Details for: TNFRSF8

Gene ID: 943

Symbol: TNFRSF8

Ensembl ID: ENSG00000120949

Description: TNF receptor superfamily member 8

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 14.8510
    Cell Significance Index: -2.3100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 9.0678
    Cell Significance Index: -2.3000
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 5.6122
    Cell Significance Index: -2.2800
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 4.8796
    Cell Significance Index: -2.5100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 1.8735
    Cell Significance Index: -2.3100
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 1.0098
    Cell Significance Index: -2.2100
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 0.7553
    Cell Significance Index: -2.3200
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.4497
    Cell Significance Index: 5.8100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.3213
    Cell Significance Index: 10.2900
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.3184
    Cell Significance Index: 7.9400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.2849
    Cell Significance Index: 10.7900
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.2655
    Cell Significance Index: 4.5500
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.2182
    Cell Significance Index: 3.5000
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.1965
    Cell Significance Index: 5.7700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.1947
    Cell Significance Index: 8.6100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.1095
    Cell Significance Index: 2.9400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.0557
    Cell Significance Index: 1.4700
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.0497
    Cell Significance Index: 0.9700
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.0467
    Cell Significance Index: 0.5900
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0457
    Cell Significance Index: 1.0000
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.0379
    Cell Significance Index: 0.6700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0214
    Cell Significance Index: 4.3000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0179
    Cell Significance Index: 3.0500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0158
    Cell Significance Index: 3.1300
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.0135
    Cell Significance Index: 0.2500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0087
    Cell Significance Index: 1.2700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0058
    Cell Significance Index: 2.0700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0026
    Cell Significance Index: 4.8600
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0021
    Cell Significance Index: 0.0300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0012
    Cell Significance Index: 1.8000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0008
    Cell Significance Index: 1.4500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0002
    Cell Significance Index: 0.2300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0006
    Cell Significance Index: -0.1100
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.0006
    Cell Significance Index: -0.0100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0010
    Cell Significance Index: -0.6100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0022
    Cell Significance Index: -1.0200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0030
    Cell Significance Index: -2.3000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0031
    Cell Significance Index: -2.2700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0041
    Cell Significance Index: -2.3100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0043
    Cell Significance Index: -2.3700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0048
    Cell Significance Index: -1.3700
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: -0.0070
    Cell Significance Index: -0.0600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0083
    Cell Significance Index: -0.9800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0087
    Cell Significance Index: -1.2000
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0092
    Cell Significance Index: -0.1200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0110
    Cell Significance Index: -1.1300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0115
    Cell Significance Index: -2.4200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0118
    Cell Significance Index: -1.5100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0129
    Cell Significance Index: -0.3700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0131
    Cell Significance Index: -1.6100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0163
    Cell Significance Index: -1.8700
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.0167
    Cell Significance Index: -0.2400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0174
    Cell Significance Index: -2.2500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0203
    Cell Significance Index: -2.1100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0211
    Cell Significance Index: -1.4200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0211
    Cell Significance Index: -1.6200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0236
    Cell Significance Index: -1.4500
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0247
    Cell Significance Index: -0.7800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0305
    Cell Significance Index: -2.2700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0309
    Cell Significance Index: -1.4500
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0358
    Cell Significance Index: -1.5600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0368
    Cell Significance Index: -1.9100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0381
