Details for: EIF4E2

Gene ID: 9470

Symbol: EIF4E2

Ensembl ID: ENSG00000135930

Description: eukaryotic translation initiation factor 4E family member 2

Associated with

Other Information

Genular Protein ID: 3717930768

Symbol: IF4E2_HUMAN

Name: Eukaryotic translation initiation factor 4E homologous protein

UniProtKB Accession Codes:

O60573 B8ZZJ9 O75349

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChEBI 10 ChiTaRS 1 ComplexPortal 4 DIP 1 DNASU 1 DisGeNET 1 EMBL 11 EPD 1 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 16 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 2 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 11 PDBsum 7 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 2 SAM 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9582349

Title: Cloning and characterization of 4EHP, a novel mammalian eIF4E-related cap-binding protein.

PubMed ID: 9582349

DOI: 10.1074/jbc.273.21.13104

PubMed ID: 15153109

Title: Characterization of mammalian eIF4E-family members.

PubMed ID: 15153109

DOI: 10.1111/j.1432-1033.2004.04149.x

PubMed ID: 9653160

Title: Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full-length cDNA cloning.

PubMed ID: 9653160

DOI: 10.1073/pnas.95.14.8175

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14623119

Title: Human homologue of ariadne promotes the ubiquitylation of translation initiation factor 4E homologous protein, 4EHP.

PubMed ID: 14623119

DOI: 10.1016/s0014-5793(03)01235-3

PubMed ID: 17289916

Title: ISG15 modification of the eIF4E cognate 4EHP enhances cap structure-binding activity of 4EHP.

PubMed ID: 17289916

DOI: 10.1101/gad.1521607

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22751931

Title: A novel 4EHP-GIGYF2 translational repressor complex is essential for mammalian development.

PubMed ID: 22751931

DOI: 10.1128/mcb.00455-12

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 23991149

Title: Investigating the consequences of eIF4E2 (4EHP) interaction with 4E-transporter on its cellular distribution in HeLa cells.

PubMed ID: 23991149

DOI: 10.1371/journal.pone.0072761

PubMed ID: 25624349

Title: The E3 ubiquitin ligase ARIH1 protects against genotoxic stress by initiating a 4EHP-mediated mRNA translation arrest.

PubMed ID: 25624349

DOI: 10.1128/mcb.01152-14

PubMed ID: 28487484

Title: Cap-binding protein 4EHP effects translation silencing by microRNAs.

PubMed ID: 28487484

DOI: 10.1073/pnas.1701488114

PubMed ID: 32726578

Title: GIGYF2 and 4EHP Inhibit Translation Initiation of Defective Messenger RNAs to Assist Ribosome-Associated Quality Control.

PubMed ID: 32726578

DOI: 10.1016/j.molcel.2020.07.007

PubMed ID: 33581076

Title: microRNA-induced translational control of antiviral immunity by the cap-binding protein 4EHP.

PubMed ID: 33581076

DOI: 10.1016/j.molcel.2021.01.030

PubMed ID: 35878012

Title: SARS-CoV-2 impairs interferon production via NSP2-induced repression of mRNA translation.

PubMed ID: 35878012

DOI: 10.1073/pnas.2204539119

PubMed ID: 17368478

Title: Structures of the human eIF4E homologous protein, h4EHP, in its m7GTP-bound and unliganded forms.

PubMed ID: 17368478

DOI: 10.1016/j.jmb.2007.02.019

Sequence Information:

  • Length: 245
  • Mass: 28362
  • Checksum: 3D3075BFA48B3C12
  • Sequence:
    • MNNKFDALKD DDSGDHDQNE ENSTQKDGEK EKTERDKNQS SSKRKAVVPG PAEHPLQYNY 
TFWYSRRTPG RPTSSQSYEQ NIKQIGTFAS VEQFWRFYSH MVRPGDLTGH SDFHLFKEGI 
KPMWEDDANK NGGKWIIRLR KGLASRCWEN LILAMLGEQF MVGEEICGAV VSVRFQEDII 
SIWNKTASDQ ATTARIRDTL RRVLNLPPNT IMEYKTHTDS IKMPGRLGPQ RLLFQNLWKP 
RLNVP

Genular Protein ID: 2750045397

Symbol: B8ZZL3_HUMAN

Name: N/A

UniProtKB Accession Codes:

B8ZZL3

Database IDs:

AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 3 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 3 Gene3D 1 GeneTree 1 GenomeRNAi 1 HGNC 1 InterPro 3 MassIVE 1 MaxQB 2 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 1 PeptideAtlas 1 Pfam 1 Proteomes 2 ProteomicsDB 1 RefSeq 1 RuleBase 1 SAM 1 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

Sequence Information:

