Details for: SIGLEC6

Gene ID: 946

Symbol: SIGLEC6

Ensembl ID: ENSG00000105492

Description: sialic acid binding Ig like lectin 6

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 6.4127
    Cell Significance Index: 171.2300
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 2.5811
    Cell Significance Index: 62.5200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.6678
    Cell Significance Index: 21.3900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.5951
    Cell Significance Index: 101.6200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.5133
    Cell Significance Index: 380.2300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.4244
    Cell Significance Index: 89.3900
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.4032
    Cell Significance Index: 8.3700
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.1488
    Cell Significance Index: 2.3600
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.1465
    Cell Significance Index: 0.8900
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0981
    Cell Significance Index: 1.4100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0716
    Cell Significance Index: 44.7200
  • Cell Name: trophoblast giant cell (CL0002488)
    Fold Change: 0.0389
    Cell Significance Index: 0.2800
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 0.0284
    Cell Significance Index: 0.2700
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.0210
    Cell Significance Index: 2.4000
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.0049
    Cell Significance Index: 0.0400
  • Cell Name: pancreatic epsilon cell (CL0005019)
    Fold Change: 0.0032
    Cell Significance Index: 0.0300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0027
    Cell Significance Index: 0.1700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.0005
    Cell Significance Index: 0.2900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0001
    Cell Significance Index: 0.0100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0005
    Cell Significance Index: -0.9200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0009
    Cell Significance Index: -1.7400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0013
    Cell Significance Index: -1.7400
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -0.0016
    Cell Significance Index: -0.0100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0016
    Cell Significance Index: -1.1900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0018
    Cell Significance Index: -1.1600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0019
    Cell Significance Index: -0.6900
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0023
    Cell Significance Index: -0.1000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0029
    Cell Significance Index: -1.3100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0038
    Cell Significance Index: -0.7700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0048
    Cell Significance Index: -1.3700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0053
    Cell Significance Index: -0.2700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0058
    Cell Significance Index: -1.0500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0064
    Cell Significance Index: -1.2700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0074
    Cell Significance Index: -1.0800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0098
    Cell Significance Index: -1.2100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0101
    Cell Significance Index: -1.1600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0102
    Cell Significance Index: -1.4000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0126
    Cell Significance Index: -1.3100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0127
    Cell Significance Index: -1.5000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0129
    Cell Significance Index: -1.3200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0168
    Cell Significance Index: -0.4500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0189
    Cell Significance Index: -1.4500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0194
    Cell Significance Index: -0.9100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0202
    Cell Significance Index: -1.3600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0246
    Cell Significance Index: -1.2800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0246
    Cell Significance Index: -1.5900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0246
    Cell Significance Index: -0.6600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0266
    Cell Significance Index: -1.4900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0268
    Cell Significance Index: -1.3900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0291
    Cell Significance Index: -1.3700
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0343
    Cell Significance Index: -1.2000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0353
    Cell Significance Index: -1.5600
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.0363
    Cell Significance Index: -0.5100
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0374
    Cell Significance Index: -0.9300
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0383
    Cell Significance Index: -0.5600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0400
    Cell Significance Index: -1.3100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0404
    Cell Significance Index: -1.4200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0410
    Cell Significance Index: -1.3100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0415
    Cell Significance Index: -1.5700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0439
    Cell Significance Index: -1.2300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0441
    Cell Significance Index: -1.2000
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0442
    Cell Significance Index: -0.7500
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.0443
    Cell Significance Index: -0.5600
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.0445
    Cell Significance Index: -0.5500
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0477
    Cell Significance Index: -1.1900
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.0497
    Cell Significance Index: -0.5900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0514
    Cell Significance Index: -1.0800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0517
    Cell Significance Index: -1.4900
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0525
    Cell Significance Index: -1.3100
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0530
    Cell Significance Index: -1.3500
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.0552
    Cell Significance Index: -1.6200
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0565
    Cell Significance Index: -1.1800
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.0572
    Cell Significance Index: -0.8200
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0591
    Cell Significance Index: -1.5100
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: -0.0591
    Cell Significance Index: -0.8300
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0592
    Cell Significance Index: -1.2800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0594
    Cell Significance Index: -0.8100
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0596
    Cell Significance Index: -0.7800
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0598
    Cell Significance Index: -0.8500
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.0599
    Cell Significance Index: -0.8700
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0608
    Cell Significance Index: -1.2900
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0612
    Cell Significance Index: -0.8100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0612
    Cell Significance Index: -1.7600
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0622
    Cell Significance Index: -1.2400
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0623
    Cell Significance Index: -0.9200
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.0631
    Cell Significance Index: -0.6000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0633
    Cell Significance Index: -1.0600
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0636
    Cell Significance Index: -1.0300
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.0639
    Cell Significance Index: -1.3000
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.0649
    Cell Significance Index: -0.6900
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0650
    Cell Significance Index: -1.2800
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.0656
    Cell Significance Index: -1.6000
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0662
    Cell Significance Index: -1.3300
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: -0.0663
    Cell Significance Index: -0.5200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0671
    Cell Significance Index: -1.4700
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0673
    Cell Significance Index: -1.3300
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.0673
    Cell Significance Index: -0.9300
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0678
    Cell Significance Index: -0.9300
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.0680
    Cell Significance Index: -1.1200
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0681
    Cell Significance Index: -1.3300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** SIGLEC6 is a type II transmembrane protein that belongs to the Ig-like lectin superfamily. Its primary function is to recognize and bind to sialic acid residues on the surface of cells, which are commonly found on glycoproteins and glycolipids. This binding event triggers various downstream signaling pathways that modulate immune responses, including the activation of immune cells and the regulation of inflammatory responses. SIGLEC6 is expressed on a wide range of cells, including colon goblet cells, enterocytes, placental trophoblasts, and GABAergic interneurons in the cerebral cortex. **Pathways and Functions:** SIGLEC6 plays a critical role in modulating immune responses through the following pathways: 1. **Adaptive Immune System:** SIGLEC6 interacts with immune cells, such as T cells and B cells, to regulate their activation and proliferation. This interaction is mediated by the binding of SIGLEC6 to sialic acid residues on the surface of immune cells. 2. **Cell-Cell Signaling:** SIGLEC6 participates in cell-cell signaling by interacting with other proteins, such as integrins and cadherins, to regulate cell adhesion and migration. 3. **Immune System:** SIGLEC6 modulates immune responses by regulating the interaction between lymphoid and non-lymphoid cells. This interaction is critical for maintaining immune homeostasis and preventing excessive inflammation. 4. **Cytosol and Extracellular Region:** SIGLEC6 is localized to the plasma membrane and cytosol, where it interacts with other proteins and signaling molecules to regulate immune responses. **Clinical Significance:** SIGLEC6 has been implicated in various diseases, including: 1. **Inflammatory Disorders:** SIGLEC6 has been shown to play a role in regulating inflammatory responses, making it a potential target for the treatment of inflammatory disorders, such as rheumatoid arthritis and multiple sclerosis. 2. **Cancer:** SIGLEC6 has been found to be overexpressed in certain types of cancer, including colon cancer, suggesting its potential role in cancer progression and metastasis. 3. **Neurological Disorders:** SIGLEC6 has been implicated in various neurological disorders, including Alzheimer's disease and Parkinson's disease, where it may play a role in regulating immune responses and inflammation. In conclusion, SIGLEC6 is a critical component of the immune system, playing a key role in modulating immune responses and regulating cell-cell interactions. Further research is needed to fully understand the mechanisms by which SIGLEC6 regulates immune responses and to explore its potential therapeutic applications in various diseases.

Genular Protein ID: 108846772

Symbol: SIGL6_HUMAN

Name: Sialic acid-binding Ig-like lectin 6

UniProtKB Accession Codes:

O43699 A8MV71 B2RTS8 C9JBE5 F8WA78 O15388 O43700

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 6 CDD 1 CTD 1 ChEBI 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 8 Ensembl 6 ExpressionAtlas 1 GO 8 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 10 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 6 RNAct 1 Reactome 1 RefSeq 6 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 9465907

Title: Molecular cloning of a novel gene similar to myeloid antigen CD33 and its specific expression in placenta.

PubMed ID: 9465907

DOI: 10.1159/000134676

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10428856

Title: OB-BP1/Siglec-6. A leptin- and sialic acid-binding protein of the immunoglobulin superfamily.

PubMed ID: 10428856

DOI: 10.1074/jbc.274.32.22729

Sequence Information:

  • Length: 453
  • Mass: 49913
  • Checksum: 9DD7FBD8F059E452
  • Sequence:
    • MQGAQEASAS EMLPLLLPLL WAGALAQERR FQLEGPESLT VQEGLCVLVP CRLPTTLPAS 
YYGYGYWFLE GADVPVATND PDEEVQEETR GRFHLLWDPR RKNCSLSIRD ARRRDNAAYF 
FRLKSKWMKY GYTSSKLSVR VMALTHRPNI SIPGTLESGH PSNLTCSVPW VCEQGTPPIF 
SWMSAAPTSL GPRTTQSSVL TITPRPQDHS TNLTCQVTFP GAGVTMERTI QLNVSYAPQK 
VAISIFQGNS AAFKILQNTS SLPVLEGQAL RLLCDADGNP PAHLSWFQGF PALNATPISN 
TGVLELPQVG SAEEGDFTCR AQHPLGSLQI SLSLFVHWKP EGRAGGVLGA VWGASITTLV 
FLCVCFIFRV KTRRKKAAQP VQNTDDVNPV MVSGSRGHQH QFQTGIVSDH PAEAGPISED 
EQELHYAVLH FHKVQPQEPK VTDTEYSEIK IHK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.