Details for: CD33

Gene ID: 945

Symbol: CD33

Ensembl ID: ENSG00000105383

Description: CD33 molecule

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 39.6669
    Cell Significance Index: -6.1700
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 16.4920
    Cell Significance Index: -6.7000
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 14.3861
    Cell Significance Index: -7.4000
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 14.1065
    Cell Significance Index: -6.6600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 8.1216
    Cell Significance Index: -2.0600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 5.0448
    Cell Significance Index: -6.2200
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 3.9259
    Cell Significance Index: 60.7400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 2.7045
    Cell Significance Index: -7.2500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 1.6092
    Cell Significance Index: -6.3500
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 1.3845
    Cell Significance Index: -3.0300
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.3402
    Cell Significance Index: 24.7700
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 1.2285
    Cell Significance Index: 8.1500
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.9614
    Cell Significance Index: 24.5600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.8380
    Cell Significance Index: 22.4200
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: 0.4762
    Cell Significance Index: 3.0400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.3180
    Cell Significance Index: 19.5000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.2137
    Cell Significance Index: 6.8500
  • Cell Name: liver dendritic cell (CL2000055)
    Fold Change: 0.1895
    Cell Significance Index: 0.5000
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.1229
    Cell Significance Index: 3.6100
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.0889
    Cell Significance Index: 0.3700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0872
    Cell Significance Index: 16.5900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0635
    Cell Significance Index: 6.2900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0628
    Cell Significance Index: 56.7500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0422
    Cell Significance Index: 0.9200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0286
    Cell Significance Index: 4.6600
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.0173
    Cell Significance Index: 0.1400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0027
    Cell Significance Index: -5.0900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0049
    Cell Significance Index: -8.9800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0058
    Cell Significance Index: -0.5900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0058
    Cell Significance Index: -8.9800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0067
    Cell Significance Index: -9.1300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0071
    Cell Significance Index: -0.2500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0075
    Cell Significance Index: -5.7100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0081
    Cell Significance Index: -6.0000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0088
    Cell Significance Index: -6.4600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0092
    Cell Significance Index: -5.0000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0100
    Cell Significance Index: -6.3800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0105
    Cell Significance Index: -5.9200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0129
    Cell Significance Index: -4.6300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0130
    Cell Significance Index: -2.7300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0156
    Cell Significance Index: -7.1000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0160
    Cell Significance Index: -4.5900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0163
    Cell Significance Index: -0.4700
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0198
    Cell Significance Index: -0.2900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.0201
    Cell Significance Index: -2.1900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0215
    Cell Significance Index: -4.2700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0221
    Cell Significance Index: -4.4300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0237
    Cell Significance Index: -3.0400
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0271
    Cell Significance Index: -0.3600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0278
    Cell Significance Index: -5.0200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0298
    Cell Significance Index: -1.3500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0324
    Cell Significance Index: -0.8100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0340
    Cell Significance Index: -5.8100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0385
    Cell Significance Index: -5.2900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0397
    Cell Significance Index: -2.5600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0417
    Cell Significance Index: -6.0600
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0424
    Cell Significance Index: -0.8800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0487
    Cell Significance Index: -2.4600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0496
    Cell Significance Index: -6.1000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0526
    Cell Significance Index: -6.1300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0542
    Cell Significance Index: -5.6400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0548
    Cell Significance Index: -7.0900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0556
    Cell Significance Index: -6.3800
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0559
    Cell Significance Index: -2.4300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0575
    Cell Significance Index: -6.7800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.0623