    Cell Significance Index: -2.4600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0394
    Cell Significance Index: -2.2100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0406
    Cell Significance Index: -1.0900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0407
    Cell Significance Index: -1.3000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0437
    Cell Significance Index: -1.4300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0441
    Cell Significance Index: -2.0000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0454
    Cell Significance Index: -1.5900
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0509
    Cell Significance Index: -1.0800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0520
    Cell Significance Index: -2.4300
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: -0.0532
    Cell Significance Index: -0.4500
  • Cell Name: acinar cell (CL0000622)
    Fold Change: -0.0541
    Cell Significance Index: -0.6800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0551
    Cell Significance Index: -1.4700
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0594
    Cell Significance Index: -1.4400
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0602
    Cell Significance Index: -1.3000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0610
    Cell Significance Index: -2.1200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0615
    Cell Significance Index: -1.7200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0617
    Cell Significance Index: -1.7600
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0618
    Cell Significance Index: -0.8000
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0625
    Cell Significance Index: -1.5600
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0655
    Cell Significance Index: -1.2800
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0683
    Cell Significance Index: -1.3500
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0692
    Cell Significance Index: -1.3900
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0693
    Cell Significance Index: -1.7700
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.0700
    Cell Significance Index: -1.0200
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: -0.0751
    Cell Significance Index: -0.6500
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0760
    Cell Significance Index: -2.7900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0763
    Cell Significance Index: -2.6800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0771
    Cell Significance Index: -2.2700
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.0778
    Cell Significance Index: -1.1300
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0811
    Cell Significance Index: -1.0400
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: -0.0814
    Cell Significance Index: -0.8900
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.0816
    Cell Significance Index: -1.6600
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.0816
    Cell Significance Index: -1.1700
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0821
    Cell Significance Index: -1.9700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0825
    Cell Significance Index: -2.1200
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0830
    Cell Significance Index: -1.2300
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0841
    Cell Significance Index: -1.7600
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0875
    Cell Significance Index: -1.8200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Structure:** TNFRSF8 is a type II transmembrane receptor, consisting of an extracellular ligand-binding domain, a transmembrane domain, and an intracellular signaling domain. 2. **Ligands:** The receptor binds to its ligands, including CD30L, which is expressed on various cell types, including immune cells and epithelial cells. 3. **Signaling pathways:** TNFRSF8 activates several signaling pathways, including the non-canonical NF-κB pathway, which regulates the expression of genes involved in immune response and cell survival. 4. **Expression:** TNFRSF8 is expressed on various cell types, including T-helper 17 cells, immature innate lymphoid cells, colon goblet cells, cardiac endothelial cells, and intestinal crypt stem cells. **Pathways and Functions:** 1. **Immune response:** TNFRSF8 plays a crucial role in regulating the immune response by modulating the activity of immune cells, such as T-helper 17 cells and mononuclear cells. 2. **Apoptosis:** The receptor induces apoptosis in certain cell types, including cancer cells, through the activation of the non-canonical NF-κB pathway. 3. **Cell proliferation:** TNFRSF8 regulates cell proliferation by modulating the expression of genes involved in cell cycle progression. 4. **Inflammation:** The receptor is involved in the regulation of inflammatory responses, including the production of cytokines and chemokines. **Clinical Significance:** 1. **Autoimmune disorders:** Dysregulation of TNFRSF8 has been implicated in autoimmune disorders, such as rheumatoid arthritis and multiple sclerosis. 2. **Cancer:** The receptor is overexpressed in certain types of cancer, including lung and colon cancer, and its dysregulation contributes to tumorigenesis. 3. **Inflammatory conditions:** TNFRSF8 is involved in the regulation of inflammatory responses, and its dysregulation contributes to conditions such as atherosclerosis and inflammatory bowel disease. 4. **Therapeutic targets:** TNFRSF8 has been identified as a potential therapeutic target for the treatment of autoimmune disorders, cancer, and inflammatory conditions. In conclusion, TNFRSF8 is a critical regulator of immune response, apoptosis, and cell proliferation. Its dysregulation contributes to various diseases, including autoimmune disorders, cancer, and inflammatory conditions. Further research is needed to fully elucidate the mechanisms by which TNFRSF8 regulates cellular processes and to identify potential therapeutic targets for the treatment of these diseases.

