Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 94.9563
Cell Significance Index: -14.7700 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 58.9016
Cell Significance Index: -14.9400 - Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 27.3142
Cell Significance Index: -14.0500 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 12.0118
Cell Significance Index: -14.8100 - Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: 5.0699
Cell Significance Index: 78.4400 - Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 2.5005
Cell Significance Index: 46.2200 - Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 2.0300
Cell Significance Index: 25.1100 - Cell Name: liver dendritic cell (CL2000055)
Fold Change: 1.5504
Cell Significance Index: 4.0900 - Cell Name: monocyte-derived dendritic cell (CL0011031)
Fold Change: 1.4587
Cell Significance Index: 25.0600 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 1.2063
Cell Significance Index: -2.6400 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.4074
Cell Significance Index: 48.0500 - Cell Name: mononuclear cell (CL0000842)
Fold Change: 0.3316
Cell Significance Index: 1.3800 - Cell Name: myeloid leukocyte (CL0000766)
Fold Change: 0.2321
Cell Significance Index: 1.8800 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.0359
Cell Significance Index: 0.9600 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: -0.0063
Cell Significance Index: -4.3600 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0073
Cell Significance Index: -13.7000 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0109
Cell Significance Index: -16.7600 - Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0114
Cell Significance Index: -21.0800 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0167
Cell Significance Index: -22.7400 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0172
Cell Significance Index: -10.9300 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0185
Cell Significance Index: -14.0400 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0201
Cell Significance Index: -14.8600 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0262
Cell Significance Index: -14.7900 - Cell Name: mononuclear phagocyte (CL0000113)
Fold Change: -0.0272
Cell Significance Index: -0.2300 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0276
Cell Significance Index: -7.9500 - Cell Name: cell in vitro (CL0001034)
Fold Change: -0.0283
Cell Significance Index: -15.4800 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: -0.0289
Cell Significance Index: -10.3800 - Cell Name: hematopoietic cell (CL0000988)
Fold Change: -0.0294
Cell Significance Index: -0.4300 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0297
Cell Significance Index: -3.0300 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0322
Cell Significance Index: -14.6100 - Cell Name: neoplastic cell (CL0001063)
Fold Change: -0.0355
Cell Significance Index: -7.0500 - Cell Name: myeloid cell (CL0000763)
Fold Change: -0.0369
Cell Significance Index: -0.4900 - Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.0577
Cell Significance Index: -3.7200 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: -0.0615
Cell Significance Index: -12.3300 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: -0.0622
Cell Significance Index: -11.2100 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0662
Cell Significance Index: -9.6200 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0704
Cell Significance Index: -14.8300 - Cell Name: central nervous system macrophage (CL0000878)
Fold Change: -0.0824
Cell Significance Index: -0.9900 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0830
Cell Significance Index: -14.1700 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.1053
Cell Significance Index: -12.9500 - Cell Name: lactocyte (CL0002325)
Fold Change: -0.1081
Cell Significance Index: -13.9600 - Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.1110
Cell Significance Index: -5.6100 - Cell Name: odontoblast (CL0000060)
Fold Change: -0.1112
Cell Significance Index: -14.2600 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.1124
Cell Significance Index: -15.4400 - Cell Name: leukocyte (CL0000738)
Fold Change: -0.1207
Cell Significance Index: -2.0500 - Cell Name: eukaryotic cell (CL0000255)
Fold Change: -0.1212
Cell Significance Index: -5.2700 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.1352
Cell Significance Index: -15.4900 - Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: -0.1386
Cell Significance Index: -4.0700 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.1418
Cell Significance Index: -14.7600 - Cell Name: Hofbauer cell (CL3000001)
Fold Change: -0.1508
Cell Significance Index: -1.2300 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.1626
Cell Significance Index: -7.6400 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.1787
Cell Significance Index: -13.7200 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.1876
Cell Significance Index: -13.9800 - Cell Name: macrophage (CL0000235)
Fold Change: -0.2096
Cell Significance Index: -2.1400 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.2247
Cell Significance Index: -15.1100 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.2310
