Change: 0.38
Marker Score: 113
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 0.38
Marker Score: 228
Cell Name: B-1 B cell (CL0000819)
Fold Change: 0.38
Marker Score: 658
Cell Name: B-1b B cell (CL0000821)
Fold Change: 0.37
Marker Score: 86
Cell Name: mature B cell (CL0000785)
Fold Change: 0.35
Marker Score: 254
Cell Name: common dendritic progenitor (CL0001029)
Fold Change: 0.32
Marker Score: 112
Cell Name: leukocyte (CL0000738)
Fold Change: 0.32
Marker Score: 182
Cell Name: inflammatory macrophage (CL0000863)
Fold Change: 0.31
Marker Score: 96
Cell Name: IgM plasma cell (CL0000986)
Fold Change: 0.29
Marker Score: 102
Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 0.29
Marker Score: 688
Cell Name: hematopoietic cell (CL0000988)
Fold Change: 0.29
Marker Score: 194
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 0.29
Marker Score: 1843
Cell Name: naive B cell (CL0000788)
Fold Change: 0.28
Marker Score: 253
Cell Name: CD38-negative naive B cell (CL0002102)
Fold Change: 0.28
Marker Score: 591
Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: 0.27
Marker Score: 113
Cell Name: neutrophil (CL0000775)
Fold Change: 0.27
Marker Score: 164
Cell Name: IgA plasma cell (CL0000987)
Fold Change: 0.27
Marker Score: 226
Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 0.26
Marker Score: 154
Cell Name: plasma cell (CL0000786)
Fold Change: 0.25
Marker Score: 282
Cell Name: early promyelocyte (CL0002154)
Fold Change: 0.25
Marker Score: 202
Cell Name: hematopoietic precursor cell (CL0008001)
Fold Change: 0.25
Marker Score: 87
Cell Name: natural killer cell (CL0000623)
Fold Change: 0.25
Marker Score: 320
Cell Name: immature B cell (CL0000816)
Fold Change: 0.24
Marker Score: 157.5
Cell Name: plasmacytoid dendritic cell (CL0000784)
Fold Change: 0.23
Marker Score: 126
Cell Name: respiratory basal cell (CL0002633)
Fold Change: 0.23
Marker Score: 336
Cell Name: myeloid dendritic cell, human (CL0001057)
Fold Change: 0.23
Marker Score: 82
Cell Name: smooth muscle myoblast (CL0000514)
Fold Change: 0.23
Marker Score: 109
Cell Name: B-2 B cell (CL0000822)
Fold Change: 0.23
Marker Score: 281
Cell Name: papillary tips cell (CL1000597)
Fold Change: 0.23
Marker Score: 46
Cell Name: CD141-positive myeloid dendritic cell (CL0002394)
Fold Change: 0.22
Marker Score: 76

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**Key characteristics**: - CD86 is a glycoprotein with a molecular weight of approximately 80 kDa. - It is expressed on the surface of activated T cells, as well as on macrophages, dendritic cells, and NK cells. - CD86 is a homophilic interaction molecule, meaning that it binds to CD28 molecules on other immune cells. - It is a key regulator of the adaptive immune response, and its expression on immune cells is often associated with immune suppression. **Pathways and functions**: - CD86 is involved in the adaptive immune response by interacting with CD28 molecules on antigen-presenting cells. - This interaction triggers the activation of the CD28/CD86 signaling pathway, which leads to the inhibition of T cell activation and proliferation. - In addition, CD86 can also interact with the Vav1 signaling pathway, which is involved in the regulation of T cell activation. - CD86 is also involved in the regulation of inflammation and fibrosis. **Clinical significance**: - Dysregulation of CD86 signaling has been linked to various diseases, including cancer, autoimmune disorders, and inflammatory diseases. - Inhibition of CD86 signaling has been shown to enhance T cell activation and improve the efficacy of cancer immunotherapy. - Therefore, CD86 is a promising target for cancer immunotherapy.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Genular Protein ID: 353467806

Symbol: CD86_HUMAN

Name: T-lymphocyte activation antigen CD86

UniProtKB Accession Codes:

P42081 A0N0P0 B7Z2F3 B7Z702 E7ETN5 E9PC27 Q13655 Q6FHB1 Q6GTS4 Q7M4L5

Database IDs:

Citations:

PubMed ID: 7694153

Title: B70 antigen is a second ligand for CTLA-4 and CD28.