    Cell Significance Index: -4.3100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0774
    Cell Significance Index: -5.9400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0803
    Cell Significance Index: -3.7800
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.0907
    Cell Significance Index: -0.7400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.0920
    Cell Significance Index: -5.5300
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0946
    Cell Significance Index: -1.8500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0948
    Cell Significance Index: -7.0700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0957
    Cell Significance Index: -2.4600
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0983
    Cell Significance Index: -1.6700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1024
    Cell Significance Index: -5.3200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1047
    Cell Significance Index: -7.0400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1120
    Cell Significance Index: -3.1300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1176
    Cell Significance Index: -7.2300
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.1213
    Cell Significance Index: -1.0300
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.1232
    Cell Significance Index: -2.9900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1242
    Cell Significance Index: -6.9700
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: -0.1268
    Cell Significance Index: -1.1600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1276
    Cell Significance Index: -6.7000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1286
    Cell Significance Index: -6.7000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1320
    Cell Significance Index: -6.1600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1452
    Cell Significance Index: -5.0900
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1560
    Cell Significance Index: -6.3900
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.1608
    Cell Significance Index: -2.3400
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.1647
    Cell Significance Index: -2.3600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1650
    Cell Significance Index: -7.3000
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.1657
    Cell Significance Index: -2.0500
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.1668
    Cell Significance Index: -1.4700
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.1714
    Cell Significance Index: -1.7500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1741
    Cell Significance Index: -5.7000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1761
    Cell Significance Index: -5.6100
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.1768
    Cell Significance Index: -2.6700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1784
    Cell Significance Index: -3.8000
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.1853
    Cell Significance Index: -2.6000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1894
    Cell Significance Index: -6.5800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1930
    Cell Significance Index: -7.3100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Cellular Expression:** CD33 is expressed in a diverse range of cell types, including myeloid cells, T-helper 17 cells, dendritic cells, enterocytes, and monocytes. 2. **Glycoprotein Structure:** CD33 is a transmembrane glycoprotein, consisting of a large extracellular domain, a transmembrane region, and a small intracellular domain. 3. **Sialic Acid Binding:** CD33 exhibits high affinity for sialic acid, a key feature of its interaction with other molecules. 4. **Regulatory Functions:** CD33 acts as a negative regulator of cell proliferation, activation, and cytokine production, influencing immune responses and inflammation. **Pathways and Functions:** 1. **Immune Regulation:** CD33 negatively regulates cell proliferation, activation, and cytokine production, modulating immune responses and inflammation. 2. **Cell-Cell Signaling:** CD33 interacts with other molecules, such as sialic acid, to regulate cell-cell signaling and trafficking. 3. **Glycosylation:** CD33's glycoprotein structure is involved in glycosylation, a process critical for protein function and cell-cell interactions. 4. **Regulation of Calcium Ion Transport:** CD33 negatively regulates calcium ion transport, influencing cellular processes such as cell signaling and proliferation. 5. **Regulation of Interleukin-1 Beta and Interleukin-8 Production:** CD33 negatively regulates the production of these pro-inflammatory cytokines, modulating immune responses. **Clinical Significance:** CD33's involvement in immune regulation and its expression in various cell types make it a valuable target for therapeutic interventions. Its role in modulating immune responses and inflammation has led to the development of CD33-targeting therapies, such as monoclonal antibodies, for the treatment of diseases like acute myeloid leukemia (AML) and non-Hodgkin lymphoma (NHL). Additionally, CD33's interaction with sialic acid and other molecules may provide insights into the development of novel immunotherapies for cancer and autoimmune diseases. **Implications for Immunology and Cancer Research:** 1. **Targeting CD33 in Cancer Therapy:** CD33-targeting therapies have shown promise in treating AML and NHL, highlighting the potential of this gene in cancer treatment. 2. **Understanding CD33's Role in Immune Regulation:** Further research into CD33's involvement in immune regulation may lead to a better understanding of immune homeostasis and the development of novel immunotherapies. 3. **Exploring CD33's Interaction with Other Molecules:** The study of CD33's interaction with sialic acid and other molecules may reveal new insights into cellular signaling and trafficking, with implications for various diseases. In conclusion, CD33 is a multifaceted gene involved in immune regulation, cellular signaling, and trafficking. Its significance in cancer therapy and immune homeostasis highlights the importance of continued research into this gene's functions and implications for immunology and cancer research.

