Details for: CD34

Gene ID: 947

Symbol: CD34

Ensembl ID: ENSG00000174059

Description: CD34 molecule

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 104.6641
    Cell Significance Index: -16.2800
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 35.6178
    Cell Significance Index: -14.4700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 13.2608
    Cell Significance Index: -16.3500
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 5.8751
    Cell Significance Index: 150.0900
  • Cell Name: glomerular capillary endothelial cell (CL1001005)
    Fold Change: 5.7124
    Cell Significance Index: 21.2900
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 5.0804
    Cell Significance Index: 30.0000
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: 5.0300
    Cell Significance Index: 32.1100
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 4.4980
    Cell Significance Index: 79.4900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 4.1991
    Cell Significance Index: -16.5700
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 4.1584
    Cell Significance Index: 81.1600
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 3.9893
    Cell Significance Index: 45.3200
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 3.9566
    Cell Significance Index: 23.9100
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 2.6330
    Cell Significance Index: 37.8700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.8961
    Cell Significance Index: 60.7300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 1.6989
    Cell Significance Index: 85.8600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.6186
    Cell Significance Index: 84.3100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.3999
    Cell Significance Index: 90.3200
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 1.2265
    Cell Significance Index: 7.6800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 1.0744
    Cell Significance Index: 28.7400
  • Cell Name: megakaryocyte progenitor cell (CL0000553)
    Fold Change: 1.0489
    Cell Significance Index: 7.5400
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.8894
    Cell Significance Index: 14.1100
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.6288
    Cell Significance Index: 9.0300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.5779
    Cell Significance Index: 26.2000
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.2925
    Cell Significance Index: 3.0300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2733
    Cell Significance Index: 44.4500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.2081
    Cell Significance Index: 5.9700
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 0.1926
    Cell Significance Index: 0.6700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1378
    Cell Significance Index: 2.9900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.1159
    Cell Significance Index: 6.9600
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.1131
    Cell Significance Index: 1.0900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0978
    Cell Significance Index: 13.4300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0460
    Cell Significance Index: 8.7500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0326
    Cell Significance Index: 0.5500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0324
    Cell Significance Index: 0.6900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0284
    Cell Significance Index: 2.8100
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.0045
    Cell Significance Index: 0.0700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0006
    Cell Significance Index: -0.4100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0008
    Cell Significance Index: -0.5200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0009
    Cell Significance Index: -0.2000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0054
    Cell Significance Index: -3.0200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0081
    Cell Significance Index: -15.1900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0091
    Cell Significance Index: -1.5600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0109
    Cell Significance Index: -1.9600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0110
    Cell Significance Index: -20.3500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0134
    Cell Significance Index: -20.6400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0156
    Cell Significance Index: -21.2100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0175
    Cell Significance Index: -7.7400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0194
    Cell Significance Index: -3.8500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0195
    Cell Significance Index: -14.3100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0205
    Cell Significance Index: -11.2000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0216
    Cell Significance Index: -13.7300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0217
    Cell Significance Index: -16.3900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0342
    Cell Significance Index: -15.5300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0427
    Cell Significance Index: -15.3100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.0484
    Cell Significance Index: -5.2700
  • Cell Name: vein endothelial cell of respiratory system (CL4033008)
    Fold Change: -0.0497
    Cell Significance Index: -0.3200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0538
    Cell Significance Index: -15.4800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0624
    Cell Significance Index: -7.6700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0653
    Cell Significance Index: -1.8800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0679
    Cell Significance Index: -8.7100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0742
    Cell Significance Index: -14.8800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.0787
    Cell Significance Index: -5.4500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0932
    Cell Significance Index: -13.5500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1066
    Cell Significance Index: -10.8900
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1129
    Cell Significance Index: -12.8900
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.1168
    Cell Significance Index: -1.7600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1192
    Cell Significance Index: -15.4000
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.1253
    Cell Significance Index: -5.4500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1325
    Cell Significance Index: -15.1800
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1335
    Cell Significance Index: -2.7700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1352
    Cell Significance Index: -2.8300
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.1366
    Cell Significance Index: -1.7500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1443
    Cell Significance Index: -11.0700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1525
    Cell Significance Index: -17.9900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1532
    Cell Significance Index: -15.9500
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.1619
    Cell Significance Index: -1.9900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1728
    Cell Significance Index: -8.1200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1804
    Cell Significance Index: -14.2900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1845
    Cell Significance Index: -21.5000
  • Cell Name: gut endothelial cell (CL0000131)
    Fold Change: -0.2039
    Cell Significance Index: -1.4000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2060
    Cell Significance Index: -15.3500
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.2093
    Cell Significance Index: -5.0700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.2440
    Cell Significance Index: -6.1000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2610
    Cell Significance Index: -17.5500
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.2691
    Cell Significance Index: -3.7000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2778
    Cell Significance Index: -17.5100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.3120
    Cell Significance Index: -19.1800
  • Cell Name: fibroblast of the aortic adventitia (CL0002547)
    Fold Change: -0.3260
    Cell Significance Index: -3.2900
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: -0.3351
    Cell Significance Index: -3.6400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3386
    Cell Significance Index: -17.7800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3461
    Cell Significance Index: -19.4200
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: -0.3581
    Cell Significance Index: -3.0300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.4012
    Cell Significance Index: -13.9400
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.4048
    Cell Significance Index: -5.1300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.4158
    Cell Significance Index: -21.6000
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: -0.4184
    Cell Significance Index: -4.4100
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.4214
    Cell Significance Index: -15.4700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.4238
    Cell Significance Index: -19.7600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.4286
    Cell Significance Index: -11.4900
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.4471
    Cell Significance Index: -13.1700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** CD34 is a transmembrane glycoprotein composed of two extracellular domains (ECDs) and a single transmembrane domain. Its extracellular domains are rich in sialic acid residues, which are important for its binding to various ligands and receptors. CD34 is expressed on the surface of hematopoietic stem cells, endothelial cells, and other cell types, including pericytes and mesangial cells. Its expression is typically lost as cells differentiate into mature blood cells or undergo apoptosis. **Pathways and Functions** CD34 is involved in numerous signaling pathways, including: 1. **Hematopoiesis**: CD34 plays a crucial role in the development and proliferation of hematopoietic stem cells, which differentiate into various blood cell types, including erythrocytes, leukocytes, and megakaryocytes. 2. **Angiogenesis**: CD34 is a key regulator of endothelial cell proliferation, migration, and differentiation, which are essential for the formation of new blood vessels. 3. **Immune system regulation**: CD34 has been implicated in the regulation of immune responses, including the activation of T cells and the production of cytokines. 4. **Cell-cell adhesion**: CD34 interacts with various ligands and receptors, including selectins and integrins, to regulate cell-cell adhesion and migration. 5. **Signaling transduction**: CD34 can bind to various signaling molecules, including growth factors and cytokines, to regulate downstream signaling pathways. **Clinical Significance** CD34 is an important marker for hematopoietic stem cells, and its expression is often used to diagnose and monitor hematopoietic disorders, such as leukemia and lymphoma. CD34 is also involved in the development of various vascular diseases, including atherosclerosis and cancer metastasis. Its expression has been identified in tumor cells, including those of breast, lung, and colon cancers. In addition, CD34 has been used as a target for the development of cancer therapies, including immunotherapy and targeted therapy. In summary, CD34 is a multifunctional molecule that plays a critical role in hematopoiesis, angiogenesis, and immune system regulation. Its expression has significant clinical implications, and its dysregulation has been implicated in various diseases, including cancer and vascular disorders. Further research is needed to fully understand the mechanisms by which CD34 regulates these biological processes and to develop effective therapeutic strategies targeting this molecule.

