Details for: CD33

Gene ID: 945

Symbol: CD33

Ensembl ID: ENSG00000105383

Description: CD33 molecule

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: 4.51
    Marker Score: 3612
  • Cell Name: myelocyte (CL0002193)
    Fold Change: 2.47
    Marker Score: 1069
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 2.46
    Marker Score: 2579
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 2.46
    Marker Score: 617
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: 2.05
    Marker Score: 1347.5
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 2
    Marker Score: 1993
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 1.9
    Marker Score: 1898
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.84
    Marker Score: 102825
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 1.68
    Marker Score: 1708
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 1.67
    Marker Score: 4149
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.61
    Marker Score: 1169
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 1.49
    Marker Score: 820
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 1.45
    Marker Score: 2828
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 1.33
    Marker Score: 1523
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 1.29
    Marker Score: 641
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 1.28
    Marker Score: 32832
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.17
    Marker Score: 485
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4814
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 1.12
    Marker Score: 547
  • Cell Name: basophil (CL0000767)
    Fold Change: 1.12
    Marker Score: 531
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.07
    Marker Score: 676
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251807
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71825
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48049
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 507
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 460
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.97
    Marker Score: 11259
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5324
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.93
    Marker Score: 372
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.93
    Marker Score: 556
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2738
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 325
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 0.9
    Marker Score: 3733
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.87
    Marker Score: 401.5
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5286
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 0.83
    Marker Score: 2146
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.8
    Marker Score: 608
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1267
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 0.78
    Marker Score: 4720
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 708
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 0.76
    Marker Score: 312
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 395
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.7
    Marker Score: 484
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 177
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 0.68
    Marker Score: 1648
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.67
    Marker Score: 1077
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 0.63
    Marker Score: 312
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.63
    Marker Score: 2579
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 0.62
    Marker Score: 280
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.58
    Marker Score: 374
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.57
    Marker Score: 685
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.54
    Marker Score: 172
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: 0.52
    Marker Score: 268
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.51
    Marker Score: 3378
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.51
    Marker Score: 562
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.49
    Marker Score: 369
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 0.43
    Marker Score: 152
  • Cell Name: pre-conventional dendritic cell (CL0002010)
    Fold Change: 0.43
    Marker Score: 127
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 0.43
    Marker Score: 178
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 0.42
    Marker Score: 145
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.42
    Marker Score: 242
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.4
    Marker Score: 737
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 0.4
    Marker Score: 197
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.4
    Marker Score: 199
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.38
    Marker Score: 101
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.38
    Marker Score: 492
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.38
    Marker Score: 258
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.37
    Marker Score: 375
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 0.35
    Marker Score: 240
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 0.34
    Marker Score: 119
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.33
    Marker Score: 337
  • Cell Name: promonocyte (CL0000559)
    Fold Change: 0.33
    Marker Score: 214
  • Cell Name: eosinophil (CL0000771)
    Fold Change: 0.3
    Marker Score: 99
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.3
    Marker Score: 197
  • Cell Name: Langerhans cell (CL0000453)
    Fold Change: 0.29
    Marker Score: 86
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.29
    Marker Score: 193
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.28
    Marker Score: 1774
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.28
    Marker Score: 851
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.25
    Marker Score: 133
  • Cell Name: colon macrophage (CL0009038)
    Fold Change: 0.25
    Marker Score: 69
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.25
    Marker Score: 143
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.25
    Marker Score: 150
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: 0.25
    Marker Score: 149
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.23
    Marker Score: 98
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.23
    Marker Score: 442.5
  • Cell Name: cord blood hematopoietic stem cell (CL2000095)
    Fold Change: 0.23
    Marker Score: 175
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.23
    Marker Score: 138
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 64
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 0.22
    Marker Score: 71
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 74
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 0.21
    Marker Score: 154
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.21
    Marker Score: 143
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.21
    Marker Score: 67
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 0.19
    Marker Score: 280
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.19
    Marker Score: 171
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.18
    Marker Score: 367
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.18
    Marker Score: 101

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Other Information

**Key characteristics:** - CD33 is a type I transmembrane protein with a molecular weight of approximately 110 kDa. - It is expressed as a disulfide-linked homodimer. - It is involved in the regulation of innate and adaptive immune responses. **Pathways and functions:** - CD33 is involved in the regulation of innate immune responses. It is expressed on macrophages and dendritic cells, which are key cells in the innate immune system. - CD33 binds to sialic acids on the surface of immune cells, which is important for the regulation of immune responses. - It is involved in the regulation of adaptive immune responses. It is expressed on activated T-cells and B-cells, and it is involved in the activation of these cells. - CD33 is also involved in the regulation of cell population proliferation, interleukin-1 beta production, interleukin-8 production, and tumor necrosis factor production. **Clinical significance:** - Mutations in the CD33 gene have been linked to a number of human diseases, including systemic sclerosis, rheumatoid arthritis, and cancer. - CD33 is a potential target for the treatment of autoimmune diseases.