Genular Protein ID: 19429687

Symbol: CD33_HUMAN

Name: Myeloid cell surface antigen CD33

UniProtKB Accession Codes:

P20138 B4E3P8 C9JEN7 F8WAL2 Q8TD24

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 2 CPTAC 1 CPTC 1 CTD 1 ChEBI 2 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 2 DrugCentral 1 EMBL 7 Ensembl 3 ExpressionAtlas 1 GO 25 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 8 PDBsum 8 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 RNAct 1 Reactome 2 RefSeq 4 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniLectin 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3139766

Title: Isolation of a cDNA encoding CD33, a differentiation antigen of myeloid progenitor cells.

PubMed ID: 3139766

PubMed ID: 11943481

Title: Genomic organization of the siglec gene locus on chromosome 19q13.4 and cloning of two new siglec pseudogenes.

PubMed ID: 11943481

DOI: 10.1016/s0378-1119(02)00432-8

PubMed ID: 16380601

Title: A study of CD33 (SIGLEC-3) antigen expression and function on activated human T and NK cells: two isoforms of CD33 are generated by alternative splicing.

PubMed ID: 16380601

DOI: 10.1189/jlb.0205096

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7718872

Title: Characterization of CD33 as a new member of the sialoadhesin family of cellular interaction molecules.

PubMed ID: 7718872

PubMed ID: 8702538

Title: A single N-linked glycosylation site is implicated in the regulation of ligand recognition by the I-type lectins CD22 and CD33.

PubMed ID: 8702538

DOI: 10.1074/jbc.271.31.18803

PubMed ID: 10556798

Title: The sialoadhesin CD33 is a myeloid-specific inhibitory receptor.

PubMed ID: 10556798

DOI: 10.1002/(sici)1521-4141(199911)29:11<3440::aid-immu3440>3.0.co;2-c

PubMed ID: 10206955

Title: The myeloid-specific sialic acid-binding receptor, CD33, associates with the protein-tyrosine phosphatases, SHP-1 and SHP-2.

PubMed ID: 10206955

DOI: 10.1074/jbc.274.17.11505

PubMed ID: 10611343

Title: Engagement of p75/AIRM1 or CD33 inhibits the proliferation of normal or leukemic myeloid cells.

PubMed ID: 10611343

DOI: 10.1073/pnas.96.26.15091

PubMed ID: 10887109

Title: Myeloid specific human CD33 is an inhibitory receptor with differential ITIM function in recruiting the phosphatases SHP-1 and SHP-2.

PubMed ID: 10887109

PubMed ID: 11320212

Title: Surface expression and function of p75/AIRM-1 or CD33 in acute myeloid leukemias: engagement of CD33 induces apoptosis of leukemic cells.

PubMed ID: 11320212

DOI: 10.1073/pnas.091097198

PubMed ID: 15597323

Title: Constitutive repressor activity of CD33 on human monocytes requires sialic acid recognition and phosphoinositide 3-kinase-mediated intracellular signaling.

PubMed ID: 15597323

DOI: 10.1002/eji.200425273

PubMed ID: 28325905

Title: Evidence for C1q-mediated crosslinking of CD33/LAIR-1 inhibitory immunoreceptors and biological control of CD33/LAIR-1 expression.

PubMed ID: 28325905

DOI: 10.1038/s41598-017-00290-w

PubMed ID: 28747436

Title: The Alzheimer's disease-protective CD33 splice variant mediates adaptive loss of function via diversion to an intracellular pool.

PubMed ID: 28747436

DOI: 10.1074/jbc.m117.799346

Sequence Information:

  • Length: 364
  • Mass: 39825
  • Checksum: 1C73E588240FBAD8
  • Sequence:
    • MPLLLLLPLL WAGALAMDPN FWLQVQESVT VQEGLCVLVP CTFFHPIPYY DKNSPVHGYW 
FREGAIISRD SPVATNKLDQ EVQEETQGRF RLLGDPSRNN CSLSIVDARR RDNGSYFFRM 
ERGSTKYSYK SPQLSVHVTD LTHRPKILIP GTLEPGHSKN LTCSVSWACE QGTPPIFSWL 
SAAPTSLGPR TTHSSVLIIT PRPQDHGTNL TCQVKFAGAG VTTERTIQLN VTYVPQNPTT 
GIFPGDGSGK QETRAGVVHG AIGGAGVTAL LALCLCLIFF IVKTHRRKAA RTAVGRNDTH 
PTTGSASPKH QKKSKLHGPT ETSSCSGAAP TVEMDEELHY ASLNFHGMNP SKDTSTEYSE 
VRTQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.