Genular Protein ID: 1536398073

Symbol: TNR8_HUMAN

Name: CD30L receptor

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 1310894

Title: Molecular cloning and expression of a new member of the nerve growth factor receptor family that is characteristic for Hodgkin's disease.

PubMed ID: 1310894

DOI: 10.1016/0092-8674(92)90180-k

PubMed ID: 7527901

Title: Opposite effects of the CD30 ligand are not due to CD30 mutations: results from cDNA cloning and sequence comparison of the CD30 antigen from different sources.

PubMed ID: 7527901

DOI: 10.1016/0161-5890(94)90051-5

PubMed ID: 8839832

Title: A variant CD30 protein lacking extracellular and transmembrane domains is induced in HL-60 by tetradecanoylphorbol acetate and is expressed in alveolar macrophages.

PubMed ID: 8839832

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8391931

Title: CD30 antigen, a marker for Hodgkin's lymphoma, is a receptor whose ligand defines an emerging family of cytokines with homology to TNF.

PubMed ID: 8391931

DOI: 10.1016/0092-8674(93)90361-s

PubMed ID: 8627180

Title: T cell receptor-dependent cell death of T cell hybridomas mediated by the CD30 cytoplasmic domain in association with tumor necrosis factor receptor-associated factors.

PubMed ID: 8627180

DOI: 10.1084/jem.183.2.669

PubMed ID: 9168896

Title: Binding sites of cytoplasmic effectors TRAF1, 2, and 3 on CD30 and other members of the TNF receptor superfamily.

PubMed ID: 9168896

DOI: 10.1006/bbrc.1997.6509

PubMed ID: 9511754

Title: Cloning and characterization of a cDNA encoding the human homolog of tumor necrosis factor receptor-associated factor 5 (TRAF5).

PubMed ID: 9511754

DOI: 10.1016/s0378-1119(97)00616-1

PubMed ID: 8999898

Title: Tumor necrosis factor receptor-associated factor (TRAF) 5 and TRAF2 are involved in CD30-mediated NFkappaB activation.

PubMed ID: 8999898

DOI: 10.1074/jbc.272.4.2042

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 10518213

Title: The structural basis for the recognition of diverse receptor sequences by TRAF2.

PubMed ID: 10518213

DOI: 10.1016/s1097-2765(00)80334-2

Sequence Information:

  • Length: 595
  • Mass: 63747
  • Checksum: 7A407CC78A6E0BC8
  • Sequence:
  • MRVLLAALGL LFLGALRAFP QDRPFEDTCH GNPSHYYDKA VRRCCYRCPM GLFPTQQCPQ 
    RPTDCRKQCE PDYYLDEADR CTACVTCSRD DLVEKTPCAW NSSRVCECRP GMFCSTSAVN 
    SCARCFFHSV CPAGMIVKFP GTAQKNTVCE PASPGVSPAC ASPENCKEPS SGTIPQAKPT 
    PVSPATSSAS TMPVRGGTRL AQEAASKLTR APDSPSSVGR PSSDPGLSPT QPCPEGSGDC 
    RKQCEPDYYL DEAGRCTACV SCSRDDLVEK TPCAWNSSRT CECRPGMICA TSATNSCARC 
    VPYPICAAET VTKPQDMAEK DTTFEAPPLG TQPDCNPTPE NGEAPASTSP TQSLLVDSQA 
    SKTLPIPTSA PVALSSTGKP VLDAGPVLFW VILVLVVVVG SSAFLLCHRR ACRKRIRQKL 
    HLCYPVQTSQ PKLELVDSRP RRSSTQLRSG ASVTEPVAEE RGLMSQPLME TCHSVGAAYL 
    ESLPLQDASP AGGPSSPRDL PEPRVSTEHT NNKIEKIYIM KADTVIVGTV KAELPEGRGL 
    AGPAEPELEE ELEADHTPHY PEQETEPPLG SCSDVMLSVE EEGKEDPLPT AASGK

Genular Protein ID: 4112690478

Symbol: A5D8T4_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 187
  • Mass: 20415
  • Checksum: C8468011380824D4
  • Sequence:
  • RRACRKRIRQ KLHLCYPVQT SQPKLELVDS RPRRSSTQLR SGASVTEPVA EERGLMSQPL 
    METCHSVGAA YLESLPLQDA SPAGGPSSPR DLPEPRVSTE HTNNKIEKIY IMKADTVIVG 
    TVKAELPEGR GLAGPAEPEL EEELEADHTP HYPEQETEPP LGSCSDVMLS VEEEGKEDPL 
    PTAASGK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.