Details for: TNFRSF8

Gene ID: 943

Symbol: TNFRSF8

Ensembl ID: ENSG00000120949

Description: TNF receptor superfamily member 8

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: 5.89
    Marker Score: 3862
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.67
    Marker Score: 3390.5
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.6
    Marker Score: 1165
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.34
    Marker Score: 2532
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.29
    Marker Score: 1283
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.26
    Marker Score: 850
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.16
    Marker Score: 483
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4811
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.13
    Marker Score: 7517
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 1.09
    Marker Score: 352
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.09
    Marker Score: 499
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71823
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48048
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.99
    Marker Score: 15417
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 505
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 458
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5316
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.92
    Marker Score: 370
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2740
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 323
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5285
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.85
    Marker Score: 380
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1256
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 705
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 392
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.72
    Marker Score: 378
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.72
    Marker Score: 458
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.7
    Marker Score: 534
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 177
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.67
    Marker Score: 1392
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.62
    Marker Score: 195
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.61
    Marker Score: 289
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.54
    Marker Score: 172
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.54
    Marker Score: 240
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 0.51
    Marker Score: 165
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 0.49
    Marker Score: 385
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.49
    Marker Score: 203
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 0.48
    Marker Score: 1147
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.46
    Marker Score: 145
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.44
    Marker Score: 263
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.44
    Marker Score: 113
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 0.41
    Marker Score: 806
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.41
    Marker Score: 216
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.34
    Marker Score: 91
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.32
    Marker Score: 209
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.24
    Marker Score: 1528
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 64
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.22
    Marker Score: 127
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 73
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 0.21
    Marker Score: 88
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.21
    Marker Score: 85
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 0.21
    Marker Score: 182
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.21
    Marker Score: 120
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.2
    Marker Score: 98
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.2
    Marker Score: 73
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.19
    Marker Score: 478
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.19
    Marker Score: 77
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.18
    Marker Score: 10314
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.18
    Marker Score: 110
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.18
    Marker Score: 559
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.18
    Marker Score: 104
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.17
    Marker Score: 43
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.17
    Marker Score: 212
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.17
    Marker Score: 103
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.17
    Marker Score: 162
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 0.17
    Marker Score: 206
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.17
    Marker Score: 393
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.16
    Marker Score: 142
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.16
    Marker Score: 425
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.15
    Marker Score: 131
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.14
    Marker Score: 66
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.14
    Marker Score: 147.5
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.14
    Marker Score: 132
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.14
    Marker Score: 248
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.13
    Marker Score: 82
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.13
    Marker Score: 130
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.13
    Marker Score: 26
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.13
    Marker Score: 87
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.13
    Marker Score: 163
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.12
    Marker Score: 81
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.12
    Marker Score: 68
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 0.12
    Marker Score: 265
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.12
    Marker Score: 1539
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 0.12
    Marker Score: 26
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.11
    Marker Score: 158
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 0.11
    Marker Score: 166
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.11
    Marker Score: 195
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 0.11
    Marker Score: 287
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.11
    Marker Score: 105
  • Cell Name: cardiac mesenchymal cell (CL0000569)
    Fold Change: 0.11
    Marker Score: 27
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.11
    Marker Score: 38
  • Cell Name: centrocyte (CL0009111)
    Fold Change: 0.11
    Marker Score: 26
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.11
    Marker Score: 656
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.11
    Marker Score: 184
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.11
    Marker Score: 108
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.11
    Marker Score: 26
  • Cell Name: IgA plasmablast (CL0000984)
    Fold Change: 0.1
    Marker Score: 27

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Other Information

**Key characteristics:** - TNFRSF8 is a cell surface protein that is expressed on activated T cells, B cells, dendritic cells, and macrophages. - It is a member of the TNF receptor superfamily, which is a family of cell surface receptors that are expressed on a variety of immune cells. - TNFRSF8 is a ligand for the TNFR2 receptor, which is expressed on activated T cells and macrophages. **Pathways and functions:** - TNFRSF8 is a key regulator of T cell activation. - It is expressed on activated T cells and is required for the activation of these cells. - TNFRSF8 is also expressed on dendritic cells and macrophages, and it is required for the activation of these cells. - The binding of TNF to TNFRSF8 on dendritic cells and macrophages triggers the activation of these cells, which leads to the production of cytokines and other immune molecules that promote inflammation. **Clinical significance:** - Mutations in TNFRSF8 have been linked to a number of autoimmune diseases, including rheumatoid arthritis, Crohn's disease, and psoriasis. - TNFRSF8 is a potential target for therapy in autoimmune diseases that are characterized by inflammation. - By blocking the interaction between TNF and TNFRSF8, it may be possible to suppress inflammation and improve disease symptoms.