Genular Protein ID: 19429687

Symbol: CD33_HUMAN

Name: Myeloid cell surface antigen CD33

UniProtKB Accession Codes:

P20138 B4E3P8 C9JEN7 F8WAL2 Q8TD24

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 2 CPTAC 1 CPTC 1 CTD 1 ChEBI 2 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 2 DrugCentral 1 EMBL 7 EPD 1 Ensembl 3 ExpressionAtlas 1 GO 25 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 14 PDBsum 8 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 RNAct 1 Reactome 2 RefSeq 4 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniLectin 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3139766

Title: Isolation of a cDNA encoding CD33, a differentiation antigen of myeloid progenitor cells.

PubMed ID: 3139766

PubMed ID: 11943481

Title: Genomic organization of the siglec gene locus on chromosome 19q13.4 and cloning of two new siglec pseudogenes.

PubMed ID: 11943481

DOI: 10.1016/s0378-1119(02)00432-8

PubMed ID: 16380601

Title: A study of CD33 (SIGLEC-3) antigen expression and function on activated human T and NK cells: two isoforms of CD33 are generated by alternative splicing.

PubMed ID: 16380601

DOI: 10.1189/jlb.0205096

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7718872

Title: Characterization of CD33 as a new member of the sialoadhesin family of cellular interaction molecules.

PubMed ID: 7718872

PubMed ID: 8702538

Title: A single N-linked glycosylation site is implicated in the regulation of ligand recognition by the I-type lectins CD22 and CD33.

PubMed ID: 8702538

DOI: 10.1074/jbc.271.31.18803

PubMed ID: 10556798

Title: The sialoadhesin CD33 is a myeloid-specific inhibitory receptor.

PubMed ID: 10556798

DOI: 10.1002/(sici)1521-4141(199911)29:11<3440::aid-immu3440>3.0.co;2-c

PubMed ID: 10206955

Title: The myeloid-specific sialic acid-binding receptor, CD33, associates with the protein-tyrosine phosphatases, SHP-1 and SHP-2.

PubMed ID: 10206955

DOI: 10.1074/jbc.274.17.11505

PubMed ID: 10611343

Title: Engagement of p75/AIRM1 or CD33 inhibits the proliferation of normal or leukemic myeloid cells.

PubMed ID: 10611343

DOI: 10.1073/pnas.96.26.15091

PubMed ID: 10887109

Title: Myeloid specific human CD33 is an inhibitory receptor with differential ITIM function in recruiting the phosphatases SHP-1 and SHP-2.

PubMed ID: 10887109

PubMed ID: 11320212

Title: Surface expression and function of p75/AIRM-1 or CD33 in acute myeloid leukemias: engagement of CD33 induces apoptosis of leukemic cells.

PubMed ID: 11320212

DOI: 10.1073/pnas.091097198

PubMed ID: 15597323

Title: Constitutive repressor activity of CD33 on human monocytes requires sialic acid recognition and phosphoinositide 3-kinase-mediated intracellular signaling.

PubMed ID: 15597323

DOI: 10.1002/eji.200425273

PubMed ID: 28325905

Title: Evidence for C1q-mediated crosslinking of CD33/LAIR-1 inhibitory immunoreceptors and biological control of CD33/LAIR-1 expression.

PubMed ID: 28325905

DOI: 10.1038/s41598-017-00290-w

PubMed ID: 28747436

Title: The Alzheimer's disease-protective CD33 splice variant mediates adaptive loss of function via diversion to an intracellular pool.

PubMed ID: 28747436

DOI: 10.1074/jbc.m117.799346

Sequence Information:

  • Length: 364
  • Mass: 39825
  • Checksum: 1C73E588240FBAD8
  • Sequence:
    • MPLLLLLPLL WAGALAMDPN FWLQVQESVT VQEGLCVLVP CTFFHPIPYY DKNSPVHGYW 
FREGAIISRD SPVATNKLDQ EVQEETQGRF RLLGDPSRNN CSLSIVDARR RDNGSYFFRM 
ERGSTKYSYK SPQLSVHVTD LTHRPKILIP GTLEPGHSKN LTCSVSWACE QGTPPIFSWL 
SAAPTSLGPR TTHSSVLIIT PRPQDHGTNL TCQVKFAGAG VTTERTIQLN VTYVPQNPTT 
GIFPGDGSGK QETRAGVVHG AIGGAGVTAL LALCLCLIFF IVKTHRRKAA RTAVGRNDTH 
PTTGSASPKH QKKSKLHGPT ETSSCSGAAP TVEMDEELHY ASLNFHGMNP SKDTSTEYSE 
VRTQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.