IL27RA | ENSG00000104998 | NCBI 9466

Details for: IL27RA

Gene ID: 9466

Symbol: IL27RA

Ensembl ID: ENSG00000104998

Description: interleukin 27 receptor subunit alpha

Associated with

Cytokine signaling in immune system
(R-HSA-1280215)
Immune system
(R-HSA-168256)
Interleukin-12 family signaling
(R-HSA-447115)
Interleukin-27 signaling
(R-HSA-9020956)
Interleukin-35 signalling
(R-HSA-8984722)
Signaling by interleukins
(R-HSA-449147)
Cell surface receptor signaling pathway
(GO:0007166)
Cytokine-mediated signaling pathway
(GO:0019221)
Cytokine binding
(GO:0019955)
Defense response to gram-positive bacterium
(GO:0050830)
External side of plasma membrane
(GO:0009897)
Immune response
(GO:0006955)
Interleukin-27 receptor activity
(GO:0045509)
Interleukin-27-mediated signaling pathway
(GO:0070106)
Negative regulation of interleukin-6 production
(GO:0032715)
Negative regulation of interleukin-17 production
(GO:0032700)
Negative regulation of neuron apoptotic process
(GO:0043524)
Negative regulation of t-helper 17 type immune response
(GO:2000317)
Negative regulation of t cell extravasation
(GO:2000408)
Negative regulation of tumor necrosis factor production
(GO:0032720)
Negative regulation of type 2 immune response
(GO:0002829)
Plasma membrane
(GO:0005886)
Positive regulation of t-helper 1 type immune response
(GO:0002827)
Positive regulation of type ii interferon production
(GO:0032729)
Protein binding
(GO:0005515)
Receptor complex
(GO:0043235)
Regulation of isotype switching to igg isotypes
(GO:0048302)
Transmembrane signaling receptor activity
(GO:0004888)

Other Information

Proteins

Interleukin-27 receptor subunit alpha

Genular Protein ID: 2749961401

Symbol: I27RA_HUMAN

Name: Interleukin-27 receptor subunit alpha

UniProtKB Accession Codes:

Q6UWB1 A0N0L1 O60624

Database IDs:

Citations:

PubMed ID: 9600072

Title: Cloning and characterization of a novel class I cytokine receptor.

PubMed ID: 9600072

DOI: 10.1006/bbrc.1998.8576

PubMed ID: 11057672

Title: Development of Th1-type immune responses requires the type I cytokine receptor TCCR.

PubMed ID: 11057672

DOI: 10.1038/35038103

PubMed ID: 12975309

Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

PubMed ID: 12975309

DOI: 10.1101/gr.1293003

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14764690

Title: WSX-1 and glycoprotein 130 constitute a signal-transducing receptor for IL-27.

PubMed ID: 14764690

DOI: 10.4049/jimmunol.172.4.2225

PubMed ID: 19386761

Title: Humanin inhibits neuronal cell death by interacting with a cytokine receptor complex or complexes involving CNTF receptor alpha/WSX-1/gp130.

PubMed ID: 19386761

DOI: 10.1091/mbc.e09-02-0168

Sequence Information:

Length: 636
Mass: 69474
Checksum: DC7DAAABA643CE97
Sequence:

MRGGRGAPFW LWPLPKLALL PLLWVLFQRT RPQGSAGPLQ CYGVGPLGDL NCSWEPLGDL 
GAPSELHLQS QKYRSNKTQT VAVAAGRSWV AIPREQLTMS DKLLVWGTKA GQPLWPPVFV 
NLETQMKPNA PRLGPDVDFS EDDPLEATVH WAPPTWPSHK VLICQFHYRR CQEAAWTLLE 
PELKTIPLTP VEIQDLELAT GYKVYGRCRM EKEEDLWGEW SPILSFQTPP SAPKDVWVSG 
NLCGTPGGEE PLLLWKAPGP CVQVSYKVWF WVGGRELSPE GITCCCSLIP SGAEWARVSA 
VNATSWEPLT NLSLVCLDSA SAPRSVAVSS IAGSTELLVT WQPGPGEPLE HVVDWARDGD 
PLEKLNWVRL PPGNLSALLP GNFTVGVPYR ITVTAVSASG LASASSVWGF REELAPLVGP 
TLWRLQDAPP GTPAIAWGEV PRHQLRGHLT HYTLCAQSGT SPSVCMNVSG NTQSVTLPDL 
PWGPCELWVT ASTIAGQGPP GPILRLHLPD NTLRWKVLPG ILFLWGLFLL GCGLSLATSG 
RCYHLRHKVL PRWVWEKVPD PANSSSGQPH MEQVPEAQPL GDLPILEVEE MEPPPVMESS 
QPAQATAPLD SGYEKHFLPT PEELGLLGPP RPQVLA

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: IL27RA

Associated with

Other Information

Cloning and characterization of a novel class I cytokine receptor. PubMed ID: 9600072

Development of Th1-type immune responses requires the type I cytokine receptor TCCR. PubMed ID: 11057672

The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. PubMed ID: 12975309

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

WSX-1 and glycoprotein 130 constitute a signal-transducing receptor for IL-27. PubMed ID: 14764690