Genular Protein ID: 1536398073

Symbol: TNR8_HUMAN

Name: CD30L receptor

UniProtKB Accession Codes:

P28908 B1AN79 B9EGD9 D3YTD8 Q6P4D9

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 3 DrugCentral 1 ELM 1 EMBL 8 EPD 1 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 11 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 1 RefSeq 2 SAM 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1310894

Title: Molecular cloning and expression of a new member of the nerve growth factor receptor family that is characteristic for Hodgkin's disease.

PubMed ID: 1310894

DOI: 10.1016/0092-8674(92)90180-k

PubMed ID: 7527901

Title: Opposite effects of the CD30 ligand are not due to CD30 mutations: results from cDNA cloning and sequence comparison of the CD30 antigen from different sources.

PubMed ID: 7527901

DOI: 10.1016/0161-5890(94)90051-5

PubMed ID: 8839832

Title: A variant CD30 protein lacking extracellular and transmembrane domains is induced in HL-60 by tetradecanoylphorbol acetate and is expressed in alveolar macrophages.

PubMed ID: 8839832

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8391931

Title: CD30 antigen, a marker for Hodgkin's lymphoma, is a receptor whose ligand defines an emerging family of cytokines with homology to TNF.

PubMed ID: 8391931

DOI: 10.1016/0092-8674(93)90361-s

PubMed ID: 8627180

Title: T cell receptor-dependent cell death of T cell hybridomas mediated by the CD30 cytoplasmic domain in association with tumor necrosis factor receptor-associated factors.

PubMed ID: 8627180

DOI: 10.1084/jem.183.2.669

PubMed ID: 9168896

Title: Binding sites of cytoplasmic effectors TRAF1, 2, and 3 on CD30 and other members of the TNF receptor superfamily.

PubMed ID: 9168896

DOI: 10.1006/bbrc.1997.6509

PubMed ID: 9511754

Title: Cloning and characterization of a cDNA encoding the human homolog of tumor necrosis factor receptor-associated factor 5 (TRAF5).

PubMed ID: 9511754

DOI: 10.1016/s0378-1119(97)00616-1

PubMed ID: 8999898

Title: Tumor necrosis factor receptor-associated factor (TRAF) 5 and TRAF2 are involved in CD30-mediated NFkappaB activation.

PubMed ID: 8999898

DOI: 10.1074/jbc.272.4.2042

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 10518213

Title: The structural basis for the recognition of diverse receptor sequences by TRAF2.

PubMed ID: 10518213

DOI: 10.1016/s1097-2765(00)80334-2

Sequence Information:

  • Length: 595
  • Mass: 63747
  • Checksum: 7A407CC78A6E0BC8
  • Sequence:
    • MRVLLAALGL LFLGALRAFP QDRPFEDTCH GNPSHYYDKA VRRCCYRCPM GLFPTQQCPQ 
RPTDCRKQCE PDYYLDEADR CTACVTCSRD DLVEKTPCAW NSSRVCECRP GMFCSTSAVN 
SCARCFFHSV CPAGMIVKFP GTAQKNTVCE PASPGVSPAC ASPENCKEPS SGTIPQAKPT 
PVSPATSSAS TMPVRGGTRL AQEAASKLTR APDSPSSVGR PSSDPGLSPT QPCPEGSGDC 
RKQCEPDYYL DEAGRCTACV SCSRDDLVEK TPCAWNSSRT CECRPGMICA TSATNSCARC 
VPYPICAAET VTKPQDMAEK DTTFEAPPLG TQPDCNPTPE NGEAPASTSP TQSLLVDSQA 
SKTLPIPTSA PVALSSTGKP VLDAGPVLFW VILVLVVVVG SSAFLLCHRR ACRKRIRQKL 
HLCYPVQTSQ PKLELVDSRP RRSSTQLRSG ASVTEPVAEE RGLMSQPLME TCHSVGAAYL 
ESLPLQDASP AGGPSSPRDL PEPRVSTEHT NNKIEKIYIM KADTVIVGTV KAELPEGRGL 
AGPAEPELEE ELEADHTPHY PEQETEPPLG SCSDVMLSVE EEGKEDPLPT AASGK

Genular Protein ID: 4112690478

Symbol: A5D8T4_HUMAN

Name: N/A

UniProtKB Accession Codes:

A5D8T4

Database IDs:

AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 2 GO 2 GenomeRNAi 1 InterPro 1 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PeptideAtlas 1 RefSeq 2 SAM 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 187
  • Mass: 20415
  • Checksum: C8468011380824D4
  • Sequence:
    • RRACRKRIRQ KLHLCYPVQT SQPKLELVDS RPRRSSTQLR SGASVTEPVA EERGLMSQPL 
METCHSVGAA YLESLPLQDA SPAGGPSSPR DLPEPRVSTE HTNNKIEKIY IMKADTVIVG 
TVKAELPEGR GLAGPAEPEL EEELEADHTP HYPEQETEPP LGSCSDVMLS VEEEGKEDPL 
PTAASGK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.