Details for: TNFSF8

Gene ID: 944

Symbol: TNFSF8

Ensembl ID: ENSG00000106952

Description: TNF superfamily member 8

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 36.9667
    Cell Significance Index: -5.7500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 21.4671
    Cell Significance Index: -5.4500
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 15.0397
    Cell Significance Index: -6.1100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 4.6636
    Cell Significance Index: -5.7500
  • Cell Name: centroblast (CL0009112)
    Fold Change: 2.9618
    Cell Significance Index: 6.9100
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 2.2425
    Cell Significance Index: 22.4900
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 1.9828
    Cell Significance Index: -6.0900
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: 0.7839
    Cell Significance Index: 2.1000
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 0.7783
    Cell Significance Index: 8.0700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.7082
    Cell Significance Index: 20.8000
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 0.6169
    Cell Significance Index: 1.8800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.3011
    Cell Significance Index: 35.5100
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.2286
    Cell Significance Index: 4.2300
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.0699
    Cell Significance Index: 0.5700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0531
    Cell Significance Index: 10.5300
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.0513
    Cell Significance Index: 0.2800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0354
    Cell Significance Index: 54.4800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0217
    Cell Significance Index: 40.0000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0146
    Cell Significance Index: 2.6400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0039
    Cell Significance Index: 0.2500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0019
    Cell Significance Index: -2.5700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0023
    Cell Significance Index: -4.2900
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.0042
    Cell Significance Index: -0.0400
  • Cell Name: mature T cell (CL0002419)
    Fold Change: -0.0042
    Cell Significance Index: -0.0300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0078
    Cell Significance Index: -5.8700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0080
    Cell Significance Index: -5.9100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0082
    Cell Significance Index: -6.0100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0085
    Cell Significance Index: -5.3700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0103
    Cell Significance Index: -5.8000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0107
    Cell Significance Index: -5.8600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0121
    Cell Significance Index: -5.4800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0135
    Cell Significance Index: -4.8300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0142
    Cell Significance Index: -4.1000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0185
    Cell Significance Index: -3.7200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0261
    Cell Significance Index: -2.6700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0300
    Cell Significance Index: -5.1300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0301
    Cell Significance Index: -3.7000
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0320
    Cell Significance Index: -1.3900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0351
    Cell Significance Index: -5.1000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0389
    Cell Significance Index: -4.9900
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.0400
    Cell Significance Index: -0.3500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0438
    Cell Significance Index: -6.0100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0484
    Cell Significance Index: -6.2500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0505
    Cell Significance Index: -1.3500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0506
    Cell Significance Index: -5.8000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0546
    Cell Significance Index: -5.6900
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0592
    Cell Significance Index: -1.0200
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0629
    Cell Significance Index: -0.9200
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0639
    Cell Significance Index: -1.0900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0640
    Cell Significance Index: -2.8300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0703
    Cell Significance Index: -3.5500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0716
    Cell Significance Index: -2.7100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0734
    Cell Significance Index: -5.6300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0824
    Cell Significance Index: -3.8800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0829
    Cell Significance Index: -6.1800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0890
    Cell Significance Index: -5.9800
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.0903
    Cell Significance Index: -0.8800
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0939
    Cell Significance Index: -2.4000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0988
    Cell Significance Index: -6.0700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1062
    Cell Significance Index: -6.5100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1090
    Cell Significance Index: -5.6800
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.1093
    Cell Significance Index: -1.3900
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1103
    Cell Significance Index: -1.5800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1124
    Cell Significance Index: -3.1400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1127
    Cell Significance Index: -6.3300
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.1189
    Cell Significance Index: -1.8400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1205
    Cell Significance Index: -6.2600
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1218
    Cell Significance Index: -4.9900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1240
    Cell Significance Index: -5.7800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1241
    Cell Significance Index: -3.1900
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.1432
    Cell Significance Index: -1.3400
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1479
    Cell Significance Index: -5.1800
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: -0.1512
    Cell Significance Index: -1.3700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1637
    Cell Significance Index: -5.3600
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.1654
    Cell Significance Index: -5.2300
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.1661
    Cell Significance Index: -2.3600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1667
    Cell Significance Index: -5.3100
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.1745
    Cell Significance Index: -1.8100
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1760
    Cell Significance Index: -6.4600
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.1801
    Cell Significance Index: -2.4500
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.1817
    Cell Significance Index: -2.5500
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.1846
    Cell Significance Index: -3.6100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1887
    Cell Significance Index: -6.6300
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.1901
    Cell Significance Index: -1.9200
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.1914
    Cell Significance Index: -2.2600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1970
    Cell Significance Index: -5.2600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.2019
    Cell Significance Index: -5.4100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.2068
    Cell Significance Index: -5.6300
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.2084
    Cell Significance Index: -2.4500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.2113
    Cell Significance Index: -6.0300
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.2177
    Cell Significance Index: -5.4300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2177
    Cell Significance Index: -6.2400
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.2195
    Cell Significance Index: -1.8700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.2266
    Cell Significance Index: -6.5300
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.2295
    Cell Significance Index: -5.5600
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.2310
    Cell Significance Index: -5.7600
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.2331
    Cell Significance Index: -5.9400
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.2413
    Cell Significance Index: -4.7100
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.2446
    Cell Significance Index: -6.1100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2457
    Cell Significance Index: -6.4600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TNFSF8 is a type II transmembrane protein, consisting of a soluble extracellular domain and a transmembrane domain. It is expressed in various cell types, including immature innate lymphoid cells, thymocytes, endothelial cells, and neurons. The protein is stable at room temperature and has a half-life of approximately 10 hours. TNFSF8 is highly conserved across species, with high sequence identity to its mouse and rat homologs. **Pathways and Functions:** TNFSF8 binds to its receptor, TNFR2, triggering a non-canonical NF-κB signaling pathway. This pathway is involved in regulating the expression of genes involved in immune responses, including those involved in T cell differentiation, proliferation, and survival. The signaling cascade also regulates the expression of genes involved in cell survival and apoptosis. In addition, TNFSF8 has been shown to regulate the expression of genes involved in the defense against Gram-positive bacteria. TNFSF8 has been implicated in various immune processes, including: * T cell differentiation and proliferation * Regulation of immune cell survival and apoptosis * Defense against Gram-positive bacteria * Regulation of inflammatory responses **Clinical Significance:** TNFSF8 has been implicated in various immune-related diseases, including: * Autoimmune disorders, such as rheumatoid arthritis and lupus * Inflammatory bowel disease * Cancer, including T cell lymphoma * Neurological disorders, such as multiple sclerosis and Alzheimer's disease TNFSF8 has also been shown to have potential therapeutic applications in the treatment of autoimmune disorders and cancer. For example, TNFSF8 has been shown to inhibit the proliferation of T cells in autoimmune disorders, such as rheumatoid arthritis. Additionally, TNFSF8 has been shown to have anti-tumor effects in certain types of cancer, including T cell lymphoma. In conclusion, TNFSF8 plays a critical role in regulating immune responses and has been implicated in various immune-related diseases. Further research is needed to fully understand the mechanisms of TNFSF8 and its potential therapeutic applications. **References:** * [Insert references here] Note: The references section should include a list of relevant studies and reviews on TNFSF8 and its role in immune regulation.

Genular Protein ID: 1484903049

Symbol: TNFL8_HUMAN

Name: Tumor necrosis factor ligand superfamily member 8

UniProtKB Accession Codes:

P32971 O43404

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 1 ExpressionAtlas 1 GO 11 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PIRSF 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 8391931

Title: CD30 antigen, a marker for Hodgkin's lymphoma, is a receptor whose ligand defines an emerging family of cytokines with homology to TNF.

PubMed ID: 8391931

DOI: 10.1016/0092-8674(93)90361-s

PubMed ID: 9349718

Title: Characterisation of the human CD30 ligand gene structure.

PubMed ID: 9349718

DOI: 10.1016/s0167-4781(97)00108-5

Sequence Information:

  • Length: 234
  • Mass: 26017
  • Checksum: C653615682305B1B
  • Sequence:
    • MDPGLQQALN GMAPPGDTAM HVPAGSVASH LGTTSRSYFY LTTATLALCL VFTVATIMVL 
VVQRTDSIPN SPDNVPLKGG NCSEDLLCIL KRAPFKKSWA YLQVAKHLNK TKLSWNKDGI 
LHGVRYQDGN LVIQFPGLYF IICQLQFLVQ CPNNSVDLKL ELLINKHIKK QALVTVCESG 
MQTKHVYQNL SQFLLDYLQV NTTISVNVDT FQYIDTSTFP LENVLSIFLY SNSD

Genular Protein ID: 2997289435

Symbol: A0A087X228_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A087X228

Database IDs:

AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 1 Ensembl 2 ExpressionAtlas 1 GO 1 GeneTree 1 HGNC 1 HOGENOM 1 InterPro 1 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 2 Proteomes 2 RefSeq 1 SAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

Sequence Information:

  • Length: 164
  • Mass: 17834
  • Checksum: EEA0CCF6CDCD1AFE
  • Sequence:
    • MDPGLQQALN GMAPPGDTAM HVPAGSVASH LGTTSRSYFY LTTATLALCL VFTVATIMVL 
VVQRTDSIPN SPDNVPLKGG NCSEDLLCIL KRAPFKKSWA YLQVAKHLNK TKLSWNKDGI 
LHGVRYQDGN LVIQFPDYCG MILHHSHSTL DSGKGHCCLE TLQP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.