NTN1 | ENSG00000065320 | NCBI 9423

Details for: NTN1

Gene ID: 9423

Symbol: NTN1

Ensembl ID: ENSG00000065320

Description: netrin 1

Associated with

Axon guidance
(R-HSA-422475)
Dcc mediated attractive signaling
(R-HSA-418885)
Developmental biology
(R-HSA-1266738)
Dscam interactions
(R-HSA-376172)
Nervous system development
(R-HSA-9675108)
Netrin-1 signaling
(R-HSA-373752)
Netrin mediated repulsion signals
(R-HSA-418886)
Regulation of commissural axon pathfinding by slit and robo
(R-HSA-428542)
Role of second messengers in netrin-1 signaling
(R-HSA-418890)
Signaling by robo receptors
(R-HSA-376176)
Actin cytoskeleton
(GO:0015629)
Anterior/posterior axon guidance
(GO:0033564)
Apoptotic process
(GO:0006915)
Basement membrane
(GO:0005604)
Cdc42 protein signal transduction
(GO:0032488)
Cell-cell adhesion
(GO:0098609)
Chemorepulsion of axon
(GO:0061643)
Cytosol
(GO:0005829)
Dna-binding transcription factor activity, rna polymerase ii-specific
(GO:0000981)
Extracellular region
(GO:0005576)
Glial cell proliferation
(GO:0014009)
Inner ear morphogenesis
(GO:0042472)
Mammary gland duct morphogenesis
(GO:0060603)
Motor neuron migration
(GO:0097475)
Negative regulation of axon extension
(GO:0030517)
Nuclear migration
(GO:0007097)
Nucleoplasm
(GO:0005654)
Positive regulation of axon extension
(GO:0045773)
Positive regulation of cell motility
(GO:2000147)
Positive regulation of glial cell proliferation
(GO:0060252)
Protein binding
(GO:0005515)
Ras protein signal transduction
(GO:0007265)
Regulation of glial cell migration
(GO:1903975)
Regulation of synapse assembly
(GO:0051963)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Rna polymerase ii cis-regulatory region sequence-specific dna binding
(GO:0000978)
Substrate-dependent cell migration, cell extension
(GO:0006930)

Other Information

Proteins

Netrin-1

Genular Protein ID: 2846019426

Symbol: NET1_HUMAN

Name: Netrin-1

UniProtKB Accession Codes:

O95631 E9KL51

Database IDs:

Citations:

PubMed ID: 9950216

Title: Netrin-1: interaction with deleted in colorectal cancer (DCC) and alterations in brain tumors and neuroblastomas.

PubMed ID: 9950216

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 20736409

Title: Systematic mapping and functional analysis of a family of human epididymal secretory sperm-located proteins.

PubMed ID: 20736409

DOI: 10.1074/mcp.m110.001719

PubMed ID: 15343335

Title: Netrin-1 controls colorectal tumorigenesis by regulating apoptosis.

PubMed ID: 15343335

DOI: 10.1038/nature02788

PubMed ID: 19196994

Title: DSCAM functions as a netrin receptor in commissural axon pathfinding.

PubMed ID: 19196994

DOI: 10.1073/pnas.0811083106

PubMed ID: 28945198

Title: Mutations in the netrin-1 gene cause congenital mirror movements.

PubMed ID: 28945198

DOI: 10.1172/jci95442

PubMed ID: 28483977

Title: Uncoupling of UNC5C with Polymerized TUBB3 in Microtubules Mediates Netrin-1 Repulsion.

PubMed ID: 28483977

DOI: 10.1523/jneurosci.2617-16.2017

Sequence Information:

Length: 604
Mass: 67748
Checksum: 9827C09D0D783B27
Sequence:

MMRAVWEALA ALAAVACLVG AVRGGPGLSM FAGQAAQPDP CSDENGHPRR CIPDFVNAAF 
GKDVRVSSTC GRPPARYCVV SERGEERLRS CHLCNASDPK KAHPPAFLTD LNNPHNLTCW 
QSENYLQFPH NVTLTLSLGK KFEVTYVSLQ FCSPRPESMA IYKSMDYGRT WVPFQFYSTQ 
CRKMYNRPHR APITKQNEQE AVCTDSHTDM RPLSGGLIAF STLDGRPSAH DFDNSPVLQD 
WVTATDIRVA FSRLHTFGDE NEDDSELARD SYFYAVSDLQ VGGRCKCNGH AARCVRDRDD 
SLVCDCRHNT AGPECDRCKP FHYDRPWQRA TAREANECVA CNCNLHARRC RFNMELYKLS 
GRKSGGVCLN CRHNTAGRHC HYCKEGYYRD MGKPITHRKA CKACDCHPVG AAGKTCNQTT 
GQCPCKDGVT GITCNRCAKG YQQSRSPIAP CIKIPVAPPT TAASSVEEPE DCDSYCKASK 
GKLKINMKKY CKKDYAVQIH ILKADKAGDW WKFTVNIISV YKQGTSRIRR GDQSLWIRSR 
DIACKCPKIK PLKKYLLLGN AEDSPDQSGI VADKSSLVIQ WRDTWARRLR KFQQREKKGK 
CKKA

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: NTN1

Associated with

Other Information

Netrin-1: interaction with deleted in colorectal cancer (DCC) and alterations in brain tumors and neuroblastomas. PubMed ID: 9950216

DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. PubMed ID: 16625196

Systematic mapping and functional analysis of a family of human epididymal secretory sperm-located proteins. PubMed ID: 20736409

Netrin-1 controls colorectal tumorigenesis by regulating apoptosis. PubMed ID: 15343335

DSCAM functions as a netrin receptor in commissural axon pathfinding. PubMed ID: 19196994

Mutations in the netrin-1 gene cause congenital mirror movements. PubMed ID: 28945198

Uncoupling of UNC5C with Polymerized TUBB3 in Microtubules Mediates Netrin-1 Repulsion. PubMed ID: 28483977