PubMed ID: 7694153

DOI: 10.1038/366076a0

PubMed ID: 7694363

Title: Cloning of B7-2: a CTLA-4 counter-receptor that costimulates human T cell proliferation.

PubMed ID: 7694363

DOI: 10.1126/science.7694363

PubMed ID: 11162656

Title: Identification of an alternatively spliced variant of human CD86 mRNA.

PubMed ID: 11162656

DOI: 10.1006/bbrc.2000.4102

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7541777

Title: Genomic organization of the gene coding for the costimulatory human B-lymphocyte antigen B7-2 (CD86).

PubMed ID: 7541777

DOI: 10.1007/bf00178582

PubMed ID: 7527824

Title: CD80 (B7) and CD86 (B70) provide similar costimulatory signals for T cell proliferation, cytokine production, and generation of CTL.

PubMed ID: 7527824

PubMed ID: 7520767

Title: The B7-2 (B70) costimulatory molecule expressed by monocytes and activated B lymphocytes is the CD86 differentiation antigen.

PubMed ID: 7520767

PubMed ID: 12582153

Title: c-MIR, a human E3 ubiquitin ligase, is a functional homolog of herpesvirus proteins MIR1 and MIR2 and has similar activity.

PubMed ID: 12582153

DOI: 10.1074/jbc.m211285200

PubMed ID: 16920215

Title: Members of adenovirus species B utilize CD80 and CD86 as cellular attachment receptors.

PubMed ID: 16920215

DOI: 10.1016/j.virusres.2006.07.009

PubMed ID: 30918073

Title: By Binding CD80 and CD86, the Vaccinia Virus M2 Protein Blocks Their Interactions with both CD28 and CTLA4 and Potentiates CD80 Binding to PD-L1.

PubMed ID: 30918073

DOI: 10.1128/jvi.00207-19

PubMed ID: 11279501

Title: Structural basis for co-stimulation by the human CTLA-4/B7-2 complex.

PubMed ID: 11279501

DOI: 10.1038/35069112

PubMed ID: 12606712

Title: Crystal structure of the receptor-binding domain of human B7-2: insights into organization and signaling.

PubMed ID: 12606712

DOI: 10.1073/pnas.252771499

Sequence Information:

Length: 329
Mass: 37682
Checksum: C249DAEEB889D911
Sequence:

MDPQCTMGLS NILFVMAFLL SGAAPLKIQA YFNETADLPC QFANSQNQSL SELVVFWQDQ 
ENLVLNEVYL GKEKFDSVHS KYMGRTSFDS DSWTLRLHNL QIKDKGLYQC IIHHKKPTGM 
IRIHQMNSEL SVLANFSQPE IVPISNITEN VYINLTCSSI HGYPEPKKMS VLLRTKNSTI 
EYDGVMQKSQ DNVTELYDVS ISLSVSFPDV TSNMTIFCIL ETDKTRLLSS PFSIELEDPQ 
PPPDHIPWIT AVLPTVIICV MVFCLILWKW KKKKRPRNSY KCGTNTMERE ESEQTKKREK 
IHIPERSDEA QRVFKSSKTS SCDKSDTCF

Genular Protein ID: 3962049152

Symbol: A8K632_HUMAN

Name: N/A

UniProtKB Accession Codes:

A8K632

Database IDs:

Sequence Information:

Length: 329
Mass: 37756
Checksum: 7EDE533873336FCC
Sequence:

