GGPS1 | ENSG00000152904 | NCBI 9453

Details for: GGPS1

Gene ID: 9453

Symbol: GGPS1

Ensembl ID: ENSG00000152904

Description: geranylgeranyl diphosphate synthase 1

Associated with

Activation of gene expression by srebf (srebp)
(R-HSA-2426168)
Cholesterol biosynthesis
(R-HSA-191273)
Metabolism
(R-HSA-1430728)
Metabolism of lipids
(R-HSA-556833)
Metabolism of steroids
(R-HSA-8957322)
Regulation of cholesterol biosynthesis by srebp (srebf)
(R-HSA-1655829)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Dimethylallyltranstransferase activity
(GO:0004161)
Farnesyl diphosphate biosynthetic process
(GO:0045337)
Farnesyltranstransferase activity
(GO:0004311)
Geranyl diphosphate biosynthetic process
(GO:0033384)
Geranylgeranyl diphosphate biosynthetic process
(GO:0033386)
Geranyltranstransferase activity
(GO:0004337)
Identical protein binding
(GO:0042802)
Isoprenoid biosynthetic process
(GO:0008299)
Isoprenoid metabolic process
(GO:0006720)
Metal ion binding
(GO:0046872)
Nucleoplasm
(GO:0005654)
Perinuclear region of cytoplasm
(GO:0048471)
Prenyltransferase activity
(GO:0004659)
Protein binding
(GO:0005515)
Z disc
(GO:0030018)

Other Information

Proteins

Geranylgeranyl pyrophosphate synthase

Genular Protein ID: 1433569015

Symbol: GGPPS_HUMAN

Name: Geranylgeranyl pyrophosphate synthase

UniProtKB Accession Codes:

O95749 A8MVQ8 Q5T2C8 Q6NW19

Database IDs:

Citations:

PubMed ID: 9741684

Title: Human geranylgeranyl diphosphate synthase: isolation of the cDNA, chromosomal mapping and tissue expression.

PubMed ID: 9741684

PubMed ID: 10026212

Title: Human geranylgeranyl diphosphate synthase. cDNA cloning and expression.

PubMed ID: 10026212

DOI: 10.1074/jbc.274.9.5888

PubMed ID: 10931946

Title: Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning.

PubMed ID: 10931946

DOI: 10.1073/pnas.160270997

PubMed ID: 10101267

Title: Identification of the GGPS1 genes encoding geranylgeranyl diphosphate synthases from mouse and human.

PubMed ID: 10101267

DOI: 10.1016/s1388-1981(99)00028-1

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 32403198

Title: GGPS1 Mutations Cause Muscular Dystrophy/Hearing Loss/Ovarian Insufficiency Syndrome.

PubMed ID: 32403198

DOI: 10.1002/ana.25772

PubMed ID: 16698791

Title: The crystal structure of human geranylgeranyl pyrophosphate synthase reveals a novel hexameric arrangement and inhibitory product binding.

PubMed ID: 16698791

DOI: 10.1074/jbc.m602603200

Sequence Information:

Length: 300
Mass: 34871
Checksum: F5D1959274BEE27A
Sequence:

MEKTQETVQR ILLEPYKYLL QLPGKQVRTK LSQAFNHWLK VPEDKLQIII EVTEMLHNAS 
LLIDDIEDNS KLRRGFPVAH SIYGIPSVIN SANYVYFLGL EKVLTLDHPD AVKLFTRQLL 
ELHQGQGLDI YWRDNYTCPT EEEYKAMVLQ KTGGLFGLAV GLMQLFSDYK EDLKPLLNTL 
GLFFQIRDDY ANLHSKEYSE NKSFCEDLTE GKFSFPTIHA IWSRPESTQV QNILRQRTEN 
IDIKKYCVHY LEDVGSFEYT RNTLKELEAK AYKQIDARGG NPELVALVKH LSKMFKEENE

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: GGPS1

Associated with

Other Information

Human geranylgeranyl diphosphate synthase: isolation of the cDNA, chromosomal mapping and tissue expression. PubMed ID: 9741684

Human geranylgeranyl diphosphate synthase. cDNA cloning and expression. PubMed ID: 10026212

Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. PubMed ID: 10931946

Identification of the GGPS1 genes encoding geranylgeranyl diphosphate synthases from mouse and human. PubMed ID: 10101267

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence and biological annotation of human chromosome 1. PubMed ID: 16710414

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Initial characterization of the human central proteome. PubMed ID: 21269460

N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. PubMed ID: 22814378

GGPS1 Mutations Cause Muscular Dystrophy/Hearing Loss/Ovarian Insufficiency Syndrome. PubMed ID: 32403198

The crystal structure of human geranylgeranyl pyrophosphate synthase reveals a novel hexameric arrangement and inhibitory product binding. PubMed ID: 16698791