Genular Protein ID: 2465656206

Symbol: CD34_HUMAN

Name: Hematopoietic progenitor cell antigen CD34

UniProtKB Accession Codes:

P28906 A8K664 Q15970 Q15971 Q5JTA3 Q5JTA4 Q9UJB1

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 16 Ensembl 2 ExpressionAtlas 1 GO 39 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 2 PRINTS 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 1 RefSeq 2 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1370171

Title: Molecular cloning of a cDNA encoding CD34, a sialomucin of human hematopoietic stem cells.

PubMed ID: 1370171

PubMed ID: 1374051

Title: Structure of the gene encoding CD34, a human hematopoietic stem cell antigen.

PubMed ID: 1374051

DOI: 10.1016/0888-7543(92)90310-o

PubMed ID: 7678811

Title: Two alternative forms of cDNA encoding CD34.

PubMed ID: 7678811

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2462139

Title: Structural and partial amino acid sequence analysis of the human hemopoietic progenitor cell antigen CD34.

PubMed ID: 2462139

PubMed ID: 1694174

Title: Activated protein kinase C directly phosphorylates the CD34 antigen on hematopoietic cells.

PubMed ID: 1694174

DOI: 10.1016/s0021-9258(19)38556-4

Sequence Information:

  • Length: 385
  • Mass: 40716
  • Checksum: BC581A8FCFFE2BB3
  • Sequence:
    • MLVRRGARAG PRMPRGWTAL CLLSLLPSGF MSLDNNGTAT PELPTQGTFS NVSTNVSYQE 
TTTPSTLGST SLHPVSQHGN EATTNITETT VKFTSTSVIT SVYGNTNSSV QSQTSVISTV 
FTTPANVSTP ETTLKPSLSP GNVSDLSTTS TSLATSPTKP YTSSSPILSD IKAEIKCSGI 
REVKLTQGIC LEQNKTSSCA EFKKDRGEGL ARVLCGEEQA DADAGAQVCS LLLAQSEVRP 
QCLLLVLANR TEISSKLQLM KKHQSDLKKL GILDFTEQDV ASHQSYSQKT LIALVTSGAL 
LAVLGITGYF LMNRRSWSPT GERLGEDPYY TENGGGQGYS SGPGTSPEAQ GKASVNRGAQ 
ENGTGQATSR NGHSARQHVV ADTEL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.