  • Length: 200
  • Mass: 23248
  • Checksum: 00045C4E138F95D0
  • Sequence:
    • MNNKFDALKD DDSGDHDQNE ENSTQKDGEK EKTERDKNQS SSKRKVEQFW RFYSHMVRPG 
DLTGHSDFHL FKEGIKPMWE DDANKNGGKW IIRLRKGLAS RCWENLILAM LGEQFMVGEE 
ICGAVVSVRF QEDIISIWNK TASDQATTAR IRDTLRRVLN LPPNTIMEYK THTDSIKMPG 
RLGPQRLLFQ NLWKPRLNVP

Genular Protein ID: 2573201793

Symbol: A0A8I5KSA5_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A8I5KSA5

Database IDs:

CTD 1 EMBL 3 EPD 1 Ensembl 2 GO 3 Gene3D 1 GeneTree 1 HGNC 1 InterPro 3 MaxQB 1 NCBI Taxonomy 1 PANTHER 2 PROSITE 1 Pfam 1 Proteomes 2 RefSeq 1 RuleBase 1 SAM 1 SMR 1 SUPFAM 1

Citations:

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

Sequence Information:

  • Length: 191
  • Mass: 22106
  • Checksum: 6693D8441138F3EA
  • Sequence:
    • MNNKFDALKD DDSGDHDQNE ENSTQKDGEK EKTERDKNQS SSKRKVEQFW RFYSHMVRPG 
DLTGHSDFHL FKEGIKPMWE DDANKNGGKW IIRLRKGLAS RCWENLILAM LGEQFMVGEE 
ICGAVVSVRF QEDIISIWNK TASDQATTAR IRDTLRRVLN LPPNTIMEYK THTDSIKAWE 
EFHGLVNSSG R

Genular Protein ID: 2812467461

Symbol: Q59FE1_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q59FE1

Database IDs:

AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 EMBL 2 GO 3 Gene3D 1 GenomeRNAi 1 InterPro 3 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 1 PeptideAtlas 1 Pfam 1 RefSeq 3 RuleBase 1 SAM 1 SMR 1 SUPFAM 1

Sequence Information:

  • Length: 243
  • Mass: 27829
  • Checksum: 5B40CDC9AD1B40D2
  • Sequence:
    • GSGDSGGERM NNKFDALKDD DSGDHDQNEE NSTQKDGEKE KTERDKNQSS SKRKAVVPGP 
AEHPLQYNYT FWYSRRTPGR PTSSQSYEQN IKQIGTFASV EQFWRFYSHM VRPGDLTGHS 
DFHLFKEGIK PMWEDDANKN GGKWIIRLRK GLASRCWENL ILAMLGEQFM VGEEICGAVV 
SVRFQEDIIS IWNKTASDQA TTARIRDTLR RVLNLPPNTI MEYKTHTDSI KDNSSFRNTK 
ITL

Genular Protein ID: 2613155645

Symbol: B9A023_HUMAN

Name: N/A

UniProtKB Accession Codes:

B9A023

Database IDs:

AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 3 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 3 Gene3D 1 GeneTree 1 GenomeRNAi 1 HGNC 1 InterPro 3 MassIVE 1 MaxQB 2 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 1 PeptideAtlas 1 Pfam 1 Proteomes 2 ProteomicsDB 1 RefSeq 1 RuleBase 1 SAM 1 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

Sequence Information:

  • Length: 189
  • Mass: 21913
  • Checksum: 890DD40044663AEC
  • Sequence:
    • MNNKFDALKD DDSGDHDQNE ENSTQKDGEK EKTERDKNQS SSKRKVEQFW RFYSHMVRPG 
DLTGHSDFHL FKEGIKPMWE DDANKNGGKW IIRLRKGLAS RCWENLILAM LGEQFMVGEE 
ICGAVVSVRF QEDIISIWNK TASDQATTAR IRDTLRRVLN LPPNTIMEYK THTDSIKDNS 
SFRNTKITL

Genular Protein ID: 3450466682

Symbol: B8ZZ50_HUMAN

Name: N/A

UniProtKB Accession Codes:

B8ZZ50

Database IDs:

AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 3 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 3 Gene3D 1 GeneTree 1 GenomeRNAi 1 HGNC 1 InterPro 3 MassIVE 1 MaxQB 2 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 1 Pfam 1 Proteomes 2 ProteomicsDB 1 RefSeq 1 RuleBase 1 SAM 1 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

Sequence Information:

  • Length: 236
  • Mass: 27219
  • Checksum: 14ED5779A02BEC24
  • Sequence:
    • MNNKFDALKD DDSGDHDQNE ENSTQKDGEK EKTERDKNQS SSKRKAVVPG PAEHPLQYNY 
TFWYSRRTPG RPTSSQSYEQ NIKQIGTFAS VEQFWRFYSH MVRPGDLTGH SDFHLFKEGI 
KPMWEDDANK NGGKWIIRLR KGLASRCWEN LILAMLGEQF MVGEEICGAV VSVRFQEDII 
SIWNKTASDQ ATTARIRDTL RRVLNLPPNT IMEYKTHTDS IKAWEEFHGL VNSSGR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.