MDPQCTMGLS NILFVMAFLL SGAAPLKIQA YFNETADLPC QFANSQNQSL SELVVFWQDQ 
ENLVLNEVYL GKEKFDSVHS KYMGRTSFDS DSWTLRLHNL QIKDKGLYQC IIHHKKPTGM 
IRIHQMNFEL SVLANFSQPE IVPISNITEN VYINLTCSSI HGYPEPKKMS VLLRTKNSTI 
EYDGIMQKSQ DNVTELYDVS ISLSVSFPDV TSNMTIFCIL ETDKTRLLSS PFSIELEDPQ 
PPPDHIPWIT AVLPTVIICV MVFCLILWKW KKKKRPRNSY KCGTNTMERE ESEQTKKREK 
IHIPERSDEA QRVFKSSKTS SCDKSDTCF

Genular Protein ID: 2914387160

Symbol: A0A0X9R4E0_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A0X9R4E0

Database IDs:

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

Sequence Information:

Length: 323
Mass: 37021
Checksum: 030FEE69089B73DB
Sequence:

MGLSNILFVM AFLLSGAAPL KIQAYFNETA DLPCQFANSQ NQSLSELVVF WQDQENLVLN 
EVYLGKEKFD SVHSKYMGRT SFDSDSWTLR LHNLQIKDKG LYQCIIHHKK PTGMIRIHQM 
NSELSVLANF SQPEIVPISN ITENVYINLT CSSIHGYPEP KKMSVLLRTK NSTIEYDGIM 
QKSQDNVTEL YDVSISLSVS FPDVTSNMTI FCILETDKTR LLSSPFSIEL EDPQPPPDHI 
PWITAVLPTV IICVMVFCLI LWKWKKKKRP RNSYKCGTNT MEREESEQTK KREKIHIPER 
SDEAQRVFKS SKTSSCDKSD TCF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: CD86

Associated with

Cells (max top 100)

Other Information

B70 antigen is a second ligand for CTLA-4 and CD28. PubMed ID: 7694153

Cloning of B7-2: a CTLA-4 counter-receptor that costimulates human T cell proliferation. PubMed ID: 7694363

Identification of an alternatively spliced variant of human CD86 mRNA. PubMed ID: 11162656

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence, annotation and analysis of human chromosome 3. PubMed ID: 16641997

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Genomic organization of the gene coding for the costimulatory human B-lymphocyte antigen B7-2 (CD86). PubMed ID: 7541777

CD80 (B7) and CD86 (B70) provide similar costimulatory signals for T cell proliferation, cytokine production, and generation of CTL. PubMed ID: 7527824

The B7-2 (B70) costimulatory molecule expressed by monocytes and activated B lymphocytes is the CD86 differentiation antigen. PubMed ID: 7520767

c-MIR, a human E3 ubiquitin ligase, is a functional homolog of herpesvirus proteins MIR1 and MIR2 and has similar activity. PubMed ID: 12582153

Members of adenovirus species B utilize CD80 and CD86 as cellular attachment receptors. PubMed ID: 16920215

By Binding CD80 and CD86, the Vaccinia Virus M2 Protein Blocks Their Interactions with both CD28 and CTLA4 and Potentiates CD80 Binding to PD-L1. PubMed ID: 30918073

Structural basis for co-stimulation by the human CTLA-4/B7-2 complex. PubMed ID: 11279501

Crystal structure of the receptor-binding domain of human B7-2: insights into organization and signaling. PubMed ID: 12606712

The sequence of the human genome. PubMed ID: 11181995

Database document:

PubMed ID: 7694153

PubMed ID: 7694363

PubMed ID: 11162656

PubMed ID: 14702039

PubMed ID: 16641997

PubMed ID: 15489334

PubMed ID: 7541777

PubMed ID: 7527824

PubMed ID: 7520767

PubMed ID: 12582153

PubMed ID: 16920215

PubMed ID: 30918073

PubMed ID: 11279501

PubMed ID: 12606712

PubMed ID: 11181995