Cell Significance Index: -14.2000 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.2340
Cell Significance Index: -14.7500 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.2390
Cell Significance Index: -12.4500 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.2476
Cell Significance Index: -6.9200 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.2980
Cell Significance Index: -7.6600 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.2984
Cell Significance Index: -16.7500 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.3109
Cell Significance Index: -16.1500 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: -0.3171
Cell Significance Index: -14.3800 - Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: -0.3253
Cell Significance Index: -6.3600 - Cell Name: microglial cell (CL0000129)
Fold Change: -0.3308
Cell Significance Index: -3.8900 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.3362
Cell Significance Index: -14.8700 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.3597
Cell Significance Index: -16.7700 - Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: -0.3780
Cell Significance Index: -9.1600 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.3851
Cell Significance Index: -13.4900 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.3856
Cell Significance Index: -14.6000 - Cell Name: alveolar macrophage (CL0000583)
Fold Change: -0.3882
Cell Significance Index: -3.4200 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.3917
Cell Significance Index: -10.4600 - Cell Name: neuron associated cell (CL0000095)
Fold Change: -0.3955
Cell Significance Index: -16.2100 - Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
Fold Change: -0.4132
Cell Significance Index: -4.2800 - Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.4192
Cell Significance Index: -15.3900 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.4362
Cell Significance Index: -14.2800 - Cell Name: mature microglial cell (CL0002629)
Fold Change: -0.4468
Cell Significance Index: -4.8800 - Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.4510
Cell Significance Index: -13.2900 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.4537
Cell Significance Index: -14.4500 - Cell Name: elicited macrophage (CL0000861)
Fold Change: -0.4644
Cell Significance Index: -4.0600 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -0.4695
Cell Significance Index: -12.5800 - Cell Name: Kupffer cell (CL0000091)
Fold Change: -0.4786
Cell Significance Index: -4.3800 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.4908
Cell Significance Index: -14.0700 - Cell Name: myelocyte (CL0002193)
Fold Change: -0.4979
Cell Significance Index: -5.3200 - Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -0.5165
Cell Significance Index: -14.7400 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.5208
Cell Significance Index: -18.3000 - Cell Name: early T lineage precursor (CL0002425)
Fold Change: -0.5290
Cell Significance Index: -7.6800 - Cell Name: pro-T cell (CL0000827)
Fold Change: -0.5461
Cell Significance Index: -13.9500 - Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
Fold Change: -0.5558
Cell Significance Index: -13.8600 - Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: -0.5729
Cell Significance Index: -14.2900 - Cell Name: erythrocyte (CL0000232)
Fold Change: -0.5778
Cell Significance Index: -14.7200 - Cell Name: granulosa cell (CL0000501)
Fold Change: -0.5845
Cell Significance Index: -15.3700 - Cell Name: professional antigen presenting cell (CL0000145)
Fold Change: -0.5940
Cell Significance Index: -5.3700 - Cell Name: leptomeningeal cell (CL0000708)
Fold Change: -0.6091
Cell Significance Index: -13.0200 - Cell Name: classical monocyte (CL0000860)
Fold Change: -0.6154
Cell Significance Index: -5.7300 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: -0.6183
Cell Significance Index: -17.8200 - Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: -0.6217
Cell Significance Index: -12.6500 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.6231
Cell Significance Index: -16.9600 - Cell Name: Purkinje cell (CL0000121)
Fold Change: -0.6293
Cell Significance Index: -13.7800 - Cell Name: keratinocyte (CL0000312)
Fold Change: -0.6294
Cell Significance Index: -15.7200
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 353467806
Symbol: CD86_HUMAN
Name: T-lymphocyte activation antigen CD86
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 7694153
PubMed ID: 7694363
Title: Cloning of B7-2: a CTLA-4 counter-receptor that costimulates human T cell proliferation.
PubMed ID: 7694363
PubMed ID: 11162656
Title: Identification of an alternatively spliced variant of human CD86 mRNA.
PubMed ID: 11162656
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 16641997
Title: The DNA sequence, annotation and analysis of human chromosome 3.
PubMed ID: 16641997
DOI: 10.1038/nature04728
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 7541777
Title: Genomic organization of the gene coding for the costimulatory human B-lymphocyte antigen B7-2 (CD86).
PubMed ID: 7541777
DOI: 10.1007/bf00178582
PubMed ID: 7527824
Title: CD80 (B7) and CD86 (B70) provide similar costimulatory signals for T cell proliferation, cytokine production, and generation of CTL.
PubMed ID: 7527824
PubMed ID: 7520767
Title: The B7-2 (B70) costimulatory molecule expressed by monocytes and activated B lymphocytes is the CD86 differentiation antigen.
PubMed ID: 7520767
PubMed ID: 12196291
Title: The interaction properties of costimulatory molecules revisited.
PubMed ID: 12196291
PubMed ID: 12582153
Title: c-MIR, a human E3 ubiquitin ligase, is a functional homolog of herpesvirus proteins MIR1 and MIR2 and has similar activity.
PubMed ID: 12582153
PubMed ID: 16920215
Title: Members of adenovirus species B utilize CD80 and CD86 as cellular attachment receptors.
PubMed ID: 16920215
PubMed ID: 30918073
Title: By Binding CD80 and CD86, the Vaccinia Virus M2 Protein Blocks Their Interactions with both CD28 and CTLA4 and Potentiates CD80 Binding to PD-L1.
PubMed ID: 30918073
DOI: 10.1128/jvi.00207-19
PubMed ID: 11279501
Title: Structural basis for co-stimulation by the human CTLA-4/B7-2 complex.
PubMed ID: 11279501
DOI: 10.1038/35069112
PubMed ID: 12606712
Title: Crystal structure of the receptor-binding domain of human B7-2: insights into organization and signaling.
PubMed ID: 12606712
Sequence Information:
- Length: 329
- Mass: 37682
- Checksum: C249DAEEB889D911
- Sequence:
MDPQCTMGLS NILFVMAFLL SGAAPLKIQA YFNETADLPC QFANSQNQSL SELVVFWQDQ ENLVLNEVYL GKEKFDSVHS KYMGRTSFDS DSWTLRLHNL QIKDKGLYQC IIHHKKPTGM IRIHQMNSEL SVLANFSQPE IVPISNITEN VYINLTCSSI HGYPEPKKMS VLLRTKNSTI EYDGVMQKSQ DNVTELYDVS ISLSVSFPDV TSNMTIFCIL ETDKTRLLSS PFSIELEDPQ PPPDHIPWIT AVLPTVIICV MVFCLILWKW KKKKRPRNSY KCGTNTMERE ESEQTKKREK IHIPERSDEA QRVFKSSKTS SCDKSDTCF
Genular Protein ID: 2914387160
Symbol: A0A0X9R4E0_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 11181995
Sequence Information:
- Length: 323
- Mass: 37021
- Checksum: 030FEE69089B73DB
- Sequence:
MGLSNILFVM AFLLSGAAPL KIQAYFNETA DLPCQFANSQ NQSLSELVVF WQDQENLVLN EVYLGKEKFD SVHSKYMGRT SFDSDSWTLR LHNLQIKDKG LYQCIIHHKK PTGMIRIHQM NSELSVLANF SQPEIVPISN ITENVYINLT CSSIHGYPEP KKMSVLLRTK NSTIEYDGIM QKSQDNVTEL YDVSISLSVS FPDVTSNMTI FCILETDKTR LLSSPFSIEL EDPQPPPDHI PWITAVLPTV IICVMVFCLI LWKWKKKKRP RNSYKCGTNT MEREESEQTK KREKIHIPER SDEAQRVFKS SKTSSCDKSD TCF
Genular Protein ID: 3962049152
Symbol: A8K632_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Sequence Information:
- Length: 329
- Mass: 37756
- Checksum: 7EDE533873336FCC
- Sequence:
MDPQCTMGLS NILFVMAFLL SGAAPLKIQA YFNETADLPC QFANSQNQSL SELVVFWQDQ ENLVLNEVYL GKEKFDSVHS KYMGRTSFDS DSWTLRLHNL QIKDKGLYQC IIHHKKPTGM IRIHQMNFEL SVLANFSQPE IVPISNITEN VYINLTCSSI HGYPEPKKMS VLLRTKNSTI EYDGIMQKSQ DNVTELYDVS ISLSVSFPDV TSNMTIFCIL ETDKTRLLSS PFSIELEDPQ PPPDHIPWIT AVLPTVIICV MVFCLILWKW KKKKRPRNSY KCGTNTMERE ESEQTKKREK IHIPERSDEA QRVFKSSKTS SCDKSDTCF
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.