Details for: SIGLEC6

Gene ID: 946

Symbol: SIGLEC6

Ensembl ID: ENSG00000105492

Description: sialic acid binding Ig like lectin 6

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.62
    Marker Score: 1175
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.34
    Marker Score: 1338
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.27
    Marker Score: 4996
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.27
    Marker Score: 860
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.18
    Marker Score: 490
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4823
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.14
    Marker Score: 7592
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.1
    Marker Score: 506
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71837
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48062
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 512
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 465
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30409
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.94
    Marker Score: 377
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5357
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2742
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.91
    Marker Score: 328
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5293
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: 0.86
    Marker Score: 524
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.85
    Marker Score: 648
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.84
    Marker Score: 1358
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.82
    Marker Score: 799
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 712
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.77
    Marker Score: 1573.5
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.73
    Marker Score: 465
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7
    Marker Score: 180
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 0.62
    Marker Score: 506
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.58
    Marker Score: 460
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.55
    Marker Score: 175
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 0.5
    Marker Score: 224
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.49
    Marker Score: 130
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.49
    Marker Score: 204
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 0.48
    Marker Score: 280
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 279
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.45
    Marker Score: 850
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.44
    Marker Score: 436
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.42
    Marker Score: 184
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.4
    Marker Score: 390
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.32
    Marker Score: 323
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.31
    Marker Score: 370
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.29
    Marker Score: 166
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.26
    Marker Score: 4114
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.26
    Marker Score: 90
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 0.24
    Marker Score: 230
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.24
    Marker Score: 78
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.24
    Marker Score: 210
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.23
    Marker Score: 137
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.23
    Marker Score: 65
  • Cell Name: basophil (CL0000767)
    Fold Change: 0.23
    Marker Score: 108
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.23
    Marker Score: 236
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 75
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.21
    Marker Score: 77
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.19
    Marker Score: 1114
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.18
    Marker Score: 97
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 0.18
    Marker Score: 181
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.17
    Marker Score: 43
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.16
    Marker Score: 108
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.15
    Marker Score: 84
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.15
    Marker Score: 100
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.14
    Marker Score: 69
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.13
    Marker Score: 93
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.11
    Marker Score: 102
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.1
    Marker Score: 113
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.1
    Marker Score: 107
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 0.1
    Marker Score: 76
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1
    Marker Score: 210
  • Cell Name: pre-conventional dendritic cell (CL0002010)
    Fold Change: 0.1
    Marker Score: 29
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 0.09
    Marker Score: 244
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.09
    Marker Score: 186
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.09
    Marker Score: 97
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 0.09
    Marker Score: 30
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.08
    Marker Score: 34
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.07
    Marker Score: 79
  • Cell Name: promonocyte (CL0000559)
    Fold Change: 0.07
    Marker Score: 42
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 0.06
    Marker Score: 23
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 0.06
    Marker Score: 38
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.06
    Marker Score: 742
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.06
    Marker Score: 62
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.06
    Marker Score: 14
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 0.06
    Marker Score: 34
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.06
    Marker Score: 50
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.05
    Marker Score: 30
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: 0.05
    Marker Score: 22
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.05
    Marker Score: 13
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.05
    Marker Score: 2982
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.05
    Marker Score: 41
  • Cell Name: B-1b B cell (CL0000821)
    Fold Change: 0.05
    Marker Score: 11
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.05
    Marker Score: 30
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.05
    Marker Score: 12
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.05
    Marker Score: 24.5
  • Cell Name: IgA plasmablast (CL0000984)
    Fold Change: 0.05
    Marker Score: 12
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 0.04
    Marker Score: 40
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.04
    Marker Score: 29
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.04
    Marker Score: 25
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.04
    Marker Score: 71
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.04
    Marker Score: 12
  • Cell Name: Langerhans cell (CL0000453)
    Fold Change: 0.04
    Marker Score: 12
  • Cell Name: myeloid dendritic cell, human (CL0001057)
    Fold Change: 0.04
    Marker Score: 14

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Other Information

**Key characteristics:** * SIGLEC6 is a glycoprotein that is composed of 12 extracellular domain immunoglobulin heavy chains and 12 extracellular domain immunoglobulin light chains. * It is expressed on the cell surface of immune cells and is involved in the regulation of immune responses. * It is a ligand for sialic acid, which is a sugar molecule that is expressed on the surface of many immune cells. * It is involved in the regulation of inflammation and immune tolerance. **Pathways and functions:** * SIGLEC6 is involved in the regulation of inflammation. It is expressed on immune cells and is thought to play a role in the regulation of inflammation by binding to sialic acid on immune cells and triggering a signaling cascade that leads to the inhibition of inflammation. * It is also involved in the regulation of immune tolerance. It is expressed on dendritic cells and is thought to play a role in the regulation of immune tolerance by binding to sialic acid on dendritic cells and triggering the suppression of immune responses. **Clinical significance:** * Mutations in the SIGLEC6 gene have been linked to several autoimmune diseases, including Crohn's disease and rheumatoid arthritis. * SIGLEC6 is a potential target for the treatment of autoimmune diseases.

Genular Protein ID: 108846772

Symbol: SIGL6_HUMAN

Name: Sialic acid-binding Ig-like lectin 6

UniProtKB Accession Codes:

O43699 A8MV71 B2RTS8 C9JBE5 F8WA78 O15388 O43700

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 6 CDD 1 CTD 1 ChEBI 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 8 Ensembl 6 ExpressionAtlas 1 GO 8 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 9 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 6 RNAct 1 Reactome 1 RefSeq 6 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 9465907

Title: Molecular cloning of a novel gene similar to myeloid antigen CD33 and its specific expression in placenta.

PubMed ID: 9465907

DOI: 10.1159/000134676

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10428856

Title: OB-BP1/Siglec-6. A leptin- and sialic acid-binding protein of the immunoglobulin superfamily.

PubMed ID: 10428856

DOI: 10.1074/jbc.274.32.22729

Sequence Information:

  • Length: 453
  • Mass: 49913
  • Checksum: 9DD7FBD8F059E452
  • Sequence:
    • MQGAQEASAS EMLPLLLPLL WAGALAQERR FQLEGPESLT VQEGLCVLVP CRLPTTLPAS 
YYGYGYWFLE GADVPVATND PDEEVQEETR GRFHLLWDPR RKNCSLSIRD ARRRDNAAYF 
FRLKSKWMKY GYTSSKLSVR VMALTHRPNI SIPGTLESGH PSNLTCSVPW VCEQGTPPIF 
SWMSAAPTSL GPRTTQSSVL TITPRPQDHS TNLTCQVTFP GAGVTMERTI QLNVSYAPQK 
VAISIFQGNS AAFKILQNTS SLPVLEGQAL RLLCDADGNP PAHLSWFQGF PALNATPISN 
TGVLELPQVG SAEEGDFTCR AQHPLGSLQI SLSLFVHWKP EGRAGGVLGA VWGASITTLV 
FLCVCFIFRV KTRRKKAAQP VQNTDDVNPV MVSGSRGHQH QFQTGIVSDH PAEAGPISED 
EQELHYAVLH FHKVQPQEPK VTDTEYSEIK IHK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.