Details for: HAND2

Gene ID: 9464

Symbol: HAND2

Ensembl ID: ENSG00000164107

Description: heart and neural crest derivatives expressed 2

Associated with

  • Cardiogenesis
    (R-HSA-9733709)
  • Developmental biology
    (R-HSA-1266738)
  • Gene expression (transcription)
    (R-HSA-74160)
  • Generic transcription pathway
    (R-HSA-212436)
  • Rna polymerase ii transcription
    (R-HSA-73857)
  • Transcriptional regulation by runx2
    (R-HSA-8878166)
  • Adult heart development
    (GO:0007512)
  • Angiogenesis
    (GO:0001525)
  • Apoptotic process involved in heart morphogenesis
    (GO:0003278)
  • Cardiac neural crest cell development involved in outflow tract morphogenesis
    (GO:0061309)
  • Cardiac neural crest cell migration involved in outflow tract morphogenesis
    (GO:0003253)
  • Cardiac right ventricle formation
    (GO:0003219)
  • Cartilage morphogenesis
    (GO:0060536)
  • Cell proliferation involved in outflow tract morphogenesis
    (GO:0061325)
  • Cellular response to organic cyclic compound
    (GO:0071407)
  • Cellular response to retinoic acid
    (GO:0071300)
  • Chromatin
    (GO:0000785)
  • Coronary artery morphogenesis
    (GO:0060982)
  • Dna-binding transcription activator activity, rna polymerase ii-specific
    (GO:0001228)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • E-box binding
    (GO:0070888)
  • Embryonic digit morphogenesis
    (GO:0042733)
  • Embryonic skeletal system development
    (GO:0048706)
  • Epithelial cell apoptotic process
    (GO:1904019)
  • Heart development
    (GO:0007507)
  • Heart looping
    (GO:0001947)
  • In utero embryonic development
    (GO:0001701)
  • Mesenchymal cell proliferation
    (GO:0010463)
  • Minor groove of adenine-thymine-rich dna binding
    (GO:0003680)
  • Negative regulation of cardiac muscle cell apoptotic process
    (GO:0010667)
  • Negative regulation of epithelial cell apoptotic process
    (GO:1904036)
  • Negative regulation of gene expression
    (GO:0010629)
  • Negative regulation of osteoblast differentiation
    (GO:0045668)
  • Noradrenergic neuron differentiation
    (GO:0003357)
  • Norepinephrine biosynthetic process
    (GO:0042421)
  • Nucleus
    (GO:0005634)
  • Odontogenesis of dentin-containing tooth
    (GO:0042475)
  • Osteoblast differentiation
    (GO:0001649)
  • Outflow tract morphogenesis
    (GO:0003151)
  • Peripheral nervous system neuron development
    (GO:0048935)
  • Positive regulation of cardiac muscle hypertrophy
    (GO:0010613)
  • Positive regulation of erk1 and erk2 cascade
    (GO:0070374)
  • Positive regulation of gene expression
    (GO:0010628)
  • Positive regulation of p38mapk cascade
    (GO:1900745)
  • Positive regulation of semaphorin-plexin signaling pathway
    (GO:2001262)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Positive regulation of transcription regulatory region dna binding
    (GO:2000679)
  • Primary palate development
    (GO:1903929)
  • Protein-containing complex
    (GO:0032991)
  • Protein binding
    (GO:0005515)
  • Protein homodimerization activity
    (GO:0042803)
  • Regulation of secondary heart field cardioblast proliferation
    (GO:0003266)
  • Regulation of tissue remodeling
    (GO:0034103)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna polymerase ii-specific dna-binding transcription factor binding
    (GO:0061629)
  • Rna polymerase ii transcription regulatory region sequence-specific dna binding
    (GO:0000977)
  • Sequence-specific double-stranded dna binding
    (GO:1990837)
  • Suckling behavior
    (GO:0001967)
  • Sympathetic nervous system development
    (GO:0048485)
  • Thymus development
    (GO:0048538)
  • Tongue development
    (GO:0043586)
  • Transcription cis-regulatory region binding
    (GO:0000976)
  • Transcription coactivator binding
    (GO:0001223)
  • Transcription regulator complex
    (GO:0005667)
  • Visceral serous pericardium development
    (GO:0061032)

Other Information

Genular Protein ID: 3191406760

Symbol: HAND2_HUMAN

Name: Heart- and neural crest derivatives-expressed protein 2

UniProtKB Accession Codes:

P61296 B6ECG9 O95300 O95301 P97833 Q494T1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 1 ExpressionAtlas 1 GO 57 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 1 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9878849

Title: Molecular cloning of the human HAND2 gene.

PubMed ID: 9878849

DOI: 10.1016/s0167-4781(98)00237-1

PubMed ID: 19348682

Title: Co-regulated expression of HAND2 and DEIN by a bidirectional promoter with asymmetrical activity in neuroblastoma.

PubMed ID: 19348682

DOI: 10.1186/1471-2199-10-28

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 217
  • Mass: 23666
  • Checksum: 528F541BB2173F1E
  • Sequence:
    • MSLVGGFPHH PVVHHEGYPF AAAAAAAAAA AASRCSHEEN PYFHGWLIGH PEMSPPDYSM 
ALSYSPEYAS GAAGLDHSHY GGVPPGAGPP GLGGPRPVKR RGTANRKERR RTQSINSAFA 
ELRECIPNVP ADTKLSKIKT LRLATSYIAY LMDLLAKDDQ NGEAEAFKAE IKKTDVKEEK 
RKKELNEILK STVSSNDKKT KGRTGWPQHV WALELKQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.