MED7 | ENSG00000155868 | NCBI 9443

Details for: MED7

Gene ID: 9443

Symbol: MED7

Ensembl ID: ENSG00000155868

Description: mediator complex subunit 7

Associated with

Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Infectious disease
(R-HSA-5663205)
Metabolism
(R-HSA-1430728)
Metabolism of lipids
(R-HSA-556833)
Ppara activates gene expression
(R-HSA-1989781)
Regulation of lipid metabolism by pparalpha
(R-HSA-400206)
Respiratory syncytial virus infection pathway
(R-HSA-9820952)
Rna polymerase ii transcription
(R-HSA-73857)
Rsv-host interactions
(R-HSA-9833110)
Transcriptional regulation of white adipocyte differentiation
(R-HSA-381340)
Viral infection pathways
(R-HSA-9824446)
Core mediator complex
(GO:0070847)
Mediator complex
(GO:0016592)
Nuclear body
(GO:0016604)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Positive regulation of transcription elongation by rna polymerase ii
(GO:0032968)
Positive regulation of transcription initiation by rna polymerase ii
(GO:0060261)
Protein binding
(GO:0005515)
Protein ubiquitination
(GO:0016567)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Rna polymerase ii preinitiation complex assembly
(GO:0051123)
Somatic stem cell population maintenance
(GO:0035019)
Transcription coactivator activity
(GO:0003713)
Transcription initiation at rna polymerase ii promoter
(GO:0006367)
Transcription regulator complex
(GO:0005667)
Ubiquitin ligase complex
(GO:0000151)
Ubiquitin protein ligase activity
(GO:0061630)

Other Information

Proteins

Mediator of RNA polymerase II transcription subunit 7

Genular Protein ID: 2788529101

Symbol: MED7_HUMAN

Name: Mediator of RNA polymerase II transcription subunit 7

UniProtKB Accession Codes:

O43513

Database IDs:

Citations:

PubMed ID: 9671713

Title: Mammalian mediator of transcriptional regulation and its possible role as an end-point of signal transduction pathways.

PubMed ID: 9671713

DOI: 10.1073/pnas.95.15.8538

PubMed ID: 9989412

Title: The transcriptional cofactor complex CRSP is required for activity of the enhancer-binding protein Sp1.

PubMed ID: 9989412

DOI: 10.1038/17141

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10235267

Title: Composite co-activator ARC mediates chromatin-directed transcriptional activation.

PubMed ID: 10235267

DOI: 10.1038/19789

PubMed ID: 15175163

Title: A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology.

PubMed ID: 15175163

DOI: 10.1016/j.molcel.2004.05.006

PubMed ID: 15989967

Title: MED1/TRAP220 exists predominantly in a TRAP/Mediator subpopulation enriched in RNA polymerase II and is required for ER-mediated transcription.

PubMed ID: 15989967

DOI: 10.1016/j.molcel.2005.05.015

PubMed ID: 17709345

Title: Ubc9 fusion-directed SUMOylation identifies constitutive and inducible SUMOylation.

PubMed ID: 17709345

DOI: 10.1093/nar/gkm617

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 25218447

Title: Uncovering global SUMOylation signaling networks in a site-specific manner.

PubMed ID: 25218447

DOI: 10.1038/nsmb.2890

PubMed ID: 25114211

Title: Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli.

PubMed ID: 25114211

DOI: 10.1073/pnas.1413825111

PubMed ID: 25772364

Title: SUMO-2 orchestrates chromatin modifiers in response to DNA damage.

PubMed ID: 25772364

DOI: 10.1016/j.celrep.2015.02.033

PubMed ID: 25755297

Title: System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability.

PubMed ID: 25755297

DOI: 10.1074/mcp.o114.044792

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

Sequence Information:

Length: 233
Mass: 27245
Checksum: 9D95A2A8360B9C62
Sequence:

MGEPQQVSAL PPPPMQYIKE YTDENIQEGL APKPPPPIKD SYMMFGNQFQ CDDLIIRPLE 
SQGIERLHPM QFDHKKELRK LNMSILINFL DLLDILIRSP GSIKREEKLE DLKLLFVHVH 
HLINEYRPHQ ARETLRVMME VQKRQRLETA ERFQKHLERV IEMIQNCLAS LPDDLPHSEA 
GMRVKTEPMD ADDSNNCTGQ NEHQRENSGH RRDQIIEKDA ALCVLIDEMN ERP

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: MED7

Associated with

Other Information

Mammalian mediator of transcriptional regulation and its possible role as an end-point of signal transduction pathways. PubMed ID: 9671713

The transcriptional cofactor complex CRSP is required for activity of the enhancer-binding protein Sp1. PubMed ID: 9989412

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Composite co-activator ARC mediates chromatin-directed transcriptional activation. PubMed ID: 10235267

A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology. PubMed ID: 15175163

MED1/TRAP220 exists predominantly in a TRAP/Mediator subpopulation enriched in RNA polymerase II and is required for ER-mediated transcription. PubMed ID: 15989967

Ubc9 fusion-directed SUMOylation identifies constitutive and inducible SUMOylation. PubMed ID: 17709345

Large-scale proteomics analysis of the human kinome. PubMed ID: 19369195

Uncovering global SUMOylation signaling networks in a site-specific manner. PubMed ID: 25218447

Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli. PubMed ID: 25114211

SUMO-2 orchestrates chromatin modifiers in response to DNA damage. PubMed ID: 25772364

System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability. PubMed ID: 25755297

Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. PubMed